{"id":"https://openalex.org/W196045869","doi":null,"title":"Large granular lymphocyte leukemia. A heterogeneous lymphocytic leukemia in F344 rats.","display_name":"Large granular lymphocyte leukemia. A heterogeneous lymphocytic leukemia in F344 rats.","publication_year":1983,"publication_date":"1983-04-01","ids":{"openalex":"https://openalex.org/W196045869","mag":"196045869","pmid":"https://pubmed.ncbi.nlm.nih.gov/6837719","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1916195"},"language":"en","primary_location":{"id":"pmid:6837719","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6837719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1916195/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061909361","display_name":"Jerrold Michael Ward","orcid":"https://orcid.org/0000-0002-6350-8982","observed_orcids":["https://orcid.org/0000-0002-6350-8982"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Ward","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5082797111","display_name":"Craig W. Reynolds","orcid":"https://orcid.org/0000-0001-8203-712X","observed_orcids":["https://orcid.org/0000-0001-8203-712X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C W Reynolds","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2132,"has_fulltext":false,"cited_by_count":119,"citation_normalized_percentile":{"value":0.9264864,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"111","issue":"1","first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.017500000074505806,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/large-granular-lymphocytic-leukemia","display_name":"large granular lymphocyte leukemia","score":0.996999979019165},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.7799999713897705},{"id":"https://openalex.org/keywords/fischer-344-rats","display_name":"F344 rats","score":0.9639999866485596},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.4059999883174896},{"id":"https://openalex.org/keywords/transplantable-leukemia","display_name":"transplantable leukemia","score":0.6510000228881836},{"id":"https://openalex.org/keywords/cell-surface-antigens","display_name":"cell surface antigens","score":0.8330000042915344},{"id":"https://openalex.org/keywords/natural-cytotoxicity","display_name":"natural cytotoxicity","score":0.7409999966621399},{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.49300000071525574},{"id":"https://openalex.org/keywords/golgi-apparatus","display_name":"Golgi apparatus","score":0.8519999980926514},{"id":"https://openalex.org/keywords/beta-glucuronidase","display_name":"beta-glucuronidase","score":0.9100000262260437},{"id":"https://openalex.org/keywords/acid-phosphatase","display_name":"acid phosphatase","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.7419999837875366},{"id":"https://openalex.org/keywords/nk-cell-origin","display_name":"NK cell origin","score":0.6209999918937683},{"id":"https://openalex.org/keywords/leukemia-model","display_name":"leukemia model","score":0.3709999918937683}],"concepts":[{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6661585569381714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6462947130203247},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.623165488243103},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.6081553101539612},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6056452989578247},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.5430687069892883},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.41378918290138245},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40870004892349243},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.38909783959388733},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38767293095588684},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10086843371391296},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09224864840507507},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007945","descriptor_name":"Leukemia, Lymphoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007945","descriptor_name":"Leukemia, Lymphoid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007945","descriptor_name":"Leukemia, Lymphoid","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012376","descriptor_name":"Rodent Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012376","descriptor_name":"Rodent Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:6837719","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6837719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1916195","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1916195/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"mag:196045869","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6837719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1916195","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1916195/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W47339827","https://openalex.org/W76370051","https://openalex.org/W1499779422","https://openalex.org/W1573695673","https://openalex.org/W1592416862","https://openalex.org/W1606961088","https://openalex.org/W1631987931","https://openalex.org/W1655193342","https://openalex.org/W1762609432","https://openalex.org/W1956361313","https://openalex.org/W1985696650","https://openalex.org/W2003591608","https://openalex.org/W2019647392","https://openalex.org/W2029301086","https://openalex.org/W2045964137","https://openalex.org/W2050802204","https://openalex.org/W2078013047","https://openalex.org/W2089431102","https://openalex.org/W2101079996","https://openalex.org/W2108018670","https://openalex.org/W2140892076","https://openalex.org/W2141122084","https://openalex.org/W2145092612","https://openalex.org/W2288796028","https://openalex.org/W2340668288","https://openalex.org/W2394950358","https://openalex.org/W2435144859"],"related_works":["https://openalex.org/W1938812638","https://openalex.org/W134488706","https://openalex.org/W49057795","https://openalex.org/W2403727753","https://openalex.org/W1995958088","https://openalex.org/W1964466472","https://openalex.org/W154212416","https://openalex.org/W2049361227","https://openalex.org/W2398591183","https://openalex.org/W2413971484"],"abstract_inverted_index":{"The":[0,29,65],"morphology,":[1],"histochemistry,":[2],"cell":[3,9,90,118,141],"surface":[4,123,142,164],"antigens,":[5],"and":[6,15,73,76,100,132,140,163,187,192],"natural":[7,88],"killer":[8,89],"(NK)":[10],"activity":[11,91,139,162],"of":[12,23,36,38,48,122,148,155,174,185,189],"10":[13,16],"primary":[14],"transplantable":[17,111],"large":[18],"granular":[19],"lymphocyte":[20],"(LGL)":[21],"leukemias":[22,45,112,128,152,175],"aging":[24,39],"F344":[25,40],"rats":[26],"were":[27,46],"studied.":[28],"LGL":[30,44,107,127,151,168,191],"leukemia":[31,108],"is":[32],"the":[33,43,84,126,145,183],"major":[34],"cause":[35],"death":[37],"rats.":[41],"Morphologically,":[42],"composed":[47],"cells":[49,94,149],"with":[50,54,61,81,106],"either":[51],"pleomorphic":[52],"nuclei":[53,60],"many":[55],"intracytoplasmic":[56,63],"granules":[57,66],"or":[58],"round":[59],"few":[62],"granules.":[64],"appeared":[67,102],"to":[68,98,103,129],"be":[69,104,130],"lysosomes":[70],"containing":[71],"beta-glucuronidase":[72],"acid":[74],"phosphatase":[75],"ultrastructurally":[77],"developed":[78],"in":[79,83,150,160],"association":[80],"vesicles":[82],"Golgi":[85],"apparatus.":[86],"Splenic":[87],"against":[92],"YAC-1":[93],"varied":[95],"from":[96],"case":[97],"case,":[99],"it":[101],"associated":[105],"cells.":[109,194],"Some":[110],"had":[113],"stable":[114],"NK":[115,193],"activity.":[116],"Fluorescence-activated":[117],"sorter":[119],"(FACS)":[120],"analysis":[121],"antigens":[124,165],"revealed":[125],"heterogeneous,":[131],"there":[133],"was":[134],"no":[135],"correlation":[136],"between":[137],"cytotoxic":[138,161],"antigens.":[143],"Although":[144],"morphologic":[146],"features":[147],"resemble":[153],"those":[154],"normal":[156,190],"rat":[157],"LGLs,":[158],"differences":[159],"suggest":[166],"that":[167],"tumors":[169],"represent":[170],"a":[171,180],"heterogeneous":[172],"group":[173],"which":[176],"may":[177],"serve":[178],"as":[179],"model":[181],"for":[182],"study":[184],"origin":[186],"lineage":[188]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}