{"id":"https://openalex.org/W194555775","doi":null,"title":"An open label trial of alprazolam in comorbid irritable bowel syndrome and generalized anxiety disorder.","display_name":"An open label trial of alprazolam in comorbid irritable bowel syndrome and generalized anxiety disorder.","publication_year":1991,"publication_date":"1991-12-01","ids":{"openalex":"https://openalex.org/W194555775","mag":"194555775","pmid":"https://pubmed.ncbi.nlm.nih.gov/1752852"},"language":"en","primary_location":{"id":"pmid:1752852","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1752852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical psychiatry","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109214489","display_name":"Gary D. Tollefson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G D Tollefson","raw_affiliation_strings":["Department of Psychiatry, St. Paul-Ramsey Medical Center, Minn 55101"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, St. Paul-Ramsey Medical Center, Minn 55101","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088347299","display_name":"Michael G. Luxenberg","orcid":"https://orcid.org/0000-0002-0709-2601","observed_orcids":["https://orcid.org/0000-0002-0709-2601"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Luxenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037757121","display_name":"Rita J. Valentine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Valentine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039793176","display_name":"Gayle Dunsmore","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Dunsmore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011597490","display_name":"Sherrie L. Tollefson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S L Tollefson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7431,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.72848566,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"52","issue":"12","first_page":"502","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.04690000042319298,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11334","display_name":"Psychosomatic Disorders and Their Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alprazolam","display_name":"alprazolam","score":0.9929999709129333},{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.9879999756813049},{"id":"https://openalex.org/keywords/generalized-anxiety-disorder","display_name":"generalized anxiety disorder","score":1.0},{"id":"https://openalex.org/keywords/psychiatric-comorbidity","display_name":"psychiatric comorbidity","score":0.972000002861023},{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":0.9459999799728394},{"id":"https://openalex.org/keywords/ibs-symptom-severity","display_name":"IBS symptom severity","score":0.7620000243186951},{"id":"https://openalex.org/keywords/drug-safety-and-tolerability","display_name":"drug safety and tolerability","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C2777196872","wikidata":"https://www.wikidata.org/wiki/Q319877","display_name":"Alprazolam","level":3,"score":0.9426475763320923},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.8081969022750854},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.8008444309234619},{"id":"https://openalex.org/C2779911313","wikidata":"https://www.wikidata.org/wiki/Q845224","display_name":"Generalized anxiety disorder","level":3,"score":0.7626093626022339},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.619375467300415},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.6167697310447693},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5729407072067261},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5620013475418091},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.559318482875824},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.5346132516860962},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4542054831981659},{"id":"https://openalex.org/C2776317618","wikidata":"https://www.wikidata.org/wiki/Q544006","display_name":"Anxiety disorder","level":3,"score":0.4349890649318695},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3680853247642517},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000525","descriptor_name":"Alprazolam","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003109","descriptor_name":"Colonic Diseases, Functional","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003109","descriptor_name":"Colonic Diseases, Functional","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1752852","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1752852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical psychiatry","raw_type":"Clinical Trial"},{"id":"mag:194555775","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1752852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2079210398","https://openalex.org/W2349003223","https://openalex.org/W2368151512","https://openalex.org/W2092760765","https://openalex.org/W2402118362","https://openalex.org/W80449760","https://openalex.org/W2096154314","https://openalex.org/W2069644518","https://openalex.org/W2364073479","https://openalex.org/W1993794887"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"irritable":[2],"bowel":[3],"syndrome":[4],"(IBS)":[5],"is":[6],"very":[7],"prevalent":[8],"and":[9,44,119,137,147],"psychiatric":[10],"comorbidity":[11],"runs":[12],"high.":[13],"A":[14],"significant":[15],"proportion":[16],"of":[17,33,49,59,66,111,144],"generalized":[18,42],"anxiety":[19,43],"disorder":[20],"(GAD)":[21],"patients":[22,39],"manifest":[23],"concurrent":[24],"IBS.":[25,45],"METHOD:":[26],"We":[27],"conducted":[28],"a":[29,50,72,93,112,121,127,150],"14-week,":[30],"open-label":[31],"trial":[32],"the":[34,47,79,100,109,141],"triazolobenzodiazepine":[35],"alprazolam":[36],"in":[37,96],"32":[38],"with":[40],"comorbid":[41,145],"At":[46],"end":[48],"2-week":[51],"placebo":[52],"run-in,":[53],"eligible":[54],"subjects":[55,67],"received":[56],"6":[57],"weeks":[58],"active":[60],"drug":[61,114],"therapy.":[62],"RESULTS:":[63],"Ninety-four":[64],"percent":[65,88],"(N":[68,89],"=":[69,90,117,124],"25)":[70],"had":[71],"full":[73],"or":[74],"partial":[75],"anxiolytic":[76],"response":[77],"at":[78,108,126],"6th":[80],"treatment":[81,143],"week":[82],"(p":[83,116,123],"less":[84],"than":[85],".001).":[86],"Eighty-nine":[87],"24)":[91],"experienced":[92],"concomitant":[94],"reduction":[95],"IBS":[97],"severity.":[98],"For":[99],"majority,":[101],"these":[102],"dual":[103],"benefits":[104],"were":[105],"still":[106],"evident":[107],"conclusion":[110],"4-week":[113,128],"taper":[115],".05)":[118],"achieved":[120],"trend":[122],".07)":[125],"postdrug":[129],"discontinuation":[130],"visit.":[131],"CONCLUSION:":[132],"Alprazolam":[133],"was":[134,154],"safe,":[135],"effective,":[136],"well":[138],"tolerated":[139],"during":[140],"acute":[142],"GAD":[146],"IBS;":[148],"only":[149],"limited":[151],"posttreatment":[152],"rebound":[153],"observed.":[155]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}