{"id":"https://openalex.org/W194069455","doi":null,"title":"Design and Synthesis of Sialic Acid Conjugates as Inhibitors of EKC-causing Adenoviruses","display_name":"Design and Synthesis of Sialic Acid Conjugates as Inhibitors of EKC-causing Adenoviruses","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W194069455","mag":"194069455"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:umu-1641","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1641","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1641","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109971370","display_name":"Susanne Johansson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Susanne Johansson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5109971370"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidemic-keratoconjunctivitis","display_name":"epidemic keratoconjunctivitis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/antiviral-drug-design","display_name":"antiviral drug design","score":0.8370000123977661},{"id":"https://openalex.org/keywords/multivalent-binding","display_name":"multivalent binding","score":0.6119999885559082},{"id":"https://openalex.org/keywords/human-serum-albumin-conjugate","display_name":"human serum albumin conjugate","score":0.7139999866485596},{"id":"https://openalex.org/keywords/3-sialyllactose","display_name":"3'-sialyllactose","score":0.9599999785423279},{"id":"https://openalex.org/keywords/viral-attachment-inhibition","display_name":"viral attachment inhibition","score":0.5260000228881836},{"id":"https://openalex.org/keywords/corneal-epithelial-cells","display_name":"corneal epithelial cells","score":0.8519999980926514},{"id":"https://openalex.org/keywords/protein-carbohydrate-interactions","display_name":"carbohydrate-protein interactions","score":0.6389999985694885},{"id":"https://openalex.org/keywords/ocular-drug-delivery","display_name":"ocular drug delivery","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6337859630584717},{"id":"https://openalex.org/C2780115458","wikidata":"https://www.wikidata.org/wiki/Q419311","display_name":"Sialic acid","level":2,"score":0.6231347918510437},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4673573970794678},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4419867694377899},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.4144757091999054},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.38215339183807373},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1958131194114685},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:umu-1641","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1641","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:194069455","doi":null,"is_oa":false,"landing_page_url":"http://umu.diva-portal.org/smash/get/diva2:141663/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:umu-1641","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1641","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":130,"referenced_works":["https://openalex.org/W15542647","https://openalex.org/W95293157","https://openalex.org/W129783565","https://openalex.org/W155090258","https://openalex.org/W297526181","https://openalex.org/W399092470","https://openalex.org/W1500181036","https://openalex.org/W1508805699","https://openalex.org/W1510136884","https://openalex.org/W1510934485","https://openalex.org/W1565376547","https://openalex.org/W1595570412","https://openalex.org/W1823750347","https://openalex.org/W1930355415","https://openalex.org/W1949917588","https://openalex.org/W1964209583","https://openalex.org/W1965945970","https://openalex.org/W1966026530","https://openalex.org/W1967665391","https://openalex.org/W1969803904","https://openalex.org/W1973113001","https://openalex.org/W1976374267","https://openalex.org/W1976829964","https://openalex.org/W1979438209","https://openalex.org/W1981207136","https://openalex.org/W1983417873","https://openalex.org/W1984388879","https://openalex.org/W1985004056","https://openalex.org/W1985202545","https://openalex.org/W1986240377","https://openalex.org/W1986509391","https://openalex.org/W1987065820","https://openalex.org/W1987330592","https://openalex.org/W1988092557","https://openalex.org/W1991592905","https://openalex.org/W1992034958","https://openalex.org/W1992888087","https://openalex.org/W1997028494","https://openalex.org/W1999214312","https://openalex.org/W2000086610","https://openalex.org/W2000950139","https://openalex.org/W2001648837","https://openalex.org/W2002254486","https://openalex.org/W2006002199","https://openalex.org/W2010449044","https://openalex.org/W2011547610","https://openalex.org/W2011955959","https://openalex.org/W2013816252","https://openalex.org/W2014427579","https://openalex.org/W2015108596","https://openalex.org/W2016473356","https://openalex.org/W2016564119","https://openalex.org/W2017436619","https://openalex.org/W2022415431","https://openalex.org/W2023101263","https://openalex.org/W2026386892","https://openalex.org/W2027428082","https://openalex.org/W2027451491","https://openalex.org/W2028091357","https://openalex.org/W2028986432","https://openalex.org/W2029080316","https://openalex.org/W2029519723","https://openalex.org/W2029569059","https://openalex.org/W2030701775","https://openalex.org/W2033456415","https://openalex.org/W2036298428","https://openalex.org/W2039631672","https://openalex.org/W2043964314","https://openalex.org/W2046736708","https://openalex.org/W2046967131","https://openalex.org/W2047400336","https://openalex.org/W2048074160","https://openalex.org/W2052030759","https://openalex.org/W2056042508","https://openalex.org/W2057112987","https://openalex.org/W2057318433","https://openalex.org/W2058989696","https://openalex.org/W2059375062","https://openalex.org/W2068261875","https://openalex.org/W2077120356","https://openalex.org/W2079739212","https://openalex.org/W2082392421","https://openalex.org/W2083214508","https://openalex.org/W2086025824","https://openalex.org/W2086358466","https://openalex.org/W2087995805","https://openalex.org/W2088781420","https://openalex.org/W2090174721","https://openalex.org/W2097467042","https://openalex.org/W2110686895","https://openalex.org/W2111796195","https://openalex.org/W2111938017","https://openalex.org/W2114798556","https://openalex.org/W2118597562","https://openalex.org/W2121673753","https://openalex.org/W2126818937","https://openalex.org/W2129232972","https://openalex.org/W2129978084","https://openalex.org/W2131910359","https://openalex.org/W2135814560","https://openalex.org/W2136374567","https://openalex.org/W2140019924","https://openalex.org/W2142820798","https://openalex.org/W2145061993","https://openalex.org/W2146976502","https://openalex.org/W2149522574","https://openalex.org/W2153792353","https://openalex.org/W2156487862","https://openalex.org/W2156786214","https://openalex.org/W2157751777","https://openalex.org/W2166011716","https://openalex.org/W2169359328","https://openalex.org/W2170396812","https://openalex.org/W2170651251","https://openalex.org/W2262829041","https://openalex.org/W2321970410","https://openalex.org/W2338266679","https://openalex.org/W2395363633","https://openalex.org/W2397677772","https://openalex.org/W2399770194","https://openalex.org/W2409206557","https://openalex.org/W2411540509","https://openalex.org/W2820693144","https://openalex.org/W2907517803","https://openalex.org/W2949144712","https://openalex.org/W2949225124","https://openalex.org/W2950156419","https://openalex.org/W2950617629","https://openalex.org/W3000525006","https://openalex.org/W3021749114"],"related_works":["https://openalex.org/W1990229109","https://openalex.org/W2066928310","https://openalex.org/W2054310317","https://openalex.org/W1882212645","https://openalex.org/W2027145049","https://openalex.org/W3081319981","https://openalex.org/W1993814737","https://openalex.org/W1936712267","https://openalex.org/W1972628981","https://openalex.org/W2940991221"],"abstract_inverted_index":{"The":[0,115,331],"combat":[1],"against":[2],"viral":[3,43,130],"diseases":[4],"has":[5],"been,":[6],"and":[7,32,40,87,110,123,148,190,212,236,241,260,281,312],"still":[8],"is,":[9],"a":[10,159,307,323],"major":[11,324],"challenge":[12],"in":[13,117,135,158,205,257,338],"the":[14,25,42,47,51,68,125,137,151,156,177,199,202,272,275,278,285,304,317,321],"field":[15],"of":[16,50,112,180,192,201,214,226,232,254,277,287,295,320,326,347],"drug":[17,344],"development.":[18],"Viruses":[19],"are":[20,267],"intracellular":[21],"parasites":[22],"that":[23,176,197,265,284],"use":[24],"host":[26,52,113],"cell":[27,92,258,261],"ma-chinery":[28],"for":[29,82,106,129,345],"their":[30,107,165,242],"replication":[31],"release.":[33],"Therefore":[34],"it":[35,173],"is":[36,141,174,289],"difficult":[37],"to":[38,103,109,207,211,222,303,340],"target":[39],"destroy":[41],"particle":[44],"without":[45],"disturbing":[46],"essential":[48],"functions":[49],"cell.":[53],"This":[54,186],"thesis":[55,119,187],"describes":[56],"studies":[57],"towards":[58],"antiviral":[59,343],"agents":[60],"targeting":[61],"adenovirus":[62],"type":[63],"37":[64],"(Ad37),":[65],"which":[66],"causes":[67],"severe":[69],"ocular":[70],"infection":[71,111,213],"epidemic":[72],"keratoconjunctivitis":[73],"(EKC).":[74],"Cell":[75],"surface":[76,93],"oligosaccharides":[77],"serve":[78],"as":[79,269,329],"cellular":[80,166,203],"receptors":[81,167],"many":[83],"pathogens,":[84],"including":[85],"viruses":[86],"bacteria.":[88],"For":[89],"EKC-causing":[90],"adenoviruses,":[91],"oligo-saccharides":[94],"with":[95,164,292],"terminal":[96],"sialic":[97,138,194,227,233,239],"acid":[98,195,228],"have":[99,250],"recently":[100],"been":[101,251],"shown":[102],"be":[104,184,301,336],"critical":[105],"attachment":[108,210],"cells.":[114,219],"work":[116],"this":[118,146],"support":[120],"these":[121,255],"re-sults":[122],"identifies":[124],"minimal":[126],"binding":[127,152,259],"epitope":[128],"recognition.":[131],"As":[132],"carbo-hydrate\u2013protein":[133],"interactions":[134],"general,":[136],"acid\u2013Ad37":[139],"interaction":[140],"very":[142],"weak.":[143],"Nature":[144],"overcomes":[145],"problem":[147],"vastly":[149],"improves":[150],"affinity":[153],"by":[154],"presenting":[155],"carbohydrates":[157,328],"multivalent":[160,193,243],"fashion.":[161],"Adenoviruses":[162],"interact":[163],"via":[168],"multiple":[169],"fiber":[170],"proteins,":[171],"whereby":[172],"likely":[175],"ideal":[178],"inhibitor":[179],"adenoviral":[181,209],"infections":[182],"should":[183],"multivalent.":[185],"includes":[188],"design":[189],"synthesis":[191],"glycoconjugates":[196],"mimic":[198],"structure":[200],"receptor":[204],"order":[206],"inhibit":[208],"human":[215,246],"corneal":[216],"epithelial":[217],"(HCE)":[218],"Synthetic":[220],"routes":[221],"three":[223],"different":[224],"classes":[225],"conjugates,":[229],"i.e.":[230],"derivatives":[231],"acid,":[234],"3\u2019-sialyllactose":[235],"N-acyl":[237],"modified":[238],"acids,":[240],"counterparts":[244],"on":[245],"serum":[247],"albumine":[248],"(HSA)":[249],"developed.":[252],"Evaluation":[253],"conjugates":[256],"infectivity":[262],"assays":[263],"revealed":[264],"they":[266,314],"effective":[268],"inhibitors.":[270],"Moreover":[271],"results":[273,332],"verify":[274],"hypothesis":[276],"multivalency":[279],"effect":[280],"clearly":[282],"shows":[283],"power":[286],"inhibition":[288],"significantly":[290],"increased":[291],"higher":[293],"orders":[294],"valency.":[296],"Potential":[297],"inhibi-tors":[298],"could":[299,334],"easily":[300],"transferred":[302],"eye":[305,310],"using":[306,327],"salve":[308],"or":[309],"drops,":[311],"thereby":[313],"would":[315],"escape":[316],"metabolic":[318],"processes":[319],"body,":[322],"drawback":[325],"drugs.":[330],"herein":[333],"therefore":[335],"useful":[337],"efforts":[339],"develop":[341],"an":[342],"treatment":[346],"EKC.":[348]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}