{"id":"https://openalex.org/W1961145593","doi":"https://doi.org/10.1371/journal.pone.0116044","title":"The NOD2 Single Nucleotide Polymorphism rs72796353 (IVS4+10 A>C) Is a Predictor for Perianal Fistulas in Patients with Crohn's Disease in the Absence of Other NOD2 Mutations","display_name":"The NOD2 Single Nucleotide Polymorphism rs72796353 (IVS4+10 A>C) Is a Predictor for Perianal Fistulas in Patients with Crohn's Disease in the Absence of Other NOD2 Mutations","publication_year":2015,"publication_date":"2015-07-06","ids":{"openalex":"https://openalex.org/W1961145593","doi":"https://doi.org/10.1371/journal.pone.0116044","mag":"1961145593","pmid":"https://pubmed.ncbi.nlm.nih.gov/26147989","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4493062"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0116044","doi":"https://doi.org/10.1371/journal.pone.0116044","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0116044","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0116044&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0116044&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037150306","display_name":"Fabian Schnitzler","orcid":"https://orcid.org/0000-0001-8260-8594","observed_orcids":["https://orcid.org/0000-0001-8260-8594"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fabian Schnitzler","raw_affiliation_strings":["Department of Medicine II-Grosshadern, Ludwig-Maximilians-University (LMU), Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine II-Grosshadern, Ludwig-Maximilians-University (LMU), Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034794115","display_name":"Matthias Friedrich","orcid":"https://orcid.org/0000-0002-7551-4853","observed_orcids":["https://orcid.org/0000-0002-7551-4853"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Friedrich","raw_affiliation_strings":["Department of Medicine II-Grosshadern, Ludwig-Maximilians-University (LMU), Munich, Germany; Department of Preventive Dentistry and Periodontology, LMU, Munich, Germany","Department of Medicine II-Grosshadern, Ludwig-Maximilians-University (LMU), Munich, Germany","Department of Preventive Dentistry and Periodontology, LMU, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine II-Grosshadern, Ludwig-Maximilians-University (LMU), Munich, Germany; Department of Preventive Dentistry and Periodontology, LMU, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"Department of Medicine II-Grosshadern, Ludwig-Maximilians-University (LMU), Munich, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"Department of Preventive Dentistry and Periodontology, LMU, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021526717","display_name":"Christiane Wolf","orcid":"https://orcid.org/0000-0002-6587-7407","observed_orcids":["https://orcid.org/0000-0002-6587-7407"]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christiane Wolf","raw_affiliation_strings":["Max-Planck-Institute of Psychiatry, Biostatistics Group, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institute of Psychiatry, Biostatistics Group, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085889329","display_name":"Johannes Stallhofer","orcid":"https://orcid.org/0000-0001-8698-6103","observed_orcids":["https://orcid.org/0000-0001-8698-6103"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johannes Stallhofer","raw_affiliation_strings":["Department of Medicine II-Grosshadern, Ludwig-Maximilians-University (LMU), Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine II-Grosshadern, Ludwig-Maximilians-University (LMU), Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109071785","display_name":"Marianne Angelberger","orcid":"https://orcid.org/0000-0001-7471-2252","observed_orcids":["https://orcid.org/0000-0001-7471-2252"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marianne Angelberger","raw_affiliation_strings":["Department of Medicine II-Grosshadern, Ludwig-Maximilians-University (LMU), Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine II-Grosshadern, Ludwig-Maximilians-University (LMU), Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081904439","display_name":"Julia Diegelmann","orcid":"https://orcid.org/0009-0002-8931-709X","observed_orcids":["https://orcid.org/0009-0002-8931-709X"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Diegelmann","raw_affiliation_strings":["Department of Preventive Dentistry and Periodontology, LMU, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Dentistry and Periodontology, LMU, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083421637","display_name":"Torsten Olszak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Torsten Olszak","raw_affiliation_strings":["Department of Medicine II-Grosshadern, Ludwig-Maximilians-University (LMU), Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine II-Grosshadern, Ludwig-Maximilians-University (LMU), Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082823845","display_name":"Cornelia Tillack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Cornelia Tillack","raw_affiliation_strings":["Department of Medicine II-Grosshadern, Ludwig-Maximilians-University (LMU), Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine II-Grosshadern, Ludwig-Maximilians-University (LMU), Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086343499","display_name":"Florian Beigel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Florian Beigel","raw_affiliation_strings":["Department of Medicine II-Grosshadern, Ludwig-Maximilians-University (LMU), Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine II-Grosshadern, Ludwig-Maximilians-University (LMU), Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113682553","display_name":"Burkhard G\u00f6ke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Burkhard G\u00f6ke","raw_affiliation_strings":["Department of Medicine II-Grosshadern, Ludwig-Maximilians-University (LMU), Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine II-Grosshadern, Ludwig-Maximilians-University (LMU), Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086525751","display_name":"J\u00fcrgen Glas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Glas","raw_affiliation_strings":["Department of Human Genetics, Rheinisch-Westf\u00e4lische Technische Hochschule (RWTH) Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Rheinisch-Westf\u00e4lische Technische Hochschule (RWTH) Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108225166","display_name":"Peter Lohse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Lohse","raw_affiliation_strings":["Department of Clinical Chemistry-Grosshadern, LMU, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry-Grosshadern, LMU, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059052168","display_name":"Stephan Brand","orcid":"https://orcid.org/0000-0001-7011-0430","observed_orcids":["https://orcid.org/0000-0001-7011-0430"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Stephan Brand","raw_affiliation_strings":["Department of Medicine II-Grosshadern, Ludwig-Maximilians-University (LMU), Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine II-Grosshadern, Ludwig-Maximilians-University (LMU), Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5059052168"],"corresponding_institution_ids":["https://openalex.org/I8204097"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.2044,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.86617902,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"7","first_page":"e0116044","last_page":"e0116044"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11865","display_name":"Anorectal Disease Treatments and Outcomes","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12328","display_name":"Autoimmune and Inflammatory Disorders","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nod2","display_name":"NOD2","score":0.8149999976158142},{"id":"https://openalex.org/keywords/anal-fistula","display_name":"anal fistula","score":0.7570000290870667},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.8309999704360962},{"id":"https://openalex.org/keywords/genotype-phenotype-correlation","display_name":"genotype-phenotype correlation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/nod2-mutations","display_name":"NOD2 mutations","score":0.7609999775886536},{"id":"https://openalex.org/keywords/disease-susceptibility","display_name":"disease susceptibility","score":0.6439999938011169},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C7573103","wikidata":"https://www.wikidata.org/wiki/Q416481","display_name":"NOD2","level":4,"score":0.8672542572021484},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.844146728515625},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6625832915306091},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.6539342999458313},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.5804203152656555},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.5526840090751648},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.532164454460144},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.43819862604141235},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42292797565460205},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3928840160369873},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3375599980354309},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33146268129348755},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.31151071190834045},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25047069787979126},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16829648613929749}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012003","descriptor_name":"Rectal Fistula","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D012003","descriptor_name":"Rectal Fistula","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053473","descriptor_name":"Nod2 Signaling Adaptor Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":11,"locations":[{"id":"doi:10.1371/journal.pone.0116044","doi":"https://doi.org/10.1371/journal.pone.0116044","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0116044","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0116044&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3467092","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4493062","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26147989","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26147989","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4493062","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4493062/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.812.3528","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.812.3528","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/21/84/pone.0116044.PMC4493062.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:921afa03548a4421a5bd042ff3838452","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/921afa03548a4421a5bd042ff3838452","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 7, p e0116044 (2015)","raw_type":"article"},{"id":"pmh:oai:epub.ub.uni-muenchen.de:34190","doi":null,"is_oa":false,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-34190-4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401845","display_name":"Open access LMU (Ludwid Maxmilian's Universitat Munchen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8204097","host_organization_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","host_organization_lineage":["https://openalex.org/I8204097"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS ONE","raw_type":"doc-type:article"},{"id":"pmh:oai:figshare.com:article/1475597","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/The_NOD2_Single_Nucleotide_Polymorphism_rs72796353_IVS4_10_A_C_Is_a_Predictor_for_Perianal_Fistulas_in_Patients_with_Crohn_s_Disease_in_the_Absence_of_Other_NOD2_Mutations/1475597","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:publications.rwth-aachen.de:481765","doi":null,"is_oa":true,"landing_page_url":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-2015-04359%22","pdf_url":null,"source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS ONE 10(7), e0116044 (2015). doi:10.1371/journal.pone.0116044","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.mpg.de:item_2238869","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0029-D0EF-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS ONE","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.18154/rwth-2015-04359","doi":"https://doi.org/10.18154/rwth-2015-04359","is_oa":true,"landing_page_url":"https://doi.org/10.18154/rwth-2015-04359","pdf_url":null,"source":{"id":"https://openalex.org/S4306401033","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0116044","doi":"https://doi.org/10.1371/journal.pone.0116044","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0116044","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0116044&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G8286469608","display_name":null,"funder_award_id":"2010_EKES.32","funder_id":"https://openalex.org/F4320321672","funder_display_name":"Else Kr\u00f6ner-Fresenius-Stiftung"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321672","display_name":"Else Kr\u00f6ner-Fresenius-Stiftung","ror":"https://ror.org/03zcxha54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1961145593.pdf","grobid_xml":"https://content.openalex.org/works/W1961145593.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1642457845","https://openalex.org/W1670573097","https://openalex.org/W1979948289","https://openalex.org/W1981714996","https://openalex.org/W2003784229","https://openalex.org/W2011197968","https://openalex.org/W2027560883","https://openalex.org/W2044921808","https://openalex.org/W2048931632","https://openalex.org/W2052435488","https://openalex.org/W2061094586","https://openalex.org/W2061606433","https://openalex.org/W2064027072","https://openalex.org/W2065637841","https://openalex.org/W2076045446","https://openalex.org/W2084708009","https://openalex.org/W2091056112","https://openalex.org/W2100749285","https://openalex.org/W2101856875","https://openalex.org/W2106779017","https://openalex.org/W2109625790","https://openalex.org/W2115865518","https://openalex.org/W2119081920","https://openalex.org/W2126769079","https://openalex.org/W2143625465","https://openalex.org/W2152532561","https://openalex.org/W2161633633","https://openalex.org/W2165872127","https://openalex.org/W2171711400","https://openalex.org/W2188248802"],"related_works":["https://openalex.org/W7100105231","https://openalex.org/W2130179794","https://openalex.org/W7097792408","https://openalex.org/W2329400874","https://openalex.org/W2110946019","https://openalex.org/W2055530089","https://openalex.org/W4296270216","https://openalex.org/W2005272937","https://openalex.org/W2079177431","https://openalex.org/W2342279258"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1],"previous":[2],"study":[3,185],"suggested":[4],"an":[5],"association":[6,51,104,139,226],"of":[7,52,117,140,167,191,194,222,236],"the":[8,17,39,50,61,87,92,114,118,154,165,187,192,195,200,212,220,237,250],"single":[9],"nucleotide":[10],"polymorphism":[11],"(SNP)":[12],"rs72796353":[13,53,90,141,160,198,244],"(IVS4+10":[14],"A>C)":[15],"in":[16,150,203,209,230],"NOD2":[18,35,88,96,119,158,179,196,241],"gene":[19],"with":[20,54,76,134,142,164,219],"susceptibility":[21,45,59,146],"to":[22,113],"Crohn's":[23],"disease":[24,57,201,252],"(CD).":[25],"However,":[26,149],"this":[27,184],"finding":[28],"has":[29],"not":[30,234],"been":[31],"confirmed.":[32],"Given":[33],"that":[34,208],"variants":[36],"still":[37],"represent":[38],"most":[40],"important":[41],"predictors":[42],"for":[43,86,249],"CD":[44,72,135,143,151,210,251],"and":[46,60,80,91,100,105,129],"phenotype,":[47],"we":[48],"evaluated":[49],"inflammatory":[55],"bowel":[56],"(IBD)":[58],"IBD":[62,103],"phenotype.":[63],"METHODOLOGY:":[64],"Genomic":[65],"DNA":[66],"from":[67],"2256":[68],"Caucasians,":[69],"including":[70],"1073":[71],"patients,":[73],"464":[74],"patients":[75,152,211,231],"ulcerative":[77],"colitis":[78],"(UC),":[79],"719":[81],"healthy":[82],"controls,":[83],"was":[84,147,161],"genotyped":[85],"SNP":[89],"three":[93,155,238],"main":[94,156,239],"CD-associated":[95,157,240],"mutations":[97],"rs2066844,":[98],"rs2066845,":[99],"rs2066847.":[101],"Subsequently,":[102],"genotype-phenotype":[106,189],"analyses":[107],"were":[108],"conducted.":[109],"RESULTS:":[110],"In":[111],"contrast":[112],"strong":[115],"associations":[116],"SNPs":[120],"rs2066844":[121],"(p=3.51":[122],"x":[123,127,132,171],"10(-3)),":[124],"rs2066845":[125],"(p=1.54":[126],"10(-2)),":[128],"rs2066847":[130],"(p=1.61":[131],"10(-20))":[133],"susceptibility,":[136],"no":[137],"significant":[138],"or":[144],"UC":[145],"found.":[148],"without":[153],"mutations,":[159,242],"significantly":[162],"associated":[163,218],"development":[166,221],"perianal":[168,223],"fistulas":[169],"(p=2.78":[170],"10(-7),":[172],"OR":[173],"5.27,":[174],"[95%":[175],"CI":[176],"2.75-10.12]":[177],"vs.":[178],"wild-type":[180],"carriers).":[181],"CONCLUSION/SIGNIFICANCE:":[182],"Currently,":[183],"represents":[186],"largest":[188],"analysis":[190],"impact":[193],"variant":[197,215],"on":[199],"phenotype":[202],"IBD.":[204],"Our":[205],"data":[206],"demonstrate":[207],"IVS4+10":[213],"A>C":[214],"is":[216,227],"strongly":[217],"fistulas.":[224],"This":[225],"particularly":[228],"pronounced":[229],"who":[232],"are":[233],"carriers":[235],"suggesting":[243],"as":[245],"additional":[246],"genetic":[247],"marker":[248],"behaviour.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}