{"id":"https://openalex.org/W1959458044","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.248.6","title":"Metabolomic profiles of childhood obesity and cardiometabolic risk (248.6)","display_name":"Metabolomic profiles of childhood obesity and cardiometabolic risk (248.6)","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W1959458044","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.248.6","mag":"1959458044"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.28.1_supplement.248.6","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.248.6","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.248.6","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041410391","display_name":"Wei Perng","orcid":"https://orcid.org/0000-0001-8552-6850","observed_orcids":["https://orcid.org/0000-0001-8552-6850"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210111543","display_name":"Harvard Pilgrim Health Care","ror":"https://ror.org/01zxdeg39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210111543"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Perng","raw_affiliation_strings":["Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute BOSTON MA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute BOSTON MA United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210111543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101562930","display_name":"Matthew W. Gillman","orcid":"https://orcid.org/0000-0001-9642-8797","observed_orcids":["https://orcid.org/0000-0001-9642-8797","https://orcid.org/0000-0001-9653-3853"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210111543","display_name":"Harvard Pilgrim Health Care","ror":"https://ror.org/01zxdeg39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210111543"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Gillman","raw_affiliation_strings":["Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute BOSTON MA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute BOSTON MA United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210111543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103779672","display_name":"Steven M. Watkins","orcid":"https://orcid.org/0000-0002-3738-3768","observed_orcids":["https://orcid.org/0000-0002-3738-3768"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steve Watkins","raw_affiliation_strings":["Lipomics, A Division of Metabolon West Sacramento CA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lipomics, A Division of Metabolon West Sacramento CA United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046421306","display_name":"Mary\u2010Elizabeth Patti","orcid":"https://orcid.org/0000-0002-8163-3429","observed_orcids":["https://orcid.org/0000-0002-8163-3429"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary\u2010Elizabeth Patti","raw_affiliation_strings":["Population Medicine Joslin Diabetes Center BOSTON MA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Population Medicine Joslin Diabetes Center BOSTON MA United States","institution_ids":["https://openalex.org/I1293231726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020567229","display_name":"Abby F. Fleisch","orcid":"https://orcid.org/0000-0002-2789-6412","observed_orcids":["https://orcid.org/0000-0002-2789-6412"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abby Fleisch","raw_affiliation_strings":["Boston Children's Hospital BOSTON MA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children's Hospital BOSTON MA United States","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077350027","display_name":"Emily Oken","orcid":"https://orcid.org/0000-0003-2513-3339","observed_orcids":["https://orcid.org/0000-0003-2513-3339"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210111543","display_name":"Harvard Pilgrim Health Care","ror":"https://ror.org/01zxdeg39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210111543"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Oken","raw_affiliation_strings":["Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute BOSTON MA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute BOSTON MA United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210111543"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06476074,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.5580999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.5580999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.30219998955726624,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.053300000727176666,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/childhood-obesity","display_name":"childhood obesity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cardiometabolic-risk","display_name":"cardiometabolic risk","score":0.9120000004768372},{"id":"https://openalex.org/keywords/branched-chain-amino-acids","display_name":"branched-chain amino acids","score":0.9580000042915344},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8939999938011169},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.8769999742507935},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.8519999980926514},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.984000027179718},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9480000138282776},{"id":"https://openalex.org/keywords/untargeted-mass-spectrometry","display_name":"untargeted mass spectrometry","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.8360495567321777},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.7709410190582275},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.6196169257164001},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6141958236694336},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6112158298492432},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6073132157325745},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5474855899810791},{"id":"https://openalex.org/C2779422640","wikidata":"https://www.wikidata.org/wiki/Q3241451","display_name":"Childhood obesity","level":4,"score":0.5247071981430054},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.51298588514328},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.5066257119178772},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.43562108278274536},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.26439547538757324},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.11935880780220032},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.07618144154548645}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.28.1_supplement.248.6","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.248.6","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.248.6","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1623684340","https://openalex.org/W2155128881","https://openalex.org/W2890112454","https://openalex.org/W2923837171","https://openalex.org/W4205726970","https://openalex.org/W7099183526","https://openalex.org/W1983806465","https://openalex.org/W2475990579","https://openalex.org/W3197180507","https://openalex.org/W6957737216"],"abstract_inverted_index":{"Objective":[0],"To":[1],"identify":[2,73],"metabolite":[3,43,87,198],"patterns":[4,74],"associated":[5,175,200],"with":[6,14,30,90,176,201],"childhood":[7],"obesity,":[8],"and":[9,62,98,129,140,162,188,196],"to":[10,72,76,113,151,206],"examine":[11],"their":[12],"relations":[13,84],"cardiometabolic":[15,210],"risk":[16,211],"biomarkers.":[17],"Methods":[18],"We":[19],"quantified":[20],"350":[21],"metabolites":[22],"in":[23,146],"serum":[24],"of":[25,85,104,170,209,220],"262":[26],"children":[27,64,117],"7\u201010":[28],"y":[29],"an":[31,130],"untargeted":[32],"mass":[33],"spectrophotometry":[34],"approach.":[35],"Using":[36,78],"principal":[37],"component":[38],"analysis,":[39],"we":[40,46,82],"characterized":[41],"18":[42],"patterns.":[44],"Next,":[45],"compared":[47],"factor":[48,88,120],"scores":[49,89,121],"for":[50,122,137],"each":[51],"pattern":[52],"between":[53],"obese":[54,116],"(BMI":[55,65],"\u8805":[56],"95":[57],"%tile;":[58,68],"n":[59,69],"=":[60,70],"84)":[61],"lean":[63,114],"<":[66],"85":[67],"150)":[71],"related":[75,205],"obesity.":[77],"multivariable":[79],"linear":[80],"regression":[81],"examined":[83],"the":[86,105,147,171],"ln":[91],"transformed":[92],"HOMA\u2010IR,":[93,156],"leptin,":[94,161],"adiponectin,":[95,187],"triglycerides,":[96],"CRP,":[97],"IL\u20106.":[99,193],"Results":[100],"Approximately":[101],"half":[102],"(50.6%)":[103],"sample":[106],"were":[107,110],"boys;":[108],"58.9%":[109],"white.":[111],"Compared":[112],"children,":[115],"had":[118],"higher":[119,155,160,166,180,192],"a":[123],"branched":[124],"chain":[125],"amino":[126],"acid":[127],"(BCAA)":[128],"androstene":[131],"steroid":[132,197],"(AS)":[133],"pattern.":[134],"After":[135],"adjustment":[136],"age,":[138],"sex,":[139],"race,":[141],"every":[142],"1":[143],"unit":[144,169],"increment":[145],"BCAA":[148,195],"score":[149,173],"corresponded":[150],"7%":[152,183],"(1%,":[153,178],"14%)":[154],"15%":[157],"(6%,":[158],"25%)":[159],"31%":[163],"(14%,":[164],"49%)":[165],"CRP.":[167],"Each":[168],"AS":[172],"was":[174],"4%":[177],"7%)":[179],"triglyceride":[181],"levels,":[182],"(2%,":[184],"11%)":[185],"lower":[186],"12%":[189],"(3%,":[190],"20%)":[191],"Conclusions:":[194],"profiles":[199],"obesity":[202],"are":[203],"also":[204],"established":[207],"biomarkers":[208],"during":[212],"mid\u2010childhood.":[213],"Grant":[214],"Funding":[215],"Source":[216],":":[217],"National":[218],"Institutes":[219],"Health":[221]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}