{"id":"https://openalex.org/W1942904161","doi":null,"title":"Association of apolipoprotein E polymorphism with age-related macular degeneration and Alzheimer's disease in south-western Hungary.","display_name":"Association of apolipoprotein E polymorphism with age-related macular degeneration and Alzheimer's disease in south-western Hungary.","publication_year":2007,"publication_date":"2007-03-30","ids":{"openalex":"https://openalex.org/W1942904161","mag":"1942904161","pmid":"https://pubmed.ncbi.nlm.nih.gov/17451062"},"language":"en","primary_location":{"id":"pmid:17451062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17451062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ideggyogyaszati szemle","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102072160","display_name":"Katalin A. Kov\u00e1cs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79741316","display_name":"University of Pecs","ror":"https://ror.org/037b5pv06","country_code":"HU","type":"education","lineage":["https://openalex.org/I79741316"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Katalin A Kov\u00e1cs","raw_affiliation_strings":["Department of Ophthalmology, University of P\u00e9cs, P\u00e9cs","University of Pecs"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of P\u00e9cs, P\u00e9cs","institution_ids":["https://openalex.org/I79741316"]},{"raw_affiliation_string":"University of Pecs","institution_ids":["https://openalex.org/I79741316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002925699","display_name":"Zsuzsanna P\u00e1mer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79741316","display_name":"University of Pecs","ror":"https://ror.org/037b5pv06","country_code":"HU","type":"education","lineage":["https://openalex.org/I79741316"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Zsuzsanna P\u00e1mer","raw_affiliation_strings":["University of Pecs"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pecs","institution_ids":["https://openalex.org/I79741316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101756361","display_name":"Attila Kov\u00e1cs","orcid":"https://orcid.org/0000-0002-0444-5280","observed_orcids":["https://orcid.org/0000-0002-0444-5280"]},"institutions":[{"id":"https://openalex.org/I79741316","display_name":"University of Pecs","ror":"https://ror.org/037b5pv06","country_code":"HU","type":"education","lineage":["https://openalex.org/I79741316"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Attila Kov\u00e1cs","raw_affiliation_strings":["University of Pecs"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pecs","institution_ids":["https://openalex.org/I79741316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109527688","display_name":"S\u00e1ndor Fekete","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79741316","display_name":"University of Pecs","ror":"https://ror.org/037b5pv06","country_code":"HU","type":"education","lineage":["https://openalex.org/I79741316"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"S\u00e1ndor Fekete","raw_affiliation_strings":["PECSI TUDOMANYEGYETEM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PECSI TUDOMANYEGYETEM","institution_ids":["https://openalex.org/I79741316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084246012","display_name":"Attila Miseta","orcid":"https://orcid.org/0000-0002-7984-3347","observed_orcids":["https://orcid.org/0000-0002-7984-3347"]},"institutions":[{"id":"https://openalex.org/I79741316","display_name":"University of Pecs","ror":"https://ror.org/037b5pv06","country_code":"HU","type":"education","lineage":["https://openalex.org/I79741316"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Attila Miseta","raw_affiliation_strings":["PECSI TUDOMANYEGYETEM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PECSI TUDOMANYEGYETEM","institution_ids":["https://openalex.org/I79741316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032077148","display_name":"B\u00e1lint Kov\u00e0cs","orcid":"https://orcid.org/0000-0002-1191-0646","observed_orcids":["https://orcid.org/0000-0002-1191-0646"]},"institutions":[{"id":"https://openalex.org/I79741316","display_name":"University of Pecs","ror":"https://ror.org/037b5pv06","country_code":"HU","type":"education","lineage":["https://openalex.org/I79741316"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"B\u00e1lint Kov\u00e1cs","raw_affiliation_strings":["University of Pecs"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pecs","institution_ids":["https://openalex.org/I79741316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038242298","display_name":"G\u00e1bor L\u00e1szl\u00f3 Kov\u00e1cs","orcid":"https://orcid.org/0000-0001-5298-5401","observed_orcids":["https://orcid.org/0000-0001-5298-5401"]},"institutions":[{"id":"https://openalex.org/I79741316","display_name":"University of Pecs","ror":"https://ror.org/037b5pv06","country_code":"HU","type":"education","lineage":["https://openalex.org/I79741316"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"G\u00e1bor L Kov\u00e1cs","raw_affiliation_strings":["PECSI TUDOMANYEGYETEM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PECSI TUDOMANYEGYETEM","institution_ids":["https://openalex.org/I79741316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79741316"],"apc_list":null,"apc_paid":null,"fwci":0.3159,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.63377815,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"60","issue":"3-4","first_page":"169","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.6689000129699707,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.6689000129699707,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.20170000195503235,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.06729999929666519,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoe-polymorphism","display_name":"APOE polymorphism","score":0.9480000138282776},{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9800000190734863},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9909999966621399},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.8709999918937683},{"id":"https://openalex.org/keywords/apoe2","display_name":"APOE2","score":0.996999979019165},{"id":"https://openalex.org/keywords/apoe3","display_name":"APOE3","score":0.9129999876022339},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.8209999799728394},{"id":"https://openalex.org/keywords/total-cholesterol","display_name":"total cholesterol","score":0.7419999837875366},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9120000004768372},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9779999852180481},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.6420000195503235},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.8772432804107666},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.7612462043762207},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.6572884321212769},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6391672492027283},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5479408502578735},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5252498984336853},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5244565010070801},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5055129528045654},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3946506381034851},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3873155117034912},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3403100371360779},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3214418888092041}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006814","descriptor_name":"Hungary","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053327","descriptor_name":"Apolipoprotein E4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053329","descriptor_name":"Apolipoprotein E2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:17451062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17451062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ideggyogyaszati szemle","raw_type":"Comparative Study"},{"id":"mag:1942904161","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17451062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1995550265","https://openalex.org/W2404209422","https://openalex.org/W7168333074","https://openalex.org/W2063763497","https://openalex.org/W2156790419","https://openalex.org/W6940047559","https://openalex.org/W3148810505","https://openalex.org/W2414441486","https://openalex.org/W7047355610","https://openalex.org/W7155749911"],"abstract_inverted_index":{"BACKGROUND:":[0],"Age-related":[1],"macular":[2],"degeneration":[3],"(AMD)":[4],"and":[5,60,65,74,93,124,131,141,153,158,203],"Alzheimer":[6],"dementia":[7],"(AD)":[8],"show":[9],"similarities":[10],"(advanced":[11],"age,":[12],"formation":[13],"of":[14,16,36,55,90,108,115,135,146,181,188,196,207,217,222],"deposits":[15],"similar":[17],"content).":[18],"Recently":[19],"apolipoprotein":[20],"E":[21],"2":[22,137,209],"(apoE":[23],"2)":[24],"has":[25,45],"been":[26,47],"associated":[27],"with":[28,32,39],"AMD,":[29,71,122],"while":[30,133],"apoE4":[31],"AD.":[33],"The":[34,113,144,178,193],"question":[35],"coexistence,":[37],"especially":[38],"respect":[40],"to":[41],"the":[42,53,109,116,121,125,163,185,200,204,214,220],"genetic":[43],"background":[44],"not":[46],"studied":[48],"earlier.":[49],"We":[50],"investigated,":[51],"therefore,":[52],"occurrence":[54,187],"AMD":[56,103,189,211],"in":[57,106,120,162,213],"AD":[58,73,111,123,167,191,201],"patients":[59,77,127,168,212],"compared":[61],"their":[62],"lipid":[63],"profile":[64],"apoE":[66,97,117,136,147,197,208],"polymorphism.":[67],"METHODS:":[68],"-":[69],"49":[70],"32":[72],"27":[75],"control":[76,126],"were":[78,161,169],"examined":[79],"(risk":[80],"factors,":[81],"visual":[82],"acuity,":[83],"slit":[84],"lamp":[85],"biomicroscopy,":[86],"fundoscopy).":[87],"Following":[88],"measurement":[89],"triglyceride,":[91],"total":[92,157,174],"HDL":[94,159],"cholesterol":[95,160,175],"levels,":[96],"mutation":[98],"analysis":[99],"was":[100,104,128,138,150],"performed.":[101],"RESULTS:":[102],"found":[105],"8%":[107],"cooperating":[110],"patients.":[112,192],"prevalence":[114,145],"4":[118,198],"isoforms":[119],"2%,":[129],"47%":[130],"22%,":[132],"that":[134],"17%,":[139],"6%":[140],"7%,":[142],"respectively.":[143,155],"3":[148],"isoform":[149],"82%,":[151],"41%":[152],"71%,":[154],"Triglyceride,":[156],"reference":[164],"range;":[165],"however,":[166],"characterized":[170],"by":[171],"a":[172],"lower":[173],"value.":[176],"CONCLUSION:":[177],"new":[179],"finding":[180],"this":[182],"publication":[183],"is":[184],"rare":[186],"among":[190,199,210],"higher":[194,205],"frequency":[195,206],"population,":[202],"South-Western":[215],"region":[216],"Hungary":[218],"confirms":[219],"findings":[221],"other":[223],"investigators.":[224]},"counts_by_year":[{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
