{"id":"https://openalex.org/W1963072412","doi":"https://doi.org/10.1186/s12936-015-0951-5","title":"Enhanced artemisinin yield by expression of rol genes in Artemisia annua","display_name":"Enhanced artemisinin yield by expression of rol genes in Artemisia annua","publication_year":2015,"publication_date":"2015-10-28","ids":{"openalex":"https://openalex.org/W1963072412","doi":"https://doi.org/10.1186/s12936-015-0951-5","mag":"1963072412","pmid":"https://pubmed.ncbi.nlm.nih.gov/26510528","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4625606"},"language":"en","primary_location":{"id":"doi:10.1186/s12936-015-0951-5","doi":"https://doi.org/10.1186/s12936-015-0951-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12936-015-0951-5","pdf_url":"https://malariajournal.biomedcentral.com/counter/pdf/10.1186/s12936-015-0951-5","source":{"id":"https://openalex.org/S93003929","display_name":"Malaria Journal","issn_l":"1475-2875","issn":["1475-2875"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malaria Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://malariajournal.biomedcentral.com/counter/pdf/10.1186/s12936-015-0951-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028791523","display_name":"Erum Dilshad","orcid":"https://orcid.org/0000-0002-0854-7428","observed_orcids":["https://orcid.org/0000-0002-0854-7428"]},"institutions":[{"id":"https://openalex.org/I12469534","display_name":"Quaid-i-Azam University","ror":"https://ror.org/04s9hft57","country_code":"PK","type":"education","lineage":["https://openalex.org/I12469534"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Erum Dilshad","raw_affiliation_strings":["Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. erum.dilshad@gmail.com","Department of Biochemistry; Faculty of Biological Sciences; Quaid-i-Azam University, Islamabad; Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. erum.dilshad@gmail.com","institution_ids":["https://openalex.org/I12469534"]},{"raw_affiliation_string":"Department of Biochemistry; Faculty of Biological Sciences; Quaid-i-Azam University, Islamabad; Pakistan","institution_ids":["https://openalex.org/I12469534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073731058","display_name":"Rosa Maria Cusido","orcid":"https://orcid.org/0000-0002-8398-0619","observed_orcids":["https://orcid.org/0000-0002-8398-0619"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rosa Maria Cusido","raw_affiliation_strings":["Laboratorio de Fisiologia Vegetal, Facultad de Farmacia, Universidad de Barcelona, Barcelona, Spain. rcusido@ub.edu","Laboratorio de Fisiolog\u00eda Vegetal, Facultad de Farmacia, Universidad de Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Fisiologia Vegetal, Facultad de Farmacia, Universidad de Barcelona, Barcelona, Spain. rcusido@ub.edu","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Laboratorio de Fisiolog\u00eda Vegetal, Facultad de Farmacia, Universidad de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052395692","display_name":"Javier Palaz\u00f3n","orcid":"https://orcid.org/0000-0003-3538-6890","observed_orcids":["https://orcid.org/0000-0003-3538-6890"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Palazon","raw_affiliation_strings":["Laboratorio de Fisiologia Vegetal, Facultad de Farmacia, Universidad de Barcelona, Barcelona, Spain. javierpalazon@ub.edu","Laboratorio de Fisiolog\u00eda Vegetal, Facultad de Farmacia, Universidad de Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Fisiologia Vegetal, Facultad de Farmacia, Universidad de Barcelona, Barcelona, Spain. javierpalazon@ub.edu","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Laboratorio de Fisiolog\u00eda Vegetal, Facultad de Farmacia, Universidad de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044495854","display_name":"Karla Ram\u00edrez\u2010Estrada","orcid":"https://orcid.org/0000-0002-7840-7981","observed_orcids":["https://orcid.org/0000-0002-7840-7981"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Karla Ramirez Estrada","raw_affiliation_strings":["Laboratorio de Fisiologia Vegetal, Facultad de Farmacia, Universidad de Barcelona, Barcelona, Spain. kems3estrada@gmail.com","Laboratorio de Fisiolog\u00eda Vegetal, Facultad de Farmacia, Universidad de Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Fisiologia Vegetal, Facultad de Farmacia, Universidad de Barcelona, Barcelona, Spain. kems3estrada@gmail.com","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Laboratorio de Fisiolog\u00eda Vegetal, Facultad de Farmacia, Universidad de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051712124","display_name":"Mercedes Bonfill","orcid":"https://orcid.org/0000-0003-0664-3755","observed_orcids":["https://orcid.org/0000-0003-0664-3755"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mercedes Bonfill","raw_affiliation_strings":["Laboratorio de Fisiologia Vegetal, Facultad de Farmacia, Universidad de Barcelona, Barcelona, Spain. mbonfill@ub.edu","Laboratorio de Fisiolog\u00eda Vegetal, Facultad de Farmacia, Universidad de Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Fisiologia Vegetal, Facultad de Farmacia, Universidad de Barcelona, Barcelona, Spain. mbonfill@ub.edu","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Laboratorio de Fisiolog\u00eda Vegetal, Facultad de Farmacia, Universidad de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084123435","display_name":"Bushra Mirza","orcid":"https://orcid.org/0000-0002-4134-6636","observed_orcids":["https://orcid.org/0000-0002-4134-6636"]},"institutions":[{"id":"https://openalex.org/I12469534","display_name":"Quaid-i-Azam University","ror":"https://ror.org/04s9hft57","country_code":"PK","type":"education","lineage":["https://openalex.org/I12469534"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Bushra Mirza","raw_affiliation_strings":["Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. bushramirza@qau.edu.pk","Department of Biochemistry; Faculty of Biological Sciences; Quaid-i-Azam University, Islamabad; Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. bushramirza@qau.edu.pk","institution_ids":["https://openalex.org/I12469534"]},{"raw_affiliation_string":"Department of Biochemistry; Faculty of Biological Sciences; Quaid-i-Azam University, Islamabad; Pakistan","institution_ids":["https://openalex.org/I12469534"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5084123435"],"corresponding_institution_ids":["https://openalex.org/I12469534"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":2.0767,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.87539597,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"424","last_page":"424"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10240","display_name":"Plant tissue culture and regeneration","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artemisinin","display_name":"artemisinin","score":0.8529999852180481},{"id":"https://openalex.org/keywords/artemisia-annua","display_name":"Artemisia annua","score":0.9980000257492065},{"id":"https://openalex.org/keywords/rol-genes","display_name":"rol genes","score":0.8100000023841858},{"id":"https://openalex.org/keywords/rolb","display_name":"rolB","score":0.765999972820282},{"id":"https://openalex.org/keywords/rolc","display_name":"rolC","score":1.0},{"id":"https://openalex.org/keywords/genetically-modified-plants","display_name":"transgenic plants","score":0.7720000147819519},{"id":"https://openalex.org/keywords/artemisinin-biosynthesis","display_name":"artemisinin biosynthesis","score":0.7799999713897705},{"id":"https://openalex.org/keywords/trichome-development","display_name":"trichome development","score":0.8450000286102295},{"id":"https://openalex.org/keywords/sesquiterpene-biosynthesis","display_name":"sesquiterpene biosynthesis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cyp71av1","display_name":"CYP71AV1","score":0.9509999752044678},{"id":"https://openalex.org/keywords/aldh1","display_name":"ALDH1","score":0.9190000295639038},{"id":"https://openalex.org/keywords/artesunate","display_name":"artesunate","score":0.8970000147819519},{"id":"https://openalex.org/keywords/dihydroartemisinin","display_name":"dihydroartemisinin","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C2776120307","wikidata":"https://www.wikidata.org/wiki/Q426921","display_name":"Artemisinin","level":4,"score":0.9829373359680176},{"id":"https://openalex.org/C2779691961","wikidata":"https://www.wikidata.org/wiki/Q1308044","display_name":"Artemisia annua","level":5,"score":0.9810836315155029},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5878788828849792},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4205189645290375},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.3642372488975525},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.35783571004867554},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.34751808643341064},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.284811794757843},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014170","descriptor_name":"Transformation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016960","descriptor_name":"Agrobacterium tumefaciens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017343","descriptor_name":"Genes, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030821","descriptor_name":"Plants, Genetically Modified","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030821","descriptor_name":"Plants, Genetically Modified","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D031172","descriptor_name":"Artemisia annua","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D031172","descriptor_name":"Artemisia annua","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/s12936-015-0951-5","doi":"https://doi.org/10.1186/s12936-015-0951-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12936-015-0951-5","pdf_url":"https://malariajournal.biomedcentral.com/counter/pdf/10.1186/s12936-015-0951-5","source":{"id":"https://openalex.org/S93003929","display_name":"Malaria Journal","issn_l":"1475-2875","issn":["1475-2875"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malaria Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4625606","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4625606","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malar J","raw_type":"Text"},{"id":"pmid:26510528","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26510528","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malaria journal","raw_type":"Journal Article"},{"id":"pmh:oai:recercat.cat:2072/266467","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2445/100901","pdf_url":null,"source":{"id":"https://openalex.org/S4306402147","display_name":"RECERCAT (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.803.3821","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.803.3821","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/0b/fa/12936_2015_Article_951.PMC4625606.pdf","raw_type":"text"},{"id":"pmh:oai:diposit.ub.edu:2445/100901","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2445/100901","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s12936-015-0951-5","doi":"https://doi.org/10.1186/s12936-015-0951-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12936-015-0951-5","pdf_url":"https://malariajournal.biomedcentral.com/counter/pdf/10.1186/s12936-015-0951-5","source":{"id":"https://openalex.org/S93003929","display_name":"Malaria Journal","issn_l":"1475-2875","issn":["1475-2875"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malaria Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6735000014305115,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"},{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3336851542","display_name":null,"funder_award_id":"BIO2014-51861-R","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G4164734174","display_name":null,"funder_award_id":"2014SGR215","funder_id":"https://openalex.org/F4320321505","funder_display_name":"Generalitat de Catalunya"},{"id":"https://openalex.org/G5576324475","display_name":null,"funder_award_id":"BIO2014-51861-R","funder_id":"https://openalex.org/F4320321505","funder_display_name":"Generalitat de Catalunya"}],"funders":[{"id":"https://openalex.org/F4320321505","display_name":"Generalitat de Catalunya","ror":"https://ror.org/01bg62x04"},{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1963072412.pdf","grobid_xml":"https://content.openalex.org/works/W1963072412.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W169103684","https://openalex.org/W937887026","https://openalex.org/W1577007768","https://openalex.org/W1691600119","https://openalex.org/W1967648518","https://openalex.org/W1969962785","https://openalex.org/W1974500909","https://openalex.org/W1978072140","https://openalex.org/W1978144724","https://openalex.org/W1979347562","https://openalex.org/W1982423111","https://openalex.org/W1984365785","https://openalex.org/W1988086615","https://openalex.org/W1990849226","https://openalex.org/W2011244594","https://openalex.org/W2022259343","https://openalex.org/W2023867267","https://openalex.org/W2024936628","https://openalex.org/W2026919063","https://openalex.org/W2028192345","https://openalex.org/W2040738377","https://openalex.org/W2042741109","https://openalex.org/W2045037263","https://openalex.org/W2045056598","https://openalex.org/W2045533700","https://openalex.org/W2057823601","https://openalex.org/W2064454136","https://openalex.org/W2076029682","https://openalex.org/W2082131104","https://openalex.org/W2084179044","https://openalex.org/W2090244444","https://openalex.org/W2092641756","https://openalex.org/W2095518262","https://openalex.org/W2103676081","https://openalex.org/W2104781222","https://openalex.org/W2113165134","https://openalex.org/W2129447528","https://openalex.org/W2145813726","https://openalex.org/W2152443621","https://openalex.org/W2157827172","https://openalex.org/W2162903401","https://openalex.org/W2340170325","https://openalex.org/W2340555095","https://openalex.org/W2490809702","https://openalex.org/W4234457544","https://openalex.org/W4238052048","https://openalex.org/W6823859822"],"related_works":["https://openalex.org/W7100941259","https://openalex.org/W2183244518","https://openalex.org/W2345738558","https://openalex.org/W2907620356","https://openalex.org/W7097893374","https://openalex.org/W248724929","https://openalex.org/W4321459122","https://openalex.org/W2123530556","https://openalex.org/W2581239899","https://openalex.org/W2001707360"],"abstract_inverted_index":{"BACKGROUND:":[0],"Despite":[1],"of":[2,8,22,26,52,63,74,86,97,100,115,120,142,144,158,180,184,231,245,282,317,350,371,374],"many":[3],"advances":[4],"in":[5,28,37,211,257,267,271,276,279,290,296,303,332,344,368,386],"the":[6,13,23,29,53,60,72,91,98,140,153,177,232,258,280,310,347,351,369],"treatment":[7],"malaria,":[9],"it":[10,356],"is":[11,20,49,207],"still":[12,50],"fifth":[14],"most":[15,54],"prevalent":[16],"disease":[17],"worldwide":[18],"and":[19,132,160,197,215,218,238,273,298,362],"one":[21,51],"major":[24],"causes":[25],"death":[27],"developing":[30],"countries":[31],"which":[32,341],"accounted":[33],"for":[34,57,93,155,223],"584,000":[35],"deaths":[36],"2013,":[38],"as":[39],"estimated":[40],"by":[41,67,90,152,170],"World":[42],"Health":[43],"Organization.":[44],"Artemisinin":[45],"from":[46],"Artemisia":[47],"annua":[48,65,88,122],"effective":[55,367],"treatments":[56],"malaria.":[58],"Increasing":[59],"artemisinin":[61,145,159,164,181,185,224,372],"content":[62,373],"A.":[64,87,121,339,375],"plants":[66],"genetic":[68,118],"engineering":[69],"would":[70],"improve":[71],"availability":[73],"this":[75,80,387],"much-needed":[76],"drug.":[77],"METHODS:":[78],"In":[79],"regard,":[81],"a":[82,287],"high":[83,163],"artemisinin-yielding":[84],"hybrid":[85],"produced":[89,149],"centre":[92],"novel":[94],"agricultural":[95],"products":[96],"University":[99],"York,":[101],"UK,":[102],"was":[103,136,235,241,306,325,342,357],"selected":[104],"(artemisinin":[105],"maximally":[106],"1.4":[107],"%).":[108],"As":[109],"rol":[110,130,133,246,283,311,321,333,360,363,377,390],"genes":[111,135,319,365],"are":[112,221,366],"potential":[113],"candidates":[114],"biochemical":[116],"engineering,":[117],"transformation":[119],"with":[123,129,139,309,346],"Agrobacterium":[124],"tumefaciens":[125],"GV3101":[126],"harbouring":[127],"vectors":[128],"B":[131,247,312,361,378],"C":[134,284,322,364,391],"carried":[137,236],"out":[138],"objective":[141],"enhancement":[143,370,388],"content.":[146],"Transgenic":[147],"lines":[148],"were":[150,167,188],"analysed":[151,169],"LC-MS":[154],"quantitative":[156,173],"analysis":[157,230],"analogues.":[161],"These":[162],"yielding":[165],"transgenics":[166,335],"also":[168,326,343],"real":[171,227],"time":[172,228],"PCR":[174],"to":[175,251,262,264,293,300,328,383],"find":[176],"molecular":[178],"dynamics":[179],"enhancement.":[182],"Genes":[183],"biosynthetic":[186],"pathway":[187],"studied":[189],"including":[190],"amorphadiene":[191],"synthase":[192],"(ADS),":[193],"cytochrome":[194],"P450,":[195],"(CYP71AV1)":[196],"aldehyde":[198],"dehydrogenase":[199],"1":[200],"(ALDH1).":[201],"Trichome-specific":[202],"fatty":[203],"acyl-CoA":[204],"reductase":[205],"1(TAFR1)":[206],"an":[208],"enzyme":[209],"involved":[210],"both":[212,219],"trichome":[213,239,348],"development":[214],"sesquiterpenoid":[216],"biosynthesis":[217],"processes":[220],"important":[222],"biosynthesis.":[225],"Thus,":[226],"qPCR":[229],"TAFR1":[233,324],"gene":[234,248,285,313,334,379],"out,":[237],"density":[240,349],"determined.":[242],"RESULTS:":[243],"Transgenics":[244],"showed":[249],"two-":[250,263],"ninefold":[252,294],"(the":[253],"decimal":[254],"adds":[255],"nothing":[256],"abstract,":[259],"please":[260],"simplify":[261],"ninefold)":[265],"increase":[266,270,275,289,295,302],"artemisinin,":[268,291],"4-12-fold":[269],"artesunate":[272,297],"1.2-3-fold":[274],"dihydroartemisinin.":[277],"Whereas":[278],"case":[281],"transformants,":[286],"fourfold":[288],"four":[292],"one-":[299],"twofold":[301],"dihydroartemisinin":[304],"concentration":[305],"observed.":[307],"Transformants":[308],"had":[314],"higher":[315],"expression":[316],"these":[318],"than":[320,336,389],"transformants.":[323],"found":[327],"be":[329],"more":[330,381],"expressed":[331],"wild":[337],"type":[338],"annua,":[340,376],"accordance":[345],"respective":[352],"plant.":[353],"CONCLUSION:":[354],"Thus":[355],"proved":[358],"that":[359],"being":[380],"active":[382],"play":[384],"part":[385],"gene.":[392]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}