{"id":"https://openalex.org/W196327192","doi":null,"title":"Combination of intra-articular autologous activated peripheral blood stem cells with growth factor addition/ preservation and hyaluronic acid in conjunction with arthroscopic microdrilling mesenchymal cell stimulation Improves quality of life and regenerates articular cartilage in early osteoarthritic knee disease.","display_name":"Combination of intra-articular autologous activated peripheral blood stem cells with growth factor addition/ preservation and hyaluronic acid in conjunction with arthroscopic microdrilling mesenchymal cell stimulation Improves quality of life and regenerates articular cartilage in early osteoarthritic knee disease.","publication_year":2013,"publication_date":"2013-05-01","ids":{"openalex":"https://openalex.org/W196327192","mag":"196327192","pmid":"https://pubmed.ncbi.nlm.nih.gov/23745314"},"language":"en","primary_location":{"id":"pmid:23745314","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23745314","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Medical Association of Thailand = Chotmaihet thangphaet","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021343116","display_name":"Thana Turajane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130885","display_name":"Police General Hospital","ror":"https://ror.org/03ay8b853","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4210130885"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Thana Turajane","raw_affiliation_strings":["Stem Cell Research and Technology Center Department of Orthopedic Surgery, Police General Hospital, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Research and Technology Center Department of Orthopedic Surgery, Police General Hospital, Bangkok, Thailand","institution_ids":["https://openalex.org/I4210130885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019183574","display_name":"Ukrit Chaweewannakorn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ukrit Chaweewannakorn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081664375","display_name":"Viroj Larbpaiboonpong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Viroj Larbpaiboonpong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075305242","display_name":"Jongjate Aojanepong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jongjate Aojanepong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035988308","display_name":"Thakoon Thitiset","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thakoon Thitiset","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090299749","display_name":"Sittisak Honsawek","orcid":"https://orcid.org/0000-0003-3852-9092","observed_orcids":["https://orcid.org/0000-0003-3852-9092"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sittisak Honsawek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061021856","display_name":"Juthatip Fongsarun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juthatip Fongsarun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5070935502","display_name":"Konstantinos I. Papadopoulos","orcid":"https://orcid.org/0000-0003-0041-7853","observed_orcids":["https://orcid.org/0000-0003-0041-7853"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Konstantinos I Papadopoulos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1317,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.9040723,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"96","issue":"5","first_page":"580","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.7559999823570251},{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":0.972000002861023},{"id":"https://openalex.org/keywords/articular-cartilage-regeneration","display_name":"articular cartilage regeneration","score":0.9430000185966492},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.9819999933242798},{"id":"https://openalex.org/keywords/intra-articular-injection","display_name":"intra-articular injection","score":0.6520000100135803},{"id":"https://openalex.org/keywords/conservative-treatment-failure","display_name":"conservative treatment failure","score":0.7059999704360962},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.796999990940094},{"id":"https://openalex.org/keywords/womac","display_name":"WOMAC","score":0.6129999756813049},{"id":"https://openalex.org/keywords/kellgren-lawrence-grade","display_name":"Kellgren-Lawrence grade","score":0.7549999952316284},{"id":"https://openalex.org/keywords/proteoglycans","display_name":"proteoglycans","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9044718146324158},{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.7999467849731445},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6854236721992493},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.6745368242263794},{"id":"https://openalex.org/C2779286237","wikidata":"https://www.wikidata.org/wiki/Q3569749","display_name":"WOMAC","level":4,"score":0.5784190893173218},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.5592905282974243},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5233485102653503},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4746575653553009},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.4387798011302948},{"id":"https://openalex.org/C2779162959","wikidata":"https://www.wikidata.org/wiki/Q708232","display_name":"Arthroscopy","level":2,"score":0.4261014461517334},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.4124011993408203},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3668486475944519},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3482402563095093},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.1337968409061432},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001182","descriptor_name":"Arthroscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007270","descriptor_name":"Injections, Intra-Articular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007719","descriptor_name":"Knee Joint","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007719","descriptor_name":"Knee Joint","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014182","descriptor_name":"Transplantation, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D036102","descriptor_name":"Peripheral Blood Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:23745314","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23745314","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Medical Association of Thailand = Chotmaihet thangphaet","raw_type":"Journal Article"},{"id":"mag:1861244049","doi":null,"is_oa":false,"landing_page_url":"http://www.jmatonline.com/index.php/jmat/article/view/2552","pdf_url":null,"source":{"id":"https://openalex.org/S4210239969","display_name":"Journal of the Medical Association of Thailand","issn_l":"0125-2208","issn":["0125-2208","2408-1981"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of the Medical Association of Thailand","raw_type":null},{"id":"mag:196327192","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23745314","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W177397730","https://openalex.org/W1767338574","https://openalex.org/W1956105811","https://openalex.org/W2008508884","https://openalex.org/W2016363042","https://openalex.org/W2035963415","https://openalex.org/W2042494273","https://openalex.org/W2042580307","https://openalex.org/W2052203910","https://openalex.org/W2072216539","https://openalex.org/W2078575815","https://openalex.org/W2100445448","https://openalex.org/W2111687996","https://openalex.org/W2116678756","https://openalex.org/W2117612088","https://openalex.org/W2118788475","https://openalex.org/W2146874322","https://openalex.org/W2159468893","https://openalex.org/W2339475327","https://openalex.org/W2418112119"],"related_works":["https://openalex.org/W1861244049","https://openalex.org/W2610693322","https://openalex.org/W2333600422","https://openalex.org/W1982516485","https://openalex.org/W3207022594","https://openalex.org/W4389684101","https://openalex.org/W2087949045","https://openalex.org/W2501953636","https://openalex.org/W2945813882","https://openalex.org/W1650284538"],"abstract_inverted_index":{"BACKGROUND:":[0],"Trauma":[1],"or":[2],"osteoarthritis":[3],"(OA)":[4],"create":[5],"articular":[6,47,307],"cartilage":[7,23,48,257,308],"defects":[8],"that":[9,29,106,124,241,314],"cannot":[10],"efficiently":[11],"heal,":[12],"thus":[13],"leading":[14],"to":[15,176,205,323],"significant":[16],"long-term":[17],"disability.":[18],"Failed":[19],"conservative":[20,108,126,316],"treatment":[21,127],"in":[22,40,92,101,135,194,282,292,305,309,328],"diseases":[24],"is":[25],"a":[26],"known":[27],"condition":[28],"necessitates":[30],"repair":[31],"attempts":[32],"but":[33],"current":[34],"methods":[35],"are":[36,321],"inadequate.":[37],"Recent":[38],"studies":[39,320],"OA":[41],"animal":[42],"models":[43],"and":[44,57,115,154,162,168,181,186,196,201,235,252,300,303],"humans,":[45],"showed":[46,249],"regeneration":[49],"following":[50],"combinations":[51],"of":[52,71,142,262,294],"drilling,":[53],"adult":[54],"stem":[55,79,269],"cells,":[56],"intra-articular":[58,73,263],"hyaluronic":[59,89,279],"acid.":[60],"OBJECTIVE:":[61],"In":[62],"the":[63,66,69,213,242,246,325],"present":[64],"series,":[65],"authors":[67],"evaluated":[68,159],"combination":[70,261],"repeated":[72,150],"(IA)":[74,264],"autologous":[75,265],"activated":[76,266],"peripheral":[77,267],"blood":[78,268],"cells":[80,270],"(AAPBSC)":[81,271],"with":[82,88,94,138,144,147,272,278,284],"growth":[83,273],"factor":[84,274],"addition/preservation":[85,275],"(GFAP)":[86,276],"along":[87,146,277],"acid":[90,280],"(HA)":[91,281],"conjunction":[93,283],"arthroscopic":[95,285],"microdrilling":[96,286],"mesenchymal":[97,287],"cell":[98,178,233,243,288],"stimulation":[99,289],"(MCS)":[100,290],"early":[102,310],"osteoarthritic":[103,311],"knee":[104,312],"disease":[105,313],"failed":[107,125,315],"treatment.":[109,317],"MATERIAL":[110],"AND":[111],"METHOD:":[112],"Four":[113],"women":[114],"one":[116,200],"man":[117],"(median":[118],"age":[119],"56,":[120],"range":[121],"52-59":[122],"years)":[123],"were":[128,158,174,210],"enrolled.":[129],"Arthroscopic":[130],"MCS":[131],"was":[132],"performed":[133,175],"once":[134],"all":[136,223],"patients":[137,157,191],"subsequent":[139],"IA":[140,218],"injection":[141],"AAPBSC":[143,214],"GFAP":[145],"IA-HA":[148],"intra-operatively,":[149],"at":[151,165,199],"days":[152],"7":[153],"14.":[155],"The":[156,260],"by":[160,183,298],"WOMAC":[161,195,299],"KOO":[163,197,301],"scores":[164,198,302],"baseline,":[166],"one,":[167],"six":[169,202],"months.":[170],"Cancellous":[171],"bone":[172],"biopsies":[173],"investigate":[177],"attachment,":[179],"proliferation,":[180],"differentiation":[182],"electron":[184],"microscopy":[185,230],"histological":[187,238],"staining.":[188],"RESULTS:":[189],"All":[190],"improved":[192],"significantly":[193],"months":[203],"compared":[204],"baseline.":[206],"No":[207],"adverse":[208],"effects":[209],"seen":[211],"during":[212],"harvesting,":[215],"arthroscopy":[216],"and/or":[217],"injections.":[219],"One":[220],"month":[221],"post-surgery,":[222],"pain":[224],"medications":[225],"could":[226],"be":[227],"withdrawn.":[228],"Electron":[229],"scanning":[231],"revealed":[232],"attachment":[234],"proliferation":[236],"while":[237],"analysis":[239],"demonstrated":[240],"layer":[244],"on":[245],"cancellous":[247],"scaffold":[248],"increased":[250],"proteoglycan":[251],"glycosaminoglycan":[253],"content":[254],"indicating":[255],"hyaline":[256],"presence.":[258],"CONCLUSION:":[259],"resulted":[291],"Quality":[293],"Life":[295],"improvements":[296],"measured":[297],"succeeded":[304],"regenerating":[306],"Further":[318],"controlled":[319],"warranted":[322],"confirm":[324],"above":[326],"results":[327],"larger":[329],"groups.":[330]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
