{"id":"https://openalex.org/W1955979283","doi":"https://doi.org/10.1002/pds.2167","title":"Electronic database to detect drug\u2013drug interactions between antidepressants and oral anticancer drugs from a cancer center in Singapore: implications to clinicians","display_name":"Electronic database to detect drug\u2013drug interactions between antidepressants and oral anticancer drugs from a cancer center in Singapore: implications to clinicians","publication_year":2011,"publication_date":"2011-07-05","ids":{"openalex":"https://openalex.org/W1955979283","doi":"https://doi.org/10.1002/pds.2167","mag":"1955979283","pmid":"https://pubmed.ncbi.nlm.nih.gov/21732473"},"language":"en","primary_location":{"id":"doi:10.1002/pds.2167","doi":"https://doi.org/10.1002/pds.2167","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pds.2167","pdf_url":null,"source":{"id":"https://openalex.org/S140231191","display_name":"Pharmacoepidemiology and Drug Safety","issn_l":"1053-8569","issn":["1053-8569","1099-1557"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacoepidemiology and Drug Safety","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060981830","display_name":"Alexandre Chan","orcid":"https://orcid.org/0000-0003-4391-4219","observed_orcids":["https://orcid.org/0000-0003-4391-4219"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210137145","display_name":"National Cancer Centre Singapore","ror":"https://ror.org/03bqk3e80","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210137145"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Alexandre Chan","raw_affiliation_strings":["Department of Pharmacy, National Cancer Centre Singapore, Singapore","Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, National Cancer Centre Singapore, Singapore","institution_ids":["https://openalex.org/I4210137145"]},{"raw_affiliation_string":"Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081704110","display_name":"Kevin Yi\u2010Lwern Yap","orcid":"https://orcid.org/0000-0001-7322-4396","observed_orcids":["https://orcid.org/0000-0001-7322-4396"]},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kevin Yi\u2010Lwern Yap","raw_affiliation_strings":["Institute of Digital Healthcare, WMG, University of Warwick, Coventry, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Digital Healthcare, WMG, University of Warwick, Coventry, UK","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dorothy Koh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Dorothy Koh","raw_affiliation_strings":["Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055654863","display_name":"Xiu Hui Low","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Xiu Hui Low","raw_affiliation_strings":["Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082548734","display_name":"Yin Ting Cheung","orcid":"https://orcid.org/0000-0001-9874-8938","observed_orcids":["https://orcid.org/0000-0001-9874-8938"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yin Ting Cheung","raw_affiliation_strings":["Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":null,"display_name":"from the Onco\u2010Informatics (onco\u2010informatics.com) Group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"from the Onco\u2010Informatics (onco\u2010informatics.com) Group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060981830"],"corresponding_institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210137145"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":2.1392,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.86570275,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"20","issue":"9","first_page":"939","last_page":"947"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10350","display_name":"Electronic Health Records Systems","score":0.029400000348687172,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.984000027179718},{"id":"https://openalex.org/keywords/oral-anticancer-drugs","display_name":"oral anticancer drugs","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pharmacokinetic-interactions","display_name":"pharmacokinetic interactions","score":0.8679999709129333},{"id":"https://openalex.org/keywords/pharmacodynamic-interactions","display_name":"pharmacodynamic interactions","score":1.0},{"id":"https://openalex.org/keywords/cancer-patients","display_name":"cancer patients","score":0.8029999732971191},{"id":"https://openalex.org/keywords/medication-use","display_name":"medication use","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8320086002349854},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7715990543365479},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.578616738319397},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.5567003488540649},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.5465412735939026},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4681675136089325},{"id":"https://openalex.org/C97320921","wikidata":"https://www.wikidata.org/wiki/Q718753","display_name":"Drug interaction","level":3,"score":0.4660058617591858},{"id":"https://openalex.org/C3018146709","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Anticancer drug","level":3,"score":0.45479753613471985},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4231816828250885},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4163275361061096},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32088905572891235},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.25842174887657166},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.11766743659973145},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012846","descriptor_name":"Singapore","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/pds.2167","doi":"https://doi.org/10.1002/pds.2167","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pds.2167","pdf_url":null,"source":{"id":"https://openalex.org/S140231191","display_name":"Pharmacoepidemiology and Drug Safety","issn_l":"1053-8569","issn":["1053-8569","1099-1557"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacoepidemiology and Drug Safety","raw_type":"journal-article"},{"id":"pmid:21732473","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21732473","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacoepidemiology and drug safety","raw_type":"Journal Article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/105914","doi":null,"is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/105914","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2933888187","display_name":null,"funder_award_id":"R-148-000-108-133","funder_id":"https://openalex.org/F4320320698","funder_display_name":"National University of Singapore"}],"funders":[{"id":"https://openalex.org/F4320320698","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W32006757","https://openalex.org/W1555818592","https://openalex.org/W1782483823","https://openalex.org/W1905936368","https://openalex.org/W1968835178","https://openalex.org/W1971524878","https://openalex.org/W1983640879","https://openalex.org/W1997530992","https://openalex.org/W2008174801","https://openalex.org/W2020335896","https://openalex.org/W2045026063","https://openalex.org/W2047246104","https://openalex.org/W2071890704","https://openalex.org/W2089328592","https://openalex.org/W2111473993","https://openalex.org/W2117638467","https://openalex.org/W2121823208","https://openalex.org/W2135836557","https://openalex.org/W2170214247","https://openalex.org/W3147217391"],"related_works":["https://openalex.org/W2032797381","https://openalex.org/W1971524878","https://openalex.org/W1976847560","https://openalex.org/W3157523975","https://openalex.org/W3120744713","https://openalex.org/W3186364284","https://openalex.org/W2014576637","https://openalex.org/W2133200616","https://openalex.org/W2085393530","https://openalex.org/W2154397622"],"abstract_inverted_index":{"BACKGROUND:":[0],"Electronic":[1],"drug":[2,18,148,155,175],"interaction":[3,45],"databases":[4,227],"are":[5,30],"often":[6],"utilized":[7,41],"in":[8,33,214],"clinical":[9,215],"practice":[10],"to":[11,49,72,180,193],"detect":[12],"for":[13,228],"possible":[14],"drug-drug":[15,44],"interactions":[16,29,208],"between":[17,59,83],"pairs.":[19,149],"It":[20],"is":[21],"uncertain,":[22],"however,":[23],"whether":[24],"most":[25],"of":[26,53,93,109,113,116,144,152,172,187,197,205,223],"these":[27,37,94,132],"detections":[28],"clinically":[31,178],"important":[32],"practice.":[34,216],"To":[35],"demonstrate":[36],"issues,":[38],"this":[39],"study":[40,218],"a":[42,56,88,220],"comprehensive":[43],"(DDI)":[46],"electronic":[47,201,225],"database":[48,104],"elucidate":[50],"the":[51,74,107,153,163,173,206],"prevalence":[52],"DDIs":[54],"at":[55,87],"cancer":[57,89],"centre":[58],"antidepressants":[60,80,233],"and":[61,85,127,162,232],"oral":[62,81,125,230],"anticancer":[63],"drugs":[64],"(ACDs).":[65],"METHODS:":[66],"Drug":[67],"utilization":[68],"reports":[69],"were":[70,77,96,142,165,177],"retrieved":[71],"determine":[73],"patients":[75,95,141],"who":[76],"prescribed":[78],"with":[79,168],"ACDs":[82,231],"2006":[84],"2009":[86],"center.":[90],"Medication":[91],"records":[92],"retrospectively":[97],"examined":[98],"using":[99],"OncoRx,":[100],"an":[101,124,128,194],"internet-based":[102],"oncology-specific":[103],"that":[105],"allows":[106],"identification":[108],"DDIs.":[110,139,234],"RESULTS:":[111],"Out":[112],"910":[114],"users":[115,143],"antidepressants,":[117],"about":[118,134],"one-third":[119],"(281":[120],"patients,":[121,133],"30.9%)":[122],"used":[123],"ACD":[126],"antidepressant":[129],"concomitantly.":[130],"From":[131],"one-fifth":[135],"(21.0%)":[136],"had":[137],"potential":[138],"These":[140],"17":[145,154,174],"potentially":[146,158],"interacting":[147,182],"Ten":[150],"out":[151,171],"pairs":[156,176],"could":[157],"cause":[159,181],"pharmacokinetic":[160],"interactions,":[161,167],"rest":[164],"pharmacodynamic":[166],"only":[169],"three":[170],"documented":[179],"events.":[183],"CONCLUSION:":[184],"The":[185],"lack":[186],"screening":[188],"conditions":[189],"may":[190,209],"have":[191],"led":[192],"over":[195],"detection":[196],"DDI":[198,202,226],"combinations":[199],"by":[200],"databases.":[203],"Many":[204],"detected":[207],"not":[210],"deem":[211],"high":[212],"significance":[213],"This":[217],"exposed":[219],"major":[221],"weakness":[222],"current":[224],"detecting":[229]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
