{"id":"https://openalex.org/W1957214151","doi":"https://doi.org/10.1128/iai.49.2.286-290.1985","title":"Activation and inhibition of Limulus amebocyte lysate coagulation by chemically defined substructures of lipid A","display_name":"Activation and inhibition of Limulus amebocyte lysate coagulation by chemically defined substructures of lipid A","publication_year":1985,"publication_date":"1985-08-01","ids":{"openalex":"https://openalex.org/W1957214151","doi":"https://doi.org/10.1128/iai.49.2.286-290.1985","mag":"1957214151","pmid":"https://pubmed.ncbi.nlm.nih.gov/3894231","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/262012"},"language":"en","primary_location":{"id":"doi:10.1128/iai.49.2.286-290.1985","doi":"https://doi.org/10.1128/iai.49.2.286-290.1985","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.49.2.286-290.1985","pdf_url":"https://iai.asm.org/content/iai/49/2/286.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://iai.asm.org/content/iai/49/2/286.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086481621","display_name":"Richard A. Proctor","orcid":"https://orcid.org/0000-0003-3011-7958","observed_orcids":["https://orcid.org/0000-0003-3011-7958"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R A Proctor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5017490500","display_name":"J A Textor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Textor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0593,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.76233218,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"49","issue":"2","first_page":"286","last_page":"290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-a","display_name":"lipid A","score":0.9440000057220459},{"id":"https://openalex.org/keywords/limulus-amebocyte-lysate","display_name":"Limulus amebocyte lysate","score":0.8659999966621399},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.7670000195503235},{"id":"https://openalex.org/keywords/lipid-a-biosynthesis","display_name":"lipid A biosynthesis","score":0.7329999804496765},{"id":"https://openalex.org/keywords/acyl-chain-length","display_name":"acyl chain length","score":0.5899999737739563},{"id":"https://openalex.org/keywords/endotoxin-structure","display_name":"endotoxin structure","score":0.5580000281333923},{"id":"https://openalex.org/keywords/storage-stability","display_name":"storage stability","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C144464004","wikidata":"https://www.wikidata.org/wiki/Q3077338","display_name":"Lipid A","level":3,"score":0.9253268241882324},{"id":"https://openalex.org/C118859902","wikidata":"https://www.wikidata.org/wiki/Q133516","display_name":"Monosaccharide","level":2,"score":0.8755388259887695},{"id":"https://openalex.org/C2776040547","wikidata":"https://www.wikidata.org/wiki/Q6549968","display_name":"Limulus amebocyte lysate","level":3,"score":0.8669915199279785},{"id":"https://openalex.org/C2776487282","wikidata":"https://www.wikidata.org/wiki/Q2104567","display_name":"Limulus","level":2,"score":0.7040945291519165},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6759256720542908},{"id":"https://openalex.org/C2777346074","wikidata":"https://www.wikidata.org/wiki/Q173600","display_name":"Disaccharide","level":2,"score":0.6725994944572449},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49657613039016724},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.4281516671180725},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.38151904940605164},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37015849351882935},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.05816236138343811},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008033","descriptor_name":"Limulus Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008050","descriptor_name":"Lipid A","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008050","descriptor_name":"Lipid A","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009005","descriptor_name":"Monosaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012486","descriptor_name":"Salmonella typhimurium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1128/iai.49.2.286-290.1985","doi":"https://doi.org/10.1128/iai.49.2.286-290.1985","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.49.2.286-290.1985","pdf_url":"https://iai.asm.org/content/iai/49/2/286.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:262012","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/262012","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:3894231","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3894231","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1128/iai.49.2.286-290.1985","doi":"https://doi.org/10.1128/iai.49.2.286-290.1985","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.49.2.286-290.1985","pdf_url":"https://iai.asm.org/content/iai/49/2/286.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4226611628","display_name":"SYNTHESIS AND FUNCTION OF MEMBRANE PHOSPHOLIPIDS","funder_award_id":"2r01am019551-09","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6397069505","display_name":"BIOGENESIS OF MEMBRANE LIPIDS IN ANIMAL CELLS","funder_award_id":"5r01am021722-08","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1957214151.pdf"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W177429321","https://openalex.org/W183722190","https://openalex.org/W1001340442","https://openalex.org/W1021542322","https://openalex.org/W1495579311","https://openalex.org/W1503877960","https://openalex.org/W1506948612","https://openalex.org/W1562797470","https://openalex.org/W1578067645","https://openalex.org/W1588987269","https://openalex.org/W1620819564","https://openalex.org/W1788271644","https://openalex.org/W1848206786","https://openalex.org/W1875566670","https://openalex.org/W1894396731","https://openalex.org/W1974168011","https://openalex.org/W2001709906","https://openalex.org/W2065481435","https://openalex.org/W2088551409","https://openalex.org/W2102829518","https://openalex.org/W2125984730","https://openalex.org/W2266438888","https://openalex.org/W2399573024","https://openalex.org/W2402610822","https://openalex.org/W2417653419"],"related_works":["https://openalex.org/W6889785262","https://openalex.org/W2125984730","https://openalex.org/W2126356011","https://openalex.org/W331322873","https://openalex.org/W2146749940","https://openalex.org/W2071830150","https://openalex.org/W1960928873","https://openalex.org/W1570615664","https://openalex.org/W2039043885","https://openalex.org/W1547634707"],"abstract_inverted_index":{"Recent":[0],"work":[1],"with":[2],"lipid":[3,19,65,78,100,145],"mutants":[4],"of":[5,18,38,40,44,64,77,84,111,120,160,175],"Escherichia":[6],"coli":[7],"and":[8,21,32,43,61,86,148,164],"Salmonella":[9],"typhimurium":[10],"has":[11,22],"helped":[12],"to":[13,138],"elucidate":[14],"the":[15,74,88,118,121,154,161,167],"correct":[16],"structure":[17],"A":[20,66,79,101,146],"suggested":[23],"a":[24],"biosynthetic":[25],"pathway.":[26],"Precursor":[27],"molecules":[28],"include":[29],"diacylglucosamine":[30],"1-phosphates":[31],"tetraacyl":[33],"disaccharide":[34,62],"bis-phosphates.":[35],"The":[36],"activities":[37,119],"several":[39],"these":[41,144],"compounds":[42],"their":[45,129],"derivatives":[46,149,170],"were":[47,123,132],"measured":[48],"by":[49,97],"Limulus":[50],"amebocyte":[51],"lysate":[52],"(LAL)":[53],"assay.":[54],"We":[55],"report":[56],"that":[57,117],"(i)":[58],"both":[59],"mono-":[60],"precursors":[63,147],"activate":[67],"LAL,":[68,85],"(ii)":[69],"two":[70],"acyl":[71],"chains":[72],"on":[73],"monosaccharide":[75,99],"subunit":[76],"are":[80,172],"necessary":[81],"for":[82,158],"activation":[83,96,110,159],"(iii)":[87],"monosaccharide,":[89],"2-monoacylglucosamine":[90,104],"1-phosphate":[91,105],"can":[92],"competitively":[93],"inhibit":[94,108],"LAL":[95,162],"diacyl":[98],"precursors.":[102],"However,":[103],"did":[106],"not":[107],"endotoxin":[109],"LAL.":[112],"One":[113],"unanticipated":[114],"finding":[115],"was":[116],"monosaccharides":[122],"reduced":[124],"upon":[125],"storage":[126],"even":[127],"though":[128],"covalent":[130],"structures":[131],"unchanged.":[133],"Perhaps":[134],"this":[135],"is":[136],"due":[137],"alterations":[139],"in":[140,166],"physical":[141],"state.":[142],"Thus,":[143],"offer":[150],"some":[151],"insight":[152],"into":[153],"structural":[155],"features":[156],"required":[157],"assay":[163],"may":[165],"future":[168],"provide":[169],"which":[171],"competitive":[173],"inhibitors":[174],"endotoxin.":[176]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
