{"id":"https://openalex.org/W1962934739","doi":"https://doi.org/10.1176/ajp.155.2.207","title":"Cocaine, Ethanol, and Genotype Effects on Human Midbrain Serotonin Transporter Binding Sites and mRNA Levels","display_name":"Cocaine, Ethanol, and Genotype Effects on Human Midbrain Serotonin Transporter Binding Sites and mRNA Levels","publication_year":1998,"publication_date":"1998-02-01","ids":{"openalex":"https://openalex.org/W1962934739","doi":"https://doi.org/10.1176/ajp.155.2.207","mag":"1962934739","pmid":"https://pubmed.ncbi.nlm.nih.gov/9464199"},"language":"en","primary_location":{"id":"doi:10.1176/ajp.155.2.207","doi":"https://doi.org/10.1176/ajp.155.2.207","is_oa":false,"landing_page_url":"https://doi.org/10.1176/ajp.155.2.207","pdf_url":null,"source":{"id":"https://openalex.org/S116025658","display_name":"American Journal of Psychiatry","issn_l":"0002-953X","issn":["0002-953X","1535-7228"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316602","host_organization_name":"American Psychiatric Association","host_organization_lineage":["https://openalex.org/P4310316602"],"host_organization_lineage_names":["American Psychiatric Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062790374","display_name":"Karley Y. Little","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karley Y. Little","raw_affiliation_strings":["Department of Psychiatry, University of Michigan, Ann Arbor, USA. kylittle@umich.edu","Department of Psychiatry; University of Michigan; Ann Arbor USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Michigan, Ann Arbor, USA. kylittle@umich.edu","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Psychiatry; University of Michigan; Ann Arbor USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072184060","display_name":"Daniel P. McLaughlin","orcid":"https://orcid.org/0000-0002-7060-7321","observed_orcids":["https://orcid.org/0000-0002-7060-7321"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel P. McLaughlin","raw_affiliation_strings":["","(University of Michigan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"(University of Michigan)","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lian Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lian Zhang","raw_affiliation_strings":["","(University of Michigan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"(University of Michigan)","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023407567","display_name":"Cynthia S. Livermore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia S. Livermore","raw_affiliation_strings":["","(University of Michigan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"(University of Michigan)","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091016717","display_name":"Gregory W. Dalack","orcid":"https://orcid.org/0000-0001-6599-0111","observed_orcids":["https://orcid.org/0000-0001-6599-0111"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory W. Dalack","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086117239","display_name":"Patrick R. McFinton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick R. McFinton","raw_affiliation_strings":["","(University of Michigan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"(University of Michigan)","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088476254","display_name":"Zachary DelProposto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary S. DelProposto","raw_affiliation_strings":["","(University of Michigan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"(University of Michigan)","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103566641","display_name":"Elizabeth M. Hill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Hill","raw_affiliation_strings":["","(University of Michigan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"(University of Michigan)","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104017035","display_name":"Bader J. Cassin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bader J. Cassin","raw_affiliation_strings":["","(University of Michigan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"(University of Michigan)","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049286080","display_name":"Stanley J. Watson","orcid":"https://orcid.org/0000-0003-4980-5523","observed_orcids":["https://orcid.org/0000-0003-4980-5523"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stanley J. Watson","raw_affiliation_strings":["","Molecular and Behavioral Neuroscience Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Molecular and Behavioral Neuroscience Institute","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002090056","display_name":"Edwin H. Cook","orcid":"https://orcid.org/0000-0002-5848-5114","observed_orcids":["https://orcid.org/0000-0002-5848-5114"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin H. Cook","raw_affiliation_strings":["","(University of Michigan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"(University of Michigan)","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.3648,"has_fulltext":false,"cited_by_count":381,"citation_normalized_percentile":{"value":0.98519306,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"155","issue":"2","first_page":"207","last_page":"213"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin-transporter","display_name":"serotonin transporter","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cocaine","display_name":"cocaine","score":0.7379999756813049},{"id":"https://openalex.org/keywords/ethanol-dependence","display_name":"ethanol dependence","score":0.7639999985694885},{"id":"https://openalex.org/keywords/dorsal-raphe-nucleus","display_name":"dorsal raphe nucleus","score":0.8100000023841858},{"id":"https://openalex.org/keywords/median-raphe-nucleus","display_name":"median raphe nucleus","score":0.8820000290870667},{"id":"https://openalex.org/keywords/midbrain","display_name":"midbrain","score":0.7829999923706055},{"id":"https://openalex.org/keywords/genotype-effects","display_name":"genotype effects","score":0.4819999933242798},{"id":"https://openalex.org/keywords/dual-diagnosis","display_name":"dual diagnosis","score":0.7839999794960022},{"id":"https://openalex.org/keywords/chronic-substance-use","display_name":"chronic substance use","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C2778897192","wikidata":"https://www.wikidata.org/wiki/Q410142","display_name":"Serotonin transporter","level":4,"score":0.9618538618087769},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.7875727415084839},{"id":"https://openalex.org/C2908747647","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"Serotonin Plasma Membrane Transport Proteins","level":5,"score":0.7801955938339233},{"id":"https://openalex.org/C32610206","wikidata":"https://www.wikidata.org/wiki/Q5298804","display_name":"Dorsal raphe nucleus","level":5,"score":0.6887366771697998},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5395412445068359},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.522480845451355},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47218385338783264},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.43891647458076477},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.43250036239624023},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.35478776693344116},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3336635231971741},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.188661128282547},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15403220057487488},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09764659404754639},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0910046398639679}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008636","descriptor_name":"Mesencephalon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008636","descriptor_name":"Mesencephalon","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011869","descriptor_name":"Radioligand Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011903","descriptor_name":"Raphe Nuclei","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011903","descriptor_name":"Raphe Nuclei","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017831","descriptor_name":"Diagnosis, Dual (Psychiatry)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019970","descriptor_name":"Cocaine-Related Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D019970","descriptor_name":"Cocaine-Related Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019970","descriptor_name":"Cocaine-Related Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050486","descriptor_name":"Serotonin Plasma Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1176/ajp.155.2.207","doi":"https://doi.org/10.1176/ajp.155.2.207","is_oa":false,"landing_page_url":"https://doi.org/10.1176/ajp.155.2.207","pdf_url":null,"source":{"id":"https://openalex.org/S116025658","display_name":"American Journal of Psychiatry","issn_l":"0002-953X","issn":["0002-953X","1535-7228"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316602","host_organization_name":"American Psychiatric Association","host_organization_lineage":["https://openalex.org/P4310316602"],"host_organization_lineage_names":["American Psychiatric Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Psychiatry","raw_type":"journal-article"},{"id":"pmid:9464199","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9464199","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of psychiatry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2201729747","display_name":"MU &DELTA RECEPTORS--ROLE IN TRANSMISSION &ADDICTION","funder_award_id":"R01DA002265","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G605253752","display_name":"BRAIN DAT/5-HTT DYSREGULATION IN HUMAN COCAINE USERS","funder_award_id":"R01DA009491","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G62754510","display_name":"Molecular Elements, Neurocircuits and Mental Illness","funder_award_id":"P01MH042251","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W30537814","https://openalex.org/W65154250","https://openalex.org/W1554082519","https://openalex.org/W1593988473","https://openalex.org/W1602351583","https://openalex.org/W1977707793","https://openalex.org/W1981211257","https://openalex.org/W1983066926","https://openalex.org/W1983330867","https://openalex.org/W2003774397","https://openalex.org/W2005534453","https://openalex.org/W2006153277","https://openalex.org/W2014706474","https://openalex.org/W2014793858","https://openalex.org/W2017901088","https://openalex.org/W2021107205","https://openalex.org/W2027273151","https://openalex.org/W2027580007","https://openalex.org/W2028860498","https://openalex.org/W2032472340","https://openalex.org/W2035514944","https://openalex.org/W2040708659","https://openalex.org/W2041288853","https://openalex.org/W2044968774","https://openalex.org/W2056090799","https://openalex.org/W2071809577","https://openalex.org/W2106095564","https://openalex.org/W2109159740","https://openalex.org/W2112044829","https://openalex.org/W2114496439","https://openalex.org/W2115045018","https://openalex.org/W2328916810","https://openalex.org/W2397641494","https://openalex.org/W2482983928","https://openalex.org/W4254873958"],"related_works":["https://openalex.org/W2058165933","https://openalex.org/W2045970320","https://openalex.org/W1980605031","https://openalex.org/W2100168824","https://openalex.org/W3029636560","https://openalex.org/W2051632235","https://openalex.org/W2076658668","https://openalex.org/W6959101419","https://openalex.org/W2070106948","https://openalex.org/W2412088217"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Earlier":[1],"platelet":[2],"and":[3,36,58,82,96,110,154,197,219],"postmortem":[4,66],"brain":[5,25],"studies":[6],"have":[7,228],"found":[8,166],"alterations":[9],"in":[10,14,31,65,97,103,142,146,171,183,194,222,248],"serotonin":[11,26,45,54,59,117,138,151,155,168,239],"transporter":[12,27,46,51,55,60,139,152,156,169,189,240],"function":[13,28],"ethanol-abusing":[15],"human":[16,72],"subjects.":[17,93,148,186],"The":[18],"present":[19],"investigation":[20],"tested":[21],"the":[22,108,122,137,175,184,223],"hypothesis":[23],"that":[24,106,120,167,238],"is":[29,236],"altered":[30],"chronic":[32,249],"users":[33,78,81,144],"of":[34,71,87,91,116],"ethanol":[35,77,220,250],"cocaine,":[37],"which":[38,200,226],"might":[39],"be":[40],"related":[41],"to":[42,85,136,207,215],"a":[43,69,88,127,195,204,211,245],"common":[44],"promoter":[47,61,241],"polymorphism.":[48],"METHOD:":[49],"Serotonin":[50,188],"binding":[52,135,153,170,190],"sites,":[53],"mRNA":[56,157],"levels,":[57],"variants":[62],"were":[63,101,192],"quantified":[64],"samples":[67,105],"from":[68],"group":[70,90],"subjects":[73,172],"who":[74],"had":[75],"been":[76],"or":[79,177],"cocaine":[80,143,218],"then":[83],"compared":[84],"those":[86],"matched":[89],"comparison":[92,147],"Quantitative":[94],"autoradiographic":[95],"situ":[98],"hybridization":[99],"assays":[100],"performed":[102],"midbrain":[104],"contained":[107],"dorsal":[109,224],"median":[111],"raphe":[112,133],"nuclei":[113],"(the":[114],"location":[115],"cell":[118],"bodies":[119],"innervate":[121],"forebrain).":[123],"RESULTS:":[124],"There":[125],"was":[126,140,164,180,201],"significant":[128],"overall":[129],"cocaine-by-ethanol-by-genotype":[130],"interaction.":[131],"Dorsal":[132],"[125I]CIT":[134],"lower":[141],"than":[145],"In":[149],"addition,":[150],"levels":[158],"varied":[159],"significantly":[160,181],"by":[161],"genotype.":[162],"It":[163,235],"also":[165],"with":[173],"either":[174],"short":[176],"heterozygote":[178],"genotype":[179,242],"higher":[182],"ethanol-user":[185],"CONCLUSIONS:":[187],"sites":[191],"regulated":[193],"region-specific":[196],"substance-specific":[198],"pattern,":[199],"not":[202],"simply":[203],"local":[205],"response":[206],"functional":[208],"blockade.":[209],"Also,":[210],"reciprocal":[212],"relationship":[213],"appeared":[214],"exist":[216],"between":[217],"effects":[221],"raphe,":[225],"may":[227,243],"interesting":[229],"clinical":[230],"implications":[231],"for":[232],"dual-diagnosis":[233],"patients.":[234],"possible":[237],"play":[244],"complex":[246],"role":[247],"dependence.":[251]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}