{"id":"https://openalex.org/W19634549","doi":"https://doi.org/10.1200/jco.2009.27.15_suppl.e11560","title":"Pathologic complete response (pCR) in HER2 positive breast cancer to sequential FEC 100-docetaxel (D) plus trastuzumab (T) neoadjuvant chemotherapy (NCT)","display_name":"Pathologic complete response (pCR) in HER2 positive breast cancer to sequential FEC 100-docetaxel (D) plus trastuzumab (T) neoadjuvant chemotherapy (NCT)","publication_year":2009,"publication_date":"2009-05-20","ids":{"openalex":"https://openalex.org/W19634549","doi":"https://doi.org/10.1200/jco.2009.27.15_suppl.e11560","mag":"19634549"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2009.27.15_suppl.e11560","doi":"https://doi.org/10.1200/jco.2009.27.15_suppl.e11560","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2009.27.15_suppl.e11560","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072502548","display_name":"Philippe J. M. Chollet","orcid":"https://orcid.org/0000-0001-8457-7568","observed_orcids":["https://orcid.org/0000-0001-8457-7568"]},"institutions":[{"id":"https://openalex.org/I4210124119","display_name":"Centre Jean Perrin","ror":"https://ror.org/02pwnhd33","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124119"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. J. Chollet","raw_affiliation_strings":["Centre Jean Perrin, Clermont Ferrand, France; Centre Jean Perrin, Clermont-Ferrand, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Jean Perrin, Clermont Ferrand, France; Centre Jean Perrin, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I4210124119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090227780","display_name":"P. Dubray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124119","display_name":"Centre Jean Perrin","ror":"https://ror.org/02pwnhd33","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124119"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. Dubray","raw_affiliation_strings":["Centre Jean Perrin, Clermont Ferrand, France; Centre Jean Perrin, Clermont-Ferrand, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Jean Perrin, Clermont Ferrand, France; Centre Jean Perrin, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I4210124119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030260555","display_name":"Xavier Durando","orcid":"https://orcid.org/0000-0001-6035-3172","observed_orcids":["https://orcid.org/0000-0001-6035-3172","https://orcid.org/0000-0001-7971-9808"]},"institutions":[{"id":"https://openalex.org/I4210124119","display_name":"Centre Jean Perrin","ror":"https://ror.org/02pwnhd33","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124119"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"X. Durando","raw_affiliation_strings":["Centre Jean Perrin, Clermont Ferrand, France; Centre Jean Perrin, Clermont-Ferrand, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Jean Perrin, Clermont Ferrand, France; Centre Jean Perrin, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I4210124119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029086962","display_name":"Catherine Abrial","orcid":"https://orcid.org/0000-0002-1759-9457","observed_orcids":["https://orcid.org/0000-0002-1759-9457"]},"institutions":[{"id":"https://openalex.org/I4210124119","display_name":"Centre Jean Perrin","ror":"https://ror.org/02pwnhd33","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124119"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Abrial","raw_affiliation_strings":["Centre Jean Perrin, Clermont Ferrand, France; Centre Jean Perrin, Clermont-Ferrand, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Jean Perrin, Clermont Ferrand, France; Centre Jean Perrin, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I4210124119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012766729","display_name":"B. Nayl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124119","display_name":"Centre Jean Perrin","ror":"https://ror.org/02pwnhd33","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124119"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B. Nayl","raw_affiliation_strings":["Centre Jean Perrin, Clermont Ferrand, France; Centre Jean Perrin, Clermont-Ferrand, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Jean Perrin, Clermont Ferrand, France; Centre Jean Perrin, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I4210124119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069540694","display_name":"Marie\u2010Ange Mouret\u2010Reynier","orcid":"https://orcid.org/0000-0001-6981-1678","observed_orcids":["https://orcid.org/0000-0001-6981-1678","https://orcid.org/0000-0001-5542-5813"]},"institutions":[{"id":"https://openalex.org/I4210124119","display_name":"Centre Jean Perrin","ror":"https://ror.org/02pwnhd33","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124119"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. Mouret-Reynier","raw_affiliation_strings":["Centre Jean Perrin, Clermont Ferrand, France; Centre Jean Perrin, Clermont-Ferrand, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Jean Perrin, Clermont Ferrand, France; Centre Jean Perrin, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I4210124119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064960834","display_name":"Christophe Pomel","orcid":"https://orcid.org/0000-0003-3903-7321","observed_orcids":["https://orcid.org/0000-0003-3903-7321","https://orcid.org/0009-0008-6748-3445"]},"institutions":[{"id":"https://openalex.org/I4210124119","display_name":"Centre Jean Perrin","ror":"https://ror.org/02pwnhd33","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124119"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Pomel","raw_affiliation_strings":["Centre Jean Perrin, Clermont Ferrand, France; Centre Jean Perrin, Clermont-Ferrand, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Jean Perrin, Clermont Ferrand, France; Centre Jean Perrin, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I4210124119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083921204","display_name":"Aurelie Belliere","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124119","display_name":"Centre Jean Perrin","ror":"https://ror.org/02pwnhd33","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124119"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A. Belli\u00e8re","raw_affiliation_strings":["Centre Jean Perrin, Clermont Ferrand, France; Centre Jean Perrin, Clermont-Ferrand, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Jean Perrin, Clermont Ferrand, France; Centre Jean Perrin, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I4210124119"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Lemery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124119","display_name":"Centre Jean Perrin","ror":"https://ror.org/02pwnhd33","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124119"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S. Lemery","raw_affiliation_strings":["Centre Jean Perrin, Clermont Ferrand, France; Centre Jean Perrin, Clermont-Ferrand, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Jean Perrin, Clermont Ferrand, France; Centre Jean Perrin, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I4210124119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061340891","display_name":"Frederique Madeleine Penault-Llorca","orcid":"https://orcid.org/0000-0002-4279-5492","observed_orcids":["https://orcid.org/0000-0002-4279-5492"]},"institutions":[{"id":"https://openalex.org/I4210124119","display_name":"Centre Jean Perrin","ror":"https://ror.org/02pwnhd33","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124119"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F. Penault-Llorca","raw_affiliation_strings":["Centre Jean Perrin, Clermont Ferrand, France; Centre Jean Perrin, Clermont-Ferrand, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Jean Perrin, Clermont Ferrand, France; Centre Jean Perrin, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I4210124119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210124119"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"15_suppl","first_page":"e11560","last_page":"e11560"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.05649999901652336,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9739999771118164},{"id":"https://openalex.org/keywords/pathological-complete-response","display_name":"pathological complete response","score":0.9589999914169312},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.9580000042915344},{"id":"https://openalex.org/keywords/epirubicin","display_name":"epirubicin","score":0.902999997138977},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.8539999723434448},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":1.0},{"id":"https://openalex.org/keywords/sequential-chemotherapy","display_name":"sequential chemotherapy","score":0.9070000052452087},{"id":"https://openalex.org/keywords/inflammatory-breast-cancer","display_name":"inflammatory breast cancer","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cardiac-function","display_name":"cardiac function","score":0.49900001287460327},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.5709999799728394},{"id":"https://openalex.org/keywords/breast-conserving-surgery","display_name":"breast-conserving surgery","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9460756182670593},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.7862293720245361},{"id":"https://openalex.org/C2780835546","wikidata":"https://www.wikidata.org/wiki/Q425122","display_name":"Epirubicin","level":4,"score":0.7637380361557007},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.7354353666305542},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7056299448013306},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5651423931121826},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.498903751373291},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48762431740760803},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4866960346698761},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.46819624304771423},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.35428428649902344},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3444598317146301}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2009.27.15_suppl.e11560","doi":"https://doi.org/10.1200/jco.2009.27.15_suppl.e11560","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2009.27.15_suppl.e11560","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2589903569","https://openalex.org/W2624627361","https://openalex.org/W2243312532","https://openalex.org/W2588133229","https://openalex.org/W2589997888","https://openalex.org/W2078277595","https://openalex.org/W1970210435","https://openalex.org/W2104337757","https://openalex.org/W2912564084","https://openalex.org/W2034044377"],"abstract_inverted_index":{"e11560":[0],"Background:":[1],"Trastuzumab":[2],"plus":[3],"chemotherapy":[4],"has":[5],"become":[6],"the":[7,192,304,307],"standard":[8],"of":[9,37,44,81,97,113,173,191,253,306,332,352],"care":[10],"for":[11,309,323],"Her-2-positive":[12],"breast":[13,56,75,148,208],"cancer.":[14,209],"Recent":[15],"trials":[16],"have":[17],"shown":[18],"higher":[19],"pCR":[20,115,282,353],"rates":[21],"in":[22,65,247,348,354],"Her2-positive":[23,55,355],"tumors":[24,193,228],"with":[25,54,74,341],"trastuzumab-driven":[26],"combinations":[27],"(Buzdar,":[28],"JCO":[29],"2005;":[30],"Coudert,":[31],"Ann":[32],"Oncol,":[33,124],"2006).":[34],"The":[35],"purpose":[36],"this":[38],"study":[39],"was":[40,116,150,166,185,194,245,258,321],"to":[41,71,119,132,315,367],"review":[42],"efficacity":[43],"sequential":[45],"FEC":[46,82,237],"followed":[47,93],"by":[48,94],"D+T.":[49],"Methods:":[50],"21":[51],"patients":[52],"(pts)":[53],"cancer":[57,76],"(defined":[58],"as":[59,126,140],"either":[60],"immunohistochemical":[61],"3+":[62],"or":[63,106,156],"fluorescence":[64],"situ":[66],"hybridization-positive)":[67],"from":[68],"June":[69],"2006":[70],"September":[72],"2008":[73],"received":[77],"3":[78,95,101,109,155,171,179],"cycles":[79],"(c)":[80],"100":[83,86,238],"(":[84],"epirubicin":[85],"mg/m2":[87],"+":[88],"5-fluorouracil":[89],"and":[90,129,131,146,159,177,224,233,266,288,291,300],"cyclophosphamide":[91],"500mg/m2)":[92],"c":[96,158,172],"D":[98],"(100mg/m2)":[99],"every":[100,108,178],"weeks":[102,110,112,344],"+T":[103],"2mg/kg":[104],"weekly":[105],"6mg/kg":[107],"(9":[111],"T).":[114],"defined":[117],"according":[118],"Chevallier's":[120,284],"(Am":[121],"J":[122],"Clin":[123],"1993)":[125],"level":[127],"1":[128,210,225,234,319],"2":[130],"Sataloff's":[133,296],"classification":[134,285,297],"(J":[135],"Am":[136],"Coll":[137],"Surg,":[138],"1995)":[139],"grade":[141,213,217,221],"A.":[142],"A":[143],"clinical,":[144],"mammography":[145],"ultrasound":[147],"evaluation":[149,163],"performed":[151,167],"at":[152,168],"baseline,":[153,169],"after":[154,170],"4":[157,248],"before":[160,175],"surgery.":[161,277],"Cardiac":[162],"(ejection":[164],"fraction)":[165],"FEC,":[174],"surgery":[176],"months":[180],"after.":[181],"Results:":[182],"Median":[183,189],"age":[184],"52.1":[186],"years":[187],"[27\u201371].":[188],"diameter":[190],"45":[195],"mm":[196],"[10\u2013160].":[197],"All":[198],"pts":[199,205,211,249,261,268,273,279,293,313,326],"had":[200,206,262,328],"a":[201,240,263,269,349],"ductal":[202],"carcinoma.":[203],"5":[204,227,325],"inflammatory":[207],"were":[212,229],"I":[214],"SBR,":[215,219],"13":[216,260,272],"II":[218],"6":[220],"III":[222],"SBR":[223],"unspecified.":[226,235],"HR+,":[230],"15":[231],"HR-":[232],"After":[236,251],"x3,":[239],"clinical":[241,358],"partial":[242,270],"response":[243,256,265],"(PR)":[244],"obtained":[246],"(19%).":[250],"completion":[252],"NCT,clinical":[254],"objective":[255],"rate":[257,351],"95.2%:":[259],"complete":[264],"7":[267],"response.":[271],"(62%)":[274],"underwent":[275],"breast-conserving":[276],"10":[278,301],"(47.6%)":[280],"achieved":[281],"using":[283,295],"(1":[286],"HR+":[287,299],"9":[289,343],"HR-)":[290],"12":[292],"(57.1%)":[294],"(2":[298],"HR-).":[302],"At":[303],"time":[305],"analysis":[308],"cardiac":[310,359],"evaluation,":[311],"8":[312],"continued":[314],"receive":[316],"adjuvant":[317],"T.":[318],"pt":[320],"lost":[322],"follow-up.":[324],"(25%)":[327],"an":[329],"asymptomatic":[330],"drop":[331],"ejection":[333],"fraction":[334],"greater":[335],"than":[336],"10%.":[337],"Conclusions:":[338],"This":[339],"regimen":[340],"only":[342],"preoperative":[345],"trastuzumab":[346],"resulted":[347],"high":[350],"tumors,":[356],"without":[357],"events":[360],"until":[361],"now.":[362],"No":[363],"significant":[364],"financial":[365],"relationships":[366],"disclose.":[368]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-06T10:28:23.643775","created_date":"2016-06-24T00:00:00"}
