{"id":"https://openalex.org/W1950789953","doi":"https://doi.org/10.1093/jn/132.11.3286","title":"Supplementation of N-Acetylcysteine Normalizes Lipopolysaccharide-Induced Nuclear Factor \u03baB Activation and Proinflammatory Cytokine Production During Early Rehabilitation of Protein Malnourished Mice","display_name":"Supplementation of N-Acetylcysteine Normalizes Lipopolysaccharide-Induced Nuclear Factor \u03baB Activation and Proinflammatory Cytokine Production During Early Rehabilitation of Protein Malnourished Mice","publication_year":2002,"publication_date":"2002-11-01","ids":{"openalex":"https://openalex.org/W1950789953","doi":"https://doi.org/10.1093/jn/132.11.3286","mag":"1950789953","pmid":"https://pubmed.ncbi.nlm.nih.gov/12421841"},"language":"en","primary_location":{"id":"doi:10.1093/jn/132.11.3286","doi":"https://doi.org/10.1093/jn/132.11.3286","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jn/132.11.3286","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0022316622152910/pdf","source":{"id":"https://openalex.org/S88153332","display_name":"Journal of Nutrition","issn_l":"0022-3166","issn":["0022-3166","1541-6100"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/S0022316622152910/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100361923","display_name":"Jun Li","orcid":"https://orcid.org/0000-0002-7308-6576","observed_orcids":["https://orcid.org/0000-0002-7308-6576"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Li","raw_affiliation_strings":["Department of Human Nutrition, School of Dentistry, Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Nutrition, School of Dentistry, Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003868237","display_name":"Ning Quan","orcid":"https://orcid.org/0000-0001-7223-8593","observed_orcids":["https://orcid.org/0000-0001-7223-8593"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ning Quan","raw_affiliation_strings":["Division of Oral Biology, School of Dentistry, Ohio State University, Columbus, OH 43210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oral Biology, School of Dentistry, Ohio State University, Columbus, OH 43210","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110334524","display_name":"Tammy \u039c. Bray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tammy M. Bray","raw_affiliation_strings":["Department of Human Nutrition, School of Dentistry, Ohio State University, Columbus, OH 43210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Nutrition, School of Dentistry, Ohio State University, Columbus, OH 43210","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110334524"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":1.3826,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.78392283,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"132","issue":"11","first_page":"3286","last_page":"3292"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.11479999870061874,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0471000000834465,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.8999999761581421},{"id":"https://openalex.org/keywords/protein-malnutrition","display_name":"protein malnutrition","score":0.9779999852180481},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8309999704360962},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9110000133514404},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.8399999737739563},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9639999866485596},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9679999947547913},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":1.0},{"id":"https://openalex.org/keywords/ikappabalpha","display_name":"I\u03baB\u03b1","score":0.8100000023841858},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.5830000042915344},{"id":"https://openalex.org/keywords/dietary-protein-deficiency","display_name":"dietary protein deficiency","score":0.6520000100135803},{"id":"https://openalex.org/keywords/nutritional-rehabilitation","display_name":"nutritional rehabilitation","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.8501935601234436},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6446381211280823},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6163814663887024},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6122976541519165},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6074239611625671},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.6031242609024048},{"id":"https://openalex.org/C2777847592","wikidata":"https://www.wikidata.org/wiki/Q375613","display_name":"Acetylcysteine","level":3,"score":0.5739979147911072},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.551763117313385},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.46629637479782104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38157394528388977},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37990036606788635},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35098230838775635},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19515195488929749},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.08780601620674133},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07227146625518799}],"mesh":[{"descriptor_ui":"D000072000","descriptor_name":"NF-KappaB Inhibitor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011488","descriptor_name":"Protein Deficiency","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/jn/132.11.3286","doi":"https://doi.org/10.1093/jn/132.11.3286","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jn/132.11.3286","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0022316622152910/pdf","source":{"id":"https://openalex.org/S88153332","display_name":"Journal of Nutrition","issn_l":"0022-3166","issn":["0022-3166","1541-6100"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Nutrition","raw_type":"journal-article"},{"id":"pmid:12421841","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12421841","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of nutrition","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/jn/132.11.3286","doi":"https://doi.org/10.1093/jn/132.11.3286","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jn/132.11.3286","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0022316622152910/pdf","source":{"id":"https://openalex.org/S88153332","display_name":"Journal of Nutrition","issn_l":"0022-3166","issn":["0022-3166","1541-6100"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5902597192","display_name":"ZN DEFICIENCY IMPAIRS BBB INTEGRITY FR OXIDATIVE STRESS","funder_award_id":"R01NS038315","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1950789953.pdf","grobid_xml":"https://content.openalex.org/works/W1950789953.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W27933621","https://openalex.org/W105279024","https://openalex.org/W1513020808","https://openalex.org/W1590514634","https://openalex.org/W1769421195","https://openalex.org/W1797864357","https://openalex.org/W1822061653","https://openalex.org/W1831301545","https://openalex.org/W1969489226","https://openalex.org/W1978106534","https://openalex.org/W1982376300","https://openalex.org/W1984665850","https://openalex.org/W1991812740","https://openalex.org/W2008403704","https://openalex.org/W2012744796","https://openalex.org/W2037963721","https://openalex.org/W2063500033","https://openalex.org/W2068841295","https://openalex.org/W2071095297","https://openalex.org/W2074570851","https://openalex.org/W2083939188","https://openalex.org/W2085318543","https://openalex.org/W2087635405","https://openalex.org/W2088555845","https://openalex.org/W2093163694","https://openalex.org/W2095019663","https://openalex.org/W2102746051","https://openalex.org/W2104029183","https://openalex.org/W2118483777","https://openalex.org/W2142541950","https://openalex.org/W2151892297","https://openalex.org/W2163467965","https://openalex.org/W2163515708","https://openalex.org/W2166781237","https://openalex.org/W2228019489","https://openalex.org/W2273704033","https://openalex.org/W2441155557","https://openalex.org/W4245957869","https://openalex.org/W4298273896"],"related_works":["https://openalex.org/W2122476274","https://openalex.org/W2513234098","https://openalex.org/W2808640622","https://openalex.org/W2003201597","https://openalex.org/W2382827865","https://openalex.org/W2161661217","https://openalex.org/W1923233963","https://openalex.org/W2086470101","https://openalex.org/W2032592027","https://openalex.org/W7120874167"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
