{"id":"https://openalex.org/W1963496112","doi":"https://doi.org/10.1042/bj3610621","title":"Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage","display_name":"Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage","publication_year":2002,"publication_date":"2002-01-25","ids":{"openalex":"https://openalex.org/W1963496112","doi":"https://doi.org/10.1042/bj3610621","mag":"1963496112","pmid":"https://pubmed.ncbi.nlm.nih.gov/11802792","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1222345"},"language":"en","primary_location":{"id":"doi:10.1042/bj3610621","doi":"https://doi.org/10.1042/bj3610621","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj3610621","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/361/3/621/708481/bj3610621.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055039013","display_name":"Fr\u00e9d\u00e9ric Bost","orcid":"https://orcid.org/0000-0003-4509-4701","observed_orcids":["https://orcid.org/0000-0003-4509-4701"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387154757","display_name":"Universit\u00e9 Nice Sophia Antipolis","ror":"https://ror.org/02k9vew78","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394","https://openalex.org/I4387154757"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric BOST","raw_affiliation_strings":["INSERM E9911 and IFR50, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Nice Sophia Antipolis, Avenue de Valombrose, Nice 06107, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM E9911 and IFR50, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Nice Sophia Antipolis, Avenue de Valombrose, Nice 06107, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387154757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007783206","display_name":"Leslie Caron","orcid":"https://orcid.org/0000-0003-4118-2974","observed_orcids":["https://orcid.org/0000-0003-4118-2974"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387154757","display_name":"Universit\u00e9 Nice Sophia Antipolis","ror":"https://ror.org/02k9vew78","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394","https://openalex.org/I4387154757"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Leslie CARON","raw_affiliation_strings":["INSERM E9911 and IFR50, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Nice Sophia Antipolis, Avenue de Valombrose, Nice 06107, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM E9911 and IFR50, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Nice Sophia Antipolis, Avenue de Valombrose, Nice 06107, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387154757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009353400","display_name":"Ir\u00e8ne Marchetti","orcid":"https://orcid.org/0009-0002-6605-9614","observed_orcids":["https://orcid.org/0009-0002-6605-9614"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387154757","display_name":"Universit\u00e9 Nice Sophia Antipolis","ror":"https://ror.org/02k9vew78","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394","https://openalex.org/I4387154757"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ir\u00e8ne MARCHETTI","raw_affiliation_strings":["INSERM E9911 and IFR50, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Nice Sophia Antipolis, Avenue de Valombrose, Nice 06107, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM E9911 and IFR50, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Nice Sophia Antipolis, Avenue de Valombrose, Nice 06107, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387154757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084915485","display_name":"Christian Dani","orcid":"https://orcid.org/0000-0003-3228-0230","observed_orcids":["https://orcid.org/0000-0003-3228-0230"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387154757","display_name":"Universit\u00e9 Nice Sophia Antipolis","ror":"https://ror.org/02k9vew78","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394","https://openalex.org/I4387154757"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christian DANI","raw_affiliation_strings":["CNRS UMR 6543, Facult\u00e9 des Sciences, Universit\u00e9 de Nice Sophia Antipolis, Nice 06107, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS UMR 6543, Facult\u00e9 des Sciences, Universit\u00e9 de Nice Sophia Antipolis, Nice 06107, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387154757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055223267","display_name":"Yannick LE MARCHAND\u2010BRUSTEL","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387154757","display_name":"Universit\u00e9 Nice Sophia Antipolis","ror":"https://ror.org/02k9vew78","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394","https://openalex.org/I4387154757"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yannick LE MARCHAND-BRUSTEL","raw_affiliation_strings":["INSERM E9911 and IFR50 , Faculte! de Me! decine , Universite! de Nice Sophia Antipolis , Avenue de Valombrose , Nice 06107 , France , and","INSERM E9911 and IFR50, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Nice Sophia Antipolis, Avenue de Valombrose, Nice 06107, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM E9911 and IFR50 , Faculte! de Me! decine , Universite! de Nice Sophia Antipolis , Avenue de Valombrose , Nice 06107 , France , and","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387154757"]},{"raw_affiliation_string":"INSERM E9911 and IFR50, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Nice Sophia Antipolis, Avenue de Valombrose, Nice 06107, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387154757"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015247637","display_name":"Bernard Bin\u00e9truy","orcid":"https://orcid.org/0000-0001-8012-7092","observed_orcids":["https://orcid.org/0000-0001-8012-7092"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387154757","display_name":"Universit\u00e9 Nice Sophia Antipolis","ror":"https://ror.org/02k9vew78","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394","https://openalex.org/I4387154757"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bernard BIN\u00c9TRUY","raw_affiliation_strings":["INSERM E9911 and IFR50, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Nice Sophia Antipolis, Avenue de Valombrose, Nice 06107, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM E9911 and IFR50, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Nice Sophia Antipolis, Avenue de Valombrose, Nice 06107, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387154757"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5007783206"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387154757"],"apc_list":null,"apc_paid":null,"fwci":3.2506,"has_fulltext":true,"cited_by_count":189,"citation_normalized_percentile":{"value":0.93031142,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"361","issue":"3","first_page":"621","last_page":"621"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.03779999911785126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.9589999914169312},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8539999723434448},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.8050000071525574},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/lineage-commitment","display_name":"lineage commitment","score":0.6809999942779541},{"id":"https://openalex.org/keywords/pd98059","display_name":"PD98059","score":0.8960000276565552},{"id":"https://openalex.org/keywords/embryoid-bodies","display_name":"embryoid bodies","score":0.6790000200271606},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.9049999713897705},{"id":"https://openalex.org/keywords/adipocyte-lipid-binding-protein","display_name":"adipocyte lipid-binding protein","score":0.949999988079071},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.5139999985694885},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.7611249685287476},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7171107530593872},{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.6459194421768188},{"id":"https://openalex.org/C143948831","wikidata":"https://www.wikidata.org/wiki/Q3384920","display_name":"Embryoid body","level":5,"score":0.6011989712715149},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.5814495086669922},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5585536956787109},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5509525537490845},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5028635859489441},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.49847936630249023},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.4864747226238251},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.4676263928413391},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.451092004776001},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4103821814060211},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.2692912817001343},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.2229994237422943},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.191386878490448},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.18841701745986938},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07160288095474243},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.04868146777153015},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002070","descriptor_name":"Butadienes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1042/bj3610621","doi":"https://doi.org/10.1042/bj3610621","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj3610621","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"doi:10.1042/0264-6021:3610621","doi":"https://doi.org/10.1042/0264-6021:3610621","is_oa":true,"landing_page_url":"https://doi.org/10.1042/0264-6021:3610621","pdf_url":"https://portlandpress.com/biochemj/article-pdf/361/3/621/708481/bj3610621.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1222345","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1222345","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:11802792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11802792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1042/0264-6021:3610621","doi":"https://doi.org/10.1042/0264-6021:3610621","is_oa":true,"landing_page_url":"https://doi.org/10.1042/0264-6021:3610621","pdf_url":"https://portlandpress.com/biochemj/article-pdf/361/3/621/708481/bj3610621.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7675999999046326,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320327235","display_name":"Servier","ror":"https://ror.org/034e7c066"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1963496112.pdf","grobid_xml":"https://content.openalex.org/works/W1963496112.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W28018459","https://openalex.org/W1566737177","https://openalex.org/W1669533272","https://openalex.org/W1965180249","https://openalex.org/W1968703258","https://openalex.org/W1971915141","https://openalex.org/W1974159373","https://openalex.org/W1979478060","https://openalex.org/W1992160731","https://openalex.org/W1995398218","https://openalex.org/W1995754186","https://openalex.org/W1995819749","https://openalex.org/W1999468613","https://openalex.org/W2001859961","https://openalex.org/W2002519246","https://openalex.org/W2017709679","https://openalex.org/W2018855387","https://openalex.org/W2021494076","https://openalex.org/W2025135710","https://openalex.org/W2025631499","https://openalex.org/W2027090731","https://openalex.org/W2035936653","https://openalex.org/W2040070918","https://openalex.org/W2053153929","https://openalex.org/W2055807458","https://openalex.org/W2058375425","https://openalex.org/W2070466054","https://openalex.org/W2075832020","https://openalex.org/W2077880395","https://openalex.org/W2080988481","https://openalex.org/W2086262311","https://openalex.org/W2088995677","https://openalex.org/W2091673549","https://openalex.org/W2108173771","https://openalex.org/W2109950167","https://openalex.org/W2118981873","https://openalex.org/W2134812217","https://openalex.org/W2135778926","https://openalex.org/W2141568746","https://openalex.org/W2144738965","https://openalex.org/W2151807579","https://openalex.org/W2155437852","https://openalex.org/W2159047813","https://openalex.org/W2164015929","https://openalex.org/W2172677241","https://openalex.org/W2404854096"],"related_works":["https://openalex.org/W1556876610","https://openalex.org/W2092548849","https://openalex.org/W2135305006","https://openalex.org/W2153153466","https://openalex.org/W1966976677","https://openalex.org/W2111972362","https://openalex.org/W2115463333","https://openalex.org/W2159047813","https://openalex.org/W2079814058","https://openalex.org/W1507092067"],"abstract_inverted_index":{"Mouse":[0],"embryonic":[1],"stem":[2],"(ES)":[3],"cells":[4,7,18,142],"are":[5],"pluripotent":[6],"that":[8,124,169],"differentiate":[9],"into":[10,19,143],"multiple":[11],"cell":[12],"lineages.":[13],"The":[14],"commitment":[15,139,185],"of":[16,47,54,66,88,92,99,110,140,158,179,186],"ES":[17,55,141,187],"the":[20,37,45,48,67,72,86,100,111,138,155,159,183],"adipocyte":[21,106,114],"lineage":[22],"is":[23,127,172],"dependent":[24],"on":[25],"an":[26,176],"early":[27,177],"3-day":[28],"treatment":[29],"with":[30,59,94,137],"all-trans":[31],"retinoic":[32],"acid":[33],"(RA).":[34],"To":[35,84],"characterize":[36],"molecular":[38],"mechanisms":[39],"underlying":[40],"this":[41,170],"process,":[42],"we":[43,122],"examined":[44],"contribution":[46],"extracellular-signal-regulated":[49],"kinase":[50,79],"(ERK)":[51],"pathway.":[52],"Treatment":[53],"cell-derived":[56],"embryoid":[57],"bodies":[58],"RA":[60,93,131],"resulted":[61],"in":[62,162],"a":[63,96],"prolonged":[64],"activation":[65,126],"ERK":[68,89,101,125,160],"pathway,":[69,103],"but":[70],"not":[71,135],"c-Jun":[73],"N-terminal":[74],"kinase,":[75],"p38":[76],"mitogen-activated":[77],"protein":[78,116],"or":[80],"phosphoinositide":[81],"3-kinase":[82],"pathways.":[83],"investigate":[85],"role":[87,157],"activation,":[90],"co-treatment":[91],"PD98059,":[95],"specific":[97],"inhibitor":[98],"signalling":[102],"prevented":[104],"both":[105],"formation":[107],"and":[108,117,150],"expression":[109],"adipogenic":[112],"markers,":[113],"lipid-binding":[115],"peroxisome-proliferator-activated":[118],"receptor":[119],"gamma.":[120],"Furthermore,":[121],"show":[123],"required":[128,174],"only":[129],"during":[130],"treatment.":[132],"PD98059":[133],"does":[134],"interfere":[136],"other":[144],"lineages,":[145],"such":[146],"as":[147],"neurogenesis,":[148],"myogenesis":[149],"cardiomyogenesis.":[151],"As":[152],"opposed":[153],"to":[154,182],"controversial":[156],"pathway":[161,171],"terminal":[163],"differentiation,":[164],"our":[165],"results":[166],"clearly":[167],"demonstrate":[168],"specifically":[173],"at":[175],"stage":[178],"adipogenesis,":[180],"corresponding":[181],"RA-dependent":[184],"cells.":[188]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}