{"id":"https://openalex.org/W1942129679","doi":"https://doi.org/10.1158/2326-6066.cir-15-0120","title":"Fc-Receptor Interactions Regulate Both Cytotoxic and Immunomodulatory Therapeutic Antibody Effector Functions","display_name":"Fc-Receptor Interactions Regulate Both Cytotoxic and Immunomodulatory Therapeutic Antibody Effector Functions","publication_year":2015,"publication_date":"2015-07-01","ids":{"openalex":"https://openalex.org/W1942129679","doi":"https://doi.org/10.1158/2326-6066.cir-15-0120","mag":"1942129679","pmid":"https://pubmed.ncbi.nlm.nih.gov/26138698"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6066.cir-15-0120","doi":"https://doi.org/10.1158/2326-6066.cir-15-0120","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6066.cir-15-0120","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015440255","display_name":"David J. DiLillo","orcid":"https://orcid.org/0000-0003-2653-2913","observed_orcids":["https://orcid.org/0000-0003-2653-2913"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. DiLillo","raw_affiliation_strings":["The Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, New York","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007474253","display_name":"Jeffrey V. Ravetch","orcid":"https://orcid.org/0000-0003-2024-9041","observed_orcids":["https://orcid.org/0000-0003-2024-9041"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey V. Ravetch","raw_affiliation_strings":["The Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, New York","institution_ids":["https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I83399316"],"apc_list":null,"apc_paid":null,"fwci":2.3113,"has_fulltext":false,"cited_by_count":132,"citation_normalized_percentile":{"value":0.908,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"3","issue":"7","first_page":"704","last_page":"713"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fc-receptors","display_name":"Fc receptors","score":0.8889999985694885},{"id":"https://openalex.org/keywords/therapeutic-antibodies","display_name":"therapeutic antibodies","score":0.8059999942779541},{"id":"https://openalex.org/keywords/antibody-effector-functions","display_name":"antibody effector functions","score":0.9430000185966492},{"id":"https://openalex.org/keywords/antibody-dependent-cellular-cytotoxicity","display_name":"antibody-dependent cellular cytotoxicity","score":0.7940000295639038},{"id":"https://openalex.org/keywords/immunomodulatory-antibodies","display_name":"immunomodulatory antibodies","score":0.8759999871253967},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7099999785423279},{"id":"https://openalex.org/keywords/antibody-design","display_name":"antibody design","score":0.43799999356269836},{"id":"https://openalex.org/keywords/effector-cells","display_name":"effector cells","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.7917641401290894},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7426299452781677},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6210333108901978},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5985601544380188},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5566182136535645},{"id":"https://openalex.org/C40677261","wikidata":"https://www.wikidata.org/wiki/Q21418091","display_name":"Antibody-dependent cell-mediated cytotoxicity","level":4,"score":0.5407121181488037},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5210294723510742},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4311411380767822},{"id":"https://openalex.org/C45121317","wikidata":"https://www.wikidata.org/wiki/Q4927287","display_name":"Blocking antibody","level":3,"score":0.4302740693092346},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36019736528396606},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3317120671272278},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.20689594745635986},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1511530578136444},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06985387206077576}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000912","descriptor_name":"Antibodies, Neoplasm","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007116","descriptor_name":"Immunization, Passive","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/2326-6066.cir-15-0120","doi":"https://doi.org/10.1158/2326-6066.cir-15-0120","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6066.cir-15-0120","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"},{"id":"pmid:26138698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26138698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer immunology research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W76624571","https://openalex.org/W93540796","https://openalex.org/W1495576644","https://openalex.org/W1537932379","https://openalex.org/W1594149454","https://openalex.org/W1963633622","https://openalex.org/W1965962344","https://openalex.org/W1972777297","https://openalex.org/W1978929052","https://openalex.org/W1982861708","https://openalex.org/W1985136634","https://openalex.org/W1987412140","https://openalex.org/W1991388076","https://openalex.org/W2000276387","https://openalex.org/W2006128988","https://openalex.org/W2010614363","https://openalex.org/W2017390384","https://openalex.org/W2017873446","https://openalex.org/W2025966090","https://openalex.org/W2037117519","https://openalex.org/W2040777459","https://openalex.org/W2042105881","https://openalex.org/W2043946207","https://openalex.org/W2044360617","https://openalex.org/W2048787440","https://openalex.org/W2050376954","https://openalex.org/W2050400262","https://openalex.org/W2051118090","https://openalex.org/W2053313205","https://openalex.org/W2054149360","https://openalex.org/W2071875829","https://openalex.org/W2072697318","https://openalex.org/W2072770765","https://openalex.org/W2075901113","https://openalex.org/W2081717004","https://openalex.org/W2084136419","https://openalex.org/W2100288357","https://openalex.org/W2100612316","https://openalex.org/W2101581360","https://openalex.org/W2103118255","https://openalex.org/W2104088439","https://openalex.org/W2108556253","https://openalex.org/W2109440389","https://openalex.org/W2110990893","https://openalex.org/W2112123471","https://openalex.org/W2116661011","https://openalex.org/W2120319857","https://openalex.org/W2121080857","https://openalex.org/W2122080125","https://openalex.org/W2122618533","https://openalex.org/W2128402413","https://openalex.org/W2130846254","https://openalex.org/W2130867278","https://openalex.org/W2143163879","https://openalex.org/W2143620061","https://openalex.org/W2147590006","https://openalex.org/W2153908836","https://openalex.org/W2155599713","https://openalex.org/W2156106286","https://openalex.org/W2158883604","https://openalex.org/W2160762238","https://openalex.org/W2161738112","https://openalex.org/W2169948324","https://openalex.org/W2337393898"],"related_works":["https://openalex.org/W2567688249","https://openalex.org/W4220826711","https://openalex.org/W3126147677","https://openalex.org/W2015252634","https://openalex.org/W2586816871","https://openalex.org/W2315188409","https://openalex.org/W4389436431","https://openalex.org/W188600457","https://openalex.org/W2363138227","https://openalex.org/W3103755394"],"abstract_inverted_index":{"Antibodies":[0],"are":[1],"now":[2,102],"recognized":[3],"as":[4],"key":[5],"therapeutic":[6,19,65,141,152],"tools":[7],"to":[8,42,138,168],"combat":[9],"most":[10],"forms":[11],"of":[12,18,36,61,64,70,80,94,110,117,124,150,160],"malignancy.":[13],"Although":[14],"the":[15,49,68,71,77,108,111,114,121,161],"first":[16],"wave":[17],"antibodies":[20,66],"that":[21,86,104],"emerged":[22],"over":[23],"two":[24],"decades":[25],"ago":[26],"directly":[27],"target":[28,112],"tumor":[29],"cells":[30,85],"for":[31,54,157],"killing,":[32],"a":[33],"new":[34],"class":[35],"antibody":[37,82,132],"therapies":[38],"targeting":[39],"immunoregulatory":[40],"pathways":[41],"boost":[43],"antitumor":[44],"immune":[45,50,84],"responses":[46],"by":[47],"activating":[48],"system":[51],"is":[52,67,101],"poised":[53],"clinical":[55,170],"success.":[56,171],"A":[57],"notable":[58],"common":[59],"characteristic":[60],"both":[62],"classes":[63],"importance":[69],"IgG":[72],"Fc":[73,95,154],"domain,":[74],"which":[75],"connects":[76],"fine":[78],"specificity":[79],"an":[81,131],"with":[83,136],"mediate":[87,139],"antibody-triggered":[88],"effector":[89,118],"functions":[90],"through":[91,144],"their":[92],"engagement":[93,159],"receptor":[96],"(FcR)":[97],"family":[98],"members.":[99],"It":[100],"clear":[103],"multiple":[105],"variables,":[106],"including":[107],"nature":[109],"molecules,":[113],"local":[115],"presence":[116],"cells,":[119],"and":[120,129],"expression":[122],"patterns":[123],"FcRs,":[125],"will":[126,133],"dictate":[127],"whether":[128],"how":[130],"necessitate":[134],"interactions":[135],"FcRs":[137,164],"optimal":[140,158],"effects.":[142],"Thus,":[143],"careful":[145],"in":[146],"vivo":[147],"mechanistic":[148],"analyses":[149],"individual":[151],"antibodies,":[153],"domains":[155],"engineered":[156],"appropriate":[162],"cellular":[163],"must":[165],"be":[166],"designed":[167],"maximize":[169]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}