{"id":"https://openalex.org/W1943404792","doi":"https://doi.org/10.1016/s0016-5085(74)80142-3","title":"Increased Carbon Tetrachloride Hepatotoxicity, and its Mechanism, After Chronic Ethanol Consumption","display_name":"Increased Carbon Tetrachloride Hepatotoxicity, and its Mechanism, After Chronic Ethanol Consumption","publication_year":1974,"publication_date":"1974-03-01","ids":{"openalex":"https://openalex.org/W1943404792","doi":"https://doi.org/10.1016/s0016-5085(74)80142-3","mag":"1943404792","pmid":"https://pubmed.ncbi.nlm.nih.gov/4149842"},"language":"en","primary_location":{"id":"doi:10.1016/s0016-5085(74)80142-3","doi":"https://doi.org/10.1016/s0016-5085(74)80142-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0016-5085(74)80142-3","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113480699","display_name":"Yasushi Hasumura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yasushi Hasumura","raw_affiliation_strings":["Department of Medicine, Mount Sinai School of Medicine of the City University of New York; and the Liver Disease and Nutrition Laboratory, Veterans Administration Hospital, Bronx, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Mount Sinai School of Medicine of the City University of New York; and the Liver Disease and Nutrition Laboratory, Veterans Administration Hospital, Bronx, New York","institution_ids":["https://openalex.org/I174216632","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019675536","display_name":"Rolf Teschke","orcid":"https://orcid.org/0000-0001-8910-1200","observed_orcids":["https://orcid.org/0000-0001-8910-1200"]},"institutions":[{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rolf Teschke","raw_affiliation_strings":["Department of Medicine, Mount Sinai School of Medicine of the City University of New York; and the Liver Disease and Nutrition Laboratory, Veterans Administration Hospital, Bronx, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Mount Sinai School of Medicine of the City University of New York; and the Liver Disease and Nutrition Laboratory, Veterans Administration Hospital, Bronx, New York","institution_ids":["https://openalex.org/I174216632","https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113571128","display_name":"Charles S. Lieber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles S. Lieber","raw_affiliation_strings":["Department of Medicine, Mount Sinai School of Medicine of the City University of New York; and the Liver Disease and Nutrition Laboratory, Veterans Administration Hospital, Bronx, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Mount Sinai School of Medicine of the City University of New York; and the Liver Disease and Nutrition Laboratory, Veterans Administration Hospital, Bronx, New York","institution_ids":["https://openalex.org/I174216632","https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4180,"currency":"USD","value_usd":4180},"apc_paid":null,"fwci":3.2051,"has_fulltext":false,"cited_by_count":155,"citation_normalized_percentile":{"value":0.91698925,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"66","issue":"3","first_page":"415","last_page":"422"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbon-tetrachloride-hepatotoxicity","display_name":"carbon tetrachloride hepatotoxicity","score":0.9869999885559082},{"id":"https://openalex.org/keywords/chronic-alcohol-consumption","display_name":"chronic alcohol consumption","score":0.9779999852180481},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9210000038146973},{"id":"https://openalex.org/keywords/n-demethylation","display_name":"N-demethylation","score":0.5799999833106995},{"id":"https://openalex.org/keywords/glucose-6-phosphatase","display_name":"glucose-6-phosphatase","score":0.8849999904632568},{"id":"https://openalex.org/keywords/ornithine-carbamyl-transferase","display_name":"ornithine carbamyl transferase","score":0.9350000023841858},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.8090000152587891},{"id":"https://openalex.org/keywords/liver-lipid-content","display_name":"liver lipids","score":0.5270000100135803},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.4749999940395355},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.5149999856948853},{"id":"https://openalex.org/keywords/alcohol-induced-liver-injury","display_name":"alcohol-induced liver injury","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C2777359374","wikidata":"https://www.wikidata.org/wiki/Q225045","display_name":"Carbon tetrachloride","level":2,"score":0.9032770395278931},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.7177467942237854},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5660014152526855},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5066471695899963},{"id":"https://openalex.org/C30772137","wikidata":"https://www.wikidata.org/wiki/Q5164762","display_name":"Consumption (sociology)","level":2,"score":0.48090171813964844},{"id":"https://openalex.org/C2909630643","wikidata":"https://www.wikidata.org/wiki/Q225045","display_name":"CARBON TETRACHLORIDE POISONING","level":3,"score":0.4503806233406067},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2123945653438568},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1599697768688202},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000428","descriptor_name":"Alcohol Drinking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000633","descriptor_name":"Aminopyrine N-Demethylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001663","descriptor_name":"Bilirubin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002250","descriptor_name":"Carbon Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002251","descriptor_name":"Carbon Tetrachloride","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002251","descriptor_name":"Carbon Tetrachloride","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D002252","descriptor_name":"Carbon Tetrachloride Poisoning","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005952","descriptor_name":"Glucose-6-Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009954","descriptor_name":"Ornithine Carbamoyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0016-5085(74)80142-3","doi":"https://doi.org/10.1016/s0016-5085(74)80142-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0016-5085(74)80142-3","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},{"id":"pmid:4149842","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4149842","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W15153607","https://openalex.org/W140672966","https://openalex.org/W308298495","https://openalex.org/W1491419518","https://openalex.org/W1551011162","https://openalex.org/W1584984747","https://openalex.org/W1775749144","https://openalex.org/W1806194750","https://openalex.org/W1912511634","https://openalex.org/W1920512451","https://openalex.org/W1927267116","https://openalex.org/W1951469402","https://openalex.org/W1953039335","https://openalex.org/W1971702630","https://openalex.org/W1978296639","https://openalex.org/W1981292392","https://openalex.org/W1997244788","https://openalex.org/W2003049927","https://openalex.org/W2006564336","https://openalex.org/W2008997703","https://openalex.org/W2012171778","https://openalex.org/W2021686174","https://openalex.org/W2042431422","https://openalex.org/W2048304384","https://openalex.org/W2054333012","https://openalex.org/W2057077203","https://openalex.org/W2060217548","https://openalex.org/W2068111218","https://openalex.org/W2068634222","https://openalex.org/W2069007287","https://openalex.org/W2092182275","https://openalex.org/W2092763649","https://openalex.org/W2153435210","https://openalex.org/W2165154367","https://openalex.org/W2171473267","https://openalex.org/W2219157299","https://openalex.org/W2281513185","https://openalex.org/W2322118741","https://openalex.org/W2322612078","https://openalex.org/W2333992311","https://openalex.org/W2337973729","https://openalex.org/W2338673694","https://openalex.org/W2411437542","https://openalex.org/W4300578939","https://openalex.org/W6634824130","https://openalex.org/W6639838429","https://openalex.org/W6644702753"],"related_works":["https://openalex.org/W2094829132","https://openalex.org/W2088233585","https://openalex.org/W1965514199","https://openalex.org/W2026955424","https://openalex.org/W1500394302","https://openalex.org/W2075506489","https://openalex.org/W2522160508","https://openalex.org/W2095581188","https://openalex.org/W2961228541","https://openalex.org/W2057567388"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}