{"id":"https://openalex.org/W196329826","doi":"https://doi.org/10.3233/jad-141557","title":"Targeting Thrombin: An Inflammatory Neurotoxin in Alzheimer's Disease","display_name":"Targeting Thrombin: An Inflammatory Neurotoxin in Alzheimer's Disease","publication_year":2014,"publication_date":"2014-10-27","ids":{"openalex":"https://openalex.org/W196329826","doi":"https://doi.org/10.3233/jad-141557","mag":"196329826","pmid":"https://pubmed.ncbi.nlm.nih.gov/25079808"},"language":"en","primary_location":{"id":"doi:10.3233/jad-141557","doi":"https://doi.org/10.3233/jad-141557","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-141557","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088789109","display_name":"Paula Grammas","orcid":"https://orcid.org/0000-0002-2636-3550","observed_orcids":["https://orcid.org/0000-0002-2636-3550"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paula Grammas","raw_affiliation_strings":["Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX, USA","Garrison Institute on Aging, Texas Tech Health Sciences Center, Lubbock, TX, USA","Texas Alzheimer's Research and Care Consortium, Austin, TX, USA","Texas Alzheimer's Research and Care Consortium, Austin, TX, USA Garrison Institute on Aging, Texas Tech Health Sciences Center, Lubbock, TX, USA Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX, USA","institution_ids":["https://openalex.org/I926076166"]},{"raw_affiliation_string":"Garrison Institute on Aging, Texas Tech Health Sciences Center, Lubbock, TX, USA","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]},{"raw_affiliation_string":"Texas Alzheimer's Research and Care Consortium, Austin, TX, USA","institution_ids":[]},{"raw_affiliation_string":"Texas Alzheimer's Research and Care Consortium, Austin, TX, USA Garrison Institute on Aging, Texas Tech Health Sciences Center, Lubbock, TX, USA Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX, USA","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024330134","display_name":"Joseph M. Martinez","orcid":"https://orcid.org/0000-0001-9024-4209","observed_orcids":["https://orcid.org/0000-0001-9024-4209"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph M. Martinez","raw_affiliation_strings":["Garrison Institute on Aging, Texas Tech Health Sciences Center, Lubbock, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Garrison Institute on Aging, Texas Tech Health Sciences Center, Lubbock, TX, USA","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088789109"],"corresponding_institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"],"apc_list":null,"apc_paid":null,"fwci":2.4375,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.8746896,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"42","issue":"s4","first_page":"S537","last_page":"S544"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.8769999742507935},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6524059772491455},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6434833407402039},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.6292465925216675},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.598143458366394},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5953255295753479},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5937293767929077},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5328375101089478},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.529957115650177},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.5077637434005737},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48767387866973877},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.4699442684650421},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4594370722770691},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.45026543736457825},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4459036886692047},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.4279625713825226},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.42315492033958435},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3329334259033203},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31204503774642944},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22689133882522583},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1999429166316986},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15870866179466248},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.146774023771286},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.09919726848602295},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000991","descriptor_name":"Antithrombins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3233/jad-141557","doi":"https://doi.org/10.3233/jad-141557","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-141557","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},{"id":"pmid:25079808","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25079808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's disease : JAD","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8600000143051147}],"study_designs":[],"awards":[{"id":"https://openalex.org/G253186564","display_name":null,"funder_award_id":"AG-020569","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3114311027","display_name":null,"funder_award_id":"AG028367","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4128411614","display_name":"Vascular inflammation and neurotoxicity in aging brain","funder_award_id":"R01AG028367","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5172100271","display_name":"Is There a Link Between Alzheimer's and Atheroclerosis","funder_award_id":"R01AG020569","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":85,"referenced_works":["https://openalex.org/W31917496","https://openalex.org/W76306425","https://openalex.org/W197140406","https://openalex.org/W1426985082","https://openalex.org/W1509604932","https://openalex.org/W1522347780","https://openalex.org/W1576211545","https://openalex.org/W1593118353","https://openalex.org/W1593393815","https://openalex.org/W1594129908","https://openalex.org/W1602062234","https://openalex.org/W1603035992","https://openalex.org/W1615217034","https://openalex.org/W1880833927","https://openalex.org/W1982480910","https://openalex.org/W1984317956","https://openalex.org/W1988692970","https://openalex.org/W1992758695","https://openalex.org/W2000636649","https://openalex.org/W2004217814","https://openalex.org/W2005204638","https://openalex.org/W2007715810","https://openalex.org/W2011398156","https://openalex.org/W2014457711","https://openalex.org/W2015484447","https://openalex.org/W2018173903","https://openalex.org/W2019867783","https://openalex.org/W2024028741","https://openalex.org/W2032033034","https://openalex.org/W2035873080","https://openalex.org/W2036661577","https://openalex.org/W2038053189","https://openalex.org/W2039222951","https://openalex.org/W2043998212","https://openalex.org/W2045079575","https://openalex.org/W2045957183","https://openalex.org/W2052534047","https://openalex.org/W2057042201","https://openalex.org/W2057463858","https://openalex.org/W2063576429","https://openalex.org/W2065062958","https://openalex.org/W2065189761","https://openalex.org/W2074907054","https://openalex.org/W2078373333","https://openalex.org/W2079685820","https://openalex.org/W2081475948","https://openalex.org/W2082248166","https://openalex.org/W2082711424","https://openalex.org/W2082944527","https://openalex.org/W2083517812","https://openalex.org/W2087595637","https://openalex.org/W2094725172","https://openalex.org/W2096485847","https://openalex.org/W2099174317","https://openalex.org/W2100511295","https://openalex.org/W2100895769","https://openalex.org/W2102166768","https://openalex.org/W2102178368","https://openalex.org/W2102493638","https://openalex.org/W2105503070","https://openalex.org/W2110273274","https://openalex.org/W2115944392","https://openalex.org/W2120293565","https://openalex.org/W2126676163","https://openalex.org/W2126950194","https://openalex.org/W2129060891","https://openalex.org/W2130373760","https://openalex.org/W2131115138","https://openalex.org/W2131760568","https://openalex.org/W2132397828","https://openalex.org/W2133799625","https://openalex.org/W2136489990","https://openalex.org/W2138375704","https://openalex.org/W2142046013","https://openalex.org/W2145130062","https://openalex.org/W2149450071","https://openalex.org/W2155198114","https://openalex.org/W2156725274","https://openalex.org/W2157665412","https://openalex.org/W2163127200","https://openalex.org/W2164968714","https://openalex.org/W2171730321","https://openalex.org/W2324753864","https://openalex.org/W2333927183","https://openalex.org/W2955708237"],"related_works":["https://openalex.org/W1976122663","https://openalex.org/W3044030596","https://openalex.org/W2087595637","https://openalex.org/W2045079575","https://openalex.org/W2353236174","https://openalex.org/W4366827426","https://openalex.org/W3158336980","https://openalex.org/W2765929540","https://openalex.org/W2156725274","https://openalex.org/W7100826871"],"abstract_inverted_index":{"The":[0,198,232],"Alzheimer's":[1],"disease":[2,32,244],"(AD)":[3],"epidemic":[4],"proceeds":[5],"unabated.":[6],"Estimates":[7],"suggest":[8],"5.4":[9],"million":[10,14],"Americans":[11],"and":[12,52,63,79,86,121,129,137,140,159,246],"36":[13],"people":[15],"worldwide":[16],"have":[17],"AD.":[18,69],"No":[19],"single":[20,208],"mechanism":[21],"or":[22],"pathologic":[23],"mediator":[24],"can":[25],"account":[26],"for":[27,104,192,235],"AD":[28,56,85,87,105,165,178,196,202,239],"progression.":[29],"Currently":[30],"no":[31],"modifying":[33],"therapies":[34],"are":[35,144],"available.":[36],"There":[37],"is":[38,71,109,116,126,180],"a":[39,100,214],"large":[40],"literature":[41],"documenting":[42],"an":[43],"association":[44],"among":[45],"cardiovascular":[46],"risk":[47],"factors":[48],"(CVRFs),":[49],"especially":[50],"diabetes":[51],"hypoxia,":[53],"with":[54,182],"increased":[55],"incidence.":[57],"CVRFs":[58],"directly":[59,127],"impair":[60],"vascular":[61,161],"function":[62],"could":[64,189],"mediate":[65],"cerebrovascular":[66,74,142,172],"dysfunction":[67,75],"in":[68,84,118,124,133,163,177,195,238],"This":[70,107],"important":[72],"as":[73,224],"precedes":[76],"cognitive":[77],"decline":[78],"onset":[80],"of":[81,153,174,201,248],"neurodegenerative":[82],"changes":[83],"animal":[88],"models.":[89],"In":[90],"this":[91],"review":[92],"we":[93,185],"present":[94],"evidence":[95],"that":[96,170],"thrombin":[97,187,220],"may":[98],"be":[99,222],"heretofore":[101],"unexplored":[102],"target":[103,209],"therapy.":[106],"idea":[108],"based":[110],"on":[111,155,168,207],"the":[112,119,151,228],"following":[113],"observations.":[114],"Thrombin":[115,148],"elevated":[117],"brain":[120,156],"cerebral":[122],"microvasculature":[123],"AD,":[125],"neurotoxic,":[128],"causes":[130],"pro-inflammatory":[131],"effects":[132,143,152],"endothelial":[134,157],"cells,":[135],"microglia,":[136],"astrocytes.":[138],"Diabetes-":[139],"hypoxia-induced":[141],"mediated":[145],"by":[146],"thrombin.":[147],"inhibitors":[149,188,221],"block":[150],"hypoxia":[154],"cells":[158],"reduce":[160],"inflammation":[162],"transgenic":[164],"mice.":[166],"Based":[167],"reports":[169],"reducing":[171],"expression":[173],"inflammatory":[175],"proteins":[176],"mice":[179],"associated":[181],"improved":[183],"cognition,":[184],"propose":[186,219],"prove":[190],"useful":[191],"improving":[193],"cognition":[194],"patients.":[197],"next":[199],"generation":[200],"therapeutics":[203],"should":[204],"not":[205],"focus":[206],"drugs":[210,237],"but":[211],"rather":[212],"employ":[213],"multi-component":[215],"cocktail":[216],"approach.":[217],"We":[218],"considered":[223],"potential":[225],"contributors":[226],"to":[227],"dementia":[229],"therapy":[230],"pharmacopeia.":[231],"urgent":[233],"need":[234],"disease-modifying":[236],"demands":[240],"new":[241],"thinking":[242],"about":[243],"pathogenesis":[245],"exploration":[247],"novel":[249],"drug":[250],"targets.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}