{"id":"https://openalex.org/W1958248331","doi":"https://doi.org/10.1002/psc.2582","title":"Development of a neuromedin U\u2013human serum albumin conjugate as a long\u2010acting candidate for the treatment of obesity and diabetes. Comparison with the PEGylated peptide","display_name":"Development of a neuromedin U\u2013human serum albumin conjugate as a long\u2010acting candidate for the treatment of obesity and diabetes. Comparison with the PEGylated peptide","publication_year":2013,"publication_date":"2013-11-13","ids":{"openalex":"https://openalex.org/W1958248331","doi":"https://doi.org/10.1002/psc.2582","mag":"1958248331","pmid":"https://pubmed.ncbi.nlm.nih.gov/24222478"},"language":"en","primary_location":{"id":"doi:10.1002/psc.2582","doi":"https://doi.org/10.1002/psc.2582","is_oa":false,"landing_page_url":"https://doi.org/10.1002/psc.2582","pdf_url":null,"source":{"id":"https://openalex.org/S184443419","display_name":"Journal of Peptide Science","issn_l":"1075-2617","issn":["1075-2617","1099-1387"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Peptide Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084924302","display_name":"Philippe Neuner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]},{"id":"https://openalex.org/I4210149054","display_name":"IRBM","ror":"https://ror.org/03ndq5j60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210149054"]},{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH","IT"],"is_corresponding":false,"raw_author_name":"Philippe Neuner","raw_affiliation_strings":["IRBM P. Angeletti, 00040 Pomezia, RM, Italy","NIBR WSJ-507.1.02, Novartis Pharma AG, Campus, CH-4056 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRBM P. Angeletti, 00040 Pomezia, RM, Italy","institution_ids":["https://openalex.org/I4210149054"]},{"raw_affiliation_string":"NIBR WSJ-507.1.02, Novartis Pharma AG, Campus, CH-4056 Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009799313","display_name":"Andrea M. Peier","orcid":"https://orcid.org/0000-0002-8640-2275","observed_orcids":["https://orcid.org/0000-0002-8640-2275"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea M. Peier","raw_affiliation_strings":["Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ, 07065 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ, 07065 USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027410600","display_name":"Fabio Talamo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149054","display_name":"IRBM","ror":"https://ror.org/03ndq5j60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210149054"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Talamo","raw_affiliation_strings":["Department of Biological Systems Research, Research & Development at Philip Morris Products S.A., Quai Jean Renaud 5, CH 2000 Neuchatel, Switzerland","IRBM P. Angeletti, 00040 Pomezia, RM, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Systems Research, Research & Development at Philip Morris Products S.A., Quai Jean Renaud 5, CH 2000 Neuchatel, Switzerland","institution_ids":[]},{"raw_affiliation_string":"IRBM P. Angeletti, 00040 Pomezia, RM, Italy","institution_ids":["https://openalex.org/I4210149054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014423238","display_name":"Paolo Ingallinella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149054","display_name":"IRBM","ror":"https://ror.org/03ndq5j60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210149054"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Ingallinella","raw_affiliation_strings":["DiaSorin Research Center, 21040 Gerenzano, VA, Italy","IRBM P. Angeletti, 00040 Pomezia, RM, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DiaSorin Research Center, 21040 Gerenzano, VA, Italy","institution_ids":[]},{"raw_affiliation_string":"IRBM P. Angeletti, 00040 Pomezia, RM, Italy","institution_ids":["https://openalex.org/I4210149054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000269292","display_name":"Armin Lahm","orcid":"https://orcid.org/0000-0002-2859-4379","observed_orcids":["https://orcid.org/0000-0002-2859-4379"]},"institutions":[{"id":"https://openalex.org/I4210149054","display_name":"IRBM","ror":"https://ror.org/03ndq5j60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210149054"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Armin Lahm","raw_affiliation_strings":["IRBM P. Angeletti, 00040 Pomezia, RM, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRBM P. Angeletti, 00040 Pomezia, RM, Italy","institution_ids":["https://openalex.org/I4210149054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085438624","display_name":"Gaetano Barbato","orcid":"https://orcid.org/0000-0001-9840-6858","observed_orcids":["https://orcid.org/0000-0001-9840-6858"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I4210149054","display_name":"IRBM","ror":"https://ror.org/03ndq5j60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210149054"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gaetano Barbato","raw_affiliation_strings":["Department of Science and Chemical Technology, University of Tor Vergata, Rome, Italy","IRBM P. Angeletti, 00040 Pomezia, RM, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Science and Chemical Technology, University of Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"IRBM P. Angeletti, 00040 Pomezia, RM, Italy","institution_ids":["https://openalex.org/I4210149054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064210998","display_name":"Annalise Di Marco","orcid":"https://orcid.org/0000-0001-5211-6230","observed_orcids":["https://orcid.org/0000-0001-5211-6230"]},"institutions":[{"id":"https://openalex.org/I4210149054","display_name":"IRBM","ror":"https://ror.org/03ndq5j60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210149054"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annalise Di Marco","raw_affiliation_strings":["IRBM P. Angeletti, 00040 Pomezia, RM, Italy","IRBM Science Park, 00040 Pomezia, RM, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRBM P. Angeletti, 00040 Pomezia, RM, Italy","institution_ids":["https://openalex.org/I4210149054"]},{"raw_affiliation_string":"IRBM Science Park, 00040 Pomezia, RM, Italy","institution_ids":["https://openalex.org/I4210149054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103565580","display_name":"Kunal Desai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kunal Desai","raw_affiliation_strings":["Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ, 07065 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ, 07065 USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049531697","display_name":"Karolina Zytko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149054","display_name":"IRBM","ror":"https://ror.org/03ndq5j60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210149054"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Karolina Zytko","raw_affiliation_strings":["IRBM P. Angeletti, 00040 Pomezia, RM, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRBM P. Angeletti, 00040 Pomezia, RM, Italy","institution_ids":["https://openalex.org/I4210149054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104688161","display_name":"Ying Qian","orcid":"https://orcid.org/0000-0003-2370-3377","observed_orcids":["https://orcid.org/0000-0003-2370-3377"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Qian","raw_affiliation_strings":["Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ, 07065 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ, 07065 USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100543339","display_name":"Xiaobing Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaobing Du","raw_affiliation_strings":["Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ, 07065 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ, 07065 USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Davide Ricci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149054","display_name":"IRBM","ror":"https://ror.org/03ndq5j60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210149054"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Davide Ricci","raw_affiliation_strings":["IRBM P. Angeletti, 00040 Pomezia, RM, Italy","IRBM Science Park, 00040 Pomezia, RM, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRBM P. Angeletti, 00040 Pomezia, RM, Italy","institution_ids":["https://openalex.org/I4210149054"]},{"raw_affiliation_string":"IRBM Science Park, 00040 Pomezia, RM, Italy","institution_ids":["https://openalex.org/I4210149054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036851868","display_name":"Edith S. Monteagudo","orcid":"https://orcid.org/0000-0003-2471-5695","observed_orcids":["https://orcid.org/0000-0003-2471-5695"]},"institutions":[{"id":"https://openalex.org/I4210149054","display_name":"IRBM","ror":"https://ror.org/03ndq5j60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210149054"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Edith Monteagudo","raw_affiliation_strings":["IRBM P. Angeletti, 00040 Pomezia, RM, Italy","IRBM Science Park, 00040 Pomezia, RM, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRBM P. Angeletti, 00040 Pomezia, RM, Italy","institution_ids":["https://openalex.org/I4210149054"]},{"raw_affiliation_string":"IRBM Science Park, 00040 Pomezia, RM, Italy","institution_ids":["https://openalex.org/I4210149054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111594821","display_name":"Ralph Laufer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149054","display_name":"IRBM","ror":"https://ror.org/03ndq5j60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210149054"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ralph Laufer","raw_affiliation_strings":["IRBM P. Angeletti, 00040 Pomezia, RM, Italy","IRBM Science Park, 00040 Pomezia, RM, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRBM P. Angeletti, 00040 Pomezia, RM, Italy","institution_ids":["https://openalex.org/I4210149054"]},{"raw_affiliation_string":"IRBM Science Park, 00040 Pomezia, RM, Italy","institution_ids":["https://openalex.org/I4210149054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040533601","display_name":"Alessandro Pocai","orcid":"https://orcid.org/0000-0003-1450-9521","observed_orcids":["https://orcid.org/0000-0003-1450-9521"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alessandro Pocai","raw_affiliation_strings":["Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ, 07065 USA","Janssen R&D 1577 Welsh Rd & Mckean Rd Spring House PA 19477 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ, 07065 USA","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Janssen R&D 1577 Welsh Rd & Mckean Rd Spring House PA 19477 USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076781411","display_name":"Elisabetta Bianchi","orcid":"https://orcid.org/0000-0002-5302-6912","observed_orcids":["https://orcid.org/0000-0002-5302-6912"]},"institutions":[{"id":"https://openalex.org/I4210149054","display_name":"IRBM","ror":"https://ror.org/03ndq5j60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210149054"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisabetta Bianchi","raw_affiliation_strings":["IRBM P. Angeletti, 00040 Pomezia, RM, Italy","IRBM Science Park, 00040 Pomezia, RM, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRBM P. Angeletti, 00040 Pomezia, RM, Italy","institution_ids":["https://openalex.org/I4210149054"]},{"raw_affiliation_string":"IRBM Science Park, 00040 Pomezia, RM, Italy","institution_ids":["https://openalex.org/I4210149054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104039619","display_name":"Donald J. Marsh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Donald J. Marsh","raw_affiliation_strings":["Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ, 07065 USA","Department of Safety Assessment and Laboratory Animal Resources, Merck Research Laboratories, Kenilworth, NJ, 07033-1310 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ, 07065 USA","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Department of Safety Assessment and Laboratory Animal Resources, Merck Research Laboratories, Kenilworth, NJ, 07033-1310 USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016262549","display_name":"Antonello Pessi","orcid":"https://orcid.org/0000-0003-1298-2139","observed_orcids":["https://orcid.org/0000-0003-1298-2139"]},"institutions":[{"id":"https://openalex.org/I4210128854","display_name":"CEINGE Biotecnologie Avanzate Franco Salvatore (Italy)","ror":"https://ror.org/033pa2k60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210128854"]},{"id":"https://openalex.org/I4210149054","display_name":"IRBM","ror":"https://ror.org/03ndq5j60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210149054"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Antonello Pessi","raw_affiliation_strings":["CEINGE, Via Gaetano Salvatore 486, 80145 Napoli, Italy","IRBM P. Angeletti, 00040 Pomezia, RM, Italy","PeptiPharma  Viale Citt\u00e0 D'Europa 679 00144 Rome Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEINGE, Via Gaetano Salvatore 486, 80145 Napoli, Italy","institution_ids":["https://openalex.org/I4210128854"]},{"raw_affiliation_string":"IRBM P. Angeletti, 00040 Pomezia, RM, Italy","institution_ids":["https://openalex.org/I4210149054"]},{"raw_affiliation_string":"PeptiPharma  Viale Citt\u00e0 D'Europa 679 00144 Rome Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5016262549","https://openalex.org/A5104039619"],"corresponding_institution_ids":["https://openalex.org/I1285764155","https://openalex.org/I4210128854","https://openalex.org/I4210149054"],"apc_list":{"value":4030,"currency":"USD","value_usd":4030},"apc_paid":null,"fwci":1.5288,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.79553922,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"20","issue":"1","first_page":"7","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.5264000296592712,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.5264000296592712,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.1177000030875206,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.06939999759197235,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuromedin-u","display_name":"neuromedin U","score":1.0},{"id":"https://openalex.org/keywords/human-serum-albumin-conjugate","display_name":"human serum albumin conjugate","score":0.8949999809265137},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.46700000762939453},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9440000057220459},{"id":"https://openalex.org/keywords/thiol-maleimide-conjugation","display_name":"thiol-maleimide conjugation","score":0.828000009059906},{"id":"https://openalex.org/keywords/pegylated-peptide","display_name":"PEGylated peptide","score":0.8379999995231628},{"id":"https://openalex.org/keywords/anorectic-activity","display_name":"anorectic activity","score":0.9350000023841858},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.7799999713897705}],"concepts":[{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.6241013407707214},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5748456120491028},{"id":"https://openalex.org/C2778597219","wikidata":"https://www.wikidata.org/wiki/Q11721976","display_name":"Human serum albumin","level":2,"score":0.5413936972618103},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5370165109634399},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5293517708778381},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5226866006851196},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.46627524495124817},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45063748955726624},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.43907150626182556},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2651216983795166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25257954001426697},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1761721968650818},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000075462","descriptor_name":"Serum Albumin, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017981","descriptor_name":"Receptors, Neurotransmitter","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/psc.2582","doi":"https://doi.org/10.1002/psc.2582","is_oa":false,"landing_page_url":"https://doi.org/10.1002/psc.2582","pdf_url":null,"source":{"id":"https://openalex.org/S184443419","display_name":"Journal of Peptide Science","issn_l":"1075-2617","issn":["1075-2617","1099-1387"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Peptide Science","raw_type":"journal-article"},{"id":"pmid:24222478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24222478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of peptide science : an official publication of the European Peptide Society","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W62015567","https://openalex.org/W1481315855","https://openalex.org/W1488526962","https://openalex.org/W1555045491","https://openalex.org/W1972756211","https://openalex.org/W1977241343","https://openalex.org/W1986032394","https://openalex.org/W1990814744","https://openalex.org/W1992175481","https://openalex.org/W1993898431","https://openalex.org/W1996277470","https://openalex.org/W2009944038","https://openalex.org/W2012452245","https://openalex.org/W2018241808","https://openalex.org/W2021679523","https://openalex.org/W2022234371","https://openalex.org/W2027163446","https://openalex.org/W2028239287","https://openalex.org/W2030329862","https://openalex.org/W2032644190","https://openalex.org/W2034231800","https://openalex.org/W2035776098","https://openalex.org/W2041275298","https://openalex.org/W2046683256","https://openalex.org/W2051876138","https://openalex.org/W2052202496","https://openalex.org/W2052636578","https://openalex.org/W2059716194","https://openalex.org/W2060362267","https://openalex.org/W2064972543","https://openalex.org/W2070703945","https://openalex.org/W2071843728","https://openalex.org/W2075522667","https://openalex.org/W2077816930","https://openalex.org/W2078058404","https://openalex.org/W2082393618","https://openalex.org/W2083741293","https://openalex.org/W2094758813","https://openalex.org/W2112275006","https://openalex.org/W2117616142","https://openalex.org/W2124140010","https://openalex.org/W2124332120","https://openalex.org/W2127738041","https://openalex.org/W2129722309","https://openalex.org/W2132603015","https://openalex.org/W2138906847","https://openalex.org/W2141823153","https://openalex.org/W2142506011","https://openalex.org/W2147180007","https://openalex.org/W2147596827","https://openalex.org/W2150092844","https://openalex.org/W2152569314","https://openalex.org/W2153950991","https://openalex.org/W2159392554","https://openalex.org/W2313744971","https://openalex.org/W2316384478","https://openalex.org/W2322644144","https://openalex.org/W4234500488"],"related_works":["https://openalex.org/W2591383737","https://openalex.org/W1899203612","https://openalex.org/W2753580694","https://openalex.org/W2726168754","https://openalex.org/W2771864401","https://openalex.org/W3044428874","https://openalex.org/W2314688160","https://openalex.org/W2463817544","https://openalex.org/W2973470936","https://openalex.org/W887670258"],"abstract_inverted_index":{"Neuromedin":[0],"U":[1],"(NMU)":[2],"is":[3,19,37],"an":[4],"endogenous":[5],"peptide":[6,91,119],"implicated":[7],"in":[8,42,110],"the":[9,23,69,81,90,93,105,118,123,160,169],"regulation":[10],"of":[11,25,32,49,84,89,96,98,113,117,125,171],"feeding,":[12],"energy":[13],"homeostasis,":[14],"and":[15,27,71,135,173],"glycemic":[16],"control,":[17],"which":[18,63],"being":[20],"considered":[21],"for":[22,168],"therapy":[24],"obesity":[26,172],"diabetes.":[28,174],"A":[29],"key":[30],"liability":[31],"NMU":[33,50,73,79],"as":[34],"a":[35,57,86,114,126,144,153],"therapeutic":[36],"its":[38],"very":[39],"short":[40],"half-life":[41],"vivo.":[43,111],"We":[44],"show":[45],"here":[46],"that":[47,162],"conjugation":[48],"to":[51,77,122],"human":[52],"serum":[53],"albumin":[54],"(HSA)":[55],"yields":[56],"compound":[58],"with":[59,92,101,143],"long":[60],"circulatory":[61],"half-life,":[62],"maintains":[64],"full":[65],"potency":[66],"at":[67],"both":[68],"peripheral":[70],"central":[72],"receptors.":[74],"Initial":[75],"attempts":[76],"conjugate":[78,107],"via":[80],"prevalent":[82],"strategy":[83],"reacting":[85],"maleimide":[87],"derivative":[88,116],"free":[94],"thiol":[95],"Cys34":[97],"HSA":[99],"met":[100],"limited":[102],"success,":[103],"because":[104],"resulting":[106],"was":[108],"unstable":[109],"Use":[112],"haloacetyl":[115],"led":[120],"instead":[121],"formation":[124],"metabolically":[127],"stable":[128],"conjugate.":[129],"HSA-NMU":[130,149],"displayed":[131],"long-lasting,":[132],"potent":[133],"anorectic,":[134],"glucose-normalizing":[136],"activity.":[137],"When":[138],"compared":[139],"side":[140,142],"by":[141],"previously":[145],"described":[146],"PEG":[147],"conjugate,":[148],"proved":[150],"superior":[151],"on":[152],"molar":[154],"basis.":[155],"Collectively,":[156],"our":[157],"results":[158],"reinforce":[159],"notion":[161],"NMU-based":[163],"therapeutics":[164],"are":[165],"promising":[166],"candidates":[167],"treatment":[170]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
