{"id":"https://openalex.org/W1960011333","doi":"https://doi.org/10.4049/jimmunol.0903739","title":"IL-17RC Is Required for Immune Signaling via an Extended SEF/IL-17R Signaling Domain in the Cytoplasmic Tail","display_name":"IL-17RC Is Required for Immune Signaling via an Extended SEF/IL-17R Signaling Domain in the Cytoplasmic Tail","publication_year":2010,"publication_date":"2010-06-17","ids":{"openalex":"https://openalex.org/W1960011333","doi":"https://doi.org/10.4049/jimmunol.0903739","mag":"1960011333","pmid":"https://pubmed.ncbi.nlm.nih.gov/20554964","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2897912"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.0903739","doi":"https://doi.org/10.4049/jimmunol.0903739","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.0903739","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2897912","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015257895","display_name":"Allen W. Ho","orcid":"https://orcid.org/0000-0002-5861-0552","observed_orcids":["https://orcid.org/0000-0002-5861-0552"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen W Ho","raw_affiliation_strings":["Department of Oral Biology, University at Buffalo, State University of New York , Buffalo, NY 14214","Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh , Pittsburgh, PA 15261","\u2020Division of Rheumatology and Clinical Immunology, Department of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology, University at Buffalo, State University of New York , Buffalo, NY 14214","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh , Pittsburgh, PA 15261","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"\u2020Division of Rheumatology and Clinical Immunology, Department of Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101842782","display_name":"Fang Shen","orcid":"https://orcid.org/0000-0003-0084-7933","observed_orcids":["https://orcid.org/0000-0003-0084-7933"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fang Shen","raw_affiliation_strings":["Department of Oral Biology, University at Buffalo, State University of New York , Buffalo, NY 14214","Genentech, Louisiana State University , South San Francisco, CA 94080","\u2021Genentech, South San Francisco, CA 94080; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology, University at Buffalo, State University of New York , Buffalo, NY 14214","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Genentech, Louisiana State University , South San Francisco, CA 94080","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I183934855"]},{"raw_affiliation_string":"\u2021Genentech, South San Francisco, CA 94080; and","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080366618","display_name":"Heather R. Conti","orcid":"https://orcid.org/0000-0002-1491-4212","observed_orcids":["https://orcid.org/0000-0002-1491-4212"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather R Conti","raw_affiliation_strings":["Department of Oral Biology, University at Buffalo, State University of New York , Buffalo, NY 14214"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology, University at Buffalo, State University of New York , Buffalo, NY 14214","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081014317","display_name":"Nayan M Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nayan Patel","raw_affiliation_strings":["Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh , Pittsburgh, PA 15261","\u2020Division of Rheumatology and Clinical Immunology, Department of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh , Pittsburgh, PA 15261","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"\u2020Division of Rheumatology and Clinical Immunology, Department of Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051962931","display_name":"Erin E. Childs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin E Childs","raw_affiliation_strings":["Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh , Pittsburgh, PA 15261","\u2020Division of Rheumatology and Clinical Immunology, Department of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh , Pittsburgh, PA 15261","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"\u2020Division of Rheumatology and Clinical Immunology, Department of Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020370363","display_name":"Alanna Peterson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alanna C Peterson","raw_affiliation_strings":["Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh , Pittsburgh, PA 15261","\u2020Division of Rheumatology and Clinical Immunology, Department of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh , Pittsburgh, PA 15261","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"\u2020Division of Rheumatology and Clinical Immunology, Department of Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066660712","display_name":"Nydiaris Hern\u00e1ndez\u2010Santos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nydiaris Hern\u00e1ndez-Santos","raw_affiliation_strings":["Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh , Pittsburgh, PA 15261","\u2020Division of Rheumatology and Clinical Immunology, Department of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh , Pittsburgh, PA 15261","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"\u2020Division of Rheumatology and Clinical Immunology, Department of Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063111442","display_name":"Jay K. Kolls","orcid":"https://orcid.org/0000-0001-5151-6304","observed_orcids":["https://orcid.org/0000-0001-5151-6304"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay K Kolls","raw_affiliation_strings":["\u00a7Department of Genetics, Health Sciences Center, Louisiana State University, New Orleans, LA 70112"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a7Department of Genetics, Health Sciences Center, Louisiana State University, New Orleans, LA 70112","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045339445","display_name":"Larry Kane","orcid":"https://orcid.org/0000-0001-5198-516X","observed_orcids":["https://orcid.org/0000-0001-5198-516X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence P Kane","raw_affiliation_strings":["Department of Immunology, University of Pittsburgh , Pittsburgh, PA 15261"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Pittsburgh , Pittsburgh, PA 15261","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002337965","display_name":"Wenjun Ouyang","orcid":"https://orcid.org/0000-0002-1811-5864","observed_orcids":["https://orcid.org/0000-0002-1811-5864"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenjun Ouyang","raw_affiliation_strings":["Genentech, Louisiana State University , South San Francisco, CA 94080","\u2021Genentech, South San Francisco, CA 94080; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Louisiana State University , South San Francisco, CA 94080","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I183934855"]},{"raw_affiliation_string":"\u2021Genentech, South San Francisco, CA 94080; and","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049895849","display_name":"Sarah L. Gaffen","orcid":"https://orcid.org/0000-0001-8511-2041","observed_orcids":["https://orcid.org/0000-0001-8511-2041"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah L Gaffen","raw_affiliation_strings":["Department of Immunology, University of Pittsburgh , Pittsburgh, PA 15261","Department of Oral Biology, University at Buffalo, State University of New York , Buffalo, NY 14214","Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh , Pittsburgh, PA 15261","\u2020Division of Rheumatology and Clinical Immunology, Department of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Pittsburgh , Pittsburgh, PA 15261","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Oral Biology, University at Buffalo, State University of New York , Buffalo, NY 14214","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh , Pittsburgh, PA 15261","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"\u2020Division of Rheumatology and Clinical Immunology, Department of Medicine, and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101842782"],"corresponding_institution_ids":["https://openalex.org/I121820613","https://openalex.org/I183934855","https://openalex.org/I63190737"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":6.1193,"has_fulltext":false,"cited_by_count":124,"citation_normalized_percentile":{"value":0.97161546,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"185","issue":"2","first_page":"1063","last_page":"1070"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.8676999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.8676999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.11990000307559967,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-17rc","display_name":"IL-17RC","score":0.996999979019165},{"id":"https://openalex.org/keywords/il-17-signaling","display_name":"IL-17 signaling","score":0.8659999966621399},{"id":"https://openalex.org/keywords/act1","display_name":"Act1","score":0.6570000052452087},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.9710000157356262},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.6449999809265137},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7699999809265137},{"id":"https://openalex.org/keywords/neutrophil-gelatinase-associated-lipocalin","display_name":"neutrophil gelatinase-associated lipocalin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.8370000123977661},{"id":"https://openalex.org/keywords/oral-mucosal-infection","display_name":"oral mucosal infection","score":0.9330000281333923},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.4560000002384186},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6948343515396118},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6888507604598999},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6729425191879272},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.5215566158294678},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.4561828672885895},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.4238676428794861},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.3801284432411194},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1905606985092163},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14848583936691284}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002180","descriptor_name":"Candidiasis, Oral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002180","descriptor_name":"Candidiasis, Oral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009960","descriptor_name":"Oropharynx","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009960","descriptor_name":"Oropharynx","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053722","descriptor_name":"Receptors, Interleukin-17","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053722","descriptor_name":"Receptors, Interleukin-17","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D053722","descriptor_name":"Receptors, Interleukin-17","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.0903739","doi":"https://doi.org/10.4049/jimmunol.0903739","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.0903739","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:20554964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20554964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2897912","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2897912","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Immunol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2897912","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2897912","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Immunol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1095532798","display_name":"Signaling and Cell Biology of TIM-1","funder_award_id":"R56AI067544","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5095648373","display_name":null,"funder_award_id":"DE007034","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G5134792371","display_name":"Th17 Cytokines and Lung Immunity","funder_award_id":"R37HL079142","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6017308298","display_name":"Structure-Function Relationships in the IL-17 Receptor","funder_award_id":"R01AR054389","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G6230511774","display_name":null,"funder_award_id":"AI067544","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G631262536","display_name":"Regulation of T Cell Activation and Differentiation by TIM-1","funder_award_id":"R01AI067544","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G634383967","display_name":null,"funder_award_id":"R01-HL079142","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G649915027","display_name":"IL-23 / Il-17 and Lung Host Defense","funder_award_id":"7r01hl079142-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G710662029","display_name":"Comprehensive Research Training for Oral Health Sciences","funder_award_id":"T32DE007034","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G874068265","display_name":null,"funder_award_id":"HL079142","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000867717","display_name":"Cancer Immunology Training Program","funder_award_id":"T32CA082084","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G93400858","display_name":"Regulation of NF-kB by the Akt kinase","funder_award_id":"R01GM080398","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W221516563","https://openalex.org/W1504920623","https://openalex.org/W1551727579","https://openalex.org/W1561800225","https://openalex.org/W1587784817","https://openalex.org/W1805155421","https://openalex.org/W1969696561","https://openalex.org/W1975007025","https://openalex.org/W1975204978","https://openalex.org/W1987628377","https://openalex.org/W1988318286","https://openalex.org/W1993846314","https://openalex.org/W2000086986","https://openalex.org/W2004186675","https://openalex.org/W2009438958","https://openalex.org/W2016850513","https://openalex.org/W2020233428","https://openalex.org/W2021674244","https://openalex.org/W2024490058","https://openalex.org/W2065054549","https://openalex.org/W2069571875","https://openalex.org/W2070171027","https://openalex.org/W2075428144","https://openalex.org/W2083405359","https://openalex.org/W2087810525","https://openalex.org/W2087851913","https://openalex.org/W2107066107","https://openalex.org/W2114180142","https://openalex.org/W2115073769","https://openalex.org/W2115752847","https://openalex.org/W2116516945","https://openalex.org/W2140373863","https://openalex.org/W2145468317","https://openalex.org/W2156451877","https://openalex.org/W2161645061","https://openalex.org/W2166087321","https://openalex.org/W2170908195","https://openalex.org/W2171571685","https://openalex.org/W2171829791","https://openalex.org/W2299883777"],"related_works":["https://openalex.org/W2115073769","https://openalex.org/W1993846314","https://openalex.org/W170763655","https://openalex.org/W2083361647","https://openalex.org/W2021674244","https://openalex.org/W221516563","https://openalex.org/W1975204978","https://openalex.org/W4313388402","https://openalex.org/W2122165025","https://openalex.org/W2060523885"],"abstract_inverted_index":{"IL-17":[0,90],"mediates":[1],"essential":[2],"inflammatory":[3,228],"responses":[4,186,229],"in":[5,77,103,183,210,213,239],"host":[6],"defense":[7],"and":[8,18,94,156,212,230],"autoimmunity.":[9],"The":[10],"IL-17A-IL-17F":[11],"signaling":[12,37,56,102,109,208],"complex":[13],"is":[14,180,204],"composed":[15],"of":[16,21,33,60,81,88,101,137,173],"IL-17RA":[17,75],"IL-17RC,":[19],"both":[20,209],"which":[22,220],"are":[23],"necessary":[24],"for":[25,51,182,206,236],"signal":[26,52],"transduction.":[27],"To":[28,41],"date,":[29],"the":[30,43,46,82,89,107,121,138,151,158,163,193,217],"specific":[31,73],"contribution":[32],"IL-17RC":[34,47,61,68,83,122,147,160,179,203,221],"to":[35,116,128],"downstream":[36,136],"remains":[38],"poorly":[39],"understood.":[40],"define":[42],"regions":[44],"within":[45],"cytoplasmic":[48,84],"tail":[49],"required":[50,106,181],"transduction,":[53],"we":[54,176],"assayed":[55],"by":[57,192,219],"a":[58,72,78,97,112,170],"panel":[59],"deletion":[62],"mutants.":[63],"These":[64,199],"findings":[65],"reveal":[66],"that":[67,146,157,178,202],"inducibly":[69],"associates":[70],"with":[71,150,169],"glycosylated":[74],"isoform,":[76],"manner":[79],"independent":[80],"tail.":[85],"Using":[86],"expression":[87],"target":[91],"genes":[92],"IL-6":[93],"24p3/lipocalin-2":[95],"as":[96],"readout,":[98],"functional":[99,159],"reconstitution":[100],"IL-17RC(-/-)":[104],"fibroblasts":[105],"SEF/IL-17R":[108],"domain":[110],"(SEFIR),":[111],"conserved":[113],"motif":[114],"common":[115],"IL-17R":[117],"family":[118],"members.":[119],"Unexpectedly,":[120],"SEFIR":[123,139,165],"alone":[124],"was":[125,140],"not":[126],"sufficient":[127],"reconstitute":[129],"IL-17-dependent":[130,185,207,227],"signaling.":[131],"Rather,":[132],"an":[133,234],"additional":[134],"sequence":[135],"also":[141],"necessary.":[142],"We":[143],"further":[144],"found":[145],"interacts":[148],"directly":[149],"adaptor/E3":[152],"ubiquitin":[153],"ligase":[154],"Act1,":[155],"isoforms":[161],"containing":[162],"extended":[164],"region":[166],"interact":[167],"specifically":[168],"phosphorylated":[171],"isoform":[172],"Act1.":[174],"Finally,":[175],"show":[177],"vivo":[184],"during":[187],"oral":[188],"mucosal":[189],"infections":[190],"caused":[191],"human":[194],"commensal":[195],"fungus":[196],"Candida":[197],"albicans.":[198],"results":[200],"indicate":[201],"vital":[205],"vitro":[211],"vivo.":[214],"Insight":[215],"into":[216],"mechanisms":[218],"signals":[222],"helps":[223],"shed":[224],"light":[225],"on":[226],"may":[231],"ultimately":[232],"provide":[233],"avenue":[235],"therapeutic":[237],"intervention":[238],"IL-17-mediated":[240],"diseases.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
