{"id":"https://openalex.org/W1947612540","doi":"https://doi.org/10.1111/jnc.13349","title":"A new role for AMP \u2010activated protein kinase in the circadian regulation of L\u2010type voltage\u2010gated calcium channels in late\u2010stage embryonic retinal photoreceptors","display_name":"A new role for AMP \u2010activated protein kinase in the circadian regulation of L\u2010type voltage\u2010gated calcium channels in late\u2010stage embryonic retinal photoreceptors","publication_year":2015,"publication_date":"2015-09-04","ids":{"openalex":"https://openalex.org/W1947612540","doi":"https://doi.org/10.1111/jnc.13349","mag":"1947612540","pmid":"https://pubmed.ncbi.nlm.nih.gov/26337027","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4636938"},"language":"en","primary_location":{"id":"doi:10.1111/jnc.13349","doi":"https://doi.org/10.1111/jnc.13349","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jnc.13349","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4636938","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073433254","display_name":"Cathy Chia\u2010Yu Huang","orcid":"https://orcid.org/0000-0002-4091-5163","observed_orcids":["https://orcid.org/0000-0002-4091-5163"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cathy C.Y. Huang","raw_affiliation_strings":["Department of Veterinary Integrative Biosciences College of Veterinary Medicine and Biomedical Sciences Texas A&M University College Station Texas USA","Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences College of Veterinary Medicine and Biomedical Sciences Texas A&M University College Station Texas USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103422929","display_name":"Liheng Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liheng Shi","raw_affiliation_strings":["Department of Veterinary Integrative Biosciences College of Veterinary Medicine and Biomedical Sciences Texas A&M University College Station Texas USA","Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences College of Veterinary Medicine and Biomedical Sciences Texas A&M University College Station Texas USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016379690","display_name":"Chia\u2010Hung Lin","orcid":"https://orcid.org/0000-0003-0150-8001","observed_orcids":["https://orcid.org/0000-0003-0150-8001"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chia\u2010Hung Lin","raw_affiliation_strings":["Department of Veterinary Integrative Biosciences College of Veterinary Medicine and Biomedical Sciences Texas A&M University College Station Texas USA","Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences College of Veterinary Medicine and Biomedical Sciences Texas A&M University College Station Texas USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008845721","display_name":"Andy Jeesu Kim","orcid":"https://orcid.org/0000-0003-1124-0213","observed_orcids":["https://orcid.org/0000-0003-1124-0213"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andy Jeesu Kim","raw_affiliation_strings":["Department of Veterinary Integrative Biosciences College of Veterinary Medicine and Biomedical Sciences Texas A&M University College Station Texas USA","Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences College of Veterinary Medicine and Biomedical Sciences Texas A&M University College Station Texas USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043062769","display_name":"Michael Lee Ko","orcid":"https://orcid.org/0000-0002-2723-2464","observed_orcids":["https://orcid.org/0000-0002-2723-2464"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L. Ko","raw_affiliation_strings":["Department of Veterinary Integrative Biosciences College of Veterinary Medicine and Biomedical Sciences Texas A&M University College Station Texas USA","Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences College of Veterinary Medicine and Biomedical Sciences Texas A&M University College Station Texas USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076008495","display_name":"Gladys Y.\u2010P. Ko","orcid":"https://orcid.org/0000-0002-6854-777X","observed_orcids":["https://orcid.org/0000-0002-6854-777X"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gladys Y.\u2010P. Ko","raw_affiliation_strings":["Department of Veterinary Integrative Biosciences College of Veterinary Medicine and Biomedical Sciences Texas A&M University College Station Texas USA","Texas A&M Institute of Neuroscience Texas A&M University College Station Texas USA","Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences College of Veterinary Medicine and Biomedical Sciences Texas A&M University College Station Texas USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Texas A&M Institute of Neuroscience Texas A&M University College Station Texas USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5076008495"],"corresponding_institution_ids":["https://openalex.org/I91045830"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":1.472,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.7862782,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"135","issue":"4","first_page":"727","last_page":"741"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.7567999958992004,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.7567999958992004,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.2223999947309494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.8220000267028809},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.7990000247955322},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.9850000143051147},{"id":"https://openalex.org/keywords/retinal-photoreceptors","display_name":"retinal photoreceptors","score":0.9419999718666077},{"id":"https://openalex.org/keywords/embryonic-retina","display_name":"embryonic retina","score":0.8700000047683716},{"id":"https://openalex.org/keywords/ampk-phosphorylation","display_name":"AMPK phosphorylation","score":0.7639999985694885},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.7459999918937683},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.8880000114440918},{"id":"https://openalex.org/keywords/mtorc1","display_name":"mTORC1","score":0.9490000009536743},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neurotransmitter-release","display_name":"neurotransmitter release","score":0.7099999785423279},{"id":"https://openalex.org/keywords/chicken-retina","display_name":"chicken retina","score":0.6470000147819519},{"id":"https://openalex.org/keywords/energy-sensing","display_name":"energy sensing","score":0.5659999847412109},{"id":"https://openalex.org/keywords/circadian-clock","display_name":"circadian clock","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5476970076560974},{"id":"https://openalex.org/C18699975","wikidata":"https://www.wikidata.org/wiki/Q14905735","display_name":"Voltage-dependent calcium channel","level":3,"score":0.5459640622138977},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5433580875396729},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.5328346490859985},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5325445532798767},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4875456690788269},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44546523690223694},{"id":"https://openalex.org/C30979828","wikidata":"https://www.wikidata.org/wiki/Q2487620","display_name":"T-type calcium channel","level":4,"score":0.4394729435443878},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4269309341907501},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.36897796392440796},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35405391454696655},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3275578022003174},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28314411640167236},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000620","descriptor_name":"Aminoimidazole Carboxamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000620","descriptor_name":"Aminoimidazole Carboxamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005576","descriptor_name":"Colforsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007097","descriptor_name":"Imines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010078","descriptor_name":"Oxazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010786","descriptor_name":"Photoreceptor Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010786","descriptor_name":"Photoreceptor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D012265","descriptor_name":"Ribonucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020746","descriptor_name":"Calcium Channels, L-Type","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/jnc.13349","doi":"https://doi.org/10.1111/jnc.13349","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jnc.13349","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:26337027","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26337027","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4636938","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4636938","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neurochem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4636938","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4636938","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neurochem","raw_type":"Text"},"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G152576015","display_name":"Functional interactions among retinoschisin and its binding partners","funder_award_id":"R21EY023339","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G1955978931","display_name":"Circadian Rhythm in Cone Photoreceptors:  Cellular Mechanisms","funder_award_id":"R01EY017452","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W138859237","https://openalex.org/W284239171","https://openalex.org/W1523693806","https://openalex.org/W1820592996","https://openalex.org/W1964267325","https://openalex.org/W1965644332","https://openalex.org/W1968885616","https://openalex.org/W1979318277","https://openalex.org/W1979361590","https://openalex.org/W1982537119","https://openalex.org/W1985934685","https://openalex.org/W1989193989","https://openalex.org/W1993123079","https://openalex.org/W1996003588","https://openalex.org/W2004849589","https://openalex.org/W2005226793","https://openalex.org/W2006436366","https://openalex.org/W2007337163","https://openalex.org/W2013753604","https://openalex.org/W2015171350","https://openalex.org/W2016430267","https://openalex.org/W2017771024","https://openalex.org/W2018207324","https://openalex.org/W2021806378","https://openalex.org/W2022828509","https://openalex.org/W2030636484","https://openalex.org/W2031596923","https://openalex.org/W2031817173","https://openalex.org/W2034110828","https://openalex.org/W2039413757","https://openalex.org/W2039931639","https://openalex.org/W2042227355","https://openalex.org/W2045169829","https://openalex.org/W2046822015","https://openalex.org/W2046939832","https://openalex.org/W2047839366","https://openalex.org/W2049929803","https://openalex.org/W2051384280","https://openalex.org/W2052458266","https://openalex.org/W2053802535","https://openalex.org/W2054076512","https://openalex.org/W2055579594","https://openalex.org/W2056125864","https://openalex.org/W2056279586","https://openalex.org/W2060920553","https://openalex.org/W2062593534","https://openalex.org/W2065511465","https://openalex.org/W2065667098","https://openalex.org/W2066771367","https://openalex.org/W2067155699","https://openalex.org/W2069754778","https://openalex.org/W2070910260","https://openalex.org/W2073513922","https://openalex.org/W2076002276","https://openalex.org/W2079580613","https://openalex.org/W2080107084","https://openalex.org/W2082342656","https://openalex.org/W2086607543","https://openalex.org/W2086768172","https://openalex.org/W2087867196","https://openalex.org/W2088262418","https://openalex.org/W2092209687","https://openalex.org/W2094157628","https://openalex.org/W2095454212","https://openalex.org/W2101600063","https://openalex.org/W2106686068","https://openalex.org/W2107359990","https://openalex.org/W2114825009","https://openalex.org/W2128878853","https://openalex.org/W2129022768","https://openalex.org/W2142478420","https://openalex.org/W2144259858","https://openalex.org/W2147734210","https://openalex.org/W2148596718","https://openalex.org/W2149100160","https://openalex.org/W2150551377","https://openalex.org/W2155073817","https://openalex.org/W2157481078","https://openalex.org/W2159620999","https://openalex.org/W2159664830","https://openalex.org/W2161166912","https://openalex.org/W2168238948","https://openalex.org/W2171804530","https://openalex.org/W2216814192"],"related_works":["https://openalex.org/W2728312163","https://openalex.org/W1993123079","https://openalex.org/W2054076512","https://openalex.org/W7099185870","https://openalex.org/W2107359990","https://openalex.org/W2023231528","https://openalex.org/W2087181396","https://openalex.org/W4230428287","https://openalex.org/W1820592996","https://openalex.org/W4254585781"],"abstract_inverted_index":{"AMP-activated":[0,276],"protein":[1,199,277,316],"kinase":[2,224,278,314,317],"(AMPK)":[3,279],"is":[4,10,33,280,294,301],"a":[5,139,195,247,342],"cellular":[6,40,248,343],"energy":[7,249,344],"sensor,":[8,250,345],"which":[9,147],"activated":[11],"when":[12],"the":[13,36,45,67,77,86,119,124,133,152,165,176,189,202,211,215,240,254,260,273,287,304,335,349,355],"intracellular":[14,98],"ATP":[15,107,136,289,292],"production":[16],"decreases.":[17],"The":[18,184],"activities":[19],"of":[20,39,51,79,121,127,157,169,186,201,208,222,228,235,243,263,275,311,323,330,338,358],"AMPK":[21,32,63,80,93,122,158,160,187,209,217,251,299,306,346],"display":[22],"circadian":[23,37,46,69,90,125,155,166,241,261,282,336,356],"rhythms":[24,156],"in":[25,35,66,85,123,164,198,238,269,333],"various":[26],"organs":[27],"and":[28,54,61,92,114,154,225,284,320],"tissues,":[29],"indicating":[30],"that":[31,76,132,142,268],"involved":[34,65,163],"regulation":[38,126,168],"metabolism.":[41],"In":[42],"vertebrate":[43],"retina,":[44,272],"clocks":[47],"regulate":[48,102,259,354],"many":[49],"aspects":[50],"retinal":[52,68,135,288],"function":[53],"physiology,":[55],"including":[56],"light/dark":[57],"adaption,":[58],"but":[59,233,328],"whether":[60],"how":[62],"was":[64,71,88,148,161],"rhythm":[70,141,242,262,337,357],"not":[72],"known.":[73],"We":[74,105,130,266],"hypothesized":[75],"activation":[78,185,274],"(measured":[81],"as":[82,246,341],"phosphorylated":[83,298],"AMPK)":[84],"retina":[87],"under":[89,281],"control,":[91],"might":[94],"interact":[95],"with":[96,194],"other":[97],"signaling":[99,256,351],"molecules":[100],"to":[101,117,151,219,258,286,308,353],"photoreceptor":[103,128,170,264,359],"physiology.":[104,129,265,360],"combined":[106],"assays,":[108],"western":[109],"blots,":[110],"immunostaining,":[111],"patch-clamp":[112],"recordings,":[113],"pharmacological":[115],"treatments":[116],"decipher":[118],"role":[120],"found":[131,267],"overall":[134],"content":[137,293],"displayed":[138],"diurnal":[140,153],"peaked":[143],"at":[144,192,296],"early":[145],"night,":[146,297],"nearly":[149],"anti-phase":[150,285],"phosphorylation.":[159],"also":[162],"phase-dependent":[167],"L-type":[171],"voltage-gated":[172],"calcium":[173],"channels":[174],"(L-VGCCs),":[175],"ion":[177],"channel":[178],"essential":[179],"for":[180],"sustained":[181],"neurotransmitter":[182],"release.":[183],"dampened":[188],"L-VGCC":[190,212],"currents":[191],"night":[193],"corresponding":[196],"decrease":[197],"expression":[200],"L-VGCC\u03b11":[203],"pore-forming":[204],"subunit,":[205],"while":[206],"inhibition":[207],"increased":[210],"current":[213],"during":[214,303],"day.":[216,305],"appeared":[218],"be":[220,309],"upstream":[221,310],"extracellular-signal-regulated":[223],"mammalian/mechanistic":[226],"target":[227,322],"rapamycin":[229,324],"complex":[230,325],"1":[231,326],"(mTORC1)":[232,327],"downstream":[234,329],"adenylyl":[236,331],"cyclase":[237,332],"regulating":[239,334],"L-VGCCs.":[244,339],"Hence,":[245],"integrates":[252,347],"into":[253,348],"cell":[255,350],"network":[257,352],"chicken":[270],"embryonic":[271],"control":[283],"rhythm.":[290],"While":[291],"higher":[295,302],"(pAMPK)":[300],"appears":[307],"extracellular":[312],"signal-regulated":[313],"(ERK),":[315],"B":[318],"(AKT),":[319],"mammalian":[321],"Therefore,":[340]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}