{"id":"https://openalex.org/W1963274583","doi":"https://doi.org/10.1002/tox.22185","title":"Crocin and quercetin prevent PAT-induced apoptosis in mammalian cells: Involvement of ROS-mediated ER stress pathway","display_name":"Crocin and quercetin prevent PAT-induced apoptosis in mammalian cells: Involvement of ROS-mediated ER stress pathway","publication_year":2015,"publication_date":"2015-08-27","ids":{"openalex":"https://openalex.org/W1963274583","doi":"https://doi.org/10.1002/tox.22185","mag":"1963274583","pmid":"https://pubmed.ncbi.nlm.nih.gov/26314699"},"language":"en","primary_location":{"id":"doi:10.1002/tox.22185","doi":"https://doi.org/10.1002/tox.22185","is_oa":false,"landing_page_url":"https://doi.org/10.1002/tox.22185","pdf_url":null,"source":{"id":"https://openalex.org/S172436580","display_name":"Environmental Toxicology","issn_l":"1520-4081","issn":["1520-4081","1522-7278"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046936912","display_name":"Manel Boussabbeh","orcid":"https://orcid.org/0000-0002-7005-3410","observed_orcids":["https://orcid.org/0000-0002-7005-3410"]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]},{"id":"https://openalex.org/I179097149","display_name":"University of Carthage","ror":"https://ror.org/057x6za15","country_code":"TN","type":"education","lineage":["https://openalex.org/I179097149"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Manel Boussabbeh","raw_affiliation_strings":["Faculty of Dentistry, Laboratory for Research on Biologically Compatible Compounds, Rue Avicenne, Monastir, 5019 Tunisia","Faculty of Sciences of Bizetre; Carthage University; Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Dentistry, Laboratory for Research on Biologically Compatible Compounds, Rue Avicenne, Monastir, 5019 Tunisia","institution_ids":["https://openalex.org/I166928557"]},{"raw_affiliation_string":"Faculty of Sciences of Bizetre; Carthage University; Tunisia","institution_ids":["https://openalex.org/I179097149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068858715","display_name":"Alexandre Prola","orcid":"https://orcid.org/0000-0001-6667-7653","observed_orcids":["https://orcid.org/0000-0001-6667-7653"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4391768231","display_name":"Laboratoire d'Excellence en Recherche sur le M\u00e9dicament et l'Innovation Th\u00e9rapeutique","ror":"https://ror.org/035gq6r08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I4391768231"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alexandre Prola","raw_affiliation_strings":["INSERM UMR-S 1180, LabEx LERMIT; Ch\u00e2tenay-Malabry France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM UMR-S 1180, LabEx LERMIT; Ch\u00e2tenay-Malabry France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4391768231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031011494","display_name":"Intidhar Ben Salem","orcid":"https://orcid.org/0000-0002-2033-4476","observed_orcids":["https://orcid.org/0000-0002-2033-4476"]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]},{"id":"https://openalex.org/I179097149","display_name":"University of Carthage","ror":"https://ror.org/057x6za15","country_code":"TN","type":"education","lineage":["https://openalex.org/I179097149"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Intidhar Ben Salem","raw_affiliation_strings":["Faculty of Dentistry, Laboratory for Research on Biologically Compatible Compounds, Rue Avicenne, Monastir, 5019 Tunisia","Faculty of Sciences of Bizetre; Carthage University; Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Dentistry, Laboratory for Research on Biologically Compatible Compounds, Rue Avicenne, Monastir, 5019 Tunisia","institution_ids":["https://openalex.org/I166928557"]},{"raw_affiliation_string":"Faculty of Sciences of Bizetre; Carthage University; Tunisia","institution_ids":["https://openalex.org/I179097149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014978045","display_name":"Arnaud Guilbert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4391768231","display_name":"Laboratoire d'Excellence en Recherche sur le M\u00e9dicament et l'Innovation Th\u00e9rapeutique","ror":"https://ror.org/035gq6r08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I4391768231"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Arnaud Guilbert","raw_affiliation_strings":["INSERM UMR-S 1180, LabEx LERMIT; Ch\u00e2tenay-Malabry France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM UMR-S 1180, LabEx LERMIT; Ch\u00e2tenay-Malabry France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4391768231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045870220","display_name":"Hassen Bacha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Hassen Bacha","raw_affiliation_strings":["Faculty of Dentistry, Laboratory for Research on Biologically Compatible Compounds, Rue Avicenne, Monastir, 5019 Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Dentistry, Laboratory for Research on Biologically Compatible Compounds, Rue Avicenne, Monastir, 5019 Tunisia","institution_ids":["https://openalex.org/I166928557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090902139","display_name":"Christophe Lemaire","orcid":"https://orcid.org/0000-0001-6316-8781","observed_orcids":["https://orcid.org/0000-0001-6316-8781"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I195731000","display_name":"Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines","ror":"https://ror.org/03mkjjy25","country_code":"FR","type":"education","lineage":["https://openalex.org/I195731000","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4391768231","display_name":"Laboratoire d'Excellence en Recherche sur le M\u00e9dicament et l'Innovation Th\u00e9rapeutique","ror":"https://ror.org/035gq6r08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I4391768231"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christophe Lemaire","raw_affiliation_strings":["Facult\u00e9 De Pharmacie; Universit\u00e9 Paris-Sud; Ch\u00e2tenay-Malabry France","INSERM UMR-S 1180, LabEx LERMIT; Ch\u00e2tenay-Malabry France","Universit\u00e9 De Versailles Saint Quentin En Yvelines; Versailles France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facult\u00e9 De Pharmacie; Universit\u00e9 Paris-Sud; Ch\u00e2tenay-Malabry France","institution_ids":["https://openalex.org/I102197404"]},{"raw_affiliation_string":"INSERM UMR-S 1180, LabEx LERMIT; Ch\u00e2tenay-Malabry France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4391768231"]},{"raw_affiliation_string":"Universit\u00e9 De Versailles Saint Quentin En Yvelines; Versailles France","institution_ids":["https://openalex.org/I195731000"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064174696","display_name":"Salwa Abid\u2010Essefi","orcid":"https://orcid.org/0000-0002-4965-5855","observed_orcids":["https://orcid.org/0000-0002-4965-5855","https://orcid.org/0000-0002-7602-6050"]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]}],"countries":["TN"],"is_corresponding":true,"raw_author_name":"Salwa Abis-Essefi","raw_affiliation_strings":["Faculty of Dentistry, Laboratory for Research on Biologically Compatible Compounds, Rue Avicenne, Monastir, 5019 Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Dentistry, Laboratory for Research on Biologically Compatible Compounds, Rue Avicenne, Monastir, 5019 Tunisia","institution_ids":["https://openalex.org/I166928557"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5064174696"],"corresponding_institution_ids":["https://openalex.org/I166928557"],"apc_list":{"value":4120,"currency":"USD","value_usd":4120},"apc_paid":null,"fwci":3.7722,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.92079069,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"31","issue":"12","first_page":"1851","last_page":"1858"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12758","display_name":"Saffron Plant Research Studies","score":0.03229999914765358,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/patulin","display_name":"patulin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mycotoxin-toxicity","display_name":"mycotoxin toxicity","score":0.9350000023841858},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":0.9070000052452087},{"id":"https://openalex.org/keywords/crocin","display_name":"crocin","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9010000228881836},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9890000224113464},{"id":"https://openalex.org/keywords/grp78","display_name":"GRP78","score":0.9350000023841858},{"id":"https://openalex.org/keywords/gadd34","display_name":"GADD34","score":0.9929999709129333},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.8949999809265137},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8859999775886536},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.8859999775886536},{"id":"https://openalex.org/keywords/hek293-cells","display_name":"HEK293 cells","score":0.9890000224113464},{"id":"https://openalex.org/keywords/dietary-antioxidants","display_name":"dietary antioxidants","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6962187886238098},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.695177435874939},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.5797441005706787},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5716103315353394},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.5017328262329102},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.48988717794418335},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4803215563297272},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.47749823331832886},{"id":"https://openalex.org/C2777637054","wikidata":"https://www.wikidata.org/wiki/Q424767","display_name":"Crocin","level":2,"score":0.445843368768692},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4426388442516327},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4398537874221802},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4217592775821686},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.41937485337257385},{"id":"https://openalex.org/C2779550045","wikidata":"https://www.wikidata.org/wiki/Q414526","display_name":"Patulin","level":3,"score":0.41168612241744995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34331876039505005},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.18790185451507568},{"id":"https://openalex.org/C84699730","wikidata":"https://www.wikidata.org/wiki/Q422449","display_name":"Mycotoxin","level":2,"score":0.15930309891700745},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000091342","descriptor_name":"Endoplasmic Reticulum Chaperone BiP","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002338","descriptor_name":"Carotenoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010365","descriptor_name":"Patulin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D054645","descriptor_name":"Protein Phosphatase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059865","descriptor_name":"Endoplasmic Reticulum Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/tox.22185","doi":"https://doi.org/10.1002/tox.22185","is_oa":false,"landing_page_url":"https://doi.org/10.1002/tox.22185","pdf_url":null,"source":{"id":"https://openalex.org/S172436580","display_name":"Environmental Toxicology","issn_l":"1520-4081","issn":["1520-4081","1522-7278"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Toxicology","raw_type":"journal-article"},{"id":"pmid:26314699","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26314699","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1816249540","https://openalex.org/W1963564724","https://openalex.org/W1965517414","https://openalex.org/W1970633199","https://openalex.org/W1981717867","https://openalex.org/W1981798437","https://openalex.org/W1983155817","https://openalex.org/W1983310681","https://openalex.org/W1984095923","https://openalex.org/W1993148089","https://openalex.org/W1999317538","https://openalex.org/W2024908054","https://openalex.org/W2024960103","https://openalex.org/W2026248990","https://openalex.org/W2029875893","https://openalex.org/W2030048915","https://openalex.org/W2035253440","https://openalex.org/W2035365816","https://openalex.org/W2038214881","https://openalex.org/W2038483241","https://openalex.org/W2044022814","https://openalex.org/W2044963545","https://openalex.org/W2050487291","https://openalex.org/W2050798207","https://openalex.org/W2057810394","https://openalex.org/W2060947674","https://openalex.org/W2083118999","https://openalex.org/W2086621929","https://openalex.org/W2102498208","https://openalex.org/W2103894693","https://openalex.org/W2110740519","https://openalex.org/W2115482702","https://openalex.org/W2117535762","https://openalex.org/W2135166643","https://openalex.org/W2138677495","https://openalex.org/W2145810234","https://openalex.org/W2155305052"],"related_works":["https://openalex.org/W1965517414","https://openalex.org/W2268085530","https://openalex.org/W2144696913","https://openalex.org/W2738303797","https://openalex.org/W2174406346","https://openalex.org/W3101108045","https://openalex.org/W2014244748","https://openalex.org/W4389407350","https://openalex.org/W3095128132","https://openalex.org/W3197086777"],"abstract_inverted_index":{"Patulin":[0],"(PAT)":[1],"is":[2],"a":[3,85,91],"secondary":[4],"metabolite":[5],"produced":[6],"by":[7,127],"several":[8],"species":[9,62],"of":[10,13,55,77,112,150],"the":[11,53,75,78,128,136,148,151],"genera":[12],"Penicillium,":[14],"Aspergillus,":[15],"and":[16,28,41,64,88,102,114,122,132,135,160],"Byssochlamys":[17],"that":[18,109],"can":[19],"be":[20],"found":[21],"in":[22,26,97,130,138],"rotting":[23],"fruits,":[24],"especially":[25],"apples":[27],"apple-based":[29],"products.":[30],"Exposure":[31],"to":[32,38,52,73,117,146,155],"this":[33],"mycotoxin":[34],"has":[35,49],"been":[36,50],"reported":[37],"induce":[39],"intestinal":[40],"kidney":[42,104],"injuries.":[43],"The":[44],"mechanism":[45],"underlying":[46],"such":[47],"toxicity":[48,96],"linked":[51],"induction":[54],"apoptosis":[56],"which":[57],"occurred":[58],"with":[59],"reactive":[60],"oxygen":[61],"production":[63],"endoplasmic":[65],"reticulum":[66],"(ER)":[67],"stress":[68,120],"induction.":[69],"This":[70],"study":[71],"aimed":[72],"evaluate":[74],"effect":[76],"two":[79],"common":[80],"dietary":[81],"compounds":[82],"Quercetin":[83],"(QUER),":[84],"natural":[86,92],"flavonoid,":[87],"Crocin":[89],"(CRO),":[90],"carotenoid,":[93],"on":[94],"PAT-induced":[95],"human":[98],"colon":[99],"carcinoma":[100],"(HCT116)":[101],"embryonic":[103],"cells":[105],"(HEK293).":[106],"We":[107],"showed":[108],"antioxidant":[110],"properties":[111],"QUER":[113],"CRO":[115],"help":[116],"prevent":[118],"ER":[119],"activation":[121,159],"lipid":[123],"peroxidation":[124],"as":[125],"evidenced":[126],"reduction":[129],"GRP78":[131],"GADD34":[133],"expressions":[134],"decrease":[137],"malondialdehyde":[139],"production.":[140],"Furthermore,":[141],"we":[142],"demonstrated":[143],"their":[144],"ability":[145],"re-establish":[147],"loss":[149],"mitochondrial":[152],"membrane":[153],"potential":[154],"inhibit":[156],"caspase":[157],"3":[158],"DNA":[161],"fragmentation.":[162],"\u00a9":[163],"2015":[164],"Wiley":[165],"Periodicals,":[166],"Inc.":[167],"Environ":[168],"Toxicol":[169],"31:":[170],"1851-1858,":[171],"2016.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}