{"id":"https://openalex.org/W1963522337","doi":"https://doi.org/10.1093/nar/24.9.1787","title":"The Human Ubiquitin C Promoter Directs High Ubiquitous Expression of Transgenes in Mice","display_name":"The Human Ubiquitin C Promoter Directs High Ubiquitous Expression of Transgenes in Mice","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W1963522337","doi":"https://doi.org/10.1093/nar/24.9.1787","mag":"1963522337","pmid":"https://pubmed.ncbi.nlm.nih.gov/8650001","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/145851"},"language":"en","primary_location":{"id":"doi:10.1093/nar/24.9.1787","doi":"https://doi.org/10.1093/nar/24.9.1787","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/24.9.1787","pdf_url":"https://academic.oup.com/nar/article-pdf/24/9/1787/3984563/24-9-1787.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/nar/article-pdf/24/9/1787/3984563/24-9-1787.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058850160","display_name":"Michael Schorpp","orcid":"https://orcid.org/0000-0003-2067-2480","observed_orcids":["https://orcid.org/0000-0003-2067-2480"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Schorpp","raw_affiliation_strings":["Deutsches Krebsforschungszentrum Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deutsches Krebsforschungszentrum Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075855591","display_name":"Richard J\u00e4ger","orcid":"https://orcid.org/0000-0002-1623-1917","observed_orcids":["https://orcid.org/0000-0002-1623-1917"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Jager","raw_affiliation_strings":["Forschungszentrum Karlsruhe, Institut f\u00fcr Genetik, Postfach 3640, D-76021 Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Forschungszentrum Karlsruhe, Institut f\u00fcr Genetik, Postfach 3640, D-76021 Karlsruhe, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040221274","display_name":"K. Schellander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195525897","display_name":"Research Institute of Molecular Pathology","ror":"https://ror.org/02c5jsm26","country_code":"AT","type":"facility","lineage":["https://openalex.org/I195525897"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"K. Schellander","raw_affiliation_strings":["Research Institute of Molecular Pathology (IMP), Dr Bohr-Gasse 7, A-1030 Vienna, Austria","Research Institute of Molecular Pathology (IMP)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Molecular Pathology (IMP), Dr Bohr-Gasse 7, A-1030 Vienna, Austria","institution_ids":["https://openalex.org/I195525897"]},{"raw_affiliation_string":"Research Institute of Molecular Pathology (IMP)","institution_ids":["https://openalex.org/I195525897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034150617","display_name":"Johannes Schenkel","orcid":"https://orcid.org/0000-0002-3326-1130","observed_orcids":["https://orcid.org/0000-0002-3326-1130"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Schenkel","raw_affiliation_strings":["Forschungszentrum Karlsruhe, Institut f\u00fcr Genetik, Postfach 3640, D-76021 Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Forschungszentrum Karlsruhe, Institut f\u00fcr Genetik, Postfach 3640, D-76021 Karlsruhe, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004832527","display_name":"Erwin Friedrich Wagner","orcid":"https://orcid.org/0000-0001-7872-0196","observed_orcids":["https://orcid.org/0000-0001-7872-0196"]},"institutions":[{"id":"https://openalex.org/I195525897","display_name":"Research Institute of Molecular Pathology","ror":"https://ror.org/02c5jsm26","country_code":"AT","type":"facility","lineage":["https://openalex.org/I195525897"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"E. F. Wagner","raw_affiliation_strings":["Research Institute of Molecular Pathology (IMP), Dr Bohr-Gasse 7, A-1030 Vienna, Austria","Research Institute of Molecular Pathology (IMP)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Molecular Pathology (IMP), Dr Bohr-Gasse 7, A-1030 Vienna, Austria","institution_ids":["https://openalex.org/I195525897"]},{"raw_affiliation_string":"Research Institute of Molecular Pathology (IMP)","institution_ids":["https://openalex.org/I195525897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050233418","display_name":"Hans Weiher","orcid":"https://orcid.org/0000-0001-7521-9662","observed_orcids":["https://orcid.org/0000-0001-7521-9662"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Weiher","raw_affiliation_strings":["Forschungszentrum Karlsruhe, Institut f\u00fcr Genetik, Postfach 3640, D-76021 Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Forschungszentrum Karlsruhe, Institut f\u00fcr Genetik, Postfach 3640, D-76021 Karlsruhe, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015350812","display_name":"Peter E. Angel","orcid":"https://orcid.org/0000-0001-8234-5587","observed_orcids":["https://orcid.org/0000-0001-8234-5587"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"P. Angel","raw_affiliation_strings":["Deutsches Krebsforschungszentrum Heidelberg, Abteilung Signaltransduktion und Wachstumskontrolle, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deutsches Krebsforschungszentrum Heidelberg, Abteilung Signaltransduktion und Wachstumskontrolle, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015350812"],"corresponding_institution_ids":["https://openalex.org/I17937529"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":null,"fwci":0.8277,"has_fulltext":true,"cited_by_count":206,"citation_normalized_percentile":{"value":0.68945714,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"24","issue":"9","first_page":"1787","last_page":"1788"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.921999990940094},{"id":"https://openalex.org/keywords/junb","display_name":"JunB","score":0.8709999918937683},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.6970000267028809},{"id":"https://openalex.org/keywords/tissue-specific-promoters","display_name":"tissue-specific promoters","score":0.4569999873638153},{"id":"https://openalex.org/keywords/transgene-overexpression","display_name":"transgenic overexpression","score":0.5370000004768372},{"id":"https://openalex.org/keywords/ubiquitin-ligase","display_name":"ubiquitin ligase","score":0.3569999933242798},{"id":"https://openalex.org/keywords/ubiquitin-ligase-inhibitors","display_name":"ubiquitin ligase inhibitors","score":0.36800000071525574}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9578168392181396},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.7474843859672546},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6933737993240356},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5057692527770996},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45428773760795593},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4478783905506134},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4115258455276489},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3979969024658203}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014452","descriptor_name":"Ubiquitins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016758","descriptor_name":"Genes, jun","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/nar/24.9.1787","doi":"https://doi.org/10.1093/nar/24.9.1787","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/24.9.1787","pdf_url":"https://academic.oup.com/nar/article-pdf/24/9/1787/3984563/24-9-1787.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:235994","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC145851","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:8650001","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8650001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:145851","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC145851/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.323.2622","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.323.2622","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/24/9/1787.full.pdf","raw_type":"text"},{"id":"pmh:oai:pub.h-brs.de:3733","doi":null,"is_oa":false,"landing_page_url":"https://pub.h-brs.de/frontdoor/index/index/docId/3733","pdf_url":null,"source":{"id":"https://openalex.org/S4306400385","display_name":"Publication Server of Bonn-Rhein-Sieg University of Applied Sciences (Bonn-Rhein-Sieg University of Applied Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I135140700","host_organization_name":"University of Bonn","host_organization_lineage":["https://openalex.org/I135140700"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN 0305-1048","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1093/nar/24.9.1787","doi":"https://doi.org/10.1093/nar/24.9.1787","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/24.9.1787","pdf_url":"https://academic.oup.com/nar/article-pdf/24/9/1787/3984563/24-9-1787.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1963522337.pdf","grobid_xml":"https://content.openalex.org/works/W1963522337.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1535070554","https://openalex.org/W1956232719","https://openalex.org/W1985916913","https://openalex.org/W2042917826","https://openalex.org/W2061263854","https://openalex.org/W2069592391","https://openalex.org/W2077468883","https://openalex.org/W2078457332","https://openalex.org/W2085307337","https://openalex.org/W2094872845","https://openalex.org/W2129752729","https://openalex.org/W2158714866"],"related_works":["https://openalex.org/W2061904546","https://openalex.org/W7096518287","https://openalex.org/W4230127037","https://openalex.org/W2032265018","https://openalex.org/W2108912070","https://openalex.org/W2014174829","https://openalex.org/W2036161725","https://openalex.org/W2004878924","https://openalex.org/W2102353345","https://openalex.org/W1956232719"],"abstract_inverted_index":{"Transgenic":[0],"mice":[1,17],"provide":[2],"one":[3,698],"of":[4,26,30,36,69,82,93,105,114,125,133,137,166,207,213,229,253,274,291,309,315,319,331,353,371,396,411,418,420,434,452,476,483,609,627,664,687,696,699,703,720,738,773,844,850,863,926],"the":[5,19,27,31,34,42,49,52,57,80,94,103,111,115,138,163,196,214,242,275,288,292,302,310,320,326,372,387,435,453,487,558,575,583,624,628,633,644,653,665,671,675,683,688,700,704,724,739,749,785,788,795,807,811,825,861,864,889,905,924,927],"best":[6],"experimental":[7,75],"systems":[8],"to":[9,65,162,250,283,286,298,340,430,486,565,590,712,859],"study":[10],"gene":[11,119,295,323,336,797],"function":[12],"in":[13,23,86,129,180,204,218,235,260,265,374,409,425,478,506,514,522,540,570,573,600,604,741,838],"vivo.":[14],"Although":[15],"transgenic":[16,261,348,776,853],"carry":[18,271],"additional":[20],"genetic":[21],"material":[22],"every":[24],"cell":[25,220],"body,":[28],"expression":[29,92,108,124,206,216,370,385,419,475,532,568,603,827,833,862],"transgenes":[32,424,477,740],"under":[33],"control":[35,595,805,922],"constitutive":[37],"promoter/enhancer":[38,488,577],"units,":[39],"such":[40,543],"as":[41,247,544,791,793,910,919],"murine":[43,53],"major":[44],"histocompatibility":[45],"complex":[46],"promoter":[47,55,61,200,246,279,562,631,708],"H2-Kb,":[48,497],"CMV":[50,498],"enhancer/promoter,":[51],"Pgk-1":[54,500],"or":[56,301,499,521,829,852],"chicken":[58],"cytoplasmatic":[59],"\u03b2-actin":[60],"is":[62,141,201,563,611,718,908],"often":[63],"restricted":[64],"a":[66,83,87,106,126,130,157,592,605,760,804],"limited":[67],"number":[68],"tissues":[70,376,410,427,484,572,610],"(1\u20135).":[71],"However,":[72],"for":[73,169,536,598,623,784,806,881,923],"most":[74],"dominant":[76],"gain-of-function":[77],"approaches":[78],"addressing":[79],"role":[81],"given":[84,127],"protein":[85,173],"multicellular":[88],"organism":[89],"an":[90,479,774,831,894,920],"ubiquitous":[91,233,450],"transgene":[95,128,373,455,602,666,701,751,789,890],"might":[96],"be":[97,391,591],"highly":[98,142,504],"desired.":[99],"Here":[100],"we":[101,239],"report":[102],"application":[104],"powerful":[107,231,593],"vector":[109,689,834],"using":[110,759],"5\u2032-flanking":[112,587],"region":[113,280,290],"human":[116,197,243,276,303,321,468,559,584,705,725,882,906],"ubiquitin":[117,139,151,175,198,244,277,469,560,585,629,706],"C":[118,199,245,278,447,470,561,586,630,707],"that":[120,195,490,678,818,902],"allows":[121],"very":[122,202,530,606],"efficient":[123],"broad":[131,607],"range":[132,482,608],"tissues.":[134,744],"The":[135,416,449,467,662,693,715,780,885,897],"structure":[136,663],"proteins":[140,152,168,176],"conserved":[143],"during":[144],"evolution.":[145],"In":[146,227],"human,":[147],"there":[148],"exist":[149],"several":[150],"which":[153,377,574,601],"are":[154,491,503,579,799,891],"encoded":[155],"by":[156,460,496,641,754,801,893],"multigene":[158],"family":[159],"(6).":[160],"According":[161],"general":[164],"requirement":[165],"these":[167],"ATP-dependent,":[170],"non-lysosomal":[171],"intracellular":[172],"degradation":[174],"have":[177,240,679],"been":[178,534,680,820],"found":[179,535],"all":[181,375],"eukaryotic":[182],"cells":[183,238,817],"examined":[184,379],"so":[185],"far":[186],"(for":[187],"review":[188],"see":[189],"7,8).":[190],"Previous":[191],"work":[192,638],"has":[193,533],"demonstrated":[194],"active":[203],"conferring":[205],"exogenous":[208],"genes":[209],"following":[210],"transient":[211],"transfection":[212],"appropriate":[215],"vectors":[217],"various":[219,742,848],"lines":[221,356,363],"(9;":[222],"Schorpp":[223],"and":[224,232,258,269,325,328,345,358,360,365,382,402,408,422,440,442,446,509,517,525,546,551,553,619,632,651,658,674,728,731,735,765,879],"Angel,":[225],"unpublished).":[226],"view":[228],"its":[230],"activity":[234],"tissue":[236],"culture":[237],"used":[241,339,918],"regulatory":[248,501,538],"unit":[249,539,596],"drive":[251],"overexpression":[252],"two":[254,346],"cellular":[255],"genes,":[256],"junB":[257,294,421,672],"bcl-2\u03b1,":[259],"mice.":[262],"As":[263,803],"shown":[264,909],"Figure":[266],"1A,":[267],"Ubi-JunB":[268,388,750,826],"Ubi-Bcl-2\u03b1":[270],"1.2":[272],"kb":[273],"(position":[281,296],"\u22121225":[282,711],"\u22126)":[284],"fused":[285],"either":[287,697,824],"coding":[289,311],"mouse":[293,349,743,777,899],"+240":[297],"+1485;":[299],"10)":[300],"bcl-2\u03b1":[304,347,362,423,454,634,676,865,883,900],"cDNA":[305,673,677],"(11)":[306],"respectively.":[307,636],"3\u2032":[308,316,716],"sequences,":[312],"150":[313,721],"bp":[314,722],"nontranslated":[317],"sequences":[318,330,471,502,578,588],"c-jun":[322,726],"(12)":[324,727,758],"splice":[327,730],"poly(A)":[329,732],"SV40":[332,729],"were":[333,338,378,428,752,876],"inserted.":[334],"These":[335],"constructs":[337],"generate":[341],"four":[342,354],"independent":[343],"Ubi-junB":[344,355,812],"lines.":[350],"Two":[351],"out":[352],"(1598":[357],"1605)":[359],"both":[361],"(2266":[364],"2272)":[366,856],"showed":[367],"high":[368,567],"level":[369],"(Fig.":[380,414],"1B":[381,445],"C).":[383],"Efficient":[384],"from":[386,643,652,709,723,748,769,787,794,810,815,847,872,888],"construct":[389],"could":[390],"detected":[392],"at":[393],"early":[394],"stages":[395],"development":[397],"(10.5,":[398],"11.5,":[399],"12.5,":[400],"14.5":[401],"15.5":[403],"d.p.c.;":[404],"data":[405],"not":[406,465],"shown)":[407],"adult":[412,775],"animals":[413,854],"1B).":[415],"levels":[417],"some":[426],"up":[429],"20-fold":[431],"higher":[432],"than":[433],"endogenous":[436,796,898],"transcript":[437,786,901],"(e.g.":[438],"liver":[439,549],"brain,":[441,913],"brain;":[443],"Fig.":[444],"respectively).":[448],"presence":[451],"product":[456],"was":[457,639,836,857,917],"also":[458,569],"confirmed":[459],"western":[461],"blot":[462],"analysis":[463,843],"(data":[464],"shown).":[466],"described":[472],"here":[473],"allow":[474],"even":[480],"wider":[481],"compared":[485],"units":[489],"routinely":[492],"used.":[493],"Transgenes":[494],"driven":[495],"expressed":[505],"spleen,":[507,515],"lung":[508],"salivary":[510],"glands":[511],"(H2-Kb;":[512],"1),":[513],"stomach":[516,545],"heart":[518],"(CMV;":[519],"2,3),":[520],"heart,":[523],"kidney":[524],"brain":[526,547],"(Pgk-1;":[527],"4).":[528],"Only":[529],"low":[531],"each":[537],"certain":[541],"tissues,":[542],"(H2-Kb),":[548],"(CMV":[550],"Pgk-1)":[552],"spleen":[554],"(Pgk-1).":[555],"Most":[556],"importantly,":[557],"able":[564],"confer":[566],"those":[571],"other":[576],"hardly":[580],"active.":[581],"Therefore,":[582],"appear":[589],"transcriptional":[594],"useful":[597],"experiments":[599],"required.":[612],"We":[613,649],"thank":[614],"Drs":[615],"L.":[616],"E.":[617,621],"Theill":[618],"G.":[620],"Evan":[622],"kind":[625],"gifts":[626],"cDNA,":[635],"This":[637],"supported":[640],"grants":[642],"Deutsche":[645],"Forschungsgemeinschaft":[646],"(An":[647],"182/6-2,":[648],"970/5)":[650],"European":[654],"Economic":[655],"Community":[656],"Biomedicine":[657],"Health":[659],"Program.":[660],"(A)":[661],"constructs.":[667],"Dashed":[668],"boxes":[669],"represent":[670],"cloned":[681],"into":[682],"multiple":[684],"cloning":[685],"site":[686],"(MCS,":[690],"solid":[691],"box).":[692],"5\u2032":[694],"end":[695,717],"consists":[702],"position":[710],"\u22126":[713],"(9).":[714],"composed":[719],"sequences.":[733],"(B":[734],"C)":[736],"Expression":[737],"(B)":[745],"Transcripts":[746],"derived":[747,809],"monitored":[753],"RNase":[755],"protection":[756],"mapping":[757],"junB-specific":[761],"antisense":[762],"RNA":[763,768,814,846,875],"probe":[764,907],"20\u00b5g":[766],"total":[767,845,874],"10":[770],"different":[771],"organs":[772,849],"(line":[778,855],"1598).":[779],"protected":[781],"fragments":[782],"specific":[783],"(T)":[790],"well":[792,911],"(E)":[798],"indicated":[800],"arrows.":[802],"transcripts":[808,886],"transgene,":[813],"F9":[816],"had":[819],"transiently":[821],"transfected":[822],"with":[823,830,904],"vector,":[828],"empty":[832],"(RSV-O)":[835],"analyzed":[837],"parallel.":[839],"(C)":[840],"Northern":[841],"Blot":[842],"wild-type":[851],"performed":[858],"analyze":[860],"transgene.":[866],"Fifteen":[867],"\u00b5g":[868],"(or":[869],"5":[870],"\u00b5mg":[871],"skin)":[873],"electrophoresed,":[877],"blotted":[878],"probed":[880],"expression.":[884],"originated":[887],"marked":[892],"arrow":[895],"(T).":[896],"crosshybridizes":[903],"(E:":[912],"thymus).":[914],"Glyceraldehyde-3-phosphate-dehydrogenase":[915],"(GAPDH)":[916],"internal":[921],"quality":[925],"RNA.":[928]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
