{"id":"https://openalex.org/W1957072063","doi":"https://doi.org/10.1093/clinchem/21.1.113","title":"Continuous-Flow Measurement of Lactate in Blood: A Technique Adapted for Use in the Emergency Laboratory","display_name":"Continuous-Flow Measurement of Lactate in Blood: A Technique Adapted for Use in the Emergency Laboratory","publication_year":1975,"publication_date":"1975-01-01","ids":{"openalex":"https://openalex.org/W1957072063","doi":"https://doi.org/10.1093/clinchem/21.1.113","mag":"1957072063","pmid":"https://pubmed.ncbi.nlm.nih.gov/234810"},"language":"en","primary_location":{"id":"doi:10.1093/clinchem/21.1.113","doi":"https://doi.org/10.1093/clinchem/21.1.113","is_oa":false,"landing_page_url":"https://doi.org/10.1093/clinchem/21.1.113","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040007594","display_name":"Edward Boycks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1342924430","display_name":"LAC+USC Medical Center","ror":"https://ror.org/04xzj3x20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I1342924430"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Boycks","raw_affiliation_strings":["The Shock Research Unit and the Department of Medicine, University of Southern California School of Medicine, the Los Angeles County/USC Medical Center, and the Center for the Critically Ill, Hollywood Presbyterian Medical Center, Los Angeles, Calif. 90027"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Shock Research Unit and the Department of Medicine, University of Southern California School of Medicine, the Los Angeles County/USC Medical Center, and the Center for the Critically Ill, Hollywood Presbyterian Medical Center, Los Angeles, Calif. 90027","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1342924430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038410866","display_name":"Sybil Michaels","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1342924430","display_name":"LAC+USC Medical Center","ror":"https://ror.org/04xzj3x20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I1342924430"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sybil Michaels","raw_affiliation_strings":["The Shock Research Unit and the Department of Medicine, University of Southern California School of Medicine, the Los Angeles County/USC Medical Center, and the Center for the Critically Ill, Hollywood Presbyterian Medical Center, Los Angeles, Calif. 90027"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Shock Research Unit and the Department of Medicine, University of Southern California School of Medicine, the Los Angeles County/USC Medical Center, and the Center for the Critically Ill, Hollywood Presbyterian Medical Center, Los Angeles, Calif. 90027","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1342924430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112800612","display_name":"Max Harry Weil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1342924430","display_name":"LAC+USC Medical Center","ror":"https://ror.org/04xzj3x20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I1342924430"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Max Harry Weil","raw_affiliation_strings":["The Shock Research Unit and the Department of Medicine, University of Southern California School of Medicine, the Los Angeles County/USC Medical Center, and the Center for the Critically Ill, Hollywood Presbyterian Medical Center, Los Angeles, Calif. 90027"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Shock Research Unit and the Department of Medicine, University of Southern California School of Medicine, the Los Angeles County/USC Medical Center, and the Center for the Critically Ill, Hollywood Presbyterian Medical Center, Los Angeles, Calif. 90027","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1342924430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110165921","display_name":"Herbert Shubin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1342924430","display_name":"LAC+USC Medical Center","ror":"https://ror.org/04xzj3x20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I1342924430"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herbert Shubin","raw_affiliation_strings":["The Shock Research Unit and the Department of Medicine, University of Southern California School of Medicine, the Los Angeles County/USC Medical Center, and the Center for the Critically Ill, Hollywood Presbyterian Medical Center, Los Angeles, Calif. 90027"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Shock Research Unit and the Department of Medicine, University of Southern California School of Medicine, the Los Angeles County/USC Medical Center, and the Center for the Critically Ill, Hollywood Presbyterian Medical Center, Los Angeles, Calif. 90027","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1342924430"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016949827","display_name":"Edward P Marbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1342924430","display_name":"LAC+USC Medical Center","ror":"https://ror.org/04xzj3x20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I1342924430"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward P Marbach","raw_affiliation_strings":["The Shock Research Unit and the Department of Medicine, University of Southern California School of Medicine, the Los Angeles County/USC Medical Center, and the Center for the Critically Ill, Hollywood Presbyterian Medical Center, Los Angeles, Calif. 90027"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Shock Research Unit and the Department of Medicine, University of Southern California School of Medicine, the Los Angeles County/USC Medical Center, and the Center for the Critically Ill, Hollywood Presbyterian Medical Center, Los Angeles, Calif. 90027","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1342924430"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112800612"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1342924430"],"apc_list":{"value":4636,"currency":"USD","value_usd":4636},"apc_paid":null,"fwci":3.2545,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.90733479,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"21","issue":"1","first_page":"113","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10180","display_name":"Analytical chemistry methods development","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lactate-measurement","display_name":"lactate measurement","score":0.7570000290870667},{"id":"https://openalex.org/keywords/blood-lactate","display_name":"blood lactate","score":0.9700000286102295},{"id":"https://openalex.org/keywords/continuous-flow-analysis","display_name":"continuous flow analysis","score":0.7559999823570251},{"id":"https://openalex.org/keywords/automated-enzymatic-assay","display_name":"automated enzymatic assay","score":0.8880000114440918},{"id":"https://openalex.org/keywords/autoanalyzer","display_name":"autoanalyzer","score":0.9210000038146973},{"id":"https://openalex.org/keywords/emergency-laboratory","display_name":"emergency laboratory","score":0.8040000200271606},{"id":"https://openalex.org/keywords/critical-care","display_name":"intensive care","score":0.656000018119812},{"id":"https://openalex.org/keywords/assay-validation","display_name":"assay validation","score":0.37299999594688416},{"id":"https://openalex.org/keywords/reagent-stability","display_name":"reagent stability","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C170094789","wikidata":"https://www.wikidata.org/wiki/Q4826058","display_name":"AutoAnalyzer","level":2,"score":0.9720137715339661},{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.6780157685279846},{"id":"https://openalex.org/C2985264121","wikidata":"https://www.wikidata.org/wiki/Q216320","display_name":"Continuous flow","level":2,"score":0.663969874382019},{"id":"https://openalex.org/C176674119","wikidata":"https://www.wikidata.org/wiki/Q11582","display_name":"Liter","level":2,"score":0.567957878112793},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.557763934135437},{"id":"https://openalex.org/C40875361","wikidata":"https://www.wikidata.org/wiki/Q2356542","display_name":"Reagent","level":2,"score":0.5154557824134827},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4057830572128296},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39554524421691895},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12571275234222412},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.07786911725997925},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001322","descriptor_name":"Autoanalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003201","descriptor_name":"Computers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004636","descriptor_name":"Emergency Service, Hospital","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007202","descriptor_name":"Indicators and Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007773","descriptor_name":"Lactates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008722","descriptor_name":"Methods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012769","descriptor_name":"Shock","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/clinchem/21.1.113","doi":"https://doi.org/10.1093/clinchem/21.1.113","is_oa":false,"landing_page_url":"https://doi.org/10.1093/clinchem/21.1.113","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},{"id":"pmid:234810","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/234810","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical chemistry","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.624.5599","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.624.5599","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.clinchem.org/content/21/1/113.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1599250588","https://openalex.org/W2002294971","https://openalex.org/W2039899294","https://openalex.org/W2044881190","https://openalex.org/W2051105906","https://openalex.org/W2058364900","https://openalex.org/W2070981459","https://openalex.org/W2397052295","https://openalex.org/W2411306634"],"related_works":["https://openalex.org/W7095525421","https://openalex.org/W2421816163","https://openalex.org/W228757148","https://openalex.org/W2133397853","https://openalex.org/W1956561025","https://openalex.org/W2027598670","https://openalex.org/W2076254568","https://openalex.org/W2165313990","https://openalex.org/W2067152087","https://openalex.org/W86039518"],"abstract_inverted_index":{"Abstract":[0],"This":[1],"automated":[2],"enzymatic":[3],"method":[4],"for":[5,18,62,83],"analysis":[6],"of":[7,32,78],"lactate":[8],"in":[9,69,76],"blood,":[10],"adapted":[11],"from":[12],"a":[13,29],"manual":[14],"method,":[15],"is":[16,25],"designed":[17],"use":[19,71],"with":[20],"an":[21,73],"AutoAnalyzer.":[22],"Start-up":[23],"time":[24,30,88],"5":[26],"min.":[27],"After":[28],"delay":[31],"4":[33],"min,":[34],"99":[35],"samples":[36],"may":[37],"be":[38],"analyzed":[39],"per":[40],"hour.":[41],"Recovery":[42],"averaged":[43],"100.7%":[44],"(range,":[45],"99.6-101.8%).":[46],"Reproducibility":[47],"was":[48],"within":[49],"1":[50],"SD":[51],"(equivalent":[52],"to":[53],"70":[54],"\u00b5mol/liter).":[55],"Reagents":[56],"are":[57],"stable":[58],"at":[59],"room":[60],"temperature":[61],"one":[63],"month.":[64],"The":[65],"procedure":[66],"has":[67],"been":[68],"continuous":[70],"as":[72],"emergency":[74,79],"test":[75],"support":[77],"and":[80],"critical":[81],"care":[82],"three":[84],"years,":[85],"during":[86],"which":[87],"we":[89],"have":[90],"done":[91],"more":[92],"than":[93],"10":[94],"000":[95],"determinations.":[96]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}