{"id":"https://openalex.org/W1946767955","doi":null,"title":"Concomitant increases in galectin-1 and its glycoconjugate ligands (carcinoembryonic antigen, lamp-1, and lamp-2) in cultured human colon carcinoma cells by sodium butyrate.","display_name":"Concomitant increases in galectin-1 and its glycoconjugate ligands (carcinoembryonic antigen, lamp-1, and lamp-2) in cultured human colon carcinoma cells by sodium butyrate.","publication_year":1994,"publication_date":"1994-11-15","ids":{"openalex":"https://openalex.org/W1946767955","mag":"1946767955","pmid":"https://pubmed.ncbi.nlm.nih.gov/7954433"},"language":"en","primary_location":{"id":"pmid:7954433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7954433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083534584","display_name":"David W. Ohannesian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D W Ohannesian","raw_affiliation_strings":["Department of Tumor Biology, University of Texas M. D. Anderson Cancer Center, Houston 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tumor Biology, University of Texas M. D. Anderson Cancer Center, Houston 77030","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022564834","display_name":"Dafna Lotan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Lotan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063003854","display_name":"Reuben Lotan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Lotan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.529,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.8375614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"54","issue":"22","first_page":"5992","last_page":"6000"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/galectin-3","display_name":"galectin-3","score":0.9750000238418579},{"id":"https://openalex.org/keywords/sodium-butyrate","display_name":"sodium butyrate","score":0.9390000104904175},{"id":"https://openalex.org/keywords/colon-cancer-cells","display_name":"colon cancer cells","score":0.8149999976158142},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.5440000295639038},{"id":"https://openalex.org/keywords/carcinoembryonic-antigen","display_name":"carcinoembryonic antigen","score":0.8690000176429749},{"id":"https://openalex.org/keywords/lamp1","display_name":"LAMP1","score":0.9309999942779541},{"id":"https://openalex.org/keywords/lamp2","display_name":"LAMP2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cell-surface-expression","display_name":"cell surface expression","score":0.5009999871253967},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.6159999966621399},{"id":"https://openalex.org/keywords/differentiation-inducing-agents","display_name":"differentiation-inducing agents","score":0.7200000286102295},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.5019999742507935},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.5320000052452087},{"id":"https://openalex.org/keywords/cell-flattening","display_name":"cell flattening","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C2778942008","wikidata":"https://www.wikidata.org/wiki/Q305004","display_name":"Sodium butyrate","level":3,"score":0.781669020652771},{"id":"https://openalex.org/C2776979534","wikidata":"https://www.wikidata.org/wiki/Q193213","display_name":"Butyrate","level":3,"score":0.6227858066558838},{"id":"https://openalex.org/C2777387746","wikidata":"https://www.wikidata.org/wiki/Q769706","display_name":"Carcinoembryonic antigen","level":3,"score":0.5897117257118225},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5279387831687927},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5243775248527527},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48603683710098267},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.43201449513435364},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.42164507508277893},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39033693075180054},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37344151735305786},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2643307149410248},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.15384092926979065},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000943","descriptor_name":"Antigens, Differentiation","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002087","descriptor_name":"Butyrates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002272","descriptor_name":"Carcinoembryonic Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006388","descriptor_name":"Hemagglutinins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006388","descriptor_name":"Hemagglutinins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020148","descriptor_name":"Butyric Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037483","descriptor_name":"Galectin 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037502","descriptor_name":"Galectin 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051907","descriptor_name":"Lysosomal Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7954433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7954433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1946767955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7954433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1592737632","https://openalex.org/W2143194392","https://openalex.org/W2275319095","https://openalex.org/W1988575010","https://openalex.org/W1992475307","https://openalex.org/W2164905742","https://openalex.org/W2409182770","https://openalex.org/W2058352411","https://openalex.org/W2075607047","https://openalex.org/W2155328554"],"abstract_inverted_index":{"Galactoside-binding":[0],"lectins":[1],"(galectins)":[2],"with":[3,95,128,176,361],"molecular":[4],"masses":[5],"of":[6,21,33,56,69,79,92,110,130,198,203,212,249,254,272,318,364,383],"about":[7],"14.5":[8],"kilodaltons":[9,13],"(galectin-1)":[10],"and":[11,23,26,38,62,154,189,194,241,307,340,367,379],"31":[12],"(galectin-3)":[14],"have":[15,27],"been":[16,28],"found":[17,48,300],"in":[18,30,87,107,166,192,216,349,375],"a":[19,201,266],"variety":[20],"normal":[22],"malignant":[24],"cells":[25,94,179,366],"implicated":[29],"the":[31,54,67,77,88,108,131,177,196,242,255,270,279,330,345,362],"regulation":[32],"cell":[34,36,45,73,172,184,187,207,280,286,321],"growth,":[35],"adhesion,":[37],"metastasis.":[39],"The":[40,214,252],"KM12":[41,89,178,320,365],"human":[42,169,204,297],"colon":[43,103,170,205,376],"carcinoma":[44,104,171,206,377],"line":[46],"was":[47,113,125,164,219,231,244,259,276,299],"to":[49,83,265,301,303,308,372],"express":[50],"only":[51],"galectin-3.":[52],"Because":[53],"levels":[55],"both":[57],"galectins":[58],"are":[59,344,381],"developmentally":[60],"regulated":[61],"can":[63],"be":[64,359,373],"modulated":[65],"during":[66],"differentiation":[68,363],"several":[70,369],"cultured":[71],"tumor":[72],"lines,":[74],"we":[75],"studied":[76],"ability":[78],"11":[80],"differentiation-inducing":[81,100],"agents":[82],"induce":[84],"galectin-1":[85,217,275,298,325,356],"expression":[86,230,357],"cells.":[90,351],"Treatment":[91],"these":[93,350],"sodium":[96],"butyrate,":[97],"an":[98],"established":[99],"agent":[101],"for":[102],"cells,":[105],"resulted":[106],"induction":[109,161],"galectin-1,":[111],"which":[112],"detected":[114,232,245,277],"by":[115,120,162,233,262,282,292,327],"immunoblotting":[116],"as":[117,119,236,238,289,291,385],"well":[118,290],"affinity":[121],"chromatography.":[122],"This":[123],"effect":[124],"not":[126],"seen":[127],"any":[129],"10":[132],"other":[133,168],"differentiating":[134],"agents:":[135],"hexamethylene":[136],"bisacetamide,":[137],"dimethyl":[138,140],"sulfoxide,":[139],"formamide,":[141],"herbimycin":[142],"A,":[143],"mycophenolic":[144],"acid,":[145,147],"retinoic":[146],"difluoromethyl":[148],"ornithine,":[149],"dibutyryl":[150],"cAMP,":[151,153],"8-chloro":[152],"transforming":[155],"growth":[156],"factor":[157],"beta":[158],"1.":[159],"Galectin-1":[160,228],"butyrate":[163,182,223,263],"observed":[165],"seven":[167],"lines.":[173],"Further":[174],"studies":[175],"revealed":[180],"that":[181,334,355,368],"caused":[183],"flattening,":[185],"suppressed":[186],"proliferation":[188],"colony":[190],"formation":[191],"agarose,":[193],"increased":[195,261],"level":[197,218,253,271],"carcinoembryonic":[199,338],"antigen,":[200,339],"marker":[202],"differentiation,":[208],"within":[209],"48":[210],"h":[211,248],"treatment.":[213],"increase":[215],"dependent":[220],"linearly":[221],"on":[222,278,323],"concentration":[224],"(range,":[225],"1-4":[226],"mM).":[227],"mRNA":[229],"Northern":[234],"blotting":[235],"early":[237],"6":[239],"h,":[240],"protein":[243],"after":[246],"24":[247],"treatment":[250],"initiation.":[251],"constitutively":[256],"expressed":[257],"galectin-3":[258],"also":[260],"but":[264],"lesser":[267],"extent":[268],"than":[269],"galectin-1.":[273],"Butyrate-induced":[274],"surface":[281,287],"immunoprecipitation":[283,328],"from":[284,329],"radioiodinated":[285],"proteins":[288,311,348],"indirect":[293],"immunofluorescence":[294],"labeling.":[295],"Affinity-purified":[296],"bind":[302],"purified":[304],"polylactosamine-containing":[305],"glycoproteins":[306,370],"detergent-solubilized":[309],"cellular":[310],"electroblotted":[312],"onto":[313],"nitrocellulose":[314],"membranes.":[315],"Affinity":[316],"chromatography":[317],"[3H]glucosamine-labeled":[319],"extracts":[322],"immobilized":[324],"followed":[326],"lactose-eluted":[331],"material":[332],"demonstrated":[333],"lysosome-associated":[335],"membrane":[336],"glycoprotein-1,":[337],"nonspecific":[341],"cross-reacting":[342],"antigen":[343],"major":[346],"galectin-1-binding":[347],"These":[352],"results":[353],"indicate":[354],"may":[358],"associated":[360],"shown":[371],"important":[374],"adhesion":[378],"metastasis":[380],"capable":[382],"functioning":[384],"its":[386],"endogenous":[387],"ligands.":[388]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
