{"id":"https://openalex.org/W1962010571","doi":"https://doi.org/10.1002/glia.22926","title":"Regulation of astrocyte pathology by fluoxetine prevents the deterioration of Alzheimer phenotypes in an APP/PS 1 mouse model","display_name":"Regulation of astrocyte pathology by fluoxetine prevents the deterioration of Alzheimer phenotypes in an APP/PS 1 mouse model","publication_year":2015,"publication_date":"2015-10-08","ids":{"openalex":"https://openalex.org/W1962010571","doi":"https://doi.org/10.1002/glia.22926","mag":"1962010571","pmid":"https://pubmed.ncbi.nlm.nih.gov/26446044"},"language":"en","primary_location":{"id":"doi:10.1002/glia.22926","doi":"https://doi.org/10.1002/glia.22926","is_oa":false,"landing_page_url":"https://doi.org/10.1002/glia.22926","pdf_url":null,"source":{"id":"https://openalex.org/S147407642","display_name":"Glia","issn_l":"0894-1491","issn":["0894-1491","1098-1136"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100611570","display_name":"Jinping Qiao","orcid":"https://orcid.org/0000-0001-9297-7561","observed_orcids":["https://orcid.org/0000-0001-9297-7561"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I32574673","display_name":"Shantou University","ror":"https://ror.org/01a099706","country_code":"CN","type":"education","lineage":["https://openalex.org/I32574673"]},{"id":"https://openalex.org/I4210092189","display_name":"Shantou University Mental Health Center","ror":"https://ror.org/01bcxbz42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092189"]},{"id":"https://openalex.org/I4210136596","display_name":"First Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/03t1yn780","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136596"]},{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA","CN"],"is_corresponding":false,"raw_author_name":"Jinping Qiao","raw_affiliation_strings":["Clinical Laboratory The First Affiliated Hospital of Anhui Medical University Hefei Anhui People's Republic of China","Department of Anatomy and Cell Science University of Manitoba Winnipeg Manitoba Canada","Mental Health Center, Shantou University Shantou Guangdong People's Republic of China","Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China","Department of Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, Canada","Jinping Qiao and Junhui Wang contributed equally to this work","Mental Health Center, Shantou University, Shantou, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratory The First Affiliated Hospital of Anhui Medical University Hefei Anhui People's Republic of China","institution_ids":["https://openalex.org/I197869895","https://openalex.org/I4210136596"]},{"raw_affiliation_string":"Department of Anatomy and Cell Science University of Manitoba Winnipeg Manitoba Canada","institution_ids":["https://openalex.org/I46247651"]},{"raw_affiliation_string":"Mental Health Center, Shantou University Shantou Guangdong People's Republic of China","institution_ids":["https://openalex.org/I32574673","https://openalex.org/I4210092189"]},{"raw_affiliation_string":"Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China","institution_ids":["https://openalex.org/I197869895","https://openalex.org/I4210136596"]},{"raw_affiliation_string":"Department of Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I46247651"]},{"raw_affiliation_string":"Jinping Qiao and Junhui Wang contributed equally to this work","institution_ids":[]},{"raw_affiliation_string":"Mental Health Center, Shantou University, Shantou, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I32574673","https://openalex.org/I4210092189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100668358","display_name":"Junhui Wang","orcid":"https://orcid.org/0000-0003-4187-3441","observed_orcids":["https://orcid.org/0000-0003-4187-3441","https://orcid.org/0009-0008-8928-1369"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]},{"id":"https://openalex.org/I32574673","display_name":"Shantou University","ror":"https://ror.org/01a099706","country_code":"CN","type":"education","lineage":["https://openalex.org/I32574673"]},{"id":"https://openalex.org/I4210092189","display_name":"Shantou University Mental Health Center","ror":"https://ror.org/01bcxbz42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092189"]}],"countries":["CA","CN"],"is_corresponding":false,"raw_author_name":"Junhui Wang","raw_affiliation_strings":["Department of Psychiatry University of Alberta Edmonton Alberta Canada","Mental Health Center, Shantou University Shantou Guangdong People's Republic of China","Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada","Jinping Qiao and Junhui Wang contributed equally to this work","Mental Health Center, Shantou University, Shantou, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry University of Alberta Edmonton Alberta Canada","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"Mental Health Center, Shantou University Shantou Guangdong People's Republic of China","institution_ids":["https://openalex.org/I32574673","https://openalex.org/I4210092189"]},{"raw_affiliation_string":"Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"Jinping Qiao and Junhui Wang contributed equally to this work","institution_ids":[]},{"raw_affiliation_string":"Mental Health Center, Shantou University, Shantou, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I32574673","https://openalex.org/I4210092189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100732829","display_name":"Hongxing Wang","orcid":"https://orcid.org/0000-0002-7942-9330","observed_orcids":["https://orcid.org/0000-0002-7942-9330"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210112448","display_name":"Beijing Anding Hospital","ror":"https://ror.org/021ky1s64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112448"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongxing Wang","raw_affiliation_strings":["Beijing Anding Hospital, Capital Medical University Beijing People's Republic of China","Beijing Anding Hospital, Capital Medical University, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Anding Hospital, Capital Medical University Beijing People's Republic of China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210112448"]},{"raw_affiliation_string":"Beijing Anding Hospital, Capital Medical University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210112448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100732244","display_name":"Yanbo Zhang","orcid":"https://orcid.org/0000-0002-2421-157X","observed_orcids":["https://orcid.org/0000-0002-2421-157X","https://orcid.org/0009-0000-1092-8150"]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yanbo Zhang","raw_affiliation_strings":["Department of Psychiatry College of Medicine, University of Saskatchewan Saskatoon Saskatchewan Canada","Department of Psychiatry, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry College of Medicine, University of Saskatchewan Saskatoon Saskatchewan Canada","institution_ids":["https://openalex.org/I32625721"]},{"raw_affiliation_string":"Department of Psychiatry, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103213982","display_name":"Shenghua Zhu","orcid":"https://orcid.org/0000-0002-2238-4960","observed_orcids":["https://orcid.org/0000-0002-2238-4960","https://orcid.org/0009-0002-1150-0716"]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Shenghua Zhu","raw_affiliation_strings":["Department of Anatomy and Cell Science University of Manitoba Winnipeg Manitoba Canada","Department of Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Science University of Manitoba Winnipeg Manitoba Canada","institution_ids":["https://openalex.org/I46247651"]},{"raw_affiliation_string":"Department of Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003153782","display_name":"Abulimiti Adilijiang","orcid":"https://orcid.org/0000-0003-3259-6710","observed_orcids":["https://orcid.org/0000-0003-3259-6710"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Abulimiti Adilijiang","raw_affiliation_strings":["Department of Psychiatry University of Alberta Edmonton Alberta Canada","Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry University of Alberta Edmonton Alberta Canada","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102136721","display_name":"Huining Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Huining Guo","raw_affiliation_strings":["Department of Psychiatry University of Alberta Edmonton Alberta Canada","Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry University of Alberta Edmonton Alberta Canada","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051811707","display_name":"Ruiguo Zhang","orcid":"https://orcid.org/0000-0001-6839-8527","observed_orcids":["https://orcid.org/0000-0001-6839-8527"]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruiguo Zhang","raw_affiliation_strings":["Department of Psychiatry Xijing Hospital, the Fourth Military Medical University Xi'an Shanxi People's Republic of China","Department of Psychiatry, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shanxi, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry Xijing Hospital, the Fourth Military Medical University Xi'an Shanxi People's Republic of China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]},{"raw_affiliation_string":"Department of Psychiatry, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shanxi, People's Republic of China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033199090","display_name":"Wei Guo","orcid":"https://orcid.org/0000-0003-0757-9660","observed_orcids":["https://orcid.org/0000-0003-0757-9660"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210112448","display_name":"Beijing Anding Hospital","ror":"https://ror.org/021ky1s64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112448"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Guo","raw_affiliation_strings":["Beijing Anding Hospital, Capital Medical University Beijing People's Republic of China","Beijing Anding Hospital, Capital Medical University, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Anding Hospital, Capital Medical University Beijing People's Republic of China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210112448"]},{"raw_affiliation_string":"Beijing Anding Hospital, Capital Medical University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210112448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086818420","display_name":"Gang Luo","orcid":"https://orcid.org/0000-0003-1544-1434","observed_orcids":["https://orcid.org/0000-0003-1544-1434"]},"institutions":[{"id":"https://openalex.org/I4210155511","display_name":"First Affiliated Hospital of Henan University","ror":"https://ror.org/0536rsk67","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210155511"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gang Luo","raw_affiliation_strings":["Department of Neurology First Affiliated Hospital of Henan University  Henan People's Republic of China","Department of Neurology, First Affiliated Hospital of Henan University, Henan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology First Affiliated Hospital of Henan University  Henan People's Republic of China","institution_ids":["https://openalex.org/I4210155511"]},{"raw_affiliation_string":"Department of Neurology, First Affiliated Hospital of Henan University, Henan, People's Republic of China","institution_ids":["https://openalex.org/I4210155511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038160415","display_name":"Yiqing Qiu","orcid":"https://orcid.org/0000-0002-5212-1117","observed_orcids":["https://orcid.org/0000-0002-5212-1117"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiqing Qiu","raw_affiliation_strings":["Department of Neurosurgery Shanghai Changhai Hospital, Secondary Military Medical University Shanghai People's Republic of China","Department of Neurosurgery, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Shanghai Changhai Hospital, Secondary Military Medical University Shanghai People's Republic of China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]},{"raw_affiliation_string":"Department of Neurosurgery, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046703379","display_name":"Haiyun Xu","orcid":"https://orcid.org/0000-0002-0752-6502","observed_orcids":["https://orcid.org/0000-0002-0752-6502","https://orcid.org/0009-0002-4778-3906"]},"institutions":[{"id":"https://openalex.org/I32574673","display_name":"Shantou University","ror":"https://ror.org/01a099706","country_code":"CN","type":"education","lineage":["https://openalex.org/I32574673"]},{"id":"https://openalex.org/I4210092189","display_name":"Shantou University Mental Health Center","ror":"https://ror.org/01bcxbz42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092189"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyun Xu","raw_affiliation_strings":["Mental Health Center, Shantou University Shantou Guangdong People's Republic of China","Mental Health Center, Shantou University, Shantou, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mental Health Center, Shantou University Shantou Guangdong People's Republic of China","institution_ids":["https://openalex.org/I32574673","https://openalex.org/I4210092189"]},{"raw_affiliation_string":"Mental Health Center, Shantou University, Shantou, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I32574673","https://openalex.org/I4210092189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042773174","display_name":"Jiming Kong","orcid":"https://orcid.org/0000-0002-2859-9831","observed_orcids":["https://orcid.org/0000-0002-2859-9831"]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jiming Kong","raw_affiliation_strings":["Department of Anatomy and Cell Science University of Manitoba Winnipeg Manitoba Canada","Department of Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Science University of Manitoba Winnipeg Manitoba Canada","institution_ids":["https://openalex.org/I46247651"]},{"raw_affiliation_string":"Department of Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083469596","display_name":"Qingjun Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32574673","display_name":"Shantou University","ror":"https://ror.org/01a099706","country_code":"CN","type":"education","lineage":["https://openalex.org/I32574673"]},{"id":"https://openalex.org/I4210092189","display_name":"Shantou University Mental Health Center","ror":"https://ror.org/01bcxbz42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092189"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qingjun Huang","raw_affiliation_strings":["Mental Health Center, Shantou University Shantou Guangdong People's Republic of China","Mental Health Center, Shantou University, Shantou, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mental Health Center, Shantou University Shantou Guangdong People's Republic of China","institution_ids":["https://openalex.org/I32574673","https://openalex.org/I4210092189"]},{"raw_affiliation_string":"Mental Health Center, Shantou University, Shantou, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I32574673","https://openalex.org/I4210092189"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100678721","display_name":"Xin\u2010Min Li","orcid":"https://orcid.org/0000-0001-8546-8590","observed_orcids":["https://orcid.org/0000-0001-8546-8590","https://orcid.org/0000-0001-8618-0089"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Xin\u2010Min Li","raw_affiliation_strings":["Department of Psychiatry University of Alberta Edmonton Alberta Canada","Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry University of Alberta Edmonton Alberta Canada","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada","institution_ids":["https://openalex.org/I154425047"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5083469596","https://openalex.org/A5100678721"],"corresponding_institution_ids":["https://openalex.org/I154425047","https://openalex.org/I32574673","https://openalex.org/I4210092189"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":3.671,"has_fulltext":false,"cited_by_count":80,"citation_normalized_percentile":{"value":0.92726583,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"64","issue":"2","first_page":"240","last_page":"254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9240000247955322},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9789999723434448},{"id":"https://openalex.org/keywords/fluoxetine","display_name":"fluoxetine","score":0.9079999923706055},{"id":"https://openalex.org/keywords/app-ps1-mice","display_name":"APP/PS1 mice","score":0.8560000061988831},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.6019999980926514},{"id":"https://openalex.org/keywords/synaptotoxicity","display_name":"synaptotoxicity","score":0.75},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.8050000071525574},{"id":"https://openalex.org/keywords/5-ht2-receptor","display_name":"5-HT2 receptor","score":0.8009999990463257},{"id":"https://openalex.org/keywords/neuron-astrocyte-interactions","display_name":"astrocyte-neuron interaction","score":0.6880000233650208},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7160000205039978},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.7400000095367432},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.621999979019165},{"id":"https://openalex.org/keywords/dendritic-complexity","display_name":"dendritic complexity","score":0.6100000143051147},{"id":"https://openalex.org/keywords/axonal-branching","display_name":"axon branching","score":0.9089999794960022}],"concepts":[{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.9199986457824707},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7942877411842346},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6902023553848267},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5752949118614197},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5242229700088501},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.4985339641571045},{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.4693402051925659},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.4682154655456543},{"id":"https://openalex.org/C2780884517","wikidata":"https://www.wikidata.org/wiki/Q177105","display_name":"Neuroglia","level":3,"score":0.43677523732185364},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4122306704521179},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27175384759902954},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23280903697013855},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.22133806347846985},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.20528936386108398},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16855546832084656},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.1096949577331543},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07609018683433533},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005473","descriptor_name":"Fluoxetine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005473","descriptor_name":"Fluoxetine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005473","descriptor_name":"Fluoxetine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044348","descriptor_name":"Receptors, Serotonin, 5-HT2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044348","descriptor_name":"Receptors, Serotonin, 5-HT2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044348","descriptor_name":"Receptors, Serotonin, 5-HT2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/glia.22926","doi":"https://doi.org/10.1002/glia.22926","is_oa":false,"landing_page_url":"https://doi.org/10.1002/glia.22926","pdf_url":null,"source":{"id":"https://openalex.org/S147407642","display_name":"Glia","issn_l":"0894-1491","issn":["0894-1491","1098-1136"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"journal-article"},{"id":"pmid:26446044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26446044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7099999785423279,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3646640766","display_name":null,"funder_award_id":"1508085QH173","funder_id":"https://openalex.org/F4320334897","funder_display_name":"Natural Science Foundation of Anhui Province"},{"id":"https://openalex.org/G5241046672","display_name":null,"funder_award_id":"81501187","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321819","display_name":"Manitoba Mental Health Research Foundation","ror":null},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334897","display_name":"Natural Science Foundation of Anhui Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W269293841","https://openalex.org/W1479878151","https://openalex.org/W1516426911","https://openalex.org/W1607135210","https://openalex.org/W1727527723","https://openalex.org/W1798675868","https://openalex.org/W1860560156","https://openalex.org/W1867505698","https://openalex.org/W1880131416","https://openalex.org/W1886677556","https://openalex.org/W1894814115","https://openalex.org/W1925771428","https://openalex.org/W1982388019","https://openalex.org/W1990202129","https://openalex.org/W1990458250","https://openalex.org/W1994974752","https://openalex.org/W1995337975","https://openalex.org/W2000225222","https://openalex.org/W2002937059","https://openalex.org/W2007662902","https://openalex.org/W2009623771","https://openalex.org/W2010122299","https://openalex.org/W2010476270","https://openalex.org/W2015163544","https://openalex.org/W2017431945","https://openalex.org/W2017861337","https://openalex.org/W2018297039","https://openalex.org/W2022730112","https://openalex.org/W2025563134","https://openalex.org/W2030698030","https://openalex.org/W2039519914","https://openalex.org/W2041656692","https://openalex.org/W2043068812","https://openalex.org/W2050068554","https://openalex.org/W2077354947","https://openalex.org/W2086761335","https://openalex.org/W2092060809","https://openalex.org/W2096410114","https://openalex.org/W2103137532","https://openalex.org/W2103578985","https://openalex.org/W2103590691","https://openalex.org/W2116876598","https://openalex.org/W2117973743","https://openalex.org/W2124478244","https://openalex.org/W2130302474","https://openalex.org/W2138369511","https://openalex.org/W2140952868","https://openalex.org/W2142048281","https://openalex.org/W2143506713","https://openalex.org/W2146073155","https://openalex.org/W2151380506","https://openalex.org/W2154164205","https://openalex.org/W2163894029","https://openalex.org/W2165092386","https://openalex.org/W2291294329"],"related_works":["https://openalex.org/W2078844809","https://openalex.org/W1992341981","https://openalex.org/W2126960516","https://openalex.org/W1968263596","https://openalex.org/W1969844849","https://openalex.org/W1964163030","https://openalex.org/W1966242116","https://openalex.org/W2049916128","https://openalex.org/W2024854434","https://openalex.org/W2221064544"],"abstract_inverted_index":{"Studies":[0],"have":[1],"implicated":[2],"astrocytic":[3],"dysfunction":[4],"in":[5,14,34,38,106,139],"Alzheimer's":[6],"disease":[7,21],"(AD).":[8],"However,":[9],"the":[10,15,20,109,134,145],"role":[11],"of":[12,19,71,79,116,137,149,154],"astrocytes":[13,28,56,75],"pathophysiology":[16],"and":[17,48,51,68,123,141],"treatment":[18],"is":[22],"poorly":[23],"characterized.":[24],"Here,":[25],"we":[26],"identified":[27],"as":[29,62,64],"independent":[30],"key":[31],"factors":[32],"involved":[33],"several":[35],"Alzheimer-like":[36],"phenotypes":[37],"an":[39],"APP/PS1":[40,58,111],"mouse":[41],"model,":[42],"including":[43],"amyloid":[44],"pathology,":[45],"altered":[46],"neuronal":[47,104],"synaptic":[49],"properties,":[50],"impaired":[52],"cognition.":[53],"In":[54,108],"vitro":[55],"from":[57],"mice":[59],"induced":[60],"synaptotoxicity":[61],"well":[63],"reduced":[65],"dendritic":[66],"complexity":[67],"axonal":[69],"branching":[70],"hippocampal":[72,100],"neurons.":[73],"These":[74,127],"produced":[76],"high":[77],"levels":[78],"soluble":[80],"\u03b2-amyloid":[81],"(A\u03b2)":[82],"which":[83],"could":[84,97],"be":[85],"significantly":[86],"inhibited":[87,114],"by":[88],"fluoxetine":[89],"(FLX)":[90],"via":[91],"activating":[92],"serotonin":[93],"5-HT2":[94],"receptors.":[95],"FLX":[96,113,138],"also":[98,143],"protect":[99],"neurons":[101],"against":[102],"astrocyte-induced":[103],"damage":[105],"vitro.":[107],"same":[110],"mice,":[112],"activation":[115],"astrocytes,":[117],"lowered":[118],"A\u03b2":[119],"products,":[120],"ameliorated":[121],"neurotoxicity,":[122],"improved":[124],"behavioral":[125],"performance.":[126],"findings":[128],"may":[129,142],"provide":[130],"a":[131],"basis":[132],"for":[133,147],"clinical":[135],"application":[136],"patients,":[140],"lay":[144],"groundwork":[146],"exploration":[148],"other":[150],"novel":[151],"astrocyte-based":[152],"therapies":[153],"AD.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2016-06-24T00:00:00"}