{"id":"https://openalex.org/W1942895898","doi":"https://doi.org/10.1111/j.1742-1241.2010.02397.x","title":"Systematic review and meta analysis: polyethylene glycol in adults with non-organic constipation","display_name":"Systematic review and meta analysis: polyethylene glycol in adults with non-organic constipation","publication_year":2010,"publication_date":"2010-05-17","ids":{"openalex":"https://openalex.org/W1942895898","doi":"https://doi.org/10.1111/j.1742-1241.2010.02397.x","mag":"1942895898","pmid":"https://pubmed.ncbi.nlm.nih.gov/20584228"},"language":"en","primary_location":{"id":"doi:10.1111/j.1742-1241.2010.02397.x","doi":"https://doi.org/10.1111/j.1742-1241.2010.02397.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1742-1241.2010.02397.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1742-1241.2010.02397.x","source":{"id":"https://openalex.org/S22344484","display_name":"International Journal of Clinical Practice","issn_l":"1368-5031","issn":["1368-5031","1742-1241"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Clinical Practice","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1742-1241.2010.02397.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089703907","display_name":"Jonathan Belsey","orcid":"https://orcid.org/0000-0001-7283-327X","observed_orcids":["https://orcid.org/0000-0001-7283-327X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"J. D. Belsey","raw_affiliation_strings":["JB Medical Ltd, The Old Brickworks, Chapel Lane, Little Cornard, Sudbury, UK. jbelsey@jbmedical.com","JB Medical Ltd, The Old Brickworks, Chapel Lane, Little Cornard, Sudbury, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JB Medical Ltd, The Old Brickworks, Chapel Lane, Little Cornard, Sudbury, UK. jbelsey@jbmedical.com","institution_ids":[]},{"raw_affiliation_string":"JB Medical Ltd, The Old Brickworks, Chapel Lane, Little Cornard, Sudbury, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009924202","display_name":"Mike Geraint","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141803","display_name":"Norgine (United Kingdom)","ror":"https://ror.org/046zgtw08","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210136628","https://openalex.org/I4210141803"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. Geraint","raw_affiliation_strings":["Norgine Ltd, Harefield, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Norgine Ltd, Harefield, UK","institution_ids":["https://openalex.org/I4210141803"]}]},{"author_position":"last","author":{"id":null,"display_name":"T. A. Dixon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. A. Dixon","raw_affiliation_strings":["JB Medical Ltd, The Old Brickworks, Chapel Lane, Little Cornard, Sudbury, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JB Medical Ltd, The Old Brickworks, Chapel Lane, Little Cornard, Sudbury, UK","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089703907"],"corresponding_institution_ids":[],"apc_list":{"value":2350,"currency":"USD","value_usd":2350},"apc_paid":null,"fwci":0.5183,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.45265888,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"64","issue":"7","first_page":"944","last_page":"955"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10418","display_name":"Pelvic floor disorders treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12020","display_name":"Enhanced Recovery After Surgery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyethylene-glycol","display_name":"polyethylene glycol","score":0.9860000014305115},{"id":"https://openalex.org/keywords/laxatives","display_name":"laxatives","score":0.7279999852180481},{"id":"https://openalex.org/keywords/lactulose","display_name":"lactulose","score":0.8640000224113464},{"id":"https://openalex.org/keywords/stool-frequency","display_name":"stool frequency","score":0.7770000100135803},{"id":"https://openalex.org/keywords/laxative-efficacy","display_name":"laxative efficacy","score":0.7770000100135803},{"id":"https://openalex.org/keywords/adults","display_name":"adults","score":0.48500001430511475},{"id":"https://openalex.org/keywords/macrogol","display_name":"macrogol","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C2777448540","wikidata":"https://www.wikidata.org/wiki/Q422689","display_name":"Lactulose","level":2,"score":0.9444776773452759},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9320983290672302},{"id":"https://openalex.org/C2780661987","wikidata":"https://www.wikidata.org/wiki/Q217972","display_name":"Laxative","level":3,"score":0.8596380949020386},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8316730260848999},{"id":"https://openalex.org/C2781112942","wikidata":"https://www.wikidata.org/wiki/Q178436","display_name":"Constipation","level":2,"score":0.7047432661056519},{"id":"https://openalex.org/C71527416","wikidata":"https://www.wikidata.org/wiki/Q3774852","display_name":"Cathartic","level":2,"score":0.6386460065841675},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5927292108535767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5389853715896606},{"id":"https://openalex.org/C54400483","wikidata":"https://www.wikidata.org/wiki/Q1793202","display_name":"PEG ratio","level":2,"score":0.5334067344665527},{"id":"https://openalex.org/C2778435480","wikidata":"https://www.wikidata.org/wiki/Q840387","display_name":"Colonoscopy","level":4,"score":0.530356228351593},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.465692400932312},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.0609724223613739},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05686444044113159},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.055655717849731445},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003248","descriptor_name":"Constipation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003672","descriptor_name":"Defecation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004573","descriptor_name":"Electrolytes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054368","descriptor_name":"Laxatives","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1742-1241.2010.02397.x","doi":"https://doi.org/10.1111/j.1742-1241.2010.02397.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1742-1241.2010.02397.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1742-1241.2010.02397.x","source":{"id":"https://openalex.org/S22344484","display_name":"International Journal of Clinical Practice","issn_l":"1368-5031","issn":["1368-5031","1742-1241"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Clinical Practice","raw_type":"journal-article"},{"id":"pmid:20584228","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20584228","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical practice","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1742-1241.2010.02397.x","doi":"https://doi.org/10.1111/j.1742-1241.2010.02397.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1742-1241.2010.02397.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1742-1241.2010.02397.x","source":{"id":"https://openalex.org/S22344484","display_name":"International Journal of Clinical Practice","issn_l":"1368-5031","issn":["1368-5031","1742-1241"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Clinical Practice","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332137","display_name":"Norgine","ror":"https://ror.org/02vt89g81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1942895898.pdf","grobid_xml":"https://content.openalex.org/works/W1942895898.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W51561167","https://openalex.org/W141407086","https://openalex.org/W149560302","https://openalex.org/W171470717","https://openalex.org/W1481760661","https://openalex.org/W1537972189","https://openalex.org/W1968253107","https://openalex.org/W1971440285","https://openalex.org/W1986215651","https://openalex.org/W1999878585","https://openalex.org/W2012125655","https://openalex.org/W2019142191","https://openalex.org/W2024011862","https://openalex.org/W2028610080","https://openalex.org/W2043029415","https://openalex.org/W2048391965","https://openalex.org/W2050769859","https://openalex.org/W2064201279","https://openalex.org/W2071613922","https://openalex.org/W2071684431","https://openalex.org/W2076779392","https://openalex.org/W2078792098","https://openalex.org/W2081769443","https://openalex.org/W2085025198","https://openalex.org/W2090144284","https://openalex.org/W2095090829","https://openalex.org/W2107328434","https://openalex.org/W2115636891","https://openalex.org/W2124338734","https://openalex.org/W2160323354","https://openalex.org/W2164474624","https://openalex.org/W2165844124","https://openalex.org/W2166386674","https://openalex.org/W2376173628","https://openalex.org/W2386229854","https://openalex.org/W2391903913","https://openalex.org/W2416065502","https://openalex.org/W4247718302","https://openalex.org/W6606105841"],"related_works":["https://openalex.org/W171470717","https://openalex.org/W2550384951","https://openalex.org/W1975219556","https://openalex.org/W2085349650","https://openalex.org/W174829149","https://openalex.org/W2912041052","https://openalex.org/W2331527655","https://openalex.org/W1959276090","https://openalex.org/W3037394400","https://openalex.org/W2165844124"],"abstract_inverted_index":{"It":[0],"is":[1,226],"unclear":[2],"how":[3],"polyethylene":[4,72],"glycol":[5],"(PEG)":[6],"laxatives":[7],"compare":[8],"with":[9,30,100,109,117,253],"other":[10,167],"classes":[11],"of":[12,16,21,46,120,127,134],"laxative":[13,114,247],"in":[14,28,115,129,179,184,236,250],"terms":[15,62],"efficacy.":[17],"To":[18],"assess":[19],"efficacy":[20],"PEG":[22,108,176,239],"vs.":[23,157,161,166],"placebo":[24,110,173,187],"and":[25,49,163,174,204],"active":[26],"comparators":[27],"adults":[29,116],"non-organic":[31,121],"constipation.":[32,254],"Text":[33],"Word":[34],"searches":[35],"were":[36,63,123,144,156,160,165],"carried":[37],"out":[38],"on":[39,132,146],"MEDLINE,":[40],"EMBASE,":[41],"CINAHL,":[42],"Cochrane":[43],"Central":[44],"Register":[45],"Clinical":[47],"Trials":[48],"Google":[50],"Scholar":[51],"databases":[52],"covering":[53],"the":[54,135,151,227,237],"period":[55],"January":[56],"1970":[57],"to":[58,232,242],"October":[59],"2009.":[60],"Search":[61],"(constipation)":[64],"AND":[65,69],"(randomised":[66],"OR":[67,71,73,75,77,79,81,83,85,87,89,91],"randomized)":[68],"(PEG":[70],"macrogol":[74],"movicol":[76],"idrolax":[78],"miralax":[80],"transipeg":[82],"forlax":[84],"colyte":[86],"golytely":[88],"isocolan":[90],"nulytely)":[92],"NOT":[93],"colonoscopy.":[94],"Only":[95],"published":[96,235],"randomised":[97],"controlled":[98],"trials,":[99],"a":[101,112,118,180,244],"parallel-group":[102],"or":[103,111],"cross-over":[104],"design,":[105],"comparing":[106],"oral":[107],"comparator":[113],"history":[119],"constipation,":[122],"included.":[124],"The":[125],"frequency":[126],"defaecation":[128],"each":[130],"arm,":[131],"completion":[133],"protocol-defined":[136],"treatment":[137,177],"duration":[138],"was":[139,240],"extracted.":[140],"All":[141],"pooled":[142],"analyses":[143],"based":[145],"random":[147],"effect":[148],"models.":[149],"Of":[150],"20":[152],"qualifying":[153],"studies,":[154],"10":[155],"placebo,":[158],"seven":[159],"lactulose,":[162],"four":[164],"agents.":[168],"One":[169],"study":[170],"compared":[171],"PEG,":[172],"lactulose.":[175],"resulted":[178],"highly":[181],"significant":[182],"increase":[183],"defaecations/week":[185],"over":[186,205],"(all":[188,207],"studies:":[189,197,208,216],"additional":[190,198,209,217],"1.98":[191],"stools/week;":[192,200,219],"p":[193,201,212,220],"=":[194,202,213,221],"0.0003,":[195],"high-quality":[196,215],"2.34":[199],"0.0001)":[203],"lactulose":[206,249],"1":[210],"stool/week;":[211],"0.0017,":[214],"1.65":[218],"0.021).":[222],"This":[223],"meta":[224],"analysis":[225,231],"only":[228],"quantitative":[229],"statistical":[230],"have":[233],"been":[234],"field.":[238],"found":[241],"be":[243],"more":[245],"effective":[246],"than":[248],"adult":[251],"patients":[252]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}