{"id":"https://openalex.org/W1946018","doi":null,"title":"The Role of CC chemokine Receptors 6 and 7 in the Immune Response to Respiratory Syncytial Virus.","display_name":"The Role of CC chemokine Receptors 6 and 7 in the Immune Response to Respiratory Syncytial Virus.","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W1946018","mag":"1946018"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/75881","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/75881","pdf_url":"https://hdl.handle.net/2027.42/75881","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2027.42/75881","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088461955","display_name":"Lara E. Kallal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lara E. Kallal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5088461955"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.8471999764442444,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.8471999764442444,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.1363999992609024,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/respiratory-syncytial-virus","display_name":"respiratory syncytial virus","score":0.9779999852180481},{"id":"https://openalex.org/keywords/ccr6","display_name":"CCR6","score":0.9869999885559082},{"id":"https://openalex.org/keywords/ccr7","display_name":"CCR7","score":1.0},{"id":"https://openalex.org/keywords/chemokine-receptors","display_name":"chemokine receptors","score":0.9739999771118164},{"id":"https://openalex.org/keywords/immune-cell-trafficking","display_name":"immune cell trafficking","score":0.9010000228881836},{"id":"https://openalex.org/keywords/dendritic-cell-recruitment","display_name":"dendritic cell recruitment","score":0.8180000185966492},{"id":"https://openalex.org/keywords/th2-cytokines","display_name":"Th2 cytokines","score":0.972000002861023},{"id":"https://openalex.org/keywords/mucus-production","display_name":"mucus production","score":0.9490000009536743},{"id":"https://openalex.org/keywords/pulmonary-pathology","display_name":"lung pathology","score":0.6520000100135803},{"id":"https://openalex.org/keywords/lymph-node-homing","display_name":"lymph node homing","score":0.8220000267028809},{"id":"https://openalex.org/keywords/viral-clearance","display_name":"viral clearance","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.689154863357544},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6343794465065002},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.592380166053772},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.472381591796875},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.4702414870262146},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4573099613189697},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4421895146369934},{"id":"https://openalex.org/C29146819","wikidata":"https://www.wikidata.org/wiki/Q21113975","display_name":"CCL13","level":5,"score":0.4357397258281708},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41375958919525146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4063548445701599},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36407360434532166},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08026796579360962}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/75881","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/75881","pdf_url":"https://hdl.handle.net/2027.42/75881","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:1946018","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/handle/2027.42/75881","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/75881","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/75881","pdf_url":"https://hdl.handle.net/2027.42/75881","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1946018.pdf","grobid_xml":"https://content.openalex.org/works/W1946018.grobid-xml"},"referenced_works_count":291,"referenced_works":["https://openalex.org/W43830887","https://openalex.org/W149750147","https://openalex.org/W159487049","https://openalex.org/W1480767611","https://openalex.org/W1486722793","https://openalex.org/W1499978168","https://openalex.org/W1502104604","https://openalex.org/W1509473864","https://openalex.org/W1511359439","https://openalex.org/W1511825494","https://openalex.org/W1517310071","https://openalex.org/W1534594872","https://openalex.org/W1543659825","https://openalex.org/W1549296148","https://openalex.org/W1559182187","https://openalex.org/W1561788579","https://openalex.org/W1567420244","https://openalex.org/W1575585006","https://openalex.org/W1579010799","https://openalex.org/W1580762659","https://openalex.org/W1585397838","https://openalex.org/W1592851115","https://openalex.org/W1595632800","https://openalex.org/W1597726496","https://openalex.org/W1642011293","https://openalex.org/W1653683821","https://openalex.org/W1661249704","https://openalex.org/W1666510860","https://openalex.org/W1749517211","https://openalex.org/W1787048953","https://openalex.org/W1841966953","https://openalex.org/W1855035065","https://openalex.org/W1885601830","https://openalex.org/W1894593978","https://openalex.org/W1896786295","https://openalex.org/W1898933481","https://openalex.org/W1910028331","https://openalex.org/W1913350003","https://openalex.org/W1924258068","https://openalex.org/W1925238017","https://openalex.org/W1959664751","https://openalex.org/W1962132325","https://openalex.org/W1965737177","https://openalex.org/W1966911537","https://openalex.org/W1967896457","https://openalex.org/W1967994686","https://openalex.org/W1969184940","https://openalex.org/W1969686369","https://openalex.org/W1971057004","https://openalex.org/W1971571828","https://openalex.org/W1972140301","https://openalex.org/W1972755311","https://openalex.org/W1972873370","https://openalex.org/W1972998243","https://openalex.org/W1973470349","https://openalex.org/W1974542809","https://openalex.org/W1975633275","https://openalex.org/W1977981962","https://openalex.org/W1980185618","https://openalex.org/W1981046587","https://openalex.org/W1981769649","https://openalex.org/W1984155824","https://openalex.org/W1984328509","https://openalex.org/W1985311972","https://openalex.org/W1985364817","https://openalex.org/W1987550275","https://openalex.org/W1987735044","https://openalex.org/W1988008315","https://openalex.org/W1988930241","https://openalex.org/W1989195151","https://openalex.org/W1989418011","https://openalex.org/W1995445386","https://openalex.org/W1995509027","https://openalex.org/W1998444876","https://openalex.org/W1998470464","https://openalex.org/W1998515468","https://openalex.org/W1999795586","https://openalex.org/W2002851113","https://openalex.org/W2002987322","https://openalex.org/W2003687800","https://openalex.org/W2004995275","https://openalex.org/W2007121925","https://openalex.org/W2007220082","https://openalex.org/W2007761469","https://openalex.org/W2008090159","https://openalex.org/W2008161823","https://openalex.org/W2009053589","https://openalex.org/W2009074857","https://openalex.org/W2011219821","https://openalex.org/W2014750930","https://openalex.org/W2016297238","https://openalex.org/W2016850513","https://openalex.org/W2016984863","https://openalex.org/W2017218161","https://openalex.org/W2017851594","https://openalex.org/W2017971249","https://openalex.org/W2019931906","https://openalex.org/W2020191064","https://openalex.org/W2021310559","https://openalex.org/W2021420257","https://openalex.org/W2021786991","https://openalex.org/W2023128342","https://openalex.org/W2023594156","https://openalex.org/W2024085541","https://openalex.org/W2024166644","https://openalex.org/W2024292823","https://openalex.org/W2027653403","https://openalex.org/W2028653503","https://openalex.org/W2029640857","https://openalex.org/W2029790299","https://openalex.org/W2030139850","https://openalex.org/W2031302274","https://openalex.org/W2033229769","https://openalex.org/W2033281900","https://openalex.org/W2035831689","https://openalex.org/W2036128117","https://openalex.org/W2038271225","https://openalex.org/W2039118188","https://openalex.org/W2039467806","https://openalex.org/W2042586707","https://openalex.org/W2044144714","https://openalex.org/W2044580027","https://openalex.org/W2046325875","https://openalex.org/W2046637170","https://openalex.org/W2046842929","https://openalex.org/W2048706422","https://openalex.org/W2049398130","https://openalex.org/W2049843618","https://openalex.org/W2049998759","https://openalex.org/W2050646365","https://openalex.org/W2051874642","https://openalex.org/W2053869402","https://openalex.org/W2054076321","https://openalex.org/W2054686030","https://openalex.org/W2055671309","https://openalex.org/W2056520529","https://openalex.org/W2057987972","https://openalex.org/W2058870545","https://openalex.org/W2060527543","https://openalex.org/W2060616257","https://openalex.org/W2062215675","https://openalex.org/W2062367951","https://openalex.org/W2065167529","https://openalex.org/W2065708991","https://openalex.org/W2065734531","https://openalex.org/W2068639447","https://openalex.org/W2069688692","https://openalex.org/W2069891242","https://openalex.org/W2073528254","https://openalex.org/W2076889715","https://openalex.org/W2076971119","https://openalex.org/W2077290707","https://openalex.org/W2078564225","https://openalex.org/W2078706891","https://openalex.org/W2078768973","https://openalex.org/W2079439641","https://openalex.org/W2079622572","https://openalex.org/W2080798548","https://openalex.org/W2080935386","https://openalex.org/W2081114699","https://openalex.org/W2081356514","https://openalex.org/W2081487051","https://openalex.org/W2085197318","https://openalex.org/W2086700987","https://openalex.org/W2087568024","https://openalex.org/W2087829551","https://openalex.org/W2089743844","https://openalex.org/W2091180924","https://openalex.org/W2091564177","https://openalex.org/W2091655826","https://openalex.org/W2092933213","https://openalex.org/W2095516835","https://openalex.org/W2096176011","https://openalex.org/W2097296981","https://openalex.org/W2099931435","https://openalex.org/W2100349623","https://openalex.org/W2100545178","https://openalex.org/W2101292818","https://openalex.org/W2102018690","https://openalex.org/W2102826458","https://openalex.org/W2103555767","https://openalex.org/W2103728319","https://openalex.org/W2104167354","https://openalex.org/W2104898251","https://openalex.org/W2105952979","https://openalex.org/W2106962511","https://openalex.org/W2107184059","https://openalex.org/W2107303449","https://openalex.org/W2107484609","https://openalex.org/W2110491264","https://openalex.org/W2112133235","https://openalex.org/W2112284938","https://openalex.org/W2112601164","https://openalex.org/W2113328122","https://openalex.org/W2113821008","https://openalex.org/W2114123652","https://openalex.org/W2114884151","https://openalex.org/W2115252737","https://openalex.org/W2116828514","https://openalex.org/W2117342688","https://openalex.org/W2118390739","https://openalex.org/W2118526748","https://openalex.org/W2119627949","https://openalex.org/W2120010406","https://openalex.org/W2120346567","https://openalex.org/W2120750267","https://openalex.org/W2121464855","https://openalex.org/W2121602730","https://openalex.org/W2121946255","https://openalex.org/W2122402883","https://openalex.org/W2123166427","https://openalex.org/W2123817481","https://openalex.org/W2124876252","https://openalex.org/W2125115617","https://openalex.org/W2125650988","https://openalex.org/W2125798282","https://openalex.org/W2125818108","https://openalex.org/W2126246192","https://openalex.org/W2126620099","https://openalex.org/W2127440907","https://openalex.org/W2128070330","https://openalex.org/W2128212391","https://openalex.org/W2128364938","https://openalex.org/W2130188796","https://openalex.org/W2130611320","https://openalex.org/W2130892116","https://openalex.org/W2131354424","https://openalex.org/W2131815101","https://openalex.org/W2134224958","https://openalex.org/W2135341184","https://openalex.org/W2135498185","https://openalex.org/W2135790224","https://openalex.org/W2136059362","https://openalex.org/W2136357996","https://openalex.org/W2139226941","https://openalex.org/W2139668698","https://openalex.org/W2140005369","https://openalex.org/W2140117437","https://openalex.org/W2142546120","https://openalex.org/W2142623363","https://openalex.org/W2142813932","https://openalex.org/W2142877732","https://openalex.org/W2143014879","https://openalex.org/W2144217311","https://openalex.org/W2145154571","https://openalex.org/W2145783587","https://openalex.org/W2146536283","https://openalex.org/W2146934919","https://openalex.org/W2147155368","https://openalex.org/W2147516417","https://openalex.org/W2147637750","https://openalex.org/W2149004933","https://openalex.org/W2149037336","https://openalex.org/W2149789162","https://openalex.org/W2150317449","https://openalex.org/W2151109138","https://openalex.org/W2151546806","https://openalex.org/W2151966368","https://openalex.org/W2152470229","https://openalex.org/W2153215221","https://openalex.org/W2154567574","https://openalex.org/W2154896319","https://openalex.org/W2155013311","https://openalex.org/W2155081125","https://openalex.org/W2155158134","https://openalex.org/W2158259557","https://openalex.org/W2158407455","https://openalex.org/W2158722408","https://openalex.org/W2159207062","https://openalex.org/W2159252214","https://openalex.org/W2159482780","https://openalex.org/W2159987448","https://openalex.org/W2160883911","https://openalex.org/W2162792939","https://openalex.org/W2164226052","https://openalex.org/W2164386060","https://openalex.org/W2165556071","https://openalex.org/W2167717072","https://openalex.org/W2167916571","https://openalex.org/W2169390260","https://openalex.org/W2169624176","https://openalex.org/W2170055709","https://openalex.org/W2170392461","https://openalex.org/W2171293480","https://openalex.org/W2198297530","https://openalex.org/W2395006878","https://openalex.org/W2417819273","https://openalex.org/W2792745638","https://openalex.org/W2792966232","https://openalex.org/W2886978647","https://openalex.org/W4313333699"],"related_works":["https://openalex.org/W1943847793","https://openalex.org/W194340776","https://openalex.org/W55514877","https://openalex.org/W2100158520","https://openalex.org/W1515009590","https://openalex.org/W2751434647","https://openalex.org/W2142258560","https://openalex.org/W7098511732","https://openalex.org/W2049080418","https://openalex.org/W2752056026"],"abstract_inverted_index":{"Chemokines":[0],"and":[1,82,85,101,112,150,187,213],"chemokine":[2,76,79,223],"receptors":[3,80],"promote":[4,25],"the":[5,46,54,72,91,136,144,173,184,192,201],"migration":[6,180],"of":[7,27,49,56,74,139,178,181,191,196],"immune":[8,59,92,193,197,225],"cells":[9,28,141,182],"during":[10],"infectious":[11],"stimuli":[12],"as":[13,15,175,233,235],"well":[14,234],"under":[16,53],"homeostatic":[17],"conditions.":[18],"In":[19],"chronic":[20],"disease,":[21],"chemokines":[22],"can":[23],"also":[24],"influx":[26],"that":[29,44],"contributes":[30],"to":[31,63,94,123,135,183,200,230,238],"pathological":[32,128],"inflammation.":[33],"Respiratory":[34],"syncytial":[35],"virus":[36,43],"(RSV)":[37],"is":[38,45],"a":[39,114,176],"negative":[40],"sense":[41],"RNA":[42],"primary":[47],"cause":[48],"hospitalization":[50],"in":[51,90,99,121,130,143,172,204,228],"children":[52],"age":[55],"2.":[57],"Pathologic":[58],"responses":[60,212,237],"are":[61],"thought":[62],"be":[64],"responsible":[65],"for":[66,222],"RSV-associated":[67],"disease.":[68],"This":[69],"study":[70],"investigated":[71],"role":[73],"two":[75],"receptors,":[77],"CC":[78],"6":[81],"7":[83],"(CCR6":[84],"CCR7),":[86],"expressed":[87],"by":[88],"leukocytes,":[89],"response":[93,120,129,171],"RSV":[95,104,163,239],"infection.":[96,240],"Animals":[97],"deficient":[98],"CCR6":[100],"infected":[102,161],"with":[103,162],"had":[105],"enhanced":[106],"viral":[107],"clearance,":[108],"diminished":[109],"mucus":[110,151],"production,":[111],"generated":[113],"protective":[115],"Th1":[116],"effector":[117,168,209],"T":[118,169,210],"cell":[119,170,198,211,226],"comparison":[122],"wild-type":[124],"mice.":[125,158],"The":[126],"tempered":[127],"CCR6-/-":[131,157],"animals":[132],"was":[133],"due":[134],"impaired":[137,179],"recruitment":[138],"dendritic":[140],"(DC)":[142],"lung,":[145],"which":[146],"promoted":[147],"Th2":[148],"cytokines":[149],"production":[152],"when":[153],"adoptively":[154],"transferred":[155],"into":[156],"Conversely,":[159],"CCR7-/-animals":[160],"exhibited":[164],"an":[165],"exacerbated,":[166],"dysregulated":[167],"lung":[174],"result":[177],"lymph":[185,202],"nodes":[186,203],"thus":[188],"local":[189,215],"priming":[190],"response.":[194],"Restoration":[195],"trafficking":[199,227],"bone":[205],"marrow":[206],"chimeras":[207],"reestablished":[208],"abrogated":[214],"pathology.":[216],"These":[217],"studies":[218],"demonstrate":[219],"important":[220],"roles":[221],"receptor-mediated":[224],"contributing":[229],"tissue":[231],"pathology":[232],"modulating":[236]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}