{"id":"https://openalex.org/W196004681","doi":"https://doi.org/10.69645/bdro2797","title":"The roles of intrinsic disorder in protein interaction networks","display_name":"The roles of intrinsic disorder in protein interaction networks","publication_year":2013,"publication_date":"2013-08-20","ids":{"openalex":"https://openalex.org/W196004681","doi":"https://doi.org/10.69645/bdro2797","mag":"196004681"},"language":"en","primary_location":{"id":"doi:10.69645/bdro2797","doi":"https://doi.org/10.69645/bdro2797","is_oa":false,"landing_page_url":"http://dx.doi.org/10.69645/bdro2797","pdf_url":null,"source":{"id":"https://openalex.org/S4404663171","display_name":"The biomedical & life sciences collection.","issn_l":"2056-452X","issn":["2056-452X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4324004214","host_organization_name":"Henry Stewart Talks","host_organization_lineage":["https://openalex.org/P4324004214"],"host_organization_lineage_names":["Henry Stewart Talks"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biomedical & Life Sciences Collection","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083199032","display_name":"Vladimir Nikolaevich Uversky","orcid":"https://orcid.org/0000-0002-4037-5857","observed_orcids":["https://orcid.org/0000-0002-4037-5857"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vladimir N. Uversky","raw_affiliation_strings":["University of South Florida","Indiana Univ.-Purdue Univ. Indianapolis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Indiana Univ.-Purdue Univ. Indianapolis","institution_ids":["https://openalex.org/I55769427"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083199032"],"corresponding_institution_ids":["https://openalex.org/I2613432","https://openalex.org/I55769427"],"apc_list":null,"apc_paid":null,"fwci":4.7288,"has_fulltext":false,"cited_by_count":175,"citation_normalized_percentile":{"value":0.9656518,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"2013","issue":"8","first_page":"e1003303","last_page":"e1003303"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13526","display_name":"14-3-3 protein interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intrinsic-disorder","display_name":"intrinsic disorder","score":0.8579999804496765},{"id":"https://openalex.org/keywords/intrinsically-disordered-proteins","display_name":"intrinsically disordered proteins","score":0.9520000219345093},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.902999997138977},{"id":"https://openalex.org/keywords/scale-free-networks","display_name":"scale-free networks","score":0.8119999766349792},{"id":"https://openalex.org/keywords/hub-proteins","display_name":"hub proteins","score":0.8220000267028809},{"id":"https://openalex.org/keywords/binding-promiscuity","display_name":"binding promiscuity","score":0.9279999732971191},{"id":"https://openalex.org/keywords/flexible-linkers","display_name":"flexible linkers","score":0.7620000243186951},{"id":"https://openalex.org/keywords/regulatory-networks","display_name":"regulatory networks","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2778815515","wikidata":"https://www.wikidata.org/wiki/Q3408242","display_name":"Intrinsically disordered proteins","level":2,"score":0.5920595526695251},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5752981901168823},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.5569667816162109},{"id":"https://openalex.org/C2909613950","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Protein Interaction Networks","level":3,"score":0.5531010627746582},{"id":"https://openalex.org/C2779618474","wikidata":"https://www.wikidata.org/wiki/Q261290","display_name":"Promiscuity","level":2,"score":0.5196532011032104},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4601467549800873},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3854142129421234},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32920151948928833},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.18496912717819214},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1819087564945221},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.10131591558456421}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.69645/bdro2797","doi":"https://doi.org/10.69645/bdro2797","is_oa":false,"landing_page_url":"http://dx.doi.org/10.69645/bdro2797","pdf_url":null,"source":{"id":"https://openalex.org/S4404663171","display_name":"The biomedical & life sciences collection.","issn_l":"2056-452X","issn":["2056-452X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4324004214","host_organization_name":"Henry Stewart Talks","host_organization_lineage":["https://openalex.org/P4324004214"],"host_organization_lineage_names":["Henry Stewart Talks"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biomedical & Life Sciences Collection","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":197,"referenced_works":["https://openalex.org/W45157614","https://openalex.org/W116143187","https://openalex.org/W121768123","https://openalex.org/W143049927","https://openalex.org/W586885187","https://openalex.org/W1236133676","https://openalex.org/W1481607975","https://openalex.org/W1491876634","https://openalex.org/W1497456715","https://openalex.org/W1528419830","https://openalex.org/W1529055874","https://openalex.org/W1536176571","https://openalex.org/W1545247886","https://openalex.org/W1545797843","https://openalex.org/W1548068969","https://openalex.org/W1552660489","https://openalex.org/W1573579329","https://openalex.org/W1591323475","https://openalex.org/W1616510410","https://openalex.org/W1644749979","https://openalex.org/W1720678970","https://openalex.org/W1763894483","https://openalex.org/W1767701883","https://openalex.org/W1773515121","https://openalex.org/W1798376596","https://openalex.org/W1886278373","https://openalex.org/W1917951968","https://openalex.org/W1921408963","https://openalex.org/W1963823250","https://openalex.org/W1964739066","https://openalex.org/W1965127482","https://openalex.org/W1965479796","https://openalex.org/W1966781760","https://openalex.org/W1967203779","https://openalex.org/W1967638691","https://openalex.org/W1967974247","https://openalex.org/W1968996392","https://openalex.org/W1969769040","https://openalex.org/W1973849035","https://openalex.org/W1974514875","https://openalex.org/W1975516052","https://openalex.org/W1976261939","https://openalex.org/W1981076720","https://openalex.org/W1983979223","https://openalex.org/W1985056911","https://openalex.org/W1985844240","https://openalex.org/W1985921281","https://openalex.org/W1990522517","https://openalex.org/W1990743609","https://openalex.org/W1991917303","https://openalex.org/W1992310435","https://openalex.org/W1992431849","https://openalex.org/W1992787746","https://openalex.org/W1993294667","https://openalex.org/W1995862772","https://openalex.org/W1996413533","https://openalex.org/W1999328200","https://openalex.org/W2002329847","https://openalex.org/W2002404925","https://openalex.org/W2006192061","https://openalex.org/W2008620264","https://openalex.org/W2012852001","https://openalex.org/W2013270869","https://openalex.org/W2013491063","https://openalex.org/W2015646187","https://openalex.org/W2015954194","https://openalex.org/W2016170088","https://openalex.org/W2016236490","https://openalex.org/W2018633688","https://openalex.org/W2018934112","https://openalex.org/W2019011921","https://openalex.org/W2019831987","https://openalex.org/W2020761966","https://openalex.org/W2027035874","https://openalex.org/W2027216514","https://openalex.org/W2027835235","https://openalex.org/W2029375362","https://openalex.org/W2029988455","https://openalex.org/W2030490793","https://openalex.org/W2030776726","https://openalex.org/W2034424952","https://openalex.org/W2036270526","https://openalex.org/W2037433020","https://openalex.org/W2039740270","https://openalex.org/W2040370905","https://openalex.org/W2040411864","https://openalex.org/W2042715516","https://openalex.org/W2047503478","https://openalex.org/W2047537480","https://openalex.org/W2048725347","https://openalex.org/W2049476357","https://openalex.org/W2049734794","https://openalex.org/W2052606462","https://openalex.org/W2052955480","https://openalex.org/W2054111091","https://openalex.org/W2055085859","https://openalex.org/W2055805017","https://openalex.org/W2058128997","https://openalex.org/W2058138221","https://openalex.org/W2060723204","https://openalex.org/W2060750718","https://openalex.org/W2065304353","https://openalex.org/W2065942523","https://openalex.org/W2066991542","https://openalex.org/W2067503186","https://openalex.org/W2068751599","https://openalex.org/W2068817594","https://openalex.org/W2069187446","https://openalex.org/W2069900557","https://openalex.org/W2070602158","https://openalex.org/W2073745520","https://openalex.org/W2074180389","https://openalex.org/W2074443723","https://openalex.org/W2077895194","https://openalex.org/W2080672527","https://openalex.org/W2081049803","https://openalex.org/W2081621052","https://openalex.org/W2081807421","https://openalex.org/W2084076332","https://openalex.org/W2085593164","https://openalex.org/W2089218510","https://openalex.org/W2089831930","https://openalex.org/W2091566576","https://openalex.org/W2091676918","https://openalex.org/W2092104789","https://openalex.org/W2092153867","https://openalex.org/W2101472561","https://openalex.org/W2101791074","https://openalex.org/W2104315543","https://openalex.org/W2106390970","https://openalex.org/W2107903870","https://openalex.org/W2110110505","https://openalex.org/W2112090702","https://openalex.org/W2112166832","https://openalex.org/W2112811019","https://openalex.org/W2113019448","https://openalex.org/W2113654464","https://openalex.org/W2114823344","https://openalex.org/W2118498634","https://openalex.org/W2118729125","https://openalex.org/W2119502291","https://openalex.org/W2119693327","https://openalex.org/W2119751431","https://openalex.org/W2120385383","https://openalex.org/W2120881407","https://openalex.org/W2122772601","https://openalex.org/W2123180955","https://openalex.org/W2123280311","https://openalex.org/W2123500593","https://openalex.org/W2123575677","https://openalex.org/W2125022522","https://openalex.org/W2127547755","https://openalex.org/W2127650225","https://openalex.org/W2128413613","https://openalex.org/W2128549389","https://openalex.org/W2128705810","https://openalex.org/W2129170338","https://openalex.org/W2130479394","https://openalex.org/W2130687290","https://openalex.org/W2130790725","https://openalex.org/W2131135801","https://openalex.org/W2131736664","https://openalex.org/W2132179389","https://openalex.org/W2135885083","https://openalex.org/W2137110485","https://openalex.org/W2140351149","https://openalex.org/W2141378441","https://openalex.org/W2142355539","https://openalex.org/W2144885342","https://openalex.org/W2147905210","https://openalex.org/W2149472608","https://openalex.org/W2150467183","https://openalex.org/W2151480825","https://openalex.org/W2152265734","https://openalex.org/W2154244855","https://openalex.org/W2156070536","https://openalex.org/W2159136327","https://openalex.org/W2160003033","https://openalex.org/W2160846229","https://openalex.org/W2160854466","https://openalex.org/W2162720882","https://openalex.org/W2162899430","https://openalex.org/W2164328371","https://openalex.org/W2167222948","https://openalex.org/W2167680767","https://openalex.org/W2167869241","https://openalex.org/W2169927110","https://openalex.org/W2172008556","https://openalex.org/W2172414114","https://openalex.org/W2316374907","https://openalex.org/W2400322139","https://openalex.org/W2416281833","https://openalex.org/W2921811239","https://openalex.org/W2968636733","https://openalex.org/W3103071483","https://openalex.org/W3143219376","https://openalex.org/W7097257549"],"related_works":["https://openalex.org/W1975121208","https://openalex.org/W2015802360","https://openalex.org/W2170587249","https://openalex.org/W2104437738","https://openalex.org/W2042905169","https://openalex.org/W2101953406","https://openalex.org/W3153657305","https://openalex.org/W2780927228","https://openalex.org/W2065534861","https://openalex.org/W7100260869"],"abstract_inverted_index":{"Proteins":[0],"participate":[1],"in":[2,75,123,143,217],"complex":[3,29],"sets":[4],"of":[5,14,19,33,45,68,81,91,120,132,140,213],"interactions":[6,24],"that":[7,102,149,155,199],"represent":[8],"the":[9,15,20,46,104,118,130,138,166,195],"mechanistic":[10],"foundation":[11],"for":[12,169],"much":[13],"physiology":[16],"and":[17,183],"function":[18],"cell.":[21],"These":[22],"protein\u2013protein":[23,34],"are":[25,151],"organized":[26],"into":[27],"exquisitely":[28],"networks.":[30],"The":[31,65],"architecture":[32],"interaction":[35,216],"networks":[36,219],"was":[37],"recently":[38],"proposed":[39],"to":[40,86,98,106,179,209],"be":[41,73,97,115,208],"scale-free,":[42],"with":[43,55,88,194],"most":[44],"proteins":[47,83,176],"having":[48],"only":[49],"one":[50,124],"or":[51,62,125],"two":[52],"connections":[53],"but":[54],"relatively":[56],"fewer":[57],"\u2018hubs\u2019":[58],"possessing":[59],"tens,":[60],"hundreds":[61],"more":[63],"links.":[64],"high":[66],"level":[67],"hub":[69,82,170,181],"connectivity":[70],"must":[71],"somehow":[72],"reflected":[74],"protein":[76,144,171,215],"structure.":[77],"What":[78],"structural":[79,167],"quality":[80],"enables":[84],"them":[85],"interact":[87],"large":[89],"numbers":[90],"diverse":[92,110],"targets?":[93],"One":[94],"possibility":[95],"would":[96],"employ":[99],"binding":[100,201],"regions":[101],"have":[103],"ability":[105],"bind":[107,178],"multiple,":[108],"structurally":[109],"partners.":[111,127],"This":[112],"trait":[113],"can":[114,158,163,177,187],"imparted":[116],"by":[117],"incorporation":[119],"intrinsic":[121,141,156,161,185,222],"disorder":[122,142,157,162,186],"both":[126],"To":[128],"illustrate":[129],"value":[131],"such":[133],"contributions,":[134],"this":[135],"review":[136],"examines":[137],"roles":[139],"network":[145],"architecture.":[146],"We":[147],"show":[148],"there":[150],"three":[152],"general":[153],"ways":[154],"contribute:":[159],"First,":[160],"serve":[164],"as":[165],"basis":[168],"promiscuity;":[172],"secondly,":[173],"intrinsically":[174],"disordered":[175],"structured":[180],"proteins;":[182],"thirdly,":[184],"provide":[188],"flexible":[189],"linkers":[190,196],"between":[191],"functional":[192],"domains":[193],"enabling":[197],"mechanisms":[198],"facilitate":[200],"diversity.":[202],"An":[203],"important":[204],"research":[205],"direction":[206],"will":[207],"determine":[210],"what":[211],"fraction":[212],"protein\u2013":[214],"regulatory":[218],"relies":[220],"on":[221],"disorder.":[223]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":26}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}