{"id":"https://openalex.org/W1948654792","doi":"https://doi.org/10.1046/j.1469-0691.2003.00559.x","title":"Antecedent use of fluoroquinolones is associated with resistance to moxifloxacin in Clostridium difficile","display_name":"Antecedent use of fluoroquinolones is associated with resistance to moxifloxacin in Clostridium difficile","publication_year":2003,"publication_date":"2003-06-01","ids":{"openalex":"https://openalex.org/W1948654792","doi":"https://doi.org/10.1046/j.1469-0691.2003.00559.x","mag":"1948654792","pmid":"https://pubmed.ncbi.nlm.nih.gov/12848728"},"language":"en","primary_location":{"id":"doi:10.1046/j.1469-0691.2003.00559.x","doi":"https://doi.org/10.1046/j.1469-0691.2003.00559.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1469-0691.2003.00559.x","pdf_url":null,"source":{"id":"https://openalex.org/S71414007","display_name":"Clinical Microbiology and Infection","issn_l":"1198-743X","issn":["1198-743X","1469-0691"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Microbiology and Infection","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1046/j.1469-0691.2003.00559.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061001455","display_name":"G Ackermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"G. Ackermann","raw_affiliation_strings":["Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Leipzig, Germany. ackermg@medizin.uni-leipzig.de","Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Leipzig, Germany. ackermg@medizin.uni-leipzig.de","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029671726","display_name":"Yajarayma J. Tang-Feldman","orcid":"https://orcid.org/0000-0001-7765-1264","observed_orcids":["https://orcid.org/0000-0001-7765-1264"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y.J. Tang-Feldman","raw_affiliation_strings":["Department of Internal Medicine, Division of Infectious Diseases, University of California, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Infectious Diseases, University of California, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006041032","display_name":"Reiner Schaumann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R. Schaumann","raw_affiliation_strings":["Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067095683","display_name":"Jeffrey P. Henderson","orcid":"https://orcid.org/0000-0003-1755-3202","observed_orcids":["https://orcid.org/0000-0003-1755-3202"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.P. Henderson","raw_affiliation_strings":["Department of Internal Medicine, Division of Infectious Diseases, University of California, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Infectious Diseases, University of California, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017888308","display_name":"Arne Christian Rodloff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A.C. Rodloff","raw_affiliation_strings":["Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064103751","display_name":"J. Silva","orcid":"https://orcid.org/0000-0003-3967-5286","observed_orcids":["https://orcid.org/0000-0003-3967-5286"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Silva Jr","raw_affiliation_strings":["Department of Internal Medicine, Division of Infectious Diseases, University of California, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Infectious Diseases, University of California, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027994912","display_name":"Stanley Cohen","orcid":"https://orcid.org/0000-0003-3846-6028","observed_orcids":["https://orcid.org/0000-0003-3846-6028"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.H. Cohen","raw_affiliation_strings":["Department of Internal Medicine, Division of Infectious Diseases, University of California, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Infectious Diseases, University of California, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061001455"],"corresponding_institution_ids":["https://openalex.org/I926574661"],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":2.1354,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.8789582,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"6","first_page":"526","last_page":"530"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clostridioides-difficile","display_name":"Clostridium difficile","score":0.9829999804496765},{"id":"https://openalex.org/keywords/moxifloxacin-resistance","display_name":"moxifloxacin resistance","score":0.9629999995231628},{"id":"https://openalex.org/keywords/fluoroquinolone-use","display_name":"fluoroquinolone use","score":0.9359999895095825},{"id":"https://openalex.org/keywords/gyra-mutations","display_name":"gyrA mutations","score":0.7440000176429749},{"id":"https://openalex.org/keywords/dna-gyrase","display_name":"DNA gyrase","score":0.8650000095367432},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.49900001287460327},{"id":"https://openalex.org/keywords/toxigenic-strains","display_name":"toxigenic strains","score":0.7540000081062317},{"id":"https://openalex.org/keywords/clostridium-difficile-associated-diarrhea","display_name":"Clostridium difficile-associated diarrhea","score":0.8489999771118164},{"id":"https://openalex.org/keywords/prior-antibiotic-use","display_name":"prior antibiotic use","score":0.5680000185966492},{"id":"https://openalex.org/keywords/selective-pressure","display_name":"selection pressure","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C2778836808","wikidata":"https://www.wikidata.org/wiki/Q424940","display_name":"Moxifloxacin","level":3,"score":0.990688681602478},{"id":"https://openalex.org/C2994496256","wikidata":"https://www.wikidata.org/wiki/Q27031090","display_name":"Clostridium difficile","level":3,"score":0.7081847786903381},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6746253967285156},{"id":"https://openalex.org/C167125095","wikidata":"https://www.wikidata.org/wiki/Q70551687","display_name":"DNA gyrase","level":4,"score":0.5989716649055481},{"id":"https://openalex.org/C2781276175","wikidata":"https://www.wikidata.org/wiki/Q424193","display_name":"Levofloxacin","level":3,"score":0.46957728266716003},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4273239076137543},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40978050231933594},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4087424874305725},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1389692723751068},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12166246771812439},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.12017863988876343}],"mesh":[{"descriptor_ui":"D000077266","descriptor_name":"Moxifloxacin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001372","descriptor_name":"Aza Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004761","descriptor_name":"Enterocolitis, Pseudomembranous","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016360","descriptor_name":"Clostridioides difficile","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016360","descriptor_name":"Clostridioides difficile","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024841","descriptor_name":"Fluoroquinolones","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D024841","descriptor_name":"Fluoroquinolones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1469-0691.2003.00559.x","doi":"https://doi.org/10.1046/j.1469-0691.2003.00559.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1469-0691.2003.00559.x","pdf_url":null,"source":{"id":"https://openalex.org/S71414007","display_name":"Clinical Microbiology and Infection","issn_l":"1198-743X","issn":["1198-743X","1469-0691"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Microbiology and Infection","raw_type":"journal-article"},{"id":"pmid:12848728","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12848728","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1046/j.1469-0691.2003.00559.x","doi":"https://doi.org/10.1046/j.1469-0691.2003.00559.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1469-0691.2003.00559.x","pdf_url":null,"source":{"id":"https://openalex.org/S71414007","display_name":"Clinical Microbiology and Infection","issn_l":"1198-743X","issn":["1198-743X","1469-0691"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Microbiology and Infection","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1935895845","https://openalex.org/W1967295727","https://openalex.org/W2073339113","https://openalex.org/W2081417349","https://openalex.org/W2095941723","https://openalex.org/W2098533214","https://openalex.org/W2099125976","https://openalex.org/W2100641815","https://openalex.org/W2110132014","https://openalex.org/W2131305379","https://openalex.org/W2142025154","https://openalex.org/W2158023121","https://openalex.org/W2160194059","https://openalex.org/W2162981315","https://openalex.org/W2166818838","https://openalex.org/W2318911370","https://openalex.org/W2491557885"],"related_works":["https://openalex.org/W2166818838","https://openalex.org/W2122178673","https://openalex.org/W2125087041","https://openalex.org/W2166814950","https://openalex.org/W2118200177","https://openalex.org/W2106831385","https://openalex.org/W2099823842","https://openalex.org/W7100680142","https://openalex.org/W2893041290","https://openalex.org/W2206009250"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}