{"id":"https://openalex.org/W1950503177","doi":null,"title":"EFECTOS FARMACOL\u00d3GICOS SOBRE EL SISTEMA NERVIOSO CENTRAL INDUCIDOS POR CUMARINA, AISLADA DE Hygrophila tyttha LEONARD","display_name":"EFECTOS FARMACOL\u00d3GICOS SOBRE EL SISTEMA NERVIOSO CENTRAL INDUCIDOS POR CUMARINA, AISLADA DE Hygrophila tyttha LEONARD","publication_year":2007,"publication_date":"2007-01-07","ids":{"openalex":"https://openalex.org/W1950503177","mag":"1950503177"},"language":"es","primary_location":{"id":"pmh:oai:doaj.org/article:fa9bbc1185044bd49705ecb0226fad08","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fa9bbc1185044bd49705ecb0226fad08","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vitae, Vol 14, Iss 2, Pp 51-58 (2007)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/fa9bbc1185044bd49705ecb0226fad08","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Sandra Y. Ariza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36243813","display_name":"Universidad Nacional de Colombia","ror":"https://ror.org/059yx9a68","country_code":"CO","type":"education","lineage":["https://openalex.org/I36243813"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Sandra Y. Ariza","raw_affiliation_strings":["Universidad Nacional de Colombia - Sede Bogota Bogot\u00e1, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Nacional de Colombia - Sede Bogota Bogot\u00e1, Colombia","institution_ids":["https://openalex.org/I36243813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031711063","display_name":"Diana C. Rueda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36243813","display_name":"Universidad Nacional de Colombia","ror":"https://ror.org/059yx9a68","country_code":"CO","type":"education","lineage":["https://openalex.org/I36243813"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Diana C. Rueda","raw_affiliation_strings":["Universidad Nacional de Colombia - Sede Bogota Bogot\u00e1, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Nacional de Colombia - Sede Bogota Bogot\u00e1, Colombia","institution_ids":["https://openalex.org/I36243813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072106066","display_name":"Javier Rinc\u00f3n Velandia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36243813","display_name":"Universidad Nacional de Colombia","ror":"https://ror.org/059yx9a68","country_code":"CO","type":"education","lineage":["https://openalex.org/I36243813"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Javier Rinc\u00f3n V.","raw_affiliation_strings":["Universidad Nacional de Colombia - Sede Bogota Bogot\u00e1, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Nacional de Colombia - Sede Bogota Bogot\u00e1, Colombia","institution_ids":["https://openalex.org/I36243813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113705363","display_name":"Edgar Leonardo Linares","orcid":"https://orcid.org/0009-0004-3135-2030","observed_orcids":["https://orcid.org/0009-0004-3135-2030"]},"institutions":[{"id":"https://openalex.org/I36243813","display_name":"Universidad Nacional de Colombia","ror":"https://ror.org/059yx9a68","country_code":"CO","type":"education","lineage":["https://openalex.org/I36243813"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"\u00c9dgar L. Linares","raw_affiliation_strings":["Universidad Nacional de Colombia - Sede Bogota Bogot\u00e1, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Nacional de Colombia - Sede Bogota Bogot\u00e1, Colombia","institution_ids":["https://openalex.org/I36243813"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036318916","display_name":"Mario F. GUERRERO","orcid":"https://orcid.org/0000-0003-1789-1818","observed_orcids":["https://orcid.org/0000-0003-1789-1818"]},"institutions":[{"id":"https://openalex.org/I36243813","display_name":"Universidad Nacional de Colombia","ror":"https://ror.org/059yx9a68","country_code":"CO","type":"education","lineage":["https://openalex.org/I36243813"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Mario Guerrero","raw_affiliation_strings":["Universidad Nacional de Colombia - Sede Bogota Bogot\u00e1, Colombia"],"raw_orcid":"https://orcid.org/0000-0003-1789-1818","affiliations":[{"raw_affiliation_string":"Universidad Nacional de Colombia - Sede Bogota Bogot\u00e1, Colombia","institution_ids":["https://openalex.org/I36243813"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36243813"],"apc_list":null,"apc_paid":null,"fwci":2.5267,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.91114863,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"14","issue":"2","first_page":"51","last_page":"58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11973","display_name":"Plant chemical constituents analysis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acanthaceae","display_name":"Acanthaceae","score":0.921999990940094},{"id":"https://openalex.org/keywords/medicinal-plants","display_name":"medicinal plants","score":0.8130000233650208},{"id":"https://openalex.org/keywords/central-nervous-system-effects","display_name":"central nervous system effects","score":0.7940000295639038},{"id":"https://openalex.org/keywords/anxiolytic-effects","display_name":"anxiolytic effects","score":0.9929999709129333},{"id":"https://openalex.org/keywords/anticonvulsant-activity","display_name":"anticonvulsant activity","score":0.996999979019165},{"id":"https://openalex.org/keywords/sedative-effects","display_name":"sedative effects","score":0.9810000061988831},{"id":"https://openalex.org/keywords/muscle-relaxant-activity","display_name":"muscle relaxant activity","score":0.9679999947547913},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2776755955","wikidata":"https://www.wikidata.org/wiki/Q409632","display_name":"Pentobarbital","level":2,"score":0.6611020565032959},{"id":"https://openalex.org/C2777765862","wikidata":"https://www.wikidata.org/wiki/Q62903","display_name":"Anxiolytic","level":3,"score":0.6474388837814331},{"id":"https://openalex.org/C173586616","wikidata":"https://www.wikidata.org/wiki/Q5359685","display_name":"Elevated plus maze","level":3,"score":0.5459352135658264},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.543371856212616},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5032925009727478},{"id":"https://openalex.org/C2777602617","wikidata":"https://www.wikidata.org/wiki/Q847705","display_name":"Sedative","level":2,"score":0.49049729108810425},{"id":"https://openalex.org/C2777505162","wikidata":"https://www.wikidata.org/wiki/Q53475","display_name":"Acanthaceae","level":2,"score":0.4232361614704132},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36696428060531616},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.349855899810791},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.33994531631469727},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.15094098448753357},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.09878948330879211},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.04036492109298706}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:doaj.org/article:fa9bbc1185044bd49705ecb0226fad08","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fa9bbc1185044bd49705ecb0226fad08","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vitae, Vol 14, Iss 2, Pp 51-58 (2007)","raw_type":"article"},{"id":"pmh:oai:redalyc.org:169815389006","doi":null,"is_oa":false,"landing_page_url":"https://www.redalyc.org/articulo.oa?id=169815389006","pdf_url":null,"source":{"id":"https://openalex.org/S4377196100","display_name":"Redalyc (Universidad Aut\u00f3noma del Estado de M\u00e9xico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179647637","host_organization_name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","host_organization_lineage":["https://openalex.org/I179647637"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vitae (Colombia) Num.2 Vol.14","raw_type":"art\u00edculo cient\u00edfico"},{"id":"mag:1950503177","doi":null,"is_oa":true,"landing_page_url":"http://www.redalyc.org/pdf/1698/169815389006.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S111148215","display_name":"Revista Vitae","issn_l":"0121-4004","issn":["0121-4004","2145-2660"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","publindex-b","russia-white-list-4","scielo"],"host_organization":"https://openalex.org/P4310318837","host_organization_name":"Universidad de Antioquia","host_organization_lineage":["https://openalex.org/P4310318837"],"host_organization_lineage_names":["Universidad de Antioquia"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Revista Vitae","raw_type":null}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:fa9bbc1185044bd49705ecb0226fad08","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fa9bbc1185044bd49705ecb0226fad08","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vitae, Vol 14, Iss 2, Pp 51-58 (2007)","raw_type":"article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1501934895","https://openalex.org/W1533387838","https://openalex.org/W1571611873","https://openalex.org/W1965565026","https://openalex.org/W1967198016","https://openalex.org/W1969633110","https://openalex.org/W1971877407","https://openalex.org/W1979604372","https://openalex.org/W1985982760","https://openalex.org/W1990694352","https://openalex.org/W2011469832","https://openalex.org/W2014509727","https://openalex.org/W2017436597","https://openalex.org/W2018021139","https://openalex.org/W2018895167","https://openalex.org/W2019840680","https://openalex.org/W2031522940","https://openalex.org/W2032577690","https://openalex.org/W2035796563","https://openalex.org/W2046682807","https://openalex.org/W2057355532","https://openalex.org/W2069192879","https://openalex.org/W2077011602","https://openalex.org/W2102742829","https://openalex.org/W2107843728","https://openalex.org/W2110914350","https://openalex.org/W2150465569","https://openalex.org/W2166033901","https://openalex.org/W2237544985","https://openalex.org/W2259516905"],"related_works":["https://openalex.org/W4298063742","https://openalex.org/W2311185992","https://openalex.org/W1538347661","https://openalex.org/W1533387838","https://openalex.org/W2408437030","https://openalex.org/W7120697257","https://openalex.org/W4376614870","https://openalex.org/W3024074403","https://openalex.org/W2412324494","https://openalex.org/W2035336910"],"abstract_inverted_index":{"En":[0,40],"este":[1,137],"estudio":[2],"se":[3,44],"describe":[4],"el":[5,13],"aislamiento,":[6],"identificaci\u00f3n":[7],"y":[8,74,76,116],"perfil":[9],"farmacol\u00f3gico":[10],"ejercido":[11],"sobre":[12],"sistema":[14],"nervioso":[15],"central":[16,151],"por":[17,72],"cumarina":[18,86],"(1,2-benzopirona),":[19],"mol\u00e9cula":[20],"obtenida":[21],"de":[22,54,62,69,98,108,113,118,124,128,136],"la":[23,95,122],"especie":[24],"Hygrophila":[25,162,250],"tyttha":[26,163],"Leonard":[27,164],"(Acanthaceae.":[28,165],"NV:":[29],"amansamachos),":[30],"planta":[31],"medicinal":[32,173],"utilizada":[33],"popularmente":[34],"en":[35,58,94,105,110],"Colombia":[36],"con":[37],"fines":[38],"tranquilizantes.":[39],"ratones":[41],"albinos":[42],"ICR":[43,217],"llevaron":[45],"a":[46,50,134,172,241],"cabo":[47],"pruebas":[48,107],"destinadas":[49],"detectar":[51],"posible":[52],"actividad":[53,96],"tipo":[55,129],"ansiol\u00edtico":[56],"(laberinto":[57],"cruz":[59],"elevado,":[60],"enterramiento":[61,112],"esferas),":[63],"anticonvulsivante":[64,131],"(electroshock,":[65,201],"pentilentetrazol),":[66],"sedante":[67,133],"(potenciaci\u00f3n":[68],"sue\u00f1o":[70],"inducido":[71],"pentobarbital":[73],"\u00e9ter)":[75],"relajante":[77],"muscular":[78],"(prueba":[79],"del":[80],"alambre).":[81],"Los":[82],"resultados":[83],"muestran":[84],"que":[85],"(200":[87,235],"mg/kg,":[88,236],"vo)":[89],"es":[90],"un":[91],"compuesto":[92,138],"clave":[93],"farmacol\u00f3gica":[97],"esta":[99],"especie,":[100],"dados":[101],"sus":[102],"efectos":[103],"positivos":[104],"las":[106],"laberinto":[109],"cruz,":[111],"esferas,":[114],"electroshock":[115,230],"potenciaci\u00f3n":[117],"sue\u00f1o.":[119],"Esto":[120],"abre":[121],"posibilidad":[123],"encontrar":[125],"alternativas":[126],"terap\u00e9uticas":[127],"ansiol\u00edtico,":[130],"y/o":[132],"partir":[135],"natural.":[139],"This":[140,169],"study":[141],"shows":[142],"the":[143,150,181,221,225,245,257],"isolation,":[144],"identification":[145],"and":[146,205,209,231],"pharmacological":[147,246],"profile":[148],"on":[149],"nervous":[152],"system":[153],"induced":[154,248],"by":[155,249],"coumarin":[156,234],"(1-2":[157],"benzpyrone),":[158],"molecule":[159],"obtained":[160],"from":[161,268],"Vulgar":[166],"name::":[167],"\"amansamachos\").":[168],"specie":[170],"is":[171],"plant":[174],"used":[175,214],"in":[176,215,224,244],"Colombian":[177],"traditional":[178],"medicine":[179],"for":[180],"treatment":[182],"of":[183,191,259,262],"anxiety.":[184],"Tests":[185],"destined":[186],"to":[187,220,239,256],"detect":[188],"possible":[189],"activity":[190],"anxiolytic":[192],"type":[193],"(elevated":[194],"plus":[195,226],"maze,":[196,227],"marble":[197,228],"burying":[198],"behavior),":[199],"anticonvulsant":[200,264],"pentylenetetrazole),":[202],"sedative":[203,266],"(pentobarbital":[204],"ether":[206],"sleep":[207,232],"time)":[208],"miorelaxant":[210],"(wiring":[211],"test)":[212],"were":[213],"albino":[216],"mice.":[218],"According":[219],"positive":[222],"results":[223,253],"burying,":[229],"tests,":[233],"po)":[237],"seems":[238],"be":[240],"key":[242],"compound":[243],"response":[247],"tyttha.":[251],"These":[252],"may":[254],"led":[255],"finding":[258],"therapeutic":[260],"alternatives":[261],"anxiolytic,":[263],"and/or":[265],"kind":[267],"this":[269],"natural":[270],"compound.":[271]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}