{"id":"https://openalex.org/W194994231","doi":"https://doi.org/10.1016/s0021-9258(18)34981-0","title":"Human hepatic microsomal epoxide hydrolase. A structural comparison with the rat enzyme.","display_name":"Human hepatic microsomal epoxide hydrolase. A structural comparison with the rat enzyme.","publication_year":1982,"publication_date":"1982-03-01","ids":{"openalex":"https://openalex.org/W194994231","doi":"https://doi.org/10.1016/s0021-9258(18)34981-0","mag":"194994231","pmid":"https://pubmed.ncbi.nlm.nih.gov/7061444"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(18)34981-0","doi":"https://doi.org/10.1016/s0021-9258(18)34981-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)34981-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(18)34981-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111546496","display_name":"Garrett C DuBois","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G C DuBois","raw_affiliation_strings":["From the +Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205, the SDepartment of Biochemistry and Drug Metabolism,","Hoffmann-La Roche Inc., Nutley, New Jersey 07110,","fiLaboratory of Bioorganic Chemistry, National Institute of Arthritis, Diabetes, Digestiue, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the +Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205, the SDepartment of Biochemistry and Drug Metabolism,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Hoffmann-La Roche Inc., Nutley, New Jersey 07110,","institution_ids":[]},{"raw_affiliation_string":"fiLaboratory of Bioorganic Chemistry, National Institute of Arthritis, Diabetes, Digestiue, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036354240","display_name":"Ettore Appella","orcid":"https://orcid.org/0000-0003-0569-9722","observed_orcids":["https://orcid.org/0000-0003-0569-9722"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E Appella","raw_affiliation_strings":["From the +Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205, the SDepartment of Biochemistry and Drug Metabolism,","Hoffmann-La Roche Inc., Nutley, New Jersey 07110,","fiLaboratory of Bioorganic Chemistry, National Institute of Arthritis, Diabetes, Digestiue, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the +Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205, the SDepartment of Biochemistry and Drug Metabolism,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Hoffmann-La Roche Inc., Nutley, New Jersey 07110,","institution_ids":[]},{"raw_affiliation_string":"fiLaboratory of Bioorganic Chemistry, National Institute of Arthritis, Diabetes, Digestiue, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103578981","display_name":"Dene E. Ryan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D E Ryan","raw_affiliation_strings":["From the +Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205, the SDepartment of Biochemistry and Drug Metabolism,","Hoffmann-La Roche Inc., Nutley, New Jersey 07110,","fiLaboratory of Bioorganic Chemistry, National Institute of Arthritis, Diabetes, Digestiue, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the +Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205, the SDepartment of Biochemistry and Drug Metabolism,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Hoffmann-La Roche Inc., Nutley, New Jersey 07110,","institution_ids":[]},{"raw_affiliation_string":"fiLaboratory of Bioorganic Chemistry, National Institute of Arthritis, Diabetes, Digestiue, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110127727","display_name":"D. M. JERINA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D M Jerina","raw_affiliation_strings":["From the +Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205, the SDepartment of Biochemistry and Drug Metabolism,","Hoffmann-La Roche Inc., Nutley, New Jersey 07110,","fiLaboratory of Bioorganic Chemistry, National Institute of Arthritis, Diabetes, Digestiue, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the +Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205, the SDepartment of Biochemistry and Drug Metabolism,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Hoffmann-La Roche Inc., Nutley, New Jersey 07110,","institution_ids":[]},{"raw_affiliation_string":"fiLaboratory of Bioorganic Chemistry, National Institute of Arthritis, Diabetes, Digestiue, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045174225","display_name":"Wayne Levin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W Levin","raw_affiliation_strings":["From the +Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205, the SDepartment of Biochemistry and Drug Metabolism,","Hoffmann-La Roche Inc., Nutley, New Jersey 07110,","fiLaboratory of Bioorganic Chemistry, National Institute of Arthritis, Diabetes, Digestiue, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the +Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205, the SDepartment of Biochemistry and Drug Metabolism,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Hoffmann-La Roche Inc., Nutley, New Jersey 07110,","institution_ids":[]},{"raw_affiliation_string":"fiLaboratory of Bioorganic Chemistry, National Institute of Arthritis, Diabetes, Digestiue, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.5582,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.87945328,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"257","issue":"5","first_page":"2708","last_page":"2712"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0560000017285347,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.016300000250339508,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epoxide-hydrolase","display_name":"epoxide hydrolase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/human-liver-microsomes","display_name":"human liver microsomes","score":0.7459999918937683},{"id":"https://openalex.org/keywords/rat-enzyme","display_name":"rat enzyme","score":0.6830000281333923},{"id":"https://openalex.org/keywords/enzyme-structure","display_name":"enzyme structure","score":0.43700000643730164},{"id":"https://openalex.org/keywords/n-terminal-sequence","display_name":"N-terminal sequence","score":0.75},{"id":"https://openalex.org/keywords/amino-acid-composition","display_name":"amino acid composition","score":0.8019999861717224},{"id":"https://openalex.org/keywords/peptide-mapping","display_name":"peptide mapping","score":0.9599999785423279},{"id":"https://openalex.org/keywords/limited-proteolysis","display_name":"limited proteolysis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.7680000066757202},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.7829999923706055},{"id":"https://openalex.org/keywords/enzyme-homology","display_name":"enzyme homology","score":0.5669999718666077},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C101819947","wikidata":"https://www.wikidata.org/wiki/Q87444516","display_name":"Epoxide hydrolase","level":4,"score":0.7435351610183716},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.638419508934021},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.6169570088386536},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.601740300655365},{"id":"https://openalex.org/C2776671928","wikidata":"https://www.wikidata.org/wiki/Q6840292","display_name":"Microsomal epoxide hydrolase","level":5,"score":0.5930250287055969},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.592092752456665},{"id":"https://openalex.org/C2780120296","wikidata":"https://www.wikidata.org/wiki/Q96286","display_name":"Hydrolase","level":3,"score":0.46299442648887634},{"id":"https://openalex.org/C2776920199","wikidata":"https://www.wikidata.org/wiki/Q408028","display_name":"Epoxide","level":3,"score":0.462191641330719},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.07082158327102661}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003488","descriptor_name":"Cyanogen Bromide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004851","descriptor_name":"Epoxide Hydrolases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010634","descriptor_name":"Phenobarbital","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(18)34981-0","doi":"https://doi.org/10.1016/s0021-9258(18)34981-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)34981-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:7061444","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7061444","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(18)34981-0","doi":"https://doi.org/10.1016/s0021-9258(18)34981-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)34981-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W136355807","https://openalex.org/W166934553","https://openalex.org/W172739833","https://openalex.org/W1487378664","https://openalex.org/W1516752207","https://openalex.org/W1517170254","https://openalex.org/W1519899868","https://openalex.org/W1542098362","https://openalex.org/W1544070059","https://openalex.org/W1577967263","https://openalex.org/W1584147929","https://openalex.org/W1600584054","https://openalex.org/W1775964807","https://openalex.org/W1984713897","https://openalex.org/W1984778519","https://openalex.org/W2001230550","https://openalex.org/W2005826489","https://openalex.org/W2022269657","https://openalex.org/W2033203102","https://openalex.org/W2070828159","https://openalex.org/W2164358316","https://openalex.org/W2275843281","https://openalex.org/W2302601879"],"related_works":["https://openalex.org/W1487378664","https://openalex.org/W1964038282","https://openalex.org/W1544070059","https://openalex.org/W1577967263","https://openalex.org/W1968065195","https://openalex.org/W2086194453","https://openalex.org/W1541003843","https://openalex.org/W2409763874","https://openalex.org/W4239734343","https://openalex.org/W1577135326"],"abstract_inverted_index":{"Purified":[0],"human":[1,29,60,113,133,175,219,255,265],"microsomal":[2,77,237],"epoxide":[3,30,61,136,222,238,259],"hydrolase":[4,31,62,137,239,260,283],"has":[5],"been":[6],"compared":[7],"to":[8,66],"the":[9,35,40,44,49,67,74,81,92,101,107,112,118,131,174,218,228,254,264,268,277,281,285,292,301],"rat":[10,76,82,119,135,177,221,236,257,269],"enzyme":[11,78,114,275],"by":[12,140,162,180,205],"means":[13],"of":[14,28,39,48,59,73,106,111,117,130,227,280,295,303],"NHzterminal":[15],"amino":[16,19,37,108],"acid":[17,20,38,87,109],"sequencing,":[18],"composition,":[21],"and":[22,100,103,120,134,144,176,220,256,261,284,307,315],"peptide":[23,154,171,230],"mapping":[24,179,204,231],"procedures.Automated":[25],"Edman":[26],"degradation":[27],"identified":[32],"methionine":[33,160],"as":[34,272,311],"NHZ-terminal":[36],"enzyme;":[41],"in":[42,183,208,276,291,300],"addition,":[43],"next":[45],"18":[46],"residues":[47,161],"N":[50],"H":[51],"2terminal":[52],"region":[53],"were":[54,89,138,233],"also":[55,192],"identified.The":[56],"NHz-terminal":[57,71],"segment":[58],"is":[63,84],"homologous":[64],"(68%)":[65],"previously":[68],"reported":[69],"partial":[70],"sequence":[72],"purified":[75,93,98,132,240],"and,":[79],"like":[80,267],"counterpart,":[83],"highly":[85],"hydrophobic.Amino":[86],"compositions":[88],"identical":[90,127,153,170,198,234],"for":[91,156,173,201,217,235,250],"native":[94],"enzyme,":[95,266,270],"a":[96,273],"chromatographically":[97],"sample,":[99],"reduced":[102],"alkylated":[104],"enzyme.Comparison":[105],"composition":[110],"with":[115,187,212],"those":[116],"rabbit":[121],"enzymes":[122],"showed":[123,193],"similar":[124,167,195],"but":[125,168,196],"not":[126,169,197],"compositions.Peptide":[128],"maps":[129,155,172],"obtained":[139],"both":[141,157,202],"chemical":[142],"cleavage":[143,146],"enzymatic":[145],"methods.Cleavage":[147],"at":[148,159],"acid-sensitive":[149],"aspartyl-prolyl":[150],"bonds":[151],"produced":[152,166,214],"enzymes.Cleavage":[158],"cyanogen":[163],"bromide":[164],"treatment":[165],"enzymes.Peptide":[178,203],"limited":[181,206],"proteolysis":[182,207],"sodium":[184,209],"dodecyl":[185,210],"sulfate":[186,211],"Staphylococcus":[188],"aureus":[189],"V8":[190],"protease":[191],"very":[194],"fragmentation":[199],"patterns":[200,216,224],"chymotrypsin":[213],"different":[215],"hydrolase.Fragmentation":[223],"using":[225],"aIl":[226],"above":[229],"procedures":[232],"from":[241],"either":[242],"phenobarbital-treated":[243],"or":[244],"isosafrole-treated":[245],"rats.These":[246],"studies":[247],"provide":[248],"evidence":[249],"structural":[251],"similarities":[252],"between":[253],"hepatic":[258],"suggest":[262],"that":[263],"exists":[271],"single":[274],"endoplasmic":[278,293],"reticulum":[279,294],"cell.Epoxide":[282],"cytochrome":[286],"P-450":[287],"containing":[288],"monooxygenase":[289],"system":[290],"mammals":[296],"play":[297],"crucial":[298],"roles":[299],"metabolism":[302],"many":[304],"endogenous":[305],"substrates":[306],"exogenous":[308],"substances":[309],"such":[310],"drugs,":[312],"mutagens,":[313],"carcinogens,":[314],"other":[316],"toxic":[317],"compounds":[318],"(1-4).Epoxide":[319],"hy-":[320]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}