{"id":"https://openalex.org/W1963374482","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a122067","title":"Expression of Modified Cytochrome c1 Genes and Restoration of the Respiratory Function in a Yeast Mutant Lacking the Nuclear Cytochrome c1Gene1","display_name":"Expression of Modified Cytochrome c1 Genes and Restoration of the Respiratory Function in a Yeast Mutant Lacking the Nuclear Cytochrome c1Gene1","publication_year":1987,"publication_date":"1987-08-01","ids":{"openalex":"https://openalex.org/W1963374482","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a122067","mag":"1963374482","pmid":"https://pubmed.ncbi.nlm.nih.gov/2822688"},"language":"en","primary_location":{"id":"doi:10.1093/oxfordjournals.jbchem.a122067","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a122067","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.jbchem.a122067","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003784904","display_name":"Toshiharu Hase","orcid":"https://orcid.org/0000-0002-0631-3900","observed_orcids":["https://orcid.org/0000-0002-0631-3900"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiharu HASE","raw_affiliation_strings":["Department of Biology, Faculty of Science, Osaka University","Department of Biology, Faculty of Science, Osaka UniversityToyonaka, Osaka 560"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Science, Osaka University","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Biology, Faculty of Science, Osaka UniversityToyonaka, Osaka 560","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073837718","display_name":"Masayuki Harabayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki HARABAYASHI","raw_affiliation_strings":["Department of Biology, Faculty of Science, Osaka University Toyonaka, Osaka 560"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Science, Osaka University Toyonaka, Osaka 560","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110355520","display_name":"Kiyozo Kawai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153843547","display_name":"Naruto University of Education","ror":"https://ror.org/00menq219","country_code":"JP","type":"education","lineage":["https://openalex.org/I153843547"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyozo KAWAI","raw_affiliation_strings":["Department of Biology, Naruto University of Teacher Education Naruto, Tokushima 772"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Naruto University of Teacher Education Naruto, Tokushima 772","institution_ids":["https://openalex.org/I153843547"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007584917","display_name":"Hiroshi Matsubara","orcid":"https://orcid.org/0000-0003-3224-4336","observed_orcids":["https://orcid.org/0000-0003-3224-4336"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi MATSUBARA","raw_affiliation_strings":["Department of Biology, Faculty of Science, Osaka University Toyonaka, Osaka 560"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Science, Osaka University Toyonaka, Osaka 560","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3276,"currency":"USD","value_usd":3276},"apc_paid":null,"fwci":0.5509,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.61753136,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"102","issue":"2","first_page":"401","last_page":"410"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-c1","display_name":"cytochrome c1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cytochrome-bc1-complex","display_name":"cytochrome bc1 complex","score":0.6800000071525574},{"id":"https://openalex.org/keywords/mitochondrial-respiratory-chain","display_name":"mitochondrial respiratory chain","score":0.9710000157356262},{"id":"https://openalex.org/keywords/yeast-mutants","display_name":"yeast mutants","score":0.5649999976158142},{"id":"https://openalex.org/keywords/in-vivo-complementation","display_name":"in vivo complementation","score":0.7820000052452087},{"id":"https://openalex.org/keywords/c-terminal-deletion-mutants","display_name":"C-terminal deletion mutants","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7820637822151184},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.6469395756721497},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.6381090879440308},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6129173636436462},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5968722105026245},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.5741583108901978},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.5617381930351257},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5129863619804382},{"id":"https://openalex.org/C148292235","wikidata":"https://www.wikidata.org/wiki/Q3774486","display_name":"Cytochrome b","level":4,"score":0.46572989225387573},{"id":"https://openalex.org/C14471203","wikidata":"https://www.wikidata.org/wiki/Q412832","display_name":"Coenzyme Q \u2013 cytochrome c reductase","level":4,"score":0.4145592749118805},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41151291131973267},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2985385060310364},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.18418586254119873},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.06861600279808044}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003574","descriptor_name":"Cytochrome c Group","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003575","descriptor_name":"Cytochromes c1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/oxfordjournals.jbchem.a122067","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a122067","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.jbchem.a122067","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:2822688","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2822688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2081079536","https://openalex.org/W1948683976","https://openalex.org/W2075272473","https://openalex.org/W2002996229","https://openalex.org/W2089029010","https://openalex.org/W1896635935","https://openalex.org/W1916754305","https://openalex.org/W1975400635","https://openalex.org/W1972343164","https://openalex.org/W2068033271"],"abstract_inverted_index":{"Yeast":[0],"cytochrome":[1,25,51,60,87,100,160],"c1":[2,26,52,61,101],"is":[3,53,154],"a":[4,71,96,110,129],"component":[5],"of":[6,12,24,32,70,95,159],"complex":[7],"III,":[8],"an":[9,37,47],"oligomeric":[10],"enzyme":[11],"the":[13,21,28,33,93,99,104,114,122,133,145,148,157],"mitochondrial":[14],"respiratory":[15],"chain.":[16],"In":[17],"order":[18],"to":[19,42,79,132],"investigate":[20],"structural":[22],"requirement":[23],"for":[27,156],"function":[29,158],"and":[30,81,84,151],"assembly":[31],"enzyme,":[34],"we":[35],"used":[36],"in":[38,48],"vivo":[39],"complementation":[40],"assay":[41],"determine":[43],"whether":[44],"or":[45,107],"not":[46],"vitro":[49],"mutated":[50],"functional.":[54],"A":[55],"yeast":[56],"mutant":[57,76,111,126],"whose":[58],"nuclear":[59],"gene":[62,72,102,127],"was":[63,66,77],"specifically":[64],"inactivated":[65],"constructed":[67],"by":[68],"means":[69],"disruption":[73],"technique.":[74],"The":[75],"unable":[78],"respire,":[80],"lacked":[82],"spectrally":[83],"immunochemically":[85],"detectable":[86],"c1.":[88,161],"These":[89,141],"defects":[90],"disappeared":[91],"on":[92],"introduction":[94],"plasmid":[97],"carrying":[98],"coding":[103,109],"wild-type":[105],"molecule":[106,112],"one":[108],"lacking":[113],"carboxyl":[115],"(C)-terminal":[116],"17":[117,150],"amino":[118],"acid":[119],"residues.":[120],"On":[121],"other":[123],"hand,":[124],"another":[125],"with":[128],"deletion":[130],"corresponding":[131],"C-terminal":[134,149],"71":[135,152],"residues":[136,153],"showed":[137],"no":[138],"such":[139],"ability.":[140],"results":[142],"suggest":[143],"that":[144],"region":[146],"between":[147],"necessary":[155]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}