{"id":"https://openalex.org/W1945834820","doi":"https://doi.org/10.1093/clinchem/47.6.1121","title":"Relationships among Plasma Homocysteine, Cysteine, and Albumin Concentrations: Potential Utility of Assessing the Cysteine/Homocysteine Ratio","display_name":"Relationships among Plasma Homocysteine, Cysteine, and Albumin Concentrations: Potential Utility of Assessing the Cysteine/Homocysteine Ratio","publication_year":2001,"publication_date":"2001-06-01","ids":{"openalex":"https://openalex.org/W1945834820","doi":"https://doi.org/10.1093/clinchem/47.6.1121","mag":"1945834820","pmid":"https://pubmed.ncbi.nlm.nih.gov/11375307"},"language":"en","primary_location":{"id":"doi:10.1093/clinchem/47.6.1121","doi":"https://doi.org/10.1093/clinchem/47.6.1121","is_oa":false,"landing_page_url":"https://doi.org/10.1093/clinchem/47.6.1121","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055949605","display_name":"Glen L. Hortin","orcid":"https://orcid.org/0009-0005-7030-4223","observed_orcids":["https://orcid.org/0009-0005-7030-4223"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Glen L Hortin","raw_affiliation_strings":["address correspondence to this author at: Department of Laboratory Medicine, NIH, Building 10, Room 2C-407, Bethesda, MD 20892-1508; fax 301-402-1885, e-mail","Department of Laboratory Medicine, Warren Magnuson Clinical Center, NIH, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"address correspondence to this author at: Department of Laboratory Medicine, NIH, Building 10, Room 2C-407, Bethesda, MD 20892-1508; fax 301-402-1885, e-mail","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"Department of Laboratory Medicine, Warren Magnuson Clinical Center, NIH, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112281996","display_name":"Patricia Sullivan","orcid":"https://orcid.org/0009-0000-8627-8270","observed_orcids":["https://orcid.org/0009-0000-8627-8270"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia Sullivan","raw_affiliation_strings":["Department of Laboratory Medicine, Warren Magnuson Clinical Center, NIH, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Warren Magnuson Clinical Center, NIH, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027032991","display_name":"Gy\u00f6rgy Cs\u00e1k\u00f3","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gyorgy Csako","raw_affiliation_strings":["Department of Laboratory Medicine, Warren Magnuson Clinical Center, NIH, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Warren Magnuson Clinical Center, NIH, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055949605"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"],"apc_list":{"value":4636,"currency":"USD","value_usd":4636},"apc_paid":null,"fwci":1.0964,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.7516129,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"47","issue":"6","first_page":"1121","last_page":"1124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-homocysteine","display_name":"plasma homocysteine","score":0.9049999713897705},{"id":"https://openalex.org/keywords/plasma-cysteine","display_name":"plasma cysteine","score":0.8240000009536743},{"id":"https://openalex.org/keywords/hyperhomocysteinemia","display_name":"hyperhomocysteinemia","score":0.8299999833106995},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.5339999794960022},{"id":"https://openalex.org/keywords/atherosclerosis-risk","display_name":"atherosclerosis risk","score":0.6079999804496765},{"id":"https://openalex.org/keywords/thrombotic-risk","display_name":"thrombosis risk","score":0.7799999713897705},{"id":"https://openalex.org/keywords/transsulfuration-pathway","display_name":"transsulfuration pathway","score":0.7329999804496765},{"id":"https://openalex.org/keywords/homocysteine-metabolism","display_name":"homocysteine metabolism","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.8769937753677368},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.856374979019165},{"id":"https://openalex.org/C2776523773","wikidata":"https://www.wikidata.org/wiki/Q1093815","display_name":"Hyperhomocysteinemia","level":3,"score":0.7524383068084717},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7036182880401611},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.6827305555343628},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5863001346588135},{"id":"https://openalex.org/C2778322612","wikidata":"https://www.wikidata.org/wiki/Q907001","display_name":"Thiolactone","level":2,"score":0.5360880494117737},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.4320318102836609},{"id":"https://openalex.org/C165616093","wikidata":"https://www.wikidata.org/wiki/Q424232","display_name":"Serum albumin","level":2,"score":0.4214511513710022},{"id":"https://openalex.org/C2779375456","wikidata":"https://www.wikidata.org/wiki/Q994859","display_name":"Homocystinuria","level":4,"score":0.4137049913406372},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.38235944509506226},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.3133871555328369},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.14718416333198547},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06675124168395996},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06569793820381165}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006710","descriptor_name":"Homocysteine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/clinchem/47.6.1121","doi":"https://doi.org/10.1093/clinchem/47.6.1121","is_oa":false,"landing_page_url":"https://doi.org/10.1093/clinchem/47.6.1121","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},{"id":"pmid:11375307","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11375307","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W90081202","https://openalex.org/W1513696494","https://openalex.org/W1550178542","https://openalex.org/W1857028030","https://openalex.org/W1890248538","https://openalex.org/W1954829482","https://openalex.org/W2008457096","https://openalex.org/W2087642197","https://openalex.org/W2093110099","https://openalex.org/W2097881761","https://openalex.org/W2142419120","https://openalex.org/W2145898471","https://openalex.org/W2146261019","https://openalex.org/W2149997127","https://openalex.org/W2257551340","https://openalex.org/W2323783182","https://openalex.org/W2337184574"],"related_works":["https://openalex.org/W2055032002","https://openalex.org/W4308684438","https://openalex.org/W2776648129","https://openalex.org/W2295995045","https://openalex.org/W1944988264","https://openalex.org/W2167388258","https://openalex.org/W1966919944","https://openalex.org/W2363081907","https://openalex.org/W7099068867","https://openalex.org/W2041508079"],"abstract_inverted_index":{"McCully":[0],"(1)":[1],"initially":[2],"observed":[3,592],"that":[4,168,389,434,604,876,893,941,950,965,1008,1016],"patients":[5,836],"with":[6,69,202,255,260,264,361,419,576,586,601,627,654,678,702,770,837,969,1119,1130],"extremely":[7],"increased":[8,40,391,834,916,1120],"plasma":[9,155,243,253,297,425,439,446,469,731,1072,1128],"concentrations":[10,41,152,470,588,656,827],"of":[11,42,95,112,115,125,136,153,176,178,193,231,252,258,282,345,378,393,438,459,471,579,606,674,717,817,851,864,886,895,902,924,952,955,981,990,1005,1023,1056,1071,1078,1088,1099,1105,1122],"homocysteine":[12],"(Hcy)":[13],"attributable":[14,704],"to":[15,62,103,300,401,622,705,744,763,911,996],"homocystinuria":[16,703,912,959],"have":[17,107,285,729,821,946],"accelerated":[18],"atherosclerosis.":[19],"Subsequently,":[20],"even":[21],"moderate":[22],"hyperhomocysteinemia":[23,735,798],"became":[24],"recognized":[25],"as":[26,65,72,77,85,173,270,276,773,812,958,985,1002,1020,1068,1094],"a":[27,66,73,86,122,209,214,221,229,357,560,697,749,806,822,860,928,986,1054,1060,1064],"risk":[28,1007],"factor":[29],"for":[30,199,216,224,303,353,371,412,441,584,714,900,906,1140],"atherosclerosis":[31],"and":[32,84,101,157,165,170,189,228,239,267,310,429,449,456,461,474,480,495,510,525,569,597,725,741,759,831,844,853,917,927,961,976,1136,1147],"thrombosis":[33],"(2)(3)(4),":[34],"although":[35],"the":[36,52,78,113,133,140,149,179,190,197,234,250,283,301,343,394,435,452,577,602,607,615,623,633,675,708,715,721,865,877,884,887,896,904,942,953,1089,1103,1126,1134,1141],"mechanism":[37],"by":[38,247,382,696,859,983],"which":[39,94,631,907],"Hcy":[43,49,58,127,180,203,232,442,460,479,612,624,790,982],"produce":[44,972],"these":[45,96,183,727,801],"effects":[46],"is":[47,91,206,599,609,632,761,796,875,891,898,915,919,940,994,1015,1059],"uncertain.":[48],"occurs":[50],"in":[51,54,181,241,403,424,618,638,707,720,784,809,824,835,845,883,921,933,949],"circulation":[53],"multiple":[55,200],"forms,":[56,164],"including":[57,129],"linked":[59],"via":[60,233,614],"disulfides":[61,254],"albumin":[63,169,372,420],"(\u223c70%),":[64],"mixed":[67],"disulfide":[68],"Cys":[70,159,171,195,205,462,608,977],"(25%),":[71],"disulfide-linked":[74,163],"dimer":[75],"(<5%),":[76,83],"free":[79],"reduced":[80],"amino":[81,818],"acid":[82],"thiolactone":[87],"(trace)":[88],"(5)(6).":[89],"It":[90,431,890],"not":[92,207,464,692],"clear":[93],"components":[97,106,184],"are":[98,463,833,966,1037],"physiologically":[99],"active,":[100],"efforts":[102],"measure":[104],"individual":[105],"been":[108,286],"technically":[109],"challenging":[110],"because":[111,204,828],"interconversion":[114],"different":[116],"forms":[117,131,458],"during":[118],"specimen":[119],"processing.":[120],"As":[121,841],"result,":[123],"measurement":[124],"total":[126,158],"(tHcy),":[128],"all":[130],"except":[132],"trace":[134],"amount":[135,620],"thiolactone,":[137],"has":[138,196,869],"become":[139],"standard":[141],"clinical":[142],"test":[143],"(5)(6)(7).":[144],"The":[145,376,591,684,737,754,937,1012],"present":[146],"study":[147],"examined":[148],"relationships":[150],"among":[151,468],"tHcy,":[154,472],"albumin,":[156,473],"(tCys;":[160],"includes":[161],"protein-bound,":[162],"reduced).":[166],"Considering":[167],"serve":[172,1093],"covalent":[174,210],"carriers":[175],"most":[177],"circulation,":[182],"may":[185,432,820,880,945,978,1092],"affect":[186,979],"circulating":[187],"tHcy":[188,238,304,404,415,447,482,524,531,539,568,587,596,628,655,679,740,758,767,774,813,832,852,914,1010,1043,1131],"physiological":[191,1061],"action":[192],"Hcy.":[194,991],"potential":[198,222],"interactions":[201],"only":[208],"carrier":[211,987],"but":[212,407],"also":[213],"competitor":[215,223,989],"binding":[217,396,436],"sites":[218],"on":[219,294],"proteins,":[220],"uptake":[225],"into":[226],"cells,":[227],"metabolite":[230],"transulfuration":[235,616,709,888],"pathway":[236,617,710,719],"(8)(9).":[237],"tCys":[240,417,494,497,509,512,551,570,598,724,732,742,760,771,785,826,830,854,918,1026],"EDTA":[242],"were":[244],"analyzed":[245],"simultaneously":[246],"HPLC":[248,290],"after":[249,787],"reduction":[251],"tris(2-carboxyethyl)phosphine,":[256],"precipitation":[257],"proteins":[259,440],"trichloroacetic":[261],"acid,":[262],"derivatization":[263],"7-fluoro-2,1,3-benzoxadiazole-4-sulfonate":[265],"(SBD-F),":[266],"fluorescent":[268],"detection":[269],"described":[271,287],"previously":[272,288],"(10)":[273],"using":[274,356],"cystamine":[275],"an":[277,390,619,670,1003,1021,1095],"internal":[278,1096],"standard.":[279],"Performance":[280],"characteristics":[281],"assay":[284],"(10).":[289],"analysis":[291,850],"was":[292,348,351,373,380,533,559,669],"performed":[293],"151":[295],"unselected":[296],"specimens":[298,355,379,1129],"submitted":[299],"laboratory":[302],"determination.":[305],"Patients":[306],"included":[307],"75":[308],"males":[309],"76":[311],"females":[312],"(median":[313],"age,":[314],"54":[315],"years;":[316],"<20":[317],"years,":[318,323,328,333,339],"n":[319,324,329,334,340,649,665],"=":[320,325,330,335,341,483,489,498,504,513,519,650,666],"2;":[321],"20\u201339":[322],"30;":[326],"40\u201359":[327],"72;":[331],"60\u201379":[332],"42;":[336],"\u2265":[337,657],"80":[338],"4;":[342],"age":[344],"1":[346,1030],"subject":[347],"unknown).":[349],"Albumin":[350],"measured":[352],"142":[354],"Hitachi":[358],"917":[359],"analyzer":[360],"bromcresol":[362],"green":[363],"reagent":[364],"from":[365,611,1073],"Roche.":[366],"Our":[367],"nonparametric":[368,1135],"reference":[369,548,635,1138],"interval":[370],"37\u201347":[374],"g/L.":[375],"use":[377],"approved":[381],"our":[383,639],"Institutional":[384],"Review":[385],"Board.":[386],"We":[387],"anticipated":[388],"quantity":[392],"major":[395],"protein":[397],"(albumin)":[398],"might":[399],"relate":[400],"increases":[402,775,1044],"or":[405,789,988,1063,1112],"tCys,":[406],"we":[408],"found":[409],"little":[410],"evidence":[411,713],"this.":[413],"Neither":[414],"nor":[416],"correlated":[418],"(range,":[421],"25\u201348":[422],"g/L)":[423],"(Fig.":[426,571,681],"1,":[427],"A":[428],"B).":[430],"be":[433,693,745,805,856,1145],"capacity":[437],"far":[443],"exceeds":[444],"normal":[445],"(8),":[448],"factors":[450],"controlling":[451],"interchange":[453],"between":[454,478,493,508,523,567,595,723,739,757],"protein-linked":[455],"soluble":[457],"fully":[465],"understood.":[466],"Relationships":[467],"tCys.":[475],"(A),":[476],"relationship":[477,492,507,522,594,685,722,738,756],"albumin:":[481,496],"0.022":[484],"(Alb)":[485,500],"+":[486,501,516],"8.1;":[487],"r":[488,503,518],"0.02.":[490],"(B),":[491],"1.0":[499],"198;":[502],"0.07.":[505],"(C),":[506],"tHcy:":[511],"10.6":[514],"(tHcy)":[515],"141;":[517],"0.63.":[520],"(D),":[521],"tCys/tHcy":[526,643,676,810,866,878,930,943,974,1018,1050,1090,1114,1142],"ratio.":[527],"In":[528,780,800,1102],"this":[529,718,777,925,999],"study,":[530],"concentration":[532,680,778],"\u223c28-fold":[534],"lower":[535],"than":[536,652,748],"tCys:":[537],"mean":[538,550],"concentration,":[540,552],"9.0":[541],"\u03bcmol/L;":[542,554],"range,":[543,555,647,663],"4.4\u201317.7":[544],"\u03bcmol/L":[545,659],"(most":[546],"within":[547],"interval);":[549],"238":[553],"141\u2013368":[556],"\u03bcmol/L).":[557],"There":[558,668],"highly":[561],"significant":[562],"(P":[563],"<0.0001)":[564],"positive":[565],"correlation":[566,673],"1C":[572],").":[573,683],"This":[574],"agrees":[575],"observations":[578],"El-Khairy":[580],"et":[581],"al.":[582],"(11)":[583],"subjects":[585,653],"<15":[589],"\u03bcmol/L.":[590],"linear":[593,699,755],"consistent":[600],"proposition":[603],"part":[605],"derived":[610],"metabolism":[613],"proportional":[621],"concentration.":[625],"Subjects":[626],"<13":[629,1132],"\u03bcmol/L,":[630,769,1133],"upper":[634],"limit":[636],"assigned":[637],"laboratory,":[640],"had":[641,686],"higher":[642],"ratios":[644,811,1051,1115],"(mean,":[645],"29;":[646],"17\u201340;":[648],"138)":[651],"13":[658],"(mean":[660],"ratio,":[661],"20;":[662],"15\u201325;":[664],"13).":[667],"overall":[671],"negative":[672],"ratio":[677,867,879,931,944,1000,1091,1143],"1D":[682],"substantial":[687],"curvature;":[688],"therefore,":[689],"it":[690],"could":[691],"represented":[694],"well":[695],"simple":[698,750],"fit.":[700],"Individuals":[701],"defects":[706],"provide":[711],"further":[712],"importance":[716],"tHcy;":[726],"individuals":[728],"low":[730,929,973,1017,1049,1113],"despite":[733],"severe":[734],"(9).":[736],"appears":[743],"more":[746],"complex":[747],"precursor\u2013product":[751],"relationship,":[752],"however.":[753],"reported":[762],"break":[764],"down":[765],"at":[766,792,1039,1081],">15":[768],"decreasing":[772],"above":[776],"(11).":[779],"addition,":[781],"slight":[782],"decreases":[783,1027],"occur":[786],"methionine":[788],"loading":[791],"times":[793],"when":[794],"there":[795,803,1058],"transient":[797],"(12)(13).":[799],"situations,":[802],"would":[804,1116,1144],"progressive":[807],"decline":[808],"increases.":[814],"Renal":[815],"clearance":[816],"acids":[819],"role":[823],"lowering":[825],"both":[829],"renal":[838,962],"failure":[839,963],"(14).":[840],"shown":[842],"here":[843],"earlier":[846],"reports":[847],"(10)(11),":[848],"dual":[849],"can":[855],"readily":[857],"provided":[858],"chromatographic":[861],"method.":[862],"Evaluation":[863],"potentially":[868],"several":[870],"practical":[871],"consequences.":[872],"One":[873],"consequence":[874,939,1014],"reflect":[881],"abnormalities":[882],"function":[885],"pathway.":[889],"estimated":[892],"1%":[894],"population":[897],"heterozygous":[899,922],"deficiency":[901,909,923],"cystathionine-\u03b2-synthase,":[903],"enzyme":[905],"homozygous":[908],"leads":[910],"(15).":[913,936],"decreased":[920],"enzyme,":[926],"assists":[932],"identifying":[934],"heterozygotes":[935],"other":[938,1106],"physiologic":[947],"significance":[948],"some":[951],"causes":[954,1107],"hyperhomocysteinemia,":[956],"such":[957,1067],"(9)":[960],"(14),":[964],"strongly":[967],"associated":[968],"cardiovascular":[970,1006],"disease":[971],"ratios,":[975],"bioavailability":[980],"serving":[984],"Further":[992],"investigation":[993],"warranted":[995],"explore":[997],"whether":[998,1057],"serves":[1001,1019],"indicator":[1004,1022],"supplements":[1009],"measurements.":[1011],"third":[1013],"preanalytical":[1024,1065],"errors.":[1025,1124],"(10\u201320%":[1028],"over":[1029],"day)":[1031],"if":[1032],"anticoagulated":[1033],"whole":[1034,1079],"blood":[1035,1074,1080],"samples":[1036,1118],"left":[1038],"room":[1040],"temperature,":[1041],"whereas":[1042],"(30\u201390%)":[1045],"(16)(17).":[1046],"Thus,":[1047],"unusually":[1048],"should":[1052],"trigger":[1053],"review":[1055],"explanation":[1062],"problem":[1066],"delayed":[1069],"separation":[1070],"cells":[1075],"and/or":[1076],"storage":[1077],"inappropriately":[1082],"high":[1083,1111],"ambient":[1084],"temperature.":[1085],"Finally,":[1086],"evaluation":[1087],"quality":[1097],"check":[1098],"each":[1100],"analysis.":[1101],"absence":[1104],"(see":[1108],"above),":[1109],"unexpectedly":[1110],"identify":[1117],"probability":[1121],"analytical":[1123],"For":[1125],"138":[1127],"parametric":[1137],"intervals":[1139],"19\u201342":[1146],"17\u201340,":[1148],"respectively.":[1149]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
