{"id":"https://openalex.org/W1963091503","doi":"https://doi.org/10.1128/iai.51.1.193-198.1986","title":"Effect of Tamm-Horsfall urinary glycoprotein on phagocytosis and killing of type I-fimbriated Escherichia coli","display_name":"Effect of Tamm-Horsfall urinary glycoprotein on phagocytosis and killing of type I-fimbriated Escherichia coli","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W1963091503","doi":"https://doi.org/10.1128/iai.51.1.193-198.1986","mag":"1963091503","pmid":"https://pubmed.ncbi.nlm.nih.gov/2867043","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/261085"},"language":"en","primary_location":{"id":"doi:10.1128/iai.51.1.193-198.1986","doi":"https://doi.org/10.1128/iai.51.1.193-198.1986","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.51.1.193-198.1986","pdf_url":"https://iai.asm.org/content/iai/51/1/193.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://iai.asm.org/content/iai/51/1/193.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055239613","display_name":"S M Kuriyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S M Kuriyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111462299","display_name":"Fredric J. Silverblatt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F J Silverblatt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.7208,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.94654498,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"51","issue":"1","first_page":"193","last_page":"198"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uromodulin","display_name":"uromodulin","score":0.871999979019165},{"id":"https://openalex.org/keywords/urinary-glycoprotein","display_name":"urinary glycoprotein","score":0.9649999737739563},{"id":"https://openalex.org/keywords/type-1-fimbriae","display_name":"type 1 fimbriae","score":0.8989999890327454},{"id":"https://openalex.org/keywords/polymorphonuclear-leukocytes","display_name":"polymorphonuclear leukocytes","score":0.8410000205039978},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/bactericidal-activity","display_name":"bactericidal activity","score":0.7950000166893005},{"id":"https://openalex.org/keywords/mannose-binding","display_name":"mannose binding","score":0.6850000023841858},{"id":"https://openalex.org/keywords/alpha-methyl-mannoside","display_name":"alpha-methyl-D-mannoside","score":0.8840000033378601},{"id":"https://openalex.org/keywords/bacterial-virulence","display_name":"bacterial virulence","score":0.6340000033378601},{"id":"https://openalex.org/keywords/urinary-tract-infection","display_name":"urinary tract infection","score":0.6060000061988831},{"id":"https://openalex.org/keywords/pyelonephritis","display_name":"pyelonephritis","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.872520387172699},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.8257890343666077},{"id":"https://openalex.org/C74460091","wikidata":"https://www.wikidata.org/wiki/Q420024","display_name":"Tamm\u2013Horsfall protein","level":3,"score":0.7610670924186707},{"id":"https://openalex.org/C39103817","wikidata":"https://www.wikidata.org/wiki/Q1810775","display_name":"Fimbria","level":4,"score":0.7281922101974487},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.7197617292404175},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6910196542739868},{"id":"https://openalex.org/C168507396","wikidata":"https://www.wikidata.org/wiki/Q14859847","display_name":"Antibody opsonization","level":4,"score":0.5613958835601807},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5602237582206726},{"id":"https://openalex.org/C2778910516","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae","level":4,"score":0.5336350202560425},{"id":"https://openalex.org/C89372155","wikidata":"https://www.wikidata.org/wiki/Q420107","display_name":"Opsonin","level":3,"score":0.49916911125183105},{"id":"https://openalex.org/C174832134","wikidata":"https://www.wikidata.org/wiki/Q934786","display_name":"Pilus","level":4,"score":0.43941962718963623},{"id":"https://openalex.org/C155292618","wikidata":"https://www.wikidata.org/wiki/Q1137328","display_name":"Bacterial capsule","level":4,"score":0.4315243065357208},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.4237516522407532},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.30241382122039795},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.26529768109321594},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18709814548492432},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.06638792157173157},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000268","descriptor_name":"Adhesiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008362","descriptor_name":"Mannosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008766","descriptor_name":"Methylmannosides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009088","descriptor_name":"Mucoproteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D009088","descriptor_name":"Mucoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010861","descriptor_name":"Fimbriae, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058949","descriptor_name":"Uromodulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/iai.51.1.193-198.1986","doi":"https://doi.org/10.1128/iai.51.1.193-198.1986","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.51.1.193-198.1986","pdf_url":"https://iai.asm.org/content/iai/51/1/193.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:223282","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC261085","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:261085","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/261085","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:2867043","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2867043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/iai.51.1.193-198.1986","doi":"https://doi.org/10.1128/iai.51.1.193-198.1986","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.51.1.193-198.1986","pdf_url":"https://iai.asm.org/content/iai/51/1/193.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1963091503.pdf"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1514629116","https://openalex.org/W1520385356","https://openalex.org/W1603952211","https://openalex.org/W1850040337","https://openalex.org/W1870627579","https://openalex.org/W1871555078","https://openalex.org/W1965656196","https://openalex.org/W1973435045","https://openalex.org/W1974690528","https://openalex.org/W1980457285","https://openalex.org/W1991844560","https://openalex.org/W2001464721","https://openalex.org/W2003850645","https://openalex.org/W2005813215","https://openalex.org/W2020326478","https://openalex.org/W2045347928","https://openalex.org/W2068449311","https://openalex.org/W2072424528","https://openalex.org/W2080043237","https://openalex.org/W2117190793","https://openalex.org/W2158175350","https://openalex.org/W2265067966","https://openalex.org/W2314434062","https://openalex.org/W2462079715"],"related_works":["https://openalex.org/W2099853845","https://openalex.org/W1990071625","https://openalex.org/W1970480898","https://openalex.org/W2022548242","https://openalex.org/W7097993141","https://openalex.org/W2325341766","https://openalex.org/W7100046100","https://openalex.org/W2402184170","https://openalex.org/W2069784784","https://openalex.org/W2085729260"],"abstract_inverted_index":{"Human":[0],"polymorphonuclear":[1],"leukocytes":[2,188],"(PMN)":[3],"ingest":[4,91],"type":[5,44,54,77,92],"I":[6,45,55,78],"(mannose":[7],"sensitive)":[8],"fimbriated":[9],"Escherichia":[10],"coli":[11,95,205,234],"even":[12],"in":[13,146,178,189,235],"the":[14,27,99,137,212,230,236],"absence":[15],"of":[16,85,120,140,176,193,202,208,214,222,232],"antibody,":[17],"complement,":[18],"or":[19],"other":[20],"serum":[21,241],"opsonins.":[22],"Our":[23],"studies":[24],"suggest":[25],"that":[26,39],"Tamm-Horsfall":[28],"urinary":[29],"glycoprotein":[30],"(THP)":[31],"interferes":[32],"with":[33,117,125,158,187],"serum-independent":[34],"ingestion.":[35],"Electron":[36],"micrographs":[37],"showed":[38],"dissolved":[40],"THP":[41,107,141,159,246],"adhered":[42],"to":[43,88,106,153,162,171,180],"fimbriae":[46,65,79],"and":[47,80,90,144,164,238,245],"formed":[48],"a":[49,147],"pseudocapsule":[50],"around":[51],"bacteria":[52,58,100,129,177,216],"bearing":[53],"fimbriae.":[56],"Phase-variant":[57],"grown":[59],"on":[60,142],"blood":[61],"agar":[62],"neither":[63],"expressed":[64],"nor":[66],"bound":[67],"THP.":[68,82],"Affinity":[69],"column":[70],"chromatography":[71],"demonstrated":[72,191],"mannose-sensitive":[73],"binding":[74,143],"between":[75],"purified":[76,81],"The":[83],"ability":[84],"human":[86],"PMN":[87,114,156,199],"bind":[89,163],"I-fimbriated":[93],"E.":[94,204,233],"was":[96],"diminished":[97],"if":[98],"had":[101],"been":[102],"coated":[103,128],"by":[104,218],"exposure":[105],"at":[108],"physiologic":[109],"concentrations.":[110],"At":[111,196],"1":[112,197],"h,":[113,198],"were":[115,160],"associated":[116],"an":[118],"average":[119],"2.62":[121],"uncoated":[122],"bacteria,":[123],"but":[124,211],"only":[126],"0.18":[127],"(P":[130],"less":[131],"than":[132],"0.001).":[133],"alpha-Methyl":[134],"mannoside":[135,151],"blocked":[136],"observed":[138],"effect":[139],"phagocytosis":[145],"dose-dependent":[148],"fashion:":[149],"increased":[150,154,217],"led":[152],"blocking.":[155],"preincubated":[157],"able":[161],"phagocytose":[165],"normally.":[166],"There":[167],"did":[168],"not":[169],"appear":[170],"be":[172],"any":[173],"significant":[174],"clumping":[175],"suspension":[179,190],"account":[181],"for":[182],"these":[183],"effects.":[184],"Bactericidal":[185],"assays":[186],"protection":[192],"THP-coated":[194,215],"bacteria.":[195],"killed":[200],"42%":[201],"noncoated":[203],"(a":[206],"decrease":[207],"0.24":[209,223],"log),":[210],"number":[213],"75%":[219],"(an":[220],"increase":[221],"log).":[224],"These":[225],"observations":[226],"may":[227],"partially":[228],"explain":[229],"virulence":[231],"bladder":[237],"kidney,":[239],"where":[240],"activity":[242],"is":[243,247],"low":[244],"abundant.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
