{"id":"https://openalex.org/W19557470","doi":null,"title":"An experimental study of extracellular signal-regulated kinase and its interventional treatments in hepatic fibrosis.","display_name":"An experimental study of extracellular signal-regulated kinase and its interventional treatments in hepatic fibrosis.","publication_year":2008,"publication_date":"2008-02-01","ids":{"openalex":"https://openalex.org/W19557470","mag":"19557470","pmid":"https://pubmed.ncbi.nlm.nih.gov/18234639"},"language":"en","primary_location":{"id":"pmid:18234639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18234639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatobiliary & pancreatic diseases international : HBPD INT","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113728296","display_name":"Ming-De Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104667","display_name":"Chengdu Military General Hospital","ror":"https://ror.org/01bk73674","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104667"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming-De Jiang","raw_affiliation_strings":["Department of Gastroenterology, General Hospital of Chengdu Military Command, Chengdu 610083, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, General Hospital of Chengdu Military Command, Chengdu 610083, China","institution_ids":["https://openalex.org/I4210104667"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shu-Mei Zheng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shu-Mei Zheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017499077","display_name":"Hui Jing Xu","orcid":"https://orcid.org/0000-0002-7072-1706","observed_orcids":["https://orcid.org/0000-0002-7072-1706"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hui Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102789671","display_name":"Weizheng Zeng","orcid":"https://orcid.org/0000-0002-9631-6039","observed_orcids":["https://orcid.org/0000-0002-9631-6039"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei-Zheng Zeng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100419770","display_name":"Yong Zhang","orcid":"https://orcid.org/0000-0002-1303-0458","observed_orcids":["https://orcid.org/0000-0002-1303-0458","https://orcid.org/0000-0002-9916-3832","https://orcid.org/0000-0001-6577-5235"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100769313","display_name":"Haoping Sun","orcid":"https://orcid.org/0000-0003-2526-0557","observed_orcids":["https://orcid.org/0000-0003-2526-0557"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hao-Ping Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100658319","display_name":"Yunxia Wang","orcid":"https://orcid.org/0000-0003-1951-942X","observed_orcids":["https://orcid.org/0000-0003-1951-942X","https://orcid.org/0009-0009-0404-782X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yun-Xia Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049593283","display_name":"Jianping Qin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian-Ping Qin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100655845","display_name":"Xingyu Wu","orcid":"https://orcid.org/0000-0001-9289-7115","observed_orcids":["https://orcid.org/0000-0001-9289-7115"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-Ling Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6516,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.73871977,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"7","issue":"1","first_page":"51","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-signal-regulated-kinase","display_name":"extracellular signal-regulated kinase","score":0.9340000152587891},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.7900000214576721},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.9679999947547913},{"id":"https://openalex.org/keywords/pd98059","display_name":"PD98059","score":0.9380000233650208},{"id":"https://openalex.org/keywords/erk-inhibitor","display_name":"ERK inhibitor","score":0.8510000109672546},{"id":"https://openalex.org/keywords/acetaldehyde","display_name":"acetaldehyde","score":0.953000009059906},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.824999988079071},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8489999771118164},{"id":"https://openalex.org/keywords/g0-g1-phase","display_name":"G0/G1 phase","score":0.8209999799728394},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.972000002861023},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.847000002861023},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cdk4","display_name":"CDK4","score":0.9449999928474426},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6973098516464233},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.6684741377830505},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6167562007904053},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5945351719856262},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.5317417979240417},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.49080690741539},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46580439805984497},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.44860202074050903},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.437478244304657},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41551852226257324},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41089433431625366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35489583015441895},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3365177810192108},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3242748975753784},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23945319652557373},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1521853804588318}],"mesh":[{"descriptor_ui":"D000079","descriptor_name":"Acetaldehyde","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016192","descriptor_name":"Resting Phase, Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016192","descriptor_name":"Resting Phase, Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016193","descriptor_name":"G1 Phase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016193","descriptor_name":"G1 Phase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D024042","descriptor_name":"Collagen Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051358","descriptor_name":"Cyclin-Dependent Kinase 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18234639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18234639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatobiliary & pancreatic diseases international : HBPD INT","raw_type":"Journal Article"},{"id":"mag:19557470","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18234639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W95767044","https://openalex.org/W1918588012","https://openalex.org/W1972167901","https://openalex.org/W1986437545","https://openalex.org/W2000142370","https://openalex.org/W2003941771","https://openalex.org/W2009806648","https://openalex.org/W2015216325","https://openalex.org/W2024040797","https://openalex.org/W2028612481","https://openalex.org/W2031053612","https://openalex.org/W2034380866","https://openalex.org/W2041600461","https://openalex.org/W2045473266","https://openalex.org/W2046831345","https://openalex.org/W2047212476","https://openalex.org/W2053288577","https://openalex.org/W2057366938","https://openalex.org/W2058554972","https://openalex.org/W2060630008","https://openalex.org/W2062093131","https://openalex.org/W2077349247","https://openalex.org/W2086458138","https://openalex.org/W2096408603","https://openalex.org/W2107749577","https://openalex.org/W2109657386","https://openalex.org/W2117482209","https://openalex.org/W2132672261","https://openalex.org/W2137898665","https://openalex.org/W2144901682","https://openalex.org/W2159619283","https://openalex.org/W2167714337","https://openalex.org/W2167725431","https://openalex.org/W2347445663","https://openalex.org/W2367381795","https://openalex.org/W2370064173","https://openalex.org/W2376660193"],"related_works":["https://openalex.org/W2376660193","https://openalex.org/W2036250736","https://openalex.org/W2358628285","https://openalex.org/W2435184186","https://openalex.org/W2370064173","https://openalex.org/W1562160782","https://openalex.org/W2073586142","https://openalex.org/W2372012789","https://openalex.org/W2018458158","https://openalex.org/W2391590811"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,13,29,93,112,165,195],"pathogenesis":[2],"of":[3,24,31,39,44,53,59,115,158,167,174,203,210],"hepatic":[4,73],"fibrosis":[5],"and":[6,27,57,65,119,145,153,171,178,189,207],"cirrhosis":[7],"is":[8,19,220],"still":[9],"not":[10],"fully":[11],"understood.":[12],"extracellular":[14],"signal-regulated":[15],"kinase":[16],"(ERK)":[17],"pathway":[18,197],"involved":[20],"in":[21,71,132,161,181,213],"the":[22,37,47,106,124,133,151,172,199,208,228],"regulation":[23],"cell":[25,48,50,94,200,229],"proliferation":[26,102,152],"differentiation.":[28],"aim":[30],"this":[32],"study":[33],"was":[34,96,103,121,136],"to":[35,223],"investigate":[36],"effects":[38],"PD98059,":[40,192],"a":[41,155,162],"specific":[42],"inhibitor":[43],"ERK,":[45],"on":[46,227],"cycle,":[49],"proliferation,":[51,201],"secretion":[52,166,202],"type":[54,168,204],"I":[55,130,169,205],"collagen":[56,131,170,206],"expression":[58,114,173,209],"cyclin":[60,116,175],"D1":[61],"mRNA,":[62],"CDK4":[63,118,177],"mRNA":[64,70,113,180,212],"transforming":[66],"growth":[67],"factor-beta1":[68],"(TGF-beta1)":[69],"rat":[72,214],"stellate":[74],"cells":[75],"(HSCs)":[76],"stimulated":[77,83,216],"by":[78,84,98,105,138,187,217],"acetaldehyde.":[79],"METHODS:":[80],"Rat":[81],"HSCs":[82,160,183,215],"acetaldehyde":[85],"were":[86,184],"incubated":[87],"with":[88],"PD98059":[89,148],"at":[90],"different":[91],"concentrations.":[92],"cycle":[95],"analysed":[97],"flow":[99],"cytometry.":[100],"Cell":[101],"assessed":[104],"methyl":[107],"thiazolyl":[108],"tetrazolium":[109],"colorimetric":[110],"assay.":[111,141],"D1,":[117,176],"TGF-beta1":[120,179,211],"examined":[122],"using":[123],"reverse":[125],"transcriptase-polymerase":[126],"chain":[127],"reaction.":[128],"Type":[129],"culture":[134],"medium":[135],"detected":[137],"enzyme-linked":[139],"immunosorbent":[140],"RESULTS:":[142],"20,":[143],"50":[144,188],"100":[146,190],"micromol/L":[147,191],"significantly":[149],"inhibited":[150,186],"provoked":[154],"G0/G1-phase":[156],"arrest":[157],"acetaldehyde-induced":[159,182],"dose-dependent":[163],"manner.":[164],"markedly":[185],"respectively.":[193],"CONCLUSIONS:":[194],"ERK":[196],"regulates":[198],"acetaldehyde,":[218],"which":[219],"likely":[221],"related":[222],"its":[224],"regulative":[225],"effect":[226],"cycle.":[230]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}