{"id":"https://openalex.org/W19450309","doi":null,"title":"Abstract 19048: Tissue-Specific Regulation of Phospholipase C Beta-3 by Asymmetric Dimethylarginine (ADMA)","display_name":"Abstract 19048: Tissue-Specific Regulation of Phospholipase C Beta-3 by Asymmetric Dimethylarginine (ADMA)","publication_year":2010,"publication_date":"2010-11-23","ids":{"openalex":"https://openalex.org/W19450309","mag":"19450309"},"language":"en","primary_location":{"id":"mag:19450309","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/10.1161/circ.122.suppl_21.A19048","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null},"volume":null,"type":"conference-abstract","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058158077","display_name":"Tim Allhoff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tim Allhoff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020543934","display_name":"Thomas Thum","orcid":"https://orcid.org/0000-0003-4360-1511","observed_orcids":["https://orcid.org/0000-0003-4360-1511"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Thum","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4360-1511","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087713510","display_name":"Natalie Lund","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natalie Lund","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100922719","display_name":"Anna Klinke","orcid":"https://orcid.org/0000-0002-1118-4082","observed_orcids":["https://orcid.org/0000-0002-1118-4082"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Klinke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070552128","display_name":"Eike-Christin von Leitner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eike-Christin von Leitner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111740247","display_name":"Yoshimi Kakiuchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshimi Kakiuchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Claudia K\u00fchne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claudia K\u00fchne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057764662","display_name":"Edzard Schwedhelm","orcid":"https://orcid.org/0000-0003-3597-6276","observed_orcids":["https://orcid.org/0000-0003-3597-6276"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edzard Schwedhelm","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3597-6276","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087159018","display_name":"Tanja K. Rudolph","orcid":"https://orcid.org/0000-0001-8839-7476","observed_orcids":["https://orcid.org/0000-0001-8839-7476"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tanja K. Rudolph","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8839-7476","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008918690","display_name":"Volker Rudolph","orcid":"https://orcid.org/0000-0001-5385-6839","observed_orcids":["https://orcid.org/0000-0001-5385-6839"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Volker Rudolph","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5385-6839","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072159318","display_name":"Stephan Willems","orcid":"https://orcid.org/0000-0002-8890-5749","observed_orcids":["https://orcid.org/0000-0002-8890-5749"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephan Willems","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8890-5749","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109105996","display_name":"Thomas Meinertz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Meinertz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038106053","display_name":"Rainer H. B\u00f6ger","orcid":"https://orcid.org/0000-0003-3770-5357","observed_orcids":["https://orcid.org/0000-0003-3770-5357"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rainer H. B\u00f6ger","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3770-5357","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058198453","display_name":"Philip S. Tsao","orcid":"https://orcid.org/0000-0001-7274-9318","observed_orcids":["https://orcid.org/0000-0001-7274-9318"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip S. Tsao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7274-9318","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053048440","display_name":"Stephan Ernst Baldus","orcid":"https://orcid.org/0000-0001-8259-1737","observed_orcids":["https://orcid.org/0000-0001-8259-1737"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephan Baldus","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8259-1737","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111385893","display_name":"Karsten Sydow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karsten Sydow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"122","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asymmetric-dimethylarginine","display_name":"asymmetric dimethylarginine","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ddah1","display_name":"DDAH1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/aortic-tissue","display_name":"aortic tissue","score":0.7429999709129333},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8349999785423279},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-inhibition","display_name":"nitric oxide synthase inhibition","score":0.843999981880188},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C2779877776","wikidata":"https://www.wikidata.org/wiki/Q752685","display_name":"Asymmetric dimethylarginine","level":4,"score":0.8468322157859802},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7407141327857971},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7308591604232788},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6549524664878845},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.523357093334198},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.4851554036140442},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.4373529255390167},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.41163715720176697},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19974789023399353},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14505913853645325},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1175180971622467},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:19450309","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/10.1161/circ.122.suppl_21.A19048","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3173928397","https://openalex.org/W2099957438","https://openalex.org/W2887299351","https://openalex.org/W2124006262","https://openalex.org/W7100689313","https://openalex.org/W2092478685","https://openalex.org/W114871013","https://openalex.org/W126529500","https://openalex.org/W2097359245","https://openalex.org/W1970798352"],"abstract_inverted_index":{"Elevated":[0],"concentrations":[1,98],"of":[2,49,69,138],"the":[3,21],"endogenous":[4],"NO":[5,30],"synthase":[6],"inhibitor":[7],"ADMA":[8,17,84,96,115,126],"correlate":[9],"with":[10,80],"endothelial":[11],"dysfunction":[12],"and":[13,32,43,76,128,136],"increased":[14,29],"cardiovascular":[15],"risk.":[16],"is":[18],"degraded":[19],"by":[20,108],"enzyme":[22],"DDAH.":[23],"DDAH1-transgenic":[24],"(DDAH1)":[25],"mice":[26,79,93],"show":[27],"an":[28],"production":[31],"are":[33],"protected":[34],"against":[35],"inflammatory":[36],"responses":[37],"in":[38,57,66,132],"graft":[39],"coronary":[40],"artery":[41],"disease":[42],"ischemia":[44],"reperfusion":[45],"injury.":[46],"The":[47],"aim":[48],"this":[50],"study":[51],"was":[52],"to":[53],"identify":[54],"ADMA-regulated":[55],"genes":[56],"aortic":[58,67],"tissue.":[59],"Microarray":[60],"gene":[61],"expression":[62],"analyses":[63],"were":[64],"performed":[65],"tissue":[68],"DDAH1":[70,92,129],"male":[71],"mice,":[72],"wild-type":[73],"littermates":[74],"(WT),":[75],"C57Bl/6":[77],"(C57)":[78],"or":[81],"without":[82],"chronic":[83],"infusion":[85,127],"(50":[86],"mg/kg/body":[87],"weight)":[88],"via":[89],"osmotic":[90],"minipumps.":[91],"showed":[94],"lower":[95],"plasma":[97],"(DDAH1":[99],"vs.":[100,103,118,121],"WT;":[101],"0.52\u00b10.04":[102],"0.68\u00b10.05":[104],"\u03bcmol/l,":[105,123],"p<0.05)":[106],"determined":[107],"LC-MS/MS,":[109],"whereas":[110],"ADMA-treated":[111],"animals":[112],"presented":[113],"high":[114],"levels":[116],"(C57":[117],"C57+ADMA;":[119],"0.83\u00b10.03":[120],"3.30\u00b10.21":[122],"p<0.001).":[124],"Chronic":[125],"overexpression":[130],"resulted":[131],"a":[133],"significant":[134],"up-":[135],"downregulation":[137],"genes,":[139],"particular...":[140]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}