{"id":"https://openalex.org/W19491965","doi":null,"title":"Characterizing the Dynamics and Functional Role of Site-Specific Phosphorylation of G Protein-Coupled Receptors","display_name":"Characterizing the Dynamics and Functional Role of Site-Specific Phosphorylation of G Protein-Coupled Receptors","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W19491965","mag":"19491965"},"language":"en","primary_location":{"id":"pmh:oai:jdc.jefferson.edu:diss_masters-1004","doi":null,"is_oa":true,"landing_page_url":"https://jdc.jefferson.edu/diss_masters/5","pdf_url":"https://jdc.jefferson.edu/diss_masters/5","source":{"id":"https://openalex.org/S4210178181","display_name":"The Medicine Forum","issn_l":"2325-2863","issn":["2325-2863"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Full-Text Theses & Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://jdc.jefferson.edu/diss_masters/5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065437023","display_name":"John M. Busillo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"John M. Busillo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5065437023"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00170387,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9259999990463257},{"id":"https://openalex.org/keywords/site-specific-phosphorylation","display_name":"site-specific phosphorylation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/gpcr-kinases","display_name":"GPCR kinases","score":0.824999988079071},{"id":"https://openalex.org/keywords/arrestin","display_name":"arrestin","score":0.7570000290870667},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.949999988079071},{"id":"https://openalex.org/keywords/muscarinic-m3-receptor","display_name":"M3 muscarinic receptor","score":0.9330000281333923},{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/grk2","display_name":"GRK2","score":0.9520000219345093},{"id":"https://openalex.org/keywords/grk3","display_name":"GRK3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/grk6","display_name":"GRK6","score":0.9800000190734863},{"id":"https://openalex.org/keywords/grk5","display_name":"GRK5","score":0.9639999866485596},{"id":"https://openalex.org/keywords/arrestin-2","display_name":"arrestin-2","score":0.9570000171661377},{"id":"https://openalex.org/keywords/arrestin3","display_name":"arrestin3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/erk-activation","display_name":"ERK activation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/calcium-mobilization","display_name":"calcium mobilization","score":0.9169999957084656}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.632340669631958},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.5110279321670532},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5026609897613525},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5009162425994873},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39380887150764465},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37076032161712646},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.32494962215423584},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.315234899520874},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30801236629486084}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:jdc.jefferson.edu:diss_masters-1004","doi":null,"is_oa":true,"landing_page_url":"https://jdc.jefferson.edu/diss_masters/5","pdf_url":"https://jdc.jefferson.edu/diss_masters/5","source":{"id":"https://openalex.org/S4210178181","display_name":"The Medicine Forum","issn_l":"2325-2863","issn":["2325-2863"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Full-Text Theses & Dissertations","raw_type":"text"},{"id":"mag:19491965","doi":null,"is_oa":false,"landing_page_url":"https://jdc.jefferson.edu/cgi/viewcontent.cgi?article=1004&context=diss_masters","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:jdc.jefferson.edu:diss_masters-1004","doi":null,"is_oa":true,"landing_page_url":"https://jdc.jefferson.edu/diss_masters/5","pdf_url":"https://jdc.jefferson.edu/diss_masters/5","source":{"id":"https://openalex.org/S4210178181","display_name":"The Medicine Forum","issn_l":"2325-2863","issn":["2325-2863"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Full-Text Theses & Dissertations","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8771387404","display_name":"G Protein-Coupled Receptor Kinases","funder_award_id":"R01GM044944","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000304284","display_name":null,"funder_award_id":"GM47417","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320308109","display_name":"Pennsylvania Department of Health","ror":"https://ror.org/00ra1fg11"},{"id":"https://openalex.org/F4320310536","display_name":"University of Virginia","ror":"https://ror.org/0153tk833"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W19491965.pdf","grobid_xml":"https://content.openalex.org/works/W19491965.grobid-xml"},"referenced_works_count":357,"referenced_works":["https://openalex.org/W66891075","https://openalex.org/W82820957","https://openalex.org/W97158386","https://openalex.org/W1481422886","https://openalex.org/W1486102976","https://openalex.org/W1486205509","https://openalex.org/W1499511192","https://openalex.org/W1503765703","https://openalex.org/W1504031944","https://openalex.org/W1504303645","https://openalex.org/W1507225552","https://openalex.org/W1508211596","https://openalex.org/W1510842546","https://openalex.org/W1511477623","https://openalex.org/W1515479627","https://openalex.org/W1522251904","https://openalex.org/W1528193286","https://openalex.org/W1528751727","https://openalex.org/W1531083786","https://openalex.org/W1533788848","https://openalex.org/W1544916621","https://openalex.org/W1547623660","https://openalex.org/W1551351100","https://openalex.org/W1557145999","https://openalex.org/W1557524937","https://openalex.org/W1559314541","https://openalex.org/W1567845952","https://openalex.org/W1580968401","https://openalex.org/W1586392520","https://openalex.org/W1591933203","https://openalex.org/W1594333454","https://openalex.org/W1603105681","https://openalex.org/W1603274157","https://openalex.org/W1641731911","https://openalex.org/W1652605626","https://openalex.org/W1669115568","https://openalex.org/W1755902553","https://openalex.org/W1804074798","https://openalex.org/W1806371085","https://openalex.org/W1809740262","https://openalex.org/W1825353903","https://openalex.org/W1845584404","https://openalex.org/W1867673778","https://openalex.org/W1879346051","https://openalex.org/W1890185838","https://openalex.org/W1909076506","https://openalex.org/W1916021949","https://openalex.org/W1922502842","https://openalex.org/W1936405794","https://openalex.org/W1958742527","https://openalex.org/W1963685478","https://openalex.org/W1963817582","https://openalex.org/W1964083898","https://openalex.org/W1966619635","https://openalex.org/W1967352670","https://openalex.org/W1967767166","https://openalex.org/W1969032276","https://openalex.org/W1969583788","https://openalex.org/W1970676821","https://openalex.org/W1970729674","https://openalex.org/W1971273204","https://openalex.org/W1971347092","https://openalex.org/W1971505103","https://openalex.org/W1972513389","https://openalex.org/W1972760976","https://openalex.org/W1973925937","https://openalex.org/W1974132609","https://openalex.org/W1974710770","https://openalex.org/W1975740938","https://openalex.org/W1978471017","https://openalex.org/W1978919002","https://openalex.org/W1979103781","https://openalex.org/W1979197099","https://openalex.org/W1979233943","https://openalex.org/W1979670158","https://openalex.org/W1979949328","https://openalex.org/W1980475208","https://openalex.org/W1980790180","https://openalex.org/W1980982223","https://openalex.org/W1981267775","https://openalex.org/W1981572127","https://openalex.org/W1982192731","https://openalex.org/W1983798380","https://openalex.org/W1985580256","https://openalex.org/W1985759771","https://openalex.org/W1986986419","https://openalex.org/W1989707466","https://openalex.org/W1990660812","https://openalex.org/W1990906694","https://openalex.org/W1991163722","https://openalex.org/W1991459803","https://openalex.org/W1991680007","https://openalex.org/W1991863849","https://openalex.org/W1991889120","https://openalex.org/W1992553934","https://openalex.org/W1993544268","https://openalex.org/W1993717649","https://openalex.org/W1994003028","https://openalex.org/W1994015218","https://openalex.org/W1994161105","https://openalex.org/W1994573744","https://openalex.org/W1994816216","https://openalex.org/W1995605077","https://openalex.org/W1997085676","https://openalex.org/W1999153777","https://openalex.org/W1999530386","https://openalex.org/W2000949690","https://openalex.org/W2001626986","https://openalex.org/W2002567921","https://openalex.org/W2004289105","https://openalex.org/W2004948816","https://openalex.org/W2005428335","https://openalex.org/W2005975965","https://openalex.org/W2006268283","https://openalex.org/W2006398427","https://openalex.org/W2006860685","https://openalex.org/W2008652937","https://openalex.org/W2008795750","https://openalex.org/W2009537829","https://openalex.org/W2010210270","https://openalex.org/W2010638326","https://openalex.org/W2011276907","https://openalex.org/W2012571494","https://openalex.org/W2012652285","https://openalex.org/W2015290641","https://openalex.org/W2015350147","https://openalex.org/W2015893386","https://openalex.org/W2015932636","https://openalex.org/W2016261957","https://openalex.org/W2016346332","https://openalex.org/W2016410208","https://openalex.org/W2017848367","https://openalex.org/W2018448673","https://openalex.org/W2018939316","https://openalex.org/W2019985934","https://openalex.org/W2021607480","https://openalex.org/W2022957542","https://openalex.org/W2023624246","https://openalex.org/W2023661096","https://openalex.org/W2025472785","https://openalex.org/W2025692747","https://openalex.org/W2025837128","https://openalex.org/W2026933806","https://openalex.org/W2027030905","https://openalex.org/W2027587310","https://openalex.org/W2027781307","https://openalex.org/W2029052547","https://openalex.org/W2029083442","https://openalex.org/W2031509657","https://openalex.org/W2031789764","https://openalex.org/W2032527022","https://openalex.org/W2032597695","https://openalex.org/W2032790231","https://openalex.org/W2032848541","https://openalex.org/W2033119255","https://openalex.org/W2033244960","https://openalex.org/W2034930410","https://openalex.org/W2035695230","https://openalex.org/W2037751912","https://openalex.org/W2038300112","https://openalex.org/W2039146726","https://openalex.org/W2039611035","https://openalex.org/W2040942754","https://openalex.org/W2041566506","https://openalex.org/W2042017414","https://openalex.org/W2042819854","https://openalex.org/W2044415003","https://openalex.org/W2044775506","https://openalex.org/W2046455851","https://openalex.org/W2046844598","https://openalex.org/W2047782531","https://openalex.org/W2047896617","https://openalex.org/W2047988972","https://openalex.org/W2049308539","https://openalex.org/W2049820772","https://openalex.org/W2050154239","https://openalex.org/W2051560996","https://openalex.org/W2052151503","https://openalex.org/W2052288973","https://openalex.org/W2052814200","https://openalex.org/W2054120126","https://openalex.org/W2054211644","https://openalex.org/W2054923889","https://openalex.org/W2055209036","https://openalex.org/W2056037928","https://openalex.org/W2056772835","https://openalex.org/W2057648252","https://openalex.org/W2058160393","https://openalex.org/W2058334083","https://openalex.org/W2058554403","https://openalex.org/W2060207881","https://openalex.org/W2061286602","https://openalex.org/W2061431893","https://openalex.org/W2062655974","https://openalex.org/W2063014888","https://openalex.org/W2063599982","https://openalex.org/W2063840368","https://openalex.org/W2064432631","https://openalex.org/W2064603835","https://openalex.org/W2067234168","https://openalex.org/W2068711964","https://openalex.org/W2069156204","https://openalex.org/W2069547389","https://openalex.org/W2070590745","https://openalex.org/W2071132058","https://openalex.org/W2071626570","https://openalex.org/W2072178451","https://openalex.org/W2072842460","https://openalex.org/W2074450526","https://openalex.org/W2075398040","https://openalex.org/W2075951376","https://openalex.org/W2077781719","https://openalex.org/W2078373009","https://openalex.org/W2079317830","https://openalex.org/W2080519309","https://openalex.org/W2081116633","https://openalex.org/W2081495990","https://openalex.org/W2081769332","https://openalex.org/W2081921364","https://openalex.org/W2082180266","https://openalex.org/W2082180864","https://openalex.org/W2082411432","https://openalex.org/W2083334427","https://openalex.org/W2083612980","https://openalex.org/W2085668133","https://openalex.org/W2086232654","https://openalex.org/W2086459628","https://openalex.org/W2086617442","https://openalex.org/W2086759736","https://openalex.org/W2087290041","https://openalex.org/W2087886422","https://openalex.org/W2090970904","https://openalex.org/W2092632463","https://openalex.org/W2092664889","https://openalex.org/W2092964019","https://openalex.org/W2093819573","https://openalex.org/W2093881154","https://openalex.org/W2094210266","https://openalex.org/W2094570628","https://openalex.org/W2094573329","https://openalex.org/W2094999165","https://openalex.org/W2098141802","https://openalex.org/W2098509726","https://openalex.org/W2098658264","https://openalex.org/W2099376832","https://openalex.org/W2102417288","https://openalex.org/W2102518406","https://openalex.org/W2102880982","https://openalex.org/W2103838304","https://openalex.org/W2104127556","https://openalex.org/W2104477830","https://openalex.org/W2104745015","https://openalex.org/W2104918497","https://openalex.org/W2105608776","https://openalex.org/W2106241903","https://openalex.org/W2106607972","https://openalex.org/W2107679332","https://openalex.org/W2109014958","https://openalex.org/W2109325347","https://openalex.org/W2110502062","https://openalex.org/W2111361704","https://openalex.org/W2111995414","https://openalex.org/W2113012529","https://openalex.org/W2116018770","https://openalex.org/W2117754393","https://openalex.org/W2117914989","https://openalex.org/W2118526748","https://openalex.org/W2118579624","https://openalex.org/W2119258086","https://openalex.org/W2119398013","https://openalex.org/W2120023842","https://openalex.org/W2120066927","https://openalex.org/W2120365849","https://openalex.org/W2121269254","https://openalex.org/W2122053636","https://openalex.org/W2122452899","https://openalex.org/W2123895632","https://openalex.org/W2125385750","https://openalex.org/W2125468282","https://openalex.org/W2126059273","https://openalex.org/W2126597823","https://openalex.org/W2126743117","https://openalex.org/W2127286414","https://openalex.org/W2127492591","https://openalex.org/W2130632774","https://openalex.org/W2130672315","https://openalex.org/W2133347001","https://openalex.org/W2133354537","https://openalex.org/W2133420484","https://openalex.org/W2133985933","https://openalex.org/W2135235230","https://openalex.org/W2135319033","https://openalex.org/W2135453228","https://openalex.org/W2135970284","https://openalex.org/W2136394000","https://openalex.org/W2138412834","https://openalex.org/W2139354324","https://openalex.org/W2139539695","https://openalex.org/W2140220315","https://openalex.org/W2140306302","https://openalex.org/W2140556294","https://openalex.org/W2140654809","https://openalex.org/W2141030777","https://openalex.org/W2141528503","https://openalex.org/W2143071207","https://openalex.org/W2144172655","https://openalex.org/W2144744785","https://openalex.org/W2146188142","https://openalex.org/W2148379230","https://openalex.org/W2148760047","https://openalex.org/W2149303991","https://openalex.org/W2149780959","https://openalex.org/W2149963584","https://openalex.org/W2150341008","https://openalex.org/W2150833601","https://openalex.org/W2151312020","https://openalex.org/W2153776586","https://openalex.org/W2154229564","https://openalex.org/W2155728143","https://openalex.org/W2156124920","https://openalex.org/W2156323704","https://openalex.org/W2156753857","https://openalex.org/W2156878838","https://openalex.org/W2157562973","https://openalex.org/W2158049812","https://openalex.org/W2158207659","https://openalex.org/W2158294445","https://openalex.org/W2159543436","https://openalex.org/W2159588204","https://openalex.org/W2159839943","https://openalex.org/W2160536323","https://openalex.org/W2163352150","https://openalex.org/W2164167813","https://openalex.org/W2165244186","https://openalex.org/W2166005929","https://openalex.org/W2166748873","https://openalex.org/W2167070743","https://openalex.org/W2167901494","https://openalex.org/W2168050522","https://openalex.org/W2168363131","https://openalex.org/W2169101659","https://openalex.org/W2169685486","https://openalex.org/W2171384937","https://openalex.org/W2171687293","https://openalex.org/W2172226629","https://openalex.org/W2172874896","https://openalex.org/W2245006846","https://openalex.org/W2338757299","https://openalex.org/W2339809048","https://openalex.org/W2342037312","https://openalex.org/W2407761906","https://openalex.org/W2414379339","https://openalex.org/W2419295924","https://openalex.org/W2614496215","https://openalex.org/W3151472263","https://openalex.org/W4295216797","https://openalex.org/W4297631428"],"related_works":["https://openalex.org/W2049648432","https://openalex.org/W2008652937","https://openalex.org/W2917973990","https://openalex.org/W2168363131","https://openalex.org/W2062032599","https://openalex.org/W2149456372","https://openalex.org/W2023129552","https://openalex.org/W4410214377","https://openalex.org/W4290047601","https://openalex.org/W4411135085"],"abstract_inverted_index":{"Phosphorylation":[0],"of":[1,14,37,50,63,81,102,149,155,182,205],"G":[2,120,177,198],"protein-coupled":[3],"receptors":[4,92],"(GPCRs)":[5],"by":[6,41,46],"GPCR":[7,32],"kinases":[8],"(GRKs)":[9],"and":[10,66,79,89,106,114,123,132,134,136,142,180,186,200,213],"the":[11,22,35,42,47,51,64,77,82,119,147,167],"subsequent":[12],"recruitment":[13],"arrestin":[15],"is":[16,34,173],"a":[17,99,140,176,197],"well-established":[18],"paradigm":[19],"that":[20,129,171],"initiates":[21],"process":[23],"known":[24],"as":[25],"desensitization.":[26],"However,":[27],"an":[28,69],"emerging":[29],"theme":[30],"in":[31,68,95,117,145],"regulation":[33,39],"possibility":[36],"differential":[38],"dictated":[40],"phosphorylation":[43,75],"pattern":[44],"elicited":[45],"different":[48],"members":[49],"GRK":[52],"family.":[53],"Therefore,":[54],"we":[55,109],"have":[56],"used":[57],"small":[58],"interfering":[59],"RNA-mediated":[60],"knock":[61,153],"down":[62,154],"GRKs":[65],"arrestins":[67],"attempt":[70],"to":[71,112],"better":[72],"understand":[73],"how":[74],"regulates":[76],"activity":[78,148],"signaling":[80,125,160,172,209],"M3":[83,168],"muscarinic":[84],"acetylcholine":[85],"receptor":[86,190],"(M3":[87],"mAChR)":[88],"CXCR4,":[90],"two":[91],"endogenously":[93],"expressed":[94],"HEK293":[96],"cells.":[97],"Using":[98],"two-pronged":[100],"approach":[101],"assaying":[103],"calcium":[104],"mobilization":[105],"ERK":[107],"activation,":[108],"were":[110],"able":[111],"define":[113],"monitor":[115],"changes":[116],"both":[118,196,211],"protein-":[121],"dependent":[122],"\u2013independent":[124,201],"pathways.":[126],"We":[127],"found":[128],"GRK2,":[130],"3,":[131],"6,":[133],"arrestin2":[135],"3":[137],"each":[138,150],"has":[139],"distinct":[141],"separable":[143],"role":[144],"regulating":[146],"receptor.":[151,163],"Interestingly,":[152],"GRK5":[156],"did":[157],"not":[158],"effect":[159],"via":[161],"either":[162],"Our":[164],"studies":[165],"with":[166],"mAChR":[169],"suggest":[170],"strictly":[174],"through":[175],"protein-dependent":[178,199],"manner":[179],"relief":[181],"inhibitory":[183],"constraints":[184],"(GRKs":[185],"arrestins)":[187],"subsequently":[188],"enhances":[189],"function.":[191],"In":[192],"contrast,":[193],"CXCR4":[194],"uses":[195],"(arrestin-":[202],"dependent)":[203],"means":[204],"signaling.":[206],"Notably,":[207],"arrestin-dependent":[208],"requires":[210],"GRK3":[212],"6.":[214]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
