{"id":"https://openalex.org/W1963094565","doi":null,"title":"GENOTIPOS COMBINADOS -509CT/869TC DEL GEN TGFB1 ASOCIADOS CON PREECLAMPSIA","display_name":"GENOTIPOS COMBINADOS -509CT/869TC DEL GEN TGFB1 ASOCIADOS CON PREECLAMPSIA","publication_year":2015,"publication_date":"2015-01-15","ids":{"openalex":"https://openalex.org/W1963094565","mag":"1963094565"},"language":"es","primary_location":{"id":"pmh:oai:redalyc.org:37033725006","doi":null,"is_oa":false,"landing_page_url":"https://www.redalyc.org/articulo.oa?id=37033725006","pdf_url":null,"source":{"id":"https://openalex.org/S4377196100","display_name":"Redalyc (Universidad Aut\u00f3noma del Estado de M\u00e9xico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179647637","host_organization_name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","host_organization_lineage":["https://openalex.org/I179647637"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista Internacional de Contaminaci\u00f3n Ambiental (M\u00e9xico) Vol.30","raw_type":"art\u00edculo cient\u00edfico"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.atmosfera.unam.mx/editorial/rica/acervo/vol_30_especial/09-Salas.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025972107","display_name":"Jose Manuel Salas-Pacheco","orcid":"https://orcid.org/0000-0002-8256-2239","observed_orcids":["https://orcid.org/0000-0002-8256-2239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Manuel Salas Pacheco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004321958","display_name":"Fernando Vazquez Alaniz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fernando V\u00e1zquez Alan\u00edz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045662905","display_name":"Sergio Estrada Ram\u00edrez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sergio Estrada Ram\u00edrez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005787480","display_name":"Ang\u00e9lica Mar\u00eda Lechuga-Qui\u00f1ones","orcid":"https://orcid.org/0000-0002-1144-8156","observed_orcids":["https://orcid.org/0000-0002-1144-8156"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ang\u00e9lica Mar\u00eda Lechuga-Qui\u00f1ones","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1144-8156","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5070515335","display_name":"Marisela Aguilar Dur\u00e1n","orcid":"https://orcid.org/0000-0002-6788-351X","observed_orcids":["https://orcid.org/0000-0002-6788-351X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marisela Aguilar Dur\u00e1n","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"30","issue":null,"first_page":"45","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12464","display_name":"Neurological Complications and Syndromes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.8059999942779541},{"id":"https://openalex.org/keywords/combined-genotypes","display_name":"combined genotypes","score":0.9340000152587891},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8220000267028809},{"id":"https://openalex.org/keywords/hypertensive-disorders-of-pregnancy","display_name":"hypertensive disorders of pregnancy","score":0.8610000014305115},{"id":"https://openalex.org/keywords/maternal-morbidity","display_name":"maternal morbidity","score":0.5550000071525574},{"id":"https://openalex.org/keywords/trophoblast-invasion","display_name":"trophoblast invasion","score":0.6880000233650208},{"id":"https://openalex.org/keywords/hardy-weinberg-equilibrium","display_name":"Hardy-Weinberg equilibrium","score":0.7870000004768372},{"id":"https://openalex.org/keywords/allele-frequency","display_name":"allele frequency","score":0.47600001096725464},{"id":"https://openalex.org/keywords/case-control-study","display_name":"case-control study","score":0.515999972820282},{"id":"https://openalex.org/keywords/pregnant-women","display_name":"pregnant women","score":0.49300000071525574},{"id":"https://openalex.org/keywords/durango","display_name":"Durango","score":0.8980000019073486}],"concepts":[{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.5279002785682678},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.4909532368183136},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39091265201568604},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.08383753895759583}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:redalyc.org:37033725006","doi":null,"is_oa":false,"landing_page_url":"https://www.redalyc.org/articulo.oa?id=37033725006","pdf_url":null,"source":{"id":"https://openalex.org/S4377196100","display_name":"Redalyc (Universidad Aut\u00f3noma del Estado de M\u00e9xico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179647637","host_organization_name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","host_organization_lineage":["https://openalex.org/I179647637"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista Internacional de Contaminaci\u00f3n Ambiental (M\u00e9xico) Vol.30","raw_type":"art\u00edculo cient\u00edfico"},{"id":"mag:1963094565","doi":null,"is_oa":true,"landing_page_url":"http://www.atmosfera.unam.mx/editorial/rica/acervo/vol_30_especial/09-Salas.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S1006027302","display_name":"Revista Internacional de Contaminaci\u00f3n Ambiental","issn_l":"0188-4999","issn":["0188-4999"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","poland-20","russia-white-list-4","scielo"],"host_organization":"https://openalex.org/P4310319658","host_organization_name":"National Autonomous University of Mexico","host_organization_lineage":["https://openalex.org/P4310319658"],"host_organization_lineage_names":["National Autonomous University of Mexico"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Revista Internacional de Contaminaci\u00f3n Ambiental","raw_type":null}],"best_oa_location":{"id":"mag:1963094565","doi":null,"is_oa":true,"landing_page_url":"http://www.atmosfera.unam.mx/editorial/rica/acervo/vol_30_especial/09-Salas.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S1006027302","display_name":"Revista Internacional de Contaminaci\u00f3n Ambiental","issn_l":"0188-4999","issn":["0188-4999"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","poland-20","russia-white-list-4","scielo"],"host_organization":"https://openalex.org/P4310319658","host_organization_name":"National Autonomous University of Mexico","host_organization_lineage":["https://openalex.org/P4310319658"],"host_organization_lineage_names":["National Autonomous University of Mexico"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Revista Internacional de Contaminaci\u00f3n Ambiental","raw_type":null},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W171317449","https://openalex.org/W1574935202","https://openalex.org/W1883225649","https://openalex.org/W1963616068","https://openalex.org/W2002042655","https://openalex.org/W2010647829","https://openalex.org/W2017926744","https://openalex.org/W2027116308","https://openalex.org/W2037611414","https://openalex.org/W2038623905","https://openalex.org/W2044851115","https://openalex.org/W2053320906","https://openalex.org/W2061506872","https://openalex.org/W2064387196","https://openalex.org/W2065483496","https://openalex.org/W2079231160","https://openalex.org/W2102918269","https://openalex.org/W2104732966","https://openalex.org/W2107797512","https://openalex.org/W2116824990","https://openalex.org/W2126352920","https://openalex.org/W2127835798","https://openalex.org/W2134153962","https://openalex.org/W2142259789","https://openalex.org/W2142576446","https://openalex.org/W2144862023","https://openalex.org/W2157268049","https://openalex.org/W2167244209"],"related_works":["https://openalex.org/W2373408835","https://openalex.org/W2010647829","https://openalex.org/W1933297959","https://openalex.org/W7061386056","https://openalex.org/W1883225649","https://openalex.org/W4213435252","https://openalex.org/W2027372808","https://openalex.org/W4409368765","https://openalex.org/W2806428381","https://openalex.org/W2029256486"],"abstract_inverted_index":{"\"La":[0],"preeclampsia":[1,87,99,285],"es":[2,30,44,314],"un":[3,266],"desorden":[4],"multisist\u00e9mico":[5],"que":[6,161,317],"forma":[7],"parte":[8],"del":[9,16,93,100,165,331],"espectro":[10],"de":[11,27,32,39,60,69,82,86,104,107,141,151,155,170,176,182,186,200,218,240,268,284,300,321,325],"enfer":[12],"-":[13],"medades":[14],"hipertensivas":[15],"embarazo;":[17],"sus":[18],"mayores":[19],"incidencias":[20],"se":[21,72,112,118,278],"presentan":[22],"en":[23,25,49,57,75,96,109,135,173,179,216,242,247,260],"pa\u00edses":[24],"v\u00edas":[26],"desarrollo":[28],"y":[29,35,64,117,123,149,208,245,259,329],"factor":[31],"morbi-mortalidad":[33],"materna":[34],"perinatal.":[36],"El":[37,138,292,311],"Factor":[38],"Crecimiento":[40],"Transformante":[41],"\u03b21":[42],"(TGF-\u03b21)":[43],"una":[45,297],"citosina":[46,71],"multifuncional,":[47],"producida":[48],"el":[50,84,150,162,169,174,180,195,227,234,254,262,274,315],"embarazo":[51],"principalmente":[52],"por":[53,88,120,133,272],"c\u00e9lulas":[54],"trofobl\u00e1sticas,":[55],"implicada":[56],"la":[58,80,105,184,191,319,336],"regulaci\u00f3n":[59],"su":[61],"invasi\u00f3n,":[62],"proliferaci\u00f3n":[63],"diferenciaci\u00f3n.":[65],"Los":[66,129],"niveles":[67],"plasm\u00e1ticos":[68],"esta":[70],"encuentran":[73],"elevados":[74],"embarazos":[76],"con":[77,98,125,238,281,335],"preeclampsia.":[78],"Con":[79],"finalidad":[81],"determinar":[83],"riesgo":[85,282],"los":[89,198,222,243,250,322,326],"genotipos":[90,224,323],"combinados":[91,225,324],"-509CT/869TC":[92,277],"gen":[94,332],"TGFB1":[95],"mujeres":[97,115],"Hospital":[101],"General":[102],"\u201cA\u201d":[103],"Secretar\u00eda":[106],"Salud":[108],"Durango,":[110,111],"reclutaron":[113],"49":[114],"preecl\u00e1mpticas":[116],"parearon":[119],"edad":[121,152],"cronol\u00f3gica":[122],"gestacional":[124,153],"100":[126],"controles":[127,183,261],"normoevolutivos.":[128],"polimorfismos":[130,214],"fueron":[131,203],"genotipificados":[132],"PCR":[134],"tiempo":[136],"real.":[137],"rango":[139],"etario":[140],"las":[142],"participantes":[143],"fue":[144,154,168,190,233],"13":[145],"a":[146,157],"24":[147],"a\u00f1os":[148],"30":[156],"41.2":[158],"semanas.":[159],"Mientras":[160],"alelo":[163],"T":[164,209,333],"polimorfismo":[166,196],"-509C/T":[167,328],"menor":[171,201],"frecuencia":[172,185,202,239],"grupo":[175,181],"casos":[177,244],"(0.479),":[178],"ambos":[187,231],"alelos":[188,199],"(C/T)":[189],"misma":[192],"(0.5).":[193],"Para":[194],"869T/C":[197,330],"C":[204],"=":[205,210],"0.48":[206],"(casos)":[207],"0.45":[211],"(controles).":[212],"Ambos":[213],"estuvieron":[215],"Equilibro":[217],"Hardy-Weinberg.":[219],"Se":[220],"encontraron":[221],"nueve":[223],"posibles;":[226],"m\u00e1s":[228],"frecuente":[229],"para":[230,249],"grupos":[232],"doble":[235],"heterocigoto":[236],"-509CT/869TC,":[237],"0.265":[241],"0.25":[246],"controles;":[248],"casos,":[251],"le":[252],"sigue":[253],"genotipo":[255,275,293],"combinado":[256,276,294],"-509CT/869TT":[257],"(0.184)":[258],"-509TT/869CC":[263],"(0.15).":[264],"Mediante":[265],"modelo":[267],"regresi\u00f3n":[269],"log\u00edstica":[270],"ajustado":[271],"edad,":[273],"asoci\u00f3":[279],"significativamente":[280],"incrementado":[283],"(OR":[286,305],"1.334,":[287],"IC":[288,307],"95":[289,308],"%":[290,309],"1.024-1.765).":[291],"-509CC/869CC":[295],"mostr\u00f3":[296],"fuerte":[298],"tendencia":[299],"asociaci\u00f3n,":[301],"pero":[302],"no":[303],"significativa":[304],"2.202,":[306],"0.983-4.937).":[310],"presente":[312],"estudio":[313],"primero":[316],"analiza":[318],"asociaci\u00f3n":[320],"SNPs":[327],"GFB1":[334],"preeclampsia.\"":[337]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}