{"id":"https://openalex.org/W1953549360","doi":"https://doi.org/10.1016/s0026-895x(24)12308-5","title":"The Kinetics of Competitive Antagonism by Cisatracurium of Embryonic and Adult Nicotinic Acetylcholine Receptors","display_name":"The Kinetics of Competitive Antagonism by Cisatracurium of Embryonic and Adult Nicotinic Acetylcholine Receptors","publication_year":2001,"publication_date":"2001-10-01","ids":{"openalex":"https://openalex.org/W1953549360","doi":"https://doi.org/10.1016/s0026-895x(24)12308-5","mag":"1953549360","pmid":"https://pubmed.ncbi.nlm.nih.gov/11562443"},"language":"en","primary_location":{"id":"doi:10.1016/s0026-895x(24)12308-5","doi":"https://doi.org/10.1016/s0026-895x(24)12308-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0026-895x(24)12308-5","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040823719","display_name":"Deeptankar DeMazumder","orcid":"https://orcid.org/0000-0002-9322-8009","observed_orcids":["https://orcid.org/0000-0002-9322-8009"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deeptankar Demazumder","raw_affiliation_strings":["Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York, 11794-8282, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York, 11794-8282, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I59553526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074147148","display_name":"James P. Dilger","orcid":"https://orcid.org/0000-0002-8928-3283","observed_orcids":["https://orcid.org/0000-0002-8928-3283"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James P. Dilger","raw_affiliation_strings":["Stony Brook University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stony Brook University","institution_ids":["https://openalex.org/I59553526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":0.3491,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.54126246,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"60","issue":"4","first_page":"797","last_page":"807"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisatracurium","display_name":"cisatracurium","score":1.0},{"id":"https://openalex.org/keywords/nicotinic-acetylcholine-receptors","display_name":"nicotinic acetylcholine receptors","score":0.8870000243186951},{"id":"https://openalex.org/keywords/competitive-antagonism","display_name":"competitive antagonism","score":0.9639999866485596},{"id":"https://openalex.org/keywords/binding-kinetics","display_name":"binding kinetics","score":0.7049999833106995},{"id":"https://openalex.org/keywords/association-rate","display_name":"association rate","score":0.6470000147819519},{"id":"https://openalex.org/keywords/dissociation-rate","display_name":"dissociation rate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.7289999723434448},{"id":"https://openalex.org/keywords/desensitization","display_name":"desensitization","score":0.8009999990463257},{"id":"https://openalex.org/keywords/markov-model","display_name":"Markov model","score":0.8539999723434448},{"id":"https://openalex.org/keywords/muscle-relaxants","display_name":"muscle relaxants","score":0.8519999980926514},{"id":"https://openalex.org/keywords/tubocurarine","display_name":"tubocurarine","score":0.8040000200271606},{"id":"https://openalex.org/keywords/pancuronium","display_name":"pancuronium","score":1.0}],"concepts":[{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.8582965135574341},{"id":"https://openalex.org/C80161118","wikidata":"https://www.wikidata.org/wiki/Q408520","display_name":"Acetylcholine receptor","level":3,"score":0.7770785689353943},{"id":"https://openalex.org/C86811712","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Competitive antagonist","level":4,"score":0.66444993019104},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6538805365562439},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.6525301337242126},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6088911294937134},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5205846428871155},{"id":"https://openalex.org/C2779570518","wikidata":"https://www.wikidata.org/wiki/Q412256","display_name":"Nicotinic acetylcholine receptor","level":4,"score":0.4924791753292084},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.4499731957912445},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43873751163482666},{"id":"https://openalex.org/C116289061","wikidata":"https://www.wikidata.org/wiki/Q17861955","display_name":"Muscarinic acetylcholine receptor M3","level":4,"score":0.4303535521030426},{"id":"https://openalex.org/C102931765","wikidata":"https://www.wikidata.org/wiki/Q189673","display_name":"Dissociation (chemistry)","level":2,"score":0.42518121004104614},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27436089515686035},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2537751793861389},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001279","descriptor_name":"Atracurium","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001279","descriptor_name":"Atracurium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009466","descriptor_name":"Neuromuscular Blocking Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018733","descriptor_name":"Nicotinic Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0026-895x(24)12308-5","doi":"https://doi.org/10.1016/s0026-895x(24)12308-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0026-895x(24)12308-5","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},{"id":"pmid:11562443","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11562443","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmacology","raw_type":"Journal Article"},{"id":"mag:1953549360","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11562443","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2801155704","display_name":"GENERAL ANESTHETIC MECHANISM IN EXCITABLE MEMBRANES","funder_award_id":"R01GM042095","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G346569552","display_name":null,"funder_award_id":"GM-42095","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W32712655","https://openalex.org/W170493551","https://openalex.org/W187817153","https://openalex.org/W1487535219","https://openalex.org/W1529934127","https://openalex.org/W1632324362","https://openalex.org/W1822022922","https://openalex.org/W1925493235","https://openalex.org/W1951863201","https://openalex.org/W1956098004","https://openalex.org/W1965554709","https://openalex.org/W1977610402","https://openalex.org/W1983976819","https://openalex.org/W2000550470","https://openalex.org/W2005131002","https://openalex.org/W2010548947","https://openalex.org/W2014278897","https://openalex.org/W2015940242","https://openalex.org/W2018533735","https://openalex.org/W2022176386","https://openalex.org/W2022660659","https://openalex.org/W2026939737","https://openalex.org/W2029481482","https://openalex.org/W2036445713","https://openalex.org/W2044677119","https://openalex.org/W2050795206","https://openalex.org/W2079250143","https://openalex.org/W2115168696","https://openalex.org/W2118118985","https://openalex.org/W2119213855","https://openalex.org/W2120076714","https://openalex.org/W2128177218","https://openalex.org/W2136120395","https://openalex.org/W2138311296","https://openalex.org/W2154502380","https://openalex.org/W2162374559","https://openalex.org/W2165155364","https://openalex.org/W2166674578","https://openalex.org/W2417511831","https://openalex.org/W2475955676","https://openalex.org/W4211109628","https://openalex.org/W4229668875","https://openalex.org/W4241749677"],"related_works":["https://openalex.org/W2329321502","https://openalex.org/W7095645023","https://openalex.org/W2120076714","https://openalex.org/W2151847273","https://openalex.org/W7095183765","https://openalex.org/W2155496218","https://openalex.org/W2029481482","https://openalex.org/W2010672819","https://openalex.org/W1968445001","https://openalex.org/W2372760863"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}