{"id":"https://openalex.org/W1951026329","doi":"https://doi.org/10.2217/fmb.15.106","title":"Resistance to Reverse Transcriptase Inhibitors Used in the Treatment and Prevention of HIV-1 Infection","display_name":"Resistance to Reverse Transcriptase Inhibitors Used in the Treatment and Prevention of HIV-1 Infection","publication_year":2015,"publication_date":"2015-10-30","ids":{"openalex":"https://openalex.org/W1951026329","doi":"https://doi.org/10.2217/fmb.15.106","mag":"1951026329","pmid":"https://pubmed.ncbi.nlm.nih.gov/26517190","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4813512"},"language":"en","primary_location":{"id":"doi:10.2217/fmb.15.106","doi":"https://doi.org/10.2217/fmb.15.106","is_oa":false,"landing_page_url":"https://doi.org/10.2217/fmb.15.106","pdf_url":null,"source":{"id":"https://openalex.org/S129524704","display_name":"Future Microbiology","issn_l":"1746-0913","issn":["1746-0913","1746-0921"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Microbiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4813512","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044933366","display_name":"Nicolas Sluis\u2010Cremer","orcid":"https://orcid.org/0000-0003-3897-7450","observed_orcids":["https://orcid.org/0000-0003-3897-7450"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolas Sluis-Cremer","raw_affiliation_strings":["University of Pittsburgh School of Medicine, Division of Infectious Diseases, Department of Medicine S817 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh School of Medicine, Division of Infectious Diseases, Department of Medicine S817 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029881635","display_name":"Mark A. Wainberg","orcid":"https://orcid.org/0000-0002-0272-1317","observed_orcids":["https://orcid.org/0000-0002-0272-1317"]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mark A Wainberg","raw_affiliation_strings":["McGill University AIDS Center, Lady Davis Institute, Jewish General Hospital, 3755 C\u00f4te Ste-Catherine Road, Montreal, QC, H3T 1E2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University AIDS Center, Lady Davis Institute, Jewish General Hospital, 3755 C\u00f4te Ste-Catherine Road, Montreal, QC, H3T 1E2, Canada","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356","https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087052821","display_name":"Raymond F. Schinazi","orcid":"https://orcid.org/0000-0002-6688-3614","observed_orcids":["https://orcid.org/0000-0002-6688-3614"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond F Schinazi","raw_affiliation_strings":["Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University, Health Sciences Research Building, Room E-418, 1760 Haygood Drive, Atlanta, GA30322, USA","Veterans Affairs Medical Center, 1670 Clairmont Rd, Atlanta, GA30033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University, Health Sciences Research Building, Room E-418, 1760 Haygood Drive, Atlanta, GA30322, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Veterans Affairs Medical Center, 1670 Clairmont Rd, Atlanta, GA30033, USA","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I4210152539"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0115,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.68927445,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"11","first_page":"1773","last_page":"1782"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.8859999775886536},{"id":"https://openalex.org/keywords/reverse-transcriptase-inhibitors","display_name":"reverse transcriptase inhibitors","score":0.9679999947547913},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8700000047683716},{"id":"https://openalex.org/keywords/nucleoside-reverse-transcriptase-inhibitors","display_name":"nucleoside reverse transcriptase inhibitors","score":0.8769999742507935},{"id":"https://openalex.org/keywords/non-nucleoside-reverse-transcriptase-inhibitors","display_name":"non-nucleoside reverse transcriptase inhibitors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nevirapine","display_name":"nevirapine","score":0.9079999923706055},{"id":"https://openalex.org/keywords/efavirenz","display_name":"efavirenz","score":0.9980000257492065},{"id":"https://openalex.org/keywords/rilpivirine","display_name":"rilpivirine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/etravirine","display_name":"etravirine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mother-to-child-transmission","display_name":"mother-to-child transmission","score":0.7599999904632568},{"id":"https://openalex.org/keywords/pre-exposure-prophylaxis","display_name":"pre-exposure prophylaxis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cross-resistance","display_name":"cross-resistance","score":0.8820000290870667},{"id":"https://openalex.org/keywords/resistance-mutations","display_name":"resistance mutations","score":0.8180000185966492},{"id":"https://openalex.org/keywords/molecular-mechanisms-of-resistance","display_name":"molecular mechanisms of resistance","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C2780345285","wikidata":"https://www.wikidata.org/wiki/Q414762","display_name":"Etravirine","level":5,"score":0.9124042987823486},{"id":"https://openalex.org/C2779130552","wikidata":"https://www.wikidata.org/wiki/Q263713","display_name":"Nevirapine","level":5,"score":0.8882442712783813},{"id":"https://openalex.org/C2781432083","wikidata":"https://www.wikidata.org/wiki/Q422645","display_name":"Efavirenz","level":5,"score":0.8764644265174866},{"id":"https://openalex.org/C2778723075","wikidata":"https://www.wikidata.org/wiki/Q421547","display_name":"Rilpivirine","level":5,"score":0.8188269138336182},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.7024495601654053},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.607869565486908},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5808489918708801},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5774250626564026},{"id":"https://openalex.org/C2777351918","wikidata":"https://www.wikidata.org/wiki/Q421559","display_name":"Reverse-transcriptase inhibitor","level":5,"score":0.5094404816627502},{"id":"https://openalex.org/C2780775027","wikidata":"https://www.wikidata.org/wiki/Q17141389","display_name":"Salvage therapy","level":3,"score":0.45630234479904175},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.4425598084926605},{"id":"https://openalex.org/C2909970146","wikidata":"https://www.wikidata.org/wiki/Q421559","display_name":"Nucleoside Reverse Transcriptase Inhibitor","level":5,"score":0.4363619089126587},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.413971483707428},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.40320146083831787},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3916599452495575},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.28902608156204224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2784407138824463},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.2612462639808655},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2090478539466858},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.10653761029243469},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0649850070476532},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.06167683005332947},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D018445","descriptor_name":"Infectious Disease Transmission, Vertical","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D018562","descriptor_name":"Disease Transmission, Infectious","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D065129","descriptor_name":"Pre-Exposure Prophylaxis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2217/fmb.15.106","doi":"https://doi.org/10.2217/fmb.15.106","is_oa":false,"landing_page_url":"https://doi.org/10.2217/fmb.15.106","pdf_url":null,"source":{"id":"https://openalex.org/S129524704","display_name":"Future Microbiology","issn_l":"1746-0913","issn":["1746-0913","1746-0921"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Microbiology","raw_type":"journal-article"},{"id":"pmid:26517190","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26517190","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4031012","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4813512","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4813512","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4813512","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Future Microbiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4031012","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4813512","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1417593845","display_name":"NNRTI induced conformational changes in HIV-1 RT","funder_award_id":"R01GM068406","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3403508466","display_name":"Rational Design of NRTI for Drug Resistant HIV-1","funder_award_id":"R01AI071846","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8400168412","display_name":"Novel mechanisms of HIV resistance to RTIs","funder_award_id":"R01AI081571","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000885469","display_name":"Center for AIDS Research at Emory University","funder_award_id":"P30AI050409","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W41302192","https://openalex.org/W1601059238","https://openalex.org/W1981482438","https://openalex.org/W1982652851","https://openalex.org/W1985354911","https://openalex.org/W1990105675","https://openalex.org/W2000761749","https://openalex.org/W2002104731","https://openalex.org/W2002800705","https://openalex.org/W2003037761","https://openalex.org/W2009824933","https://openalex.org/W2014490323","https://openalex.org/W2019538762","https://openalex.org/W2052200516","https://openalex.org/W2068428266","https://openalex.org/W2069431872","https://openalex.org/W2076322352","https://openalex.org/W2077956544","https://openalex.org/W2080551431","https://openalex.org/W2103737563","https://openalex.org/W2103920597","https://openalex.org/W2115212891","https://openalex.org/W2117057469","https://openalex.org/W2128252589","https://openalex.org/W2135450624","https://openalex.org/W2135776147","https://openalex.org/W2137417864","https://openalex.org/W2139311359","https://openalex.org/W2145943124","https://openalex.org/W2149949524","https://openalex.org/W2150487989","https://openalex.org/W2151894999","https://openalex.org/W2155599348","https://openalex.org/W2155661911","https://openalex.org/W2161771770","https://openalex.org/W2162226934","https://openalex.org/W2167049427","https://openalex.org/W2167590829","https://openalex.org/W2168251450","https://openalex.org/W2170218446","https://openalex.org/W2323342869","https://openalex.org/W2326157483","https://openalex.org/W2330399120"],"related_works":["https://openalex.org/W941368190","https://openalex.org/W2648177381","https://openalex.org/W2342950203","https://openalex.org/W2782998738","https://openalex.org/W2005274373","https://openalex.org/W2107077764","https://openalex.org/W1506789402","https://openalex.org/W2138414945","https://openalex.org/W2414081632","https://openalex.org/W2341775020"],"abstract_inverted_index":{"Inhibitors":[0],"that":[1],"target":[2],"the":[3,15,32,40,47,60,134,140,150,158],"retroviral":[4],"enzyme":[5],"reverse":[6],"transcriptase":[7],"(RT)":[8],"have":[9],"played":[10],"an":[11,166],"indispensable":[12],"role":[13],"in":[14,77,111,129,156,172],"treatment":[16,61,159],"and":[17,34,39,52,73,89,123,160,175,182],"prevention":[18,161],"of":[19,49,62,81,96,117,136,142,152],"HIV-1":[20,63,82,137,143,173],"infection.":[21,64,83],"They":[22,65],"can":[23,108,148],"be":[24,109],"grouped":[25],"into":[26],"two":[27],"distinct":[28],"therapeutic":[29],"groups,":[30],"namely":[31],"nucleoside":[33],"nucleotide":[35],"RT":[36,42,146],"inhibitors":[37,43,147],"(NRTIs),":[38],"non-nucleoside":[41],"(NNRTIs).":[44],"NRTIs":[45],"form":[46,94],"backbones":[48],"most":[50],"first-":[51],"second-line":[53],"antiretroviral":[54],"therapy":[55],"(ART)":[56],"regimens":[57],"formulated":[58],"for":[59],"are":[66],"also":[67,91],"used":[68,92,110,128],"to":[69,93,120,132,145],"prevent":[70],"mother-to-child":[71],"transmission,":[72],"as":[74],"pre-exposure":[75],"prophylaxis":[76],"individuals":[78],"at":[79],"risk":[80],"The":[84],"NNRTIs":[85],"nevirapine":[86],"(NVP),":[87],"efavirenz":[88],"rilpivirine":[90],"part":[95],"first-line":[97],"ART":[98,113],"regimens,":[99],"although":[100],"this":[101],"is":[102],"no":[103],"longer":[104],"recommended,":[105],"while":[106],"etravirine":[107],"salvage":[112],"regimens.":[114],"A":[115],"single-dose":[116],"NVP":[118],"administered":[119],"both":[121,157],"mother":[122],"child":[124],"has":[125],"routinely":[126],"been":[127],"resource-limited":[130],"settings":[131],"reduce":[133],"rate":[135],"transmission.":[138],"Unfortunately,":[139],"development":[141],"resistance":[144],"compromise":[149],"efficacy":[151],"these":[153],"antiviral":[154],"drugs":[155],"arenas.":[162],"Here,":[163],"we":[164],"provide":[165],"up-to-date":[167],"review":[168],"on":[169],"drug-resistance":[170],"mutations":[171],"RT,":[174],"discuss":[176],"their":[177],"cross-resistance":[178],"profiles,":[179],"molecular":[180],"mechanisms":[181],"clinical":[183],"significance.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}