{"id":"https://openalex.org/W1963514643","doi":"https://doi.org/10.3109/02652048.2011.630106","title":"Formulation, optimization and evaluation of spray-dried mucoadhesive microspheres as intranasal carriers for Valsartan","display_name":"Formulation, optimization and evaluation of spray-dried mucoadhesive microspheres as intranasal carriers for Valsartan","publication_year":2011,"publication_date":"2011-11-02","ids":{"openalex":"https://openalex.org/W1963514643","doi":"https://doi.org/10.3109/02652048.2011.630106","mag":"1963514643","pmid":"https://pubmed.ncbi.nlm.nih.gov/22047546"},"language":"en","primary_location":{"id":"doi:10.3109/02652048.2011.630106","doi":"https://doi.org/10.3109/02652048.2011.630106","is_oa":false,"landing_page_url":"https://doi.org/10.3109/02652048.2011.630106","pdf_url":null,"source":{"id":"https://openalex.org/S160681128","display_name":"Journal of Microencapsulation","issn_l":"0265-2048","issn":["0265-2048","1464-5246"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Microencapsulation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036541992","display_name":"Chandrakantsing Vijaysing Pardeshi","orcid":"https://orcid.org/0000-0001-7264-0603","observed_orcids":["https://orcid.org/0000-0001-7264-0603"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chandrakant V. Pardeshi","raw_affiliation_strings":["Department of Pharmaceutics, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060136575","display_name":"Pravin V. Rajput","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pravin V. Rajput","raw_affiliation_strings":["Department of Pharmaceutics, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110918131","display_name":"Veena Shailendra Belgamwar","orcid":"https://orcid.org/0009-0008-2055-1869","observed_orcids":["https://orcid.org/0009-0008-2055-1869"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Veena S. Belgamwar","raw_affiliation_strings":["Department of Pharmaceutics, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070651078","display_name":"Avinash Ramrao Tekade","orcid":"https://orcid.org/0000-0001-8564-1859","observed_orcids":["https://orcid.org/0000-0001-8564-1859"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Avinash R. Tekade","raw_affiliation_strings":["Department of Pharmaceutics, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5070651078"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7283,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.88428764,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"29","issue":"2","first_page":"103","last_page":"114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12048","display_name":"Microencapsulation and Drying Processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valsartan","display_name":"valsartan","score":0.968999981880188},{"id":"https://openalex.org/keywords/intranasal-drug-delivery","display_name":"intranasal drug delivery","score":0.9700000286102295},{"id":"https://openalex.org/keywords/mucoadhesive-microspheres","display_name":"mucoadhesive microspheres","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hydroxypropyl-methylcellulose","display_name":"hydroxypropyl methylcellulose","score":0.828000009059906},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.44600000977516174},{"id":"https://openalex.org/keywords/factorial-design-optimization","display_name":"factorial design optimization","score":0.5899999737739563},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.75},{"id":"https://openalex.org/keywords/mucoadhesion","display_name":"mucoadhesion","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C2780020223","wikidata":"https://www.wikidata.org/wiki/Q25323681","display_name":"Mucoadhesion","level":4,"score":0.8981174230575562},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.6714185476303101},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6512264013290405},{"id":"https://openalex.org/C39519442","wikidata":"https://www.wikidata.org/wiki/Q904893","display_name":"Differential scanning calorimetry","level":2,"score":0.48969247937202454},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.4820469319820404},{"id":"https://openalex.org/C2778540859","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Swelling","level":2,"score":0.47744685411453247},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4488372206687927},{"id":"https://openalex.org/C2777387769","wikidata":"https://www.wikidata.org/wiki/Q155472","display_name":"Valsartan","level":3,"score":0.4221703112125397},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.41958245635032654},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4154318869113922},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.4027036130428314},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3514527976512909},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2936979830265045},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27487820386886597},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.23593774437904358},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.15694648027420044},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068756","descriptor_name":"Valsartan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000268","descriptor_name":"Adhesiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002152","descriptor_name":"Calorimetry, Differential Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014633","descriptor_name":"Valine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014633","descriptor_name":"Valine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014633","descriptor_name":"Valine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047228","descriptor_name":"Angiotensin II Type 1 Receptor Blockers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3109/02652048.2011.630106","doi":"https://doi.org/10.3109/02652048.2011.630106","is_oa":false,"landing_page_url":"https://doi.org/10.3109/02652048.2011.630106","pdf_url":null,"source":{"id":"https://openalex.org/S160681128","display_name":"Journal of Microencapsulation","issn_l":"0265-2048","issn":["0265-2048","1464-5246"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Microencapsulation","raw_type":"journal-article"},{"id":"pmid:22047546","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22047546","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of microencapsulation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W13604522","https://openalex.org/W207190506","https://openalex.org/W1963481363","https://openalex.org/W1970297709","https://openalex.org/W1978985018","https://openalex.org/W1987617726","https://openalex.org/W2014486769","https://openalex.org/W2018340655","https://openalex.org/W2025131341","https://openalex.org/W2027446854","https://openalex.org/W2027715406","https://openalex.org/W2038602532","https://openalex.org/W2042896447","https://openalex.org/W2052526822","https://openalex.org/W2053559208","https://openalex.org/W2055210487","https://openalex.org/W2061932684","https://openalex.org/W2074568185","https://openalex.org/W2106647432","https://openalex.org/W2107137470","https://openalex.org/W2133433956","https://openalex.org/W2135590855","https://openalex.org/W2610882567"],"related_works":["https://openalex.org/W4281668422","https://openalex.org/W3011284005","https://openalex.org/W1978985018","https://openalex.org/W2938567395","https://openalex.org/W2018722220","https://openalex.org/W3080246327","https://openalex.org/W2038780553","https://openalex.org/W2958750526","https://openalex.org/W2268618769","https://openalex.org/W4408573468"],"abstract_inverted_index":{"This":[0],"investigation":[1],"deals":[2],"with":[3,15,112,123],"the":[4,37,64,134,144],"intranasal":[5,152],"delivery":[6,149],"of":[7,25,39,41,63,95,108,127,133,146],"Valsartan,":[8],"encapsulated":[9],"in":[10,59,77,80,138],"HPMC-based":[11],"spray-dried":[12],"mucoadhesive":[13],"microspheres,":[14],"an":[16],"aim":[17],"to":[18],"provide":[19],"rapid":[20],"absorption":[21],"and":[22,50,58,90,101,115],"quick":[23],"onset":[24],"action":[26],"for":[27,36,70,151],"treating":[28],"hypertension.":[29],"A":[30],"2\u00b3-factorial":[31],"design":[32],"has":[33],"been":[34],"employed":[35],"assessment":[38],"influence":[40],"three":[42],"independent":[43],"variables,":[44],"namely":[45],"inlet":[46],"temperature,":[47],"feed-flow":[48],"rate":[49],"drug-polymer":[51],"ratio":[52],"on":[53,129],"production":[54],"yield,":[55],"particle":[56,71],"size":[57],"vitro":[60,78,81],"drug":[61,82,86,148],"diffusion":[62],"prepared":[65],"microspheres.":[66],"Microspheres":[67],"were":[68],"evaluated":[69],"size,":[72],"entrapment":[73],"efficiency,":[74],"swelling":[75],"property,":[76],"mucoadhesion,":[79],"diffusion,":[83],"ex":[84],"vivo":[85],"permeation,":[87],"histopathological":[88],"examination":[89],"stability":[91],"studies.":[92],"The":[93],"results":[94],"differential":[96],"scanning":[97,102],"calorimetry,":[98],"X-ray":[99],"diffraction":[100],"electron":[103],"microscopy":[104],"revealed":[105],"molecular":[106],"dispersion":[107],"Valsartan":[109],"into":[110],"microspheres":[111],"spherical":[113],"shape":[114],"smooth":[116],"surface.":[117],"Optimized":[118],"formulation":[119],"indicated":[120],"good":[121],"mucoadhesion":[122],"no":[124],"severe":[125],"sign":[126],"damage":[128],"nasal":[130],"mucosa.":[131],"Results":[132],"non-invasive":[135],"animal":[136],"studies":[137],"dexamethasone-induced":[139],"hypertensive":[140],"rat":[141],"model":[142],"suggested":[143],"suitability":[145],"investigated":[147],"system":[150],"administration.":[153]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}