{"id":"https://openalex.org/W1947513268","doi":null,"title":"Role of BMP signaling and ASNA1 in \u03b2-cells","display_name":"Role of BMP signaling and ASNA1 in \u03b2-cells","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W1947513268","mag":"1947513268"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:umu-1810","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1810","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1810","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075612843","display_name":"Joan Goulley","orcid":"https://orcid.org/0000-0003-1216-6473","observed_orcids":["https://orcid.org/0000-0003-1216-6473"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joan Goulley","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1216-6473","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5075612843"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bmp-signaling","display_name":"BMP signaling","score":0.9710000157356262},{"id":"https://openalex.org/keywords/bmp4","display_name":"BMP4","score":0.7730000019073486},{"id":"https://openalex.org/keywords/bmpr-ia","display_name":"BMPR-IA","score":0.9919999837875366},{"id":"https://openalex.org/keywords/beta-cell-function","display_name":"beta-cell function","score":0.7850000262260437},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.9810000061988831},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9330000281333923},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.5419999957084656},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.6299999952316284},{"id":"https://openalex.org/keywords/beta-cell-hyperplasia","display_name":"beta-cell hyperplasia","score":0.9760000109672546},{"id":"https://openalex.org/keywords/islet-development","display_name":"islet development","score":0.550000011920929},{"id":"https://openalex.org/keywords/pancreas-development","display_name":"pancreatic development","score":0.5479999780654907},{"id":"https://openalex.org/keywords/insulin-exocytosis","display_name":"insulin exocytosis","score":0.6740000247955322},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.4410000145435333},{"id":"https://openalex.org/keywords/igf-signaling","display_name":"IGF signaling","score":0.5109999775886536},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.753000020980835},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4797314703464508},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.424643337726593},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36042219400405884},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35537633299827576},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.3380788564682007}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:umu-1810","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1810","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1947513268","doi":null,"is_oa":false,"landing_page_url":"http://umu.diva-portal.org/smash/get/diva2:142067/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:umu-1810","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1810","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":187,"referenced_works":["https://openalex.org/W415762431","https://openalex.org/W1488156534","https://openalex.org/W1502963062","https://openalex.org/W1518683511","https://openalex.org/W1519258930","https://openalex.org/W1562023127","https://openalex.org/W1562291393","https://openalex.org/W1585826109","https://openalex.org/W1666089077","https://openalex.org/W1672597967","https://openalex.org/W1768073869","https://openalex.org/W1840163537","https://openalex.org/W1901140894","https://openalex.org/W1918701699","https://openalex.org/W1923939500","https://openalex.org/W1930281617","https://openalex.org/W1933247863","https://openalex.org/W1957887137","https://openalex.org/W1965583863","https://openalex.org/W1966544076","https://openalex.org/W1970713148","https://openalex.org/W1971713572","https://openalex.org/W1973185212","https://openalex.org/W1973758621","https://openalex.org/W1975173509","https://openalex.org/W1976213734","https://openalex.org/W1976757974","https://openalex.org/W1979354924","https://openalex.org/W1979518793","https://openalex.org/W1981718544","https://openalex.org/W1984288177","https://openalex.org/W1987417071","https://openalex.org/W1989167529","https://openalex.org/W1990185237","https://openalex.org/W1991999829","https://openalex.org/W1993467921","https://openalex.org/W1994531379","https://openalex.org/W1995415926","https://openalex.org/W1995573327","https://openalex.org/W1998854046","https://openalex.org/W1999209604","https://openalex.org/W2001648811","https://openalex.org/W2005754586","https://openalex.org/W2008986362","https://openalex.org/W2012213600","https://openalex.org/W2012825366","https://openalex.org/W2014174766","https://openalex.org/W2015877043","https://openalex.org/W2017478364","https://openalex.org/W2017951061","https://openalex.org/W2017961089","https://openalex.org/W2018364757","https://openalex.org/W2018788397","https://openalex.org/W2019075331","https://openalex.org/W2019601491","https://openalex.org/W2020076165","https://openalex.org/W2021384992","https://openalex.org/W2021713059","https://openalex.org/W2022697316","https://openalex.org/W2023189063","https://openalex.org/W2025019677","https://openalex.org/W2025143098","https://openalex.org/W2025397278","https://openalex.org/W2029759017","https://openalex.org/W2030243679","https://openalex.org/W2031476702","https://openalex.org/W2032322539","https://openalex.org/W2033349405","https://openalex.org/W2033663596","https://openalex.org/W2034647529","https://openalex.org/W2038353863","https://openalex.org/W2042688172","https://openalex.org/W2044384686","https://openalex.org/W2045060862","https://openalex.org/W2047645921","https://openalex.org/W2048068440","https://openalex.org/W2048248981","https://openalex.org/W2049378918","https://openalex.org/W2052270789","https://openalex.org/W2052352342","https://openalex.org/W2053330926","https://openalex.org/W2053709222","https://openalex.org/W2054704723","https://openalex.org/W2056291551","https://openalex.org/W2056860785","https://openalex.org/W2056914659","https://openalex.org/W2059467226","https://openalex.org/W2063676381","https://openalex.org/W2064405202","https://openalex.org/W2064438699","https://openalex.org/W2064439294","https://openalex.org/W2065403221","https://openalex.org/W2066884920","https://openalex.org/W2067944947","https://openalex.org/W2070985778","https://openalex.org/W2071700101","https://openalex.org/W2072985278","https://openalex.org/W2073231769","https://openalex.org/W2074528335","https://openalex.org/W2074629755","https://openalex.org/W2075091167","https://openalex.org/W2075993125","https://openalex.org/W2076439289","https://openalex.org/W2076511407","https://openalex.org/W2077742875","https://openalex.org/W2078643425","https://openalex.org/W2078780001","https://openalex.org/W2079562282","https://openalex.org/W2080473045","https://openalex.org/W2081409453","https://openalex.org/W2081530642","https://openalex.org/W2082452703","https://openalex.org/W2084707443","https://openalex.org/W2087339765","https://openalex.org/W2090847725","https://openalex.org/W2090905598","https://openalex.org/W2091942573","https://openalex.org/W2092950215","https://openalex.org/W2094074434","https://openalex.org/W2094147241","https://openalex.org/W2094367541","https://openalex.org/W2094657730","https://openalex.org/W2095380487","https://openalex.org/W2095605427","https://openalex.org/W2097198889","https://openalex.org/W2097352432","https://openalex.org/W2097784879","https://openalex.org/W2098854866","https://openalex.org/W2098915229","https://openalex.org/W2107718435","https://openalex.org/W2108791332","https://openalex.org/W2108814958","https://openalex.org/W2109286159","https://openalex.org/W2111236186","https://openalex.org/W2111612257","https://openalex.org/W2112421001","https://openalex.org/W2112944917","https://openalex.org/W2113905390","https://openalex.org/W2113978399","https://openalex.org/W2115593116","https://openalex.org/W2119893364","https://openalex.org/W2122379385","https://openalex.org/W2122603966","https://openalex.org/W2124430683","https://openalex.org/W2128167237","https://openalex.org/W2128764237","https://openalex.org/W2129537171","https://openalex.org/W2131243531","https://openalex.org/W2133162233","https://openalex.org/W2135600268","https://openalex.org/W2136585808","https://openalex.org/W2140923392","https://openalex.org/W2141191556","https://openalex.org/W2141591525","https://openalex.org/W2141610168","https://openalex.org/W2142769261","https://openalex.org/W2142986021","https://openalex.org/W2144107141","https://openalex.org/W2144444855","https://openalex.org/W2144804501","https://openalex.org/W2144830297","https://openalex.org/W2144924187","https://openalex.org/W2146423741","https://openalex.org/W2146466993","https://openalex.org/W2148365781","https://openalex.org/W2148622607","https://openalex.org/W2150095569","https://openalex.org/W2151297568","https://openalex.org/W2153605535","https://openalex.org/W2154527769","https://openalex.org/W2154568166","https://openalex.org/W2156219329","https://openalex.org/W2157292965","https://openalex.org/W2158511807","https://openalex.org/W2159306966","https://openalex.org/W2162569219","https://openalex.org/W2163961147","https://openalex.org/W2164861152","https://openalex.org/W2166051507","https://openalex.org/W2168923116","https://openalex.org/W2169009865","https://openalex.org/W2169293623","https://openalex.org/W2316713837","https://openalex.org/W2411968291","https://openalex.org/W6987196020","https://openalex.org/W7073996717","https://openalex.org/W7118118724"],"related_works":["https://openalex.org/W156597469","https://openalex.org/W2064756027","https://openalex.org/W1999760409","https://openalex.org/W2582665978","https://openalex.org/W4411295124","https://openalex.org/W2245134671","https://openalex.org/W2949015850","https://openalex.org/W4411058441","https://openalex.org/W3171822702","https://openalex.org/W2039390617"],"abstract_inverted_index":{"Patients":[0],"with":[1],"type":[2,171],"II":[3],"diabetes":[4,343],"present":[5],"alterations":[6],"in":[7,47,104,136,186,208,220,234,249,272,310,326,354,363],"glucose":[8,48,67,96,131,150],"homeostasis":[9],"due":[10,344],"to":[11,20,37,69,106,129,147,242,289,307,331,345],"insufficient":[12],"amount":[13],"of":[14,55,63,80,110,144,156,169,177,189,232,239,265,276,296,324,328,351,365,373],"insulin":[15,24,70,83,135,162,273,347,359,387],"(\u03b2-cell":[16],"dysfunction)":[17],"and":[18,32,43,57,90,114,122,158,179,183,200,210,227,279,314,334,358],"inability":[19],"properly":[21],"use":[22],"the":[23,44,64,82,87,108,145,175,253,263,266,280],"that":[25,181,198,217,228,256,321,371],"is":[26,53,86,152,165,188,223,270,361],"secreted":[27],"(insulin":[28],"resistance).":[29],"Combined":[30],"genetical":[31],"environmental":[33],"factors":[34],"are":[35,206],"believed":[36],"be":[38],"responsible":[39],"for":[40,94,119,154,225],"these":[41,366],"dysfunctions":[42],"resulting":[45],"impairment":[46],"homeostasis.":[49],"The":[50,60,125,349],"pancreatic":[51],"gland":[52],"composed":[54],"exocrine":[56],"endocrine":[58,61,74],"tissues.":[59],"part":[62],"organ":[65],"couples":[66],"sensing":[68],"release.":[71],"Within":[72],"this":[73,99],"gland,":[75],"also":[76,214],"known":[77],"as":[78,291],"islets":[79,364],"Langerhans,":[81],"secreting":[84,134],"\u03b2-cell":[85,123,127,146,222,335,382],"main":[88],"player":[89],"therefore":[91],"highly":[92],"important":[93],"proper":[95],"metabolism.":[97],"In":[98,301],"thesis,":[100],"mice":[101,243,329,340],"were":[102],"developed":[103],"order":[105],"assess":[107],"role":[109],"BMP":[111],"signaling":[112,219,248],"molecule":[113],"Arsenite":[115,259],"induced":[116,260],"ATPase-1":[117],"(Asna1)":[118],"pancreas":[120],"development":[121],"function.":[124],"mature":[126],"responds":[128],"elevated":[130,148],"levels":[132,151],"by":[133,377],"a":[137,166,311],"tightly":[138],"controlled":[139],"manner.":[140,317],"This":[141],"physiological":[142],"response":[143],"blood":[149],"critical":[153],"maintenance":[155],"normoglycaemia":[157],"impaired":[159,346],"Glucose":[160],"stimulated":[161],"secretion":[163,355],"(GSIS)":[164],"prominent":[167],"feature":[168],"overt":[170],"2":[172],"diabetes.":[173],"Thus,":[174,246],"identification":[176],"signals":[178],"pathways":[180],"ensure":[182],"stimulate":[184],"GSIS":[185],"\u03b2-cells":[187,235,250,327],"great":[190],"clinical":[191],"interest.":[192],"Here":[193,318],"we":[194,319],"show":[195,320],"(Paper":[196],"I)":[197],"BMPRIA":[199,218],"its":[201],"high":[202],"affinity":[203],"ligand":[204],"BMP4":[205,240],"expressed":[207,271],"fetal":[209],"adult":[211,221],"islets.":[212],"We":[213],"provide":[215],"evidence":[216],"required":[224],"GSIS,":[226],"both":[229,277],"transgenic":[230,322,339],"expression":[231,323,350],"Bmp4":[233],"or":[236],"systemic":[237],"administration":[238],"protein":[241],"enhances":[244],"GSIS.":[245,258],"BMP4-BMPRIA":[247],"positively":[251,380],"regulates":[252],"genetic":[254],"machinery":[255],"ensures":[257],"ATPase":[261],"(Asna1),":[262],"homologue":[264],"bacterial":[267],"ArsA":[268],"ATPase,":[269],"producing":[274],"cells":[275],"mammals":[278],"nematode":[281],"Caenorhabditis":[282],"elegans":[283],"(C.elegans).":[284],"Asna1":[285],"has":[286,304],"been":[287,305],"proposed":[288],"act":[290],"an":[292],"evolutionary":[293],"conserved":[294],"regulator":[295],"insulin/insulin":[297],"like":[298],"factor":[299],"signaling.":[300],"C.elegans,":[302],"asna-1":[303],"shown":[306],"regulate":[308],"growth":[309],"non-cell":[312],"autonomous":[313],"IGF-receptor":[315],"dependent":[316],"ASNA1":[325,338],"leads":[330],"enhanced":[332,378],"Aktactivity":[333],"hyperplasia":[336],"(manuscript).":[337],"develop,":[341],"however,":[342],"secretion.":[348,388],"genes":[352],"involved":[353],"stimulus":[356],"coupling":[357],"exocytosis":[360],"perturbed":[362],"mice.":[367],"These":[368],"data":[369],"suggest":[370],"activation":[372],"ASNA1,":[374],"here":[375],"mimicked":[376],"expression,":[379],"influences":[381],"mass":[383],"but":[384],"negatively":[385],"affects":[386]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
