{"id":"https://openalex.org/W1941948488","doi":"https://doi.org/10.1242/dev.101.2.255","title":"Localization and expression of msp130, a primary mesenchyme lineagespecific cell surface protein of the sea urchin embryo","display_name":"Localization and expression of msp130, a primary mesenchyme lineagespecific cell surface protein of the sea urchin embryo","publication_year":1987,"publication_date":"1987-10-01","ids":{"openalex":"https://openalex.org/W1941948488","doi":"https://doi.org/10.1242/dev.101.2.255","mag":"1941948488","pmid":"https://pubmed.ncbi.nlm.nih.gov/3128442"},"language":"en","primary_location":{"id":"doi:10.1242/dev.101.2.255","doi":"https://doi.org/10.1242/dev.101.2.255","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.101.2.255","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016374417","display_name":"John A. Anstrom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Anstrom","raw_affiliation_strings":["Institute for Molecular and Cellular Biology, Indiana University, Bloomington 47405"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular and Cellular Biology, Indiana University, Bloomington 47405","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111855927","display_name":"Jia En Chin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jia E. Chin","raw_affiliation_strings":["Institute for Molecular and Cellular Biology, Indiana University, Bloomington 47405"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular and Cellular Biology, Indiana University, Bloomington 47405","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081845002","display_name":"David S. Leaf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S. Leaf","raw_affiliation_strings":["Institute for Molecular and Cellular Biology, Indiana University, Bloomington 47405"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular and Cellular Biology, Indiana University, Bloomington 47405","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000644641","display_name":"Annette L. Parks","orcid":"https://orcid.org/0000-0002-4619-2277","observed_orcids":["https://orcid.org/0000-0002-4619-2277"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annette L. Parks","raw_affiliation_strings":["Indiana University Institute for Molecular and Cellular Biology and Department of Biology , , Bloomington, Indiana 47405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University Institute for Molecular and Cellular Biology and Department of Biology , , Bloomington, Indiana 47405, USA","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113538979","display_name":"Rudolf A. Raff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rudolf A. Raff","raw_affiliation_strings":["Indiana University Institute for Molecular and Cellular Biology and Department of Biology , , Bloomington, Indiana 47405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University Institute for Molecular and Cellular Biology and Department of Biology , , Bloomington, Indiana 47405, USA","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7881,"has_fulltext":false,"cited_by_count":101,"citation_normalized_percentile":{"value":0.91443558,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"101","issue":"2","first_page":"255","last_page":"265"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12841","display_name":"Echinoderm biology and ecology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-mesenchyme","display_name":"primary mesenchyme","score":0.8230000138282776},{"id":"https://openalex.org/keywords/sea-urchin-embryo","display_name":"sea urchin embryo","score":0.968999981880188},{"id":"https://openalex.org/keywords/cell-surface-proteins","display_name":"cell surface proteins","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cell-surface-antigens","display_name":"cell surface antigens","score":0.5590000152587891},{"id":"https://openalex.org/keywords/golgi-apparatus","display_name":"Golgi apparatus","score":0.6140000224113464},{"id":"https://openalex.org/keywords/n-glycosylation","display_name":"N-glycosylation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/sulphated-glycoproteins","display_name":"sulphated glycoproteins","score":0.8799999952316284},{"id":"https://openalex.org/keywords/sulfate","display_name":"sulfate","score":0.5619999766349792},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.7820000052452087},{"id":"https://openalex.org/keywords/acidic-proteins","display_name":"acidic proteins","score":0.3070000112056732}],"concepts":[{"id":"https://openalex.org/C160351604","wikidata":"https://www.wikidata.org/wiki/Q6033113","display_name":"Ingression","level":5,"score":0.9242700338363647},{"id":"https://openalex.org/C2776340970","wikidata":"https://www.wikidata.org/wiki/Q32838","display_name":"Mesenchyme","level":3,"score":0.9237270355224609},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8627826571464539},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.671749472618103},{"id":"https://openalex.org/C2777804106","wikidata":"https://www.wikidata.org/wiki/Q420263","display_name":"Blastocoel","level":5,"score":0.6285180449485779},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5643807649612427},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.5448176860809326},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5405195951461792},{"id":"https://openalex.org/C2776908312","wikidata":"https://www.wikidata.org/wiki/Q83483","display_name":"Sea urchin","level":2,"score":0.5021052360534668},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.41307756304740906},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4049837589263916},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.3370228409767151},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3228204846382141},{"id":"https://openalex.org/C129536746","wikidata":"https://www.wikidata.org/wiki/Q1141026","display_name":"Gastrulation","level":4,"score":0.2812214493751526},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15467974543571472},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.1111498773097992}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006026","descriptor_name":"Glycoside Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007525","descriptor_name":"Isoelectric Focusing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012617","descriptor_name":"Sea Urchins","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D012617","descriptor_name":"Sea Urchins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017038","descriptor_name":"Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1242/dev.101.2.255","doi":"https://doi.org/10.1242/dev.101.2.255","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.101.2.255","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmid:3128442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3128442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4167921280","display_name":null,"funder_award_id":"HD 06902","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G5195086539","display_name":"DETERMINATION OF AN EARLY EMBRYONIC CELL LINEAGE","funder_award_id":"R01HD021986","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W658059226","https://openalex.org/W1486569656","https://openalex.org/W1488846638","https://openalex.org/W1511657974","https://openalex.org/W1594508671","https://openalex.org/W1606423922","https://openalex.org/W1965739715","https://openalex.org/W1977229813","https://openalex.org/W1996585080","https://openalex.org/W1997029893","https://openalex.org/W1998696282","https://openalex.org/W1999437396","https://openalex.org/W2008013667","https://openalex.org/W2013412695","https://openalex.org/W2013708756","https://openalex.org/W2013916477","https://openalex.org/W2034528480","https://openalex.org/W2058907589","https://openalex.org/W2059709337","https://openalex.org/W2065861447","https://openalex.org/W2082897332","https://openalex.org/W2089341748","https://openalex.org/W2096428903","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2155368812","https://openalex.org/W2164033494","https://openalex.org/W2483408595","https://openalex.org/W2595846671"],"related_works":["https://openalex.org/W2058907589","https://openalex.org/W1554349383","https://openalex.org/W1620192314","https://openalex.org/W3036841788","https://openalex.org/W1991863481","https://openalex.org/W2069640207","https://openalex.org/W2020594123","https://openalex.org/W2013676217","https://openalex.org/W2034528480","https://openalex.org/W2031453878"],"abstract_inverted_index":{"In":[0,141],"this":[1,192],"report,":[2],"we":[3,83],"use":[4],"a":[5,12,22,118,196],"monoclonal":[6,170],"antibody":[7],"(B2C2)":[8],"and":[9,66,82,102,182,190],"antibodies":[10],"against":[11],"fusion":[13],"protein":[14,25,38,151,193],"(Leaf":[15],"et":[16,174,185],"al.":[17,175,186],"1987)":[18],"to":[19,27,78,109,194],"characterize":[20],"msp130,":[21,189],"cell":[23,198],"surface":[24,43,70,199],"specific":[26],"the":[28,33,42,50,59,63,68,89,104,126,158],"primary":[29,72,202],"mesenchyme":[30,73,203],"cells":[31,46],"of":[32,44,62,71,92,125,129,160,201],"sea":[34,139],"urchin":[35],"embryo.":[36],"This":[37],"first":[39],"appears":[40],"on":[41,67],"these":[45],"upon":[47],"ingression":[48],"into":[49],"blastocoel.":[51],"Immunoelectronmicroscopy":[52],"shows":[53],"that":[54,85,96,103,114,146,152,165],"msp130":[55,79,97,115,130,147],"is":[56,107,116,121,131,148],"present":[57],"in":[58,137,157],"trans":[60],"side":[61],"Golgi":[64],"apparatus":[65],"extracellular":[69],"cells.":[74,204],"Four":[75],"precursor":[76],"proteins":[77],"are":[80,135],"identified":[81],"show":[84,145,164],"B2C2":[86,105,127],"recognizes":[87],"only":[88],"mature":[90],"form":[91],"msp130.":[93],"We":[94,162],"demonstrate":[95],"contains":[98],"N-linked":[99],"carbohydrate":[100],"groups":[101],"epitope":[106,128],"sensitive":[108],"endoglycosidase":[110],"F":[111],"digestion.":[112],"Evidence":[113],"apparently":[117],"sulphated":[119],"glycoprotein":[120],"presented.":[122],"The":[123],"recognition":[124],"disrupted":[132],"when":[133],"embryos":[134],"cultured":[136],"sulphate-free":[138],"water.":[140],"addition,":[142],"two-dimensional":[143],"immunoblots":[144],"an":[149],"acidic":[150,156],"becomes":[153],"substantially":[154],"less":[155],"absence":[159],"sulphate.":[161],"also":[163],"two":[166],"other":[167],"independently":[168],"derived":[169],"antibodies,":[171],"IG8":[172],"(McClay":[173],"1983;":[176],"McClay,":[177],"Matranga":[178],"&":[179],"Wessel,":[180],"1985)":[181],"1223":[183],"(Carson":[184],"1985),":[187],"recognize":[188],"suggest":[191],"be":[195],"major":[197],"antigen":[200]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}