{"id":"https://openalex.org/W194411393","doi":null,"title":"Endocardial cushion tissue development: structural analyses on the attachment of extracellular matrix to migrating mesenchymal cell surfaces.","display_name":"Endocardial cushion tissue development: structural analyses on the attachment of extracellular matrix to migrating mesenchymal cell surfaces.","publication_year":1981,"publication_date":"1981-01-01","ids":{"openalex":"https://openalex.org/W194411393","mag":"194411393","pmid":"https://pubmed.ncbi.nlm.nih.gov/7034167"},"language":"en","primary_location":{"id":"pmid:7034167","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7034167","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scanning electron microscopy","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064610800","display_name":"Roger R. Markwald","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R R Markwald","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037300020","display_name":"J M Krook","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Krook","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045543126","display_name":"Gregory Thomas Kitten","orcid":"https://orcid.org/0000-0002-4044-9932","observed_orcids":["https://orcid.org/0000-0002-4044-9932"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G T Kitten","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5022394159","display_name":"Raymond Bruce Runyan","orcid":"https://orcid.org/0000-0002-7410-916X","observed_orcids":["https://orcid.org/0000-0002-7410-916X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R B Runyan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3381,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.4696075,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":null,"issue":"Pt 2","first_page":"261","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.38989999890327454,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.38989999890327454,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.3513000011444092,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.11180000007152557,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endocardial-cushion","display_name":"endocardial cushion","score":0.9100000262260437},{"id":"https://openalex.org/keywords/heart-development","display_name":"heart development","score":0.675000011920929},{"id":"https://openalex.org/keywords/cell-matrix-adhesion","display_name":"cell-matrix adhesion","score":0.6909999847412109},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8939999938011169},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7300000190734863},{"id":"https://openalex.org/keywords/filopodia","display_name":"filopodia","score":0.9769999980926514},{"id":"https://openalex.org/keywords/polyanions","display_name":"polyanions","score":0.753000020980835},{"id":"https://openalex.org/keywords/sulfated-glycosaminoglycans","display_name":"sulfated glycosaminoglycans","score":0.921999990940094},{"id":"https://openalex.org/keywords/fucosylated-glycoproteins","display_name":"fucosylated glycoproteins","score":0.8659999966621399},{"id":"https://openalex.org/keywords/hyaluronidase","display_name":"hyaluronidase","score":0.8420000076293945},{"id":"https://openalex.org/keywords/freeze-fracture","display_name":"freeze-fracture","score":0.671999990940094},{"id":"https://openalex.org/keywords/collagen-microfibrils","display_name":"collagen microfibrils","score":0.6790000200271606},{"id":"https://openalex.org/keywords/myocardial-cells","display_name":"myocardial cells","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C90301020","wikidata":"https://www.wikidata.org/wiki/Q14859810","display_name":"Filopodia","level":3,"score":0.8571507930755615},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.8180500864982605},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6463137269020081},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6373010873794556},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5240395665168762},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.5180135369300842},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.48476237058639526},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.46431562304496765},{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.45883908867836},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4358353912830353},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.42530637979507446},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.4143602252006531},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3848218619823456},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.30170732736587524},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25115537643432617},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20505109429359436},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003238","descriptor_name":"Connective Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004699","descriptor_name":"Endocardium","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D004699","descriptor_name":"Endocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004699","descriptor_name":"Endocardium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011554","descriptor_name":"Pseudopodia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7034167","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7034167","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scanning electron microscopy","raw_type":"Journal Article"},{"id":"mag:194411393","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7034167","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2003050289","https://openalex.org/W40882002","https://openalex.org/W2052372646","https://openalex.org/W2047059703","https://openalex.org/W1972490713","https://openalex.org/W1992317775","https://openalex.org/W2058797108","https://openalex.org/W2416534730","https://openalex.org/W2157536456","https://openalex.org/W2504747497"],"abstract_inverted_index":{"The":[0,97,122],"progressive":[1],"growth":[2,39],"and":[3,29,85,117,138,167,233,236],"eventual":[4],"fusion":[5],"of":[6,13,43,101,126,181],"the":[7,41,131,150,179,182],"atrioventricular":[8],"(AV)":[9],"endocardial":[10],"cushions":[11],"is":[12,40,226],"critical":[14],"importance":[15],"to":[16,22,62,69,73,81,89,110,129,141,201,222],"normal":[17],"embryonic":[18],"heart":[19],"development.":[20],"Failure":[21],"do":[23],"so":[24],"would":[25],"result":[26],"in":[27,36,105,218],"septal":[28],"AV":[30],"valvular":[31],"defects.":[32],"A":[33],"central":[34],"feature":[35],"initial":[37],"cushion":[38,44],"migration":[42],"tissue":[45],"(CT)":[46],"cells":[47,72,103],"through":[48],"an":[49],"heterogeneous":[50],"extracellular":[51],"matrix":[52,147],"(ECM)":[53],"which":[54,156,185,219],"has":[55],"previously":[56],"been":[57],"shown":[58],"(in":[59],"particular":[60],"hyaluronate)":[61],"modify":[63],"migratory":[64,98,224],"behavior.":[65],"Attention":[66],"was":[67,162],"directed":[68],"migrating":[70],"CT":[71,102],"determine":[74],"if":[75],"(1)":[76],"their":[77],"surfaces":[78],"physically":[79],"attach":[80],"or":[82],"bind":[83],"ECM":[84,189],"(2)":[86],"are":[87,213],"modified":[88],"suggest":[90],"a":[91,216],"morphological":[92],"basis":[93],"for":[94],"cell:matrix":[95,123],"interaction.":[96],"appendages":[99],"(filopodia)":[100],"maintained":[104],"organ":[106],"culture":[107],"attached":[108],"both":[109],"collagenous":[111],"microfibrils":[112],"coated":[113],"with":[114,188,215],"polyanionic":[115],"material":[116],"hyaluronate":[118],"(HA)":[119],"enriched":[120,146],"ECM.":[121],"associations":[124],"were":[125,139,193,205],"sufficient":[127],"strength":[128],"restrain":[130],"cell":[132,151,220],"from":[133,197],"contracting":[134],"following":[135],"freezing":[136],"procedures":[137],"labile":[140],"mild":[142],"trypsin":[143,168],"treatment.":[144],"HA":[145],"persisted":[148],"at":[149],"surface":[152,184],"even":[153],"after":[154],"treatments":[155],"removed":[157,164],"most":[158],"free":[159],"ECM,":[160],"but":[161,204],"readily":[163],"by":[165,228,238],"hyaluronidase":[166],"digestion.":[169],"Freeze":[170],"fracture":[171],"analyses":[172],"revealed":[173],"16-18":[174],"nm":[175],"particles":[176,192],"elevated":[177],"above":[178],"plane":[180],"filopodial":[183],"closely":[186],"interfaced":[187],"components.":[190],"These":[191],"variably":[194],"distributed,":[195],"ranging":[196],"almost":[198],"homogenous":[199],"dispersion":[200],"focalized":[202],"clusters,":[203],"absent":[206],"on":[207],"surrounding":[208],"non-migratory":[209],"(myocardial)":[210],"cells.":[211],"Results":[212],"consistent":[214],"model":[217],"attachment":[221],"its":[223],"substratum":[225],"mediated":[227],"polyanions":[229],"(probably":[230],"sulfated":[231],"glycosaminoglycan":[232],"fucosylated":[234],"glycoprotein)":[235],"detachment":[237],"hyaluronate.":[239]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
