{"id":"https://openalex.org/W1940407161","doi":"https://doi.org/10.1111/imb.12187","title":"The \u03b2\u2010 N \u2010acetylhexosaminidase gene family in the brown planthopper, Nilaparvata lugens","display_name":"The \u03b2\u2010 N \u2010acetylhexosaminidase gene family in the brown planthopper, Nilaparvata lugens","publication_year":2015,"publication_date":"2015-08-25","ids":{"openalex":"https://openalex.org/W1940407161","doi":"https://doi.org/10.1111/imb.12187","mag":"1940407161","pmid":"https://pubmed.ncbi.nlm.nih.gov/26304035"},"language":"en","primary_location":{"id":"doi:10.1111/imb.12187","doi":"https://doi.org/10.1111/imb.12187","is_oa":false,"landing_page_url":"https://doi.org/10.1111/imb.12187","pdf_url":null,"source":{"id":"https://openalex.org/S137961447","display_name":"Insect Molecular Biology","issn_l":"0962-1075","issn":["0962-1075","1365-2583"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Insect Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101558342","display_name":"Y. Xi","orcid":"https://orcid.org/0000-0002-4971-494X","observed_orcids":["https://orcid.org/0000-0002-4971-494X"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y. Xi","raw_affiliation_strings":["Ministry of Agriculture Key Laboratory of Agricultural Entomology, Institute of Insect Science, Zhejiang University, Hangzhou, China","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Agriculture Key Laboratory of Agricultural Entomology, Institute of Insect Science, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112286345","display_name":"Peng-Lu Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"P.\u2010L. Pan","raw_affiliation_strings":["Ministry of Agriculture Key Laboratory of Agricultural Entomology, Institute of Insect Science, Zhejiang University, Hangzhou, China","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Agriculture Key Laboratory of Agricultural Entomology, Institute of Insect Science, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055500444","display_name":"Chuan\u2010Xi Zhang","orcid":"https://orcid.org/0000-0002-7784-1188","observed_orcids":["https://orcid.org/0000-0002-7784-1188"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"C.\u2010X. Zhang","raw_affiliation_strings":["Ministry of Agriculture Key Laboratory of Agricultural Entomology, Institute of Insect Science, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Agriculture Key Laboratory of Agricultural Entomology, Institute of Insect Science, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5055500444"],"corresponding_institution_ids":["https://openalex.org/I76130692"],"apc_list":{"value":4140,"currency":"USD","value_usd":4140},"apc_paid":null,"fwci":1.3764,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.79314746,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"24","issue":"6","first_page":"601","last_page":"610"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12683","display_name":"Studies on Chitinases and Chitosanases","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12683","display_name":"Studies on Chitinases and Chitosanases","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-n-acetylhexosaminidase","display_name":"beta-N-acetylhexosaminidase","score":0.9900000095367432},{"id":"https://openalex.org/keywords/nilaparvata-lugens","display_name":"Nilaparvata lugens","score":0.9900000095367432},{"id":"https://openalex.org/keywords/gene-family","display_name":"gene family","score":0.7910000085830688},{"id":"https://openalex.org/keywords/chitin-metabolism","display_name":"chitin metabolism","score":0.8270000219345093},{"id":"https://openalex.org/keywords/chitinolytic-enzymes","display_name":"chitinolytic enzymes","score":0.8830000162124634},{"id":"https://openalex.org/keywords/chitinase","display_name":"chitinase","score":0.777999997138977},{"id":"https://openalex.org/keywords/chitin-deacetylase","display_name":"chitin deacetylase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/o-glcnacase","display_name":"O-GlcNAcase","score":0.8330000042915344},{"id":"https://openalex.org/keywords/molting","display_name":"molting","score":0.859000027179718},{"id":"https://openalex.org/keywords/cuticle-shedding","display_name":"cuticle shedding","score":0.9039999842643738},{"id":"https://openalex.org/keywords/nymphal-development","display_name":"nymphal development","score":0.49000000953674316},{"id":"https://openalex.org/keywords/female-reproductive-system","display_name":"female reproductive system","score":0.7039999961853027},{"id":"https://openalex.org/keywords/integument","display_name":"integument","score":0.8619999885559082},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.5389999747276306},{"id":"https://openalex.org/keywords/hemimetabolous-insects","display_name":"hemimetabolous insects","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9261396527290344},{"id":"https://openalex.org/C2776036430","wikidata":"https://www.wikidata.org/wiki/Q3595463","display_name":"Brown planthopper","level":3,"score":0.9235827922821045},{"id":"https://openalex.org/C2780778831","wikidata":"https://www.wikidata.org/wiki/Q424099","display_name":"Chitinase","level":3,"score":0.9058381915092468},{"id":"https://openalex.org/C2781088250","wikidata":"https://www.wikidata.org/wiki/Q161219","display_name":"Chitin","level":3,"score":0.869909942150116},{"id":"https://openalex.org/C41905685","wikidata":"https://www.wikidata.org/wiki/Q381084","display_name":"Moulting","level":3,"score":0.7238147854804993},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5694240927696228},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5685321092605591},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.5552433133125305},{"id":"https://openalex.org/C30055919","wikidata":"https://www.wikidata.org/wiki/Q1566548","display_name":"Cuticle (hair)","level":2,"score":0.5050321221351624},{"id":"https://openalex.org/C2780992308","wikidata":"https://www.wikidata.org/wiki/Q24787583","display_name":"Chitin synthase","level":4,"score":0.47619450092315674},{"id":"https://openalex.org/C85323577","wikidata":"https://www.wikidata.org/wiki/Q258362","display_name":"Nymph","level":2,"score":0.4159732460975647},{"id":"https://openalex.org/C2777516416","wikidata":"https://www.wikidata.org/wiki/Q1570985","display_name":"Planthopper","level":3,"score":0.4152466356754303},{"id":"https://openalex.org/C2191507","wikidata":"https://www.wikidata.org/wiki/Q7277185","display_name":"RNA silencing","level":5,"score":0.41248857975006104},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3728541433811188},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35791152715682983},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3415522575378418},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.3057605028152466},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26302778720855713},{"id":"https://openalex.org/C2778908745","wikidata":"https://www.wikidata.org/wiki/Q26371","display_name":"Hemiptera","level":2,"score":0.09812450408935547},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.07589492201805115},{"id":"https://openalex.org/C173758957","wikidata":"https://www.wikidata.org/wiki/Q129270","display_name":"Larva","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001619","descriptor_name":"beta-N-Acetylhexosaminidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001619","descriptor_name":"beta-N-Acetylhexosaminidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006430","descriptor_name":"Hemiptera","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006430","descriptor_name":"Hemiptera","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006430","descriptor_name":"Hemiptera","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012330","descriptor_name":"RNA, Double-Stranded","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012330","descriptor_name":"RNA, Double-Stranded","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018978","descriptor_name":"Molting","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019476","descriptor_name":"Insect Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019476","descriptor_name":"Insect Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034582","descriptor_name":"Integumentary System","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049750","descriptor_name":"Genome, Insect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/imb.12187","doi":"https://doi.org/10.1111/imb.12187","is_oa":false,"landing_page_url":"https://doi.org/10.1111/imb.12187","pdf_url":null,"source":{"id":"https://openalex.org/S137961447","display_name":"Insect Molecular Biology","issn_l":"0962-1075","issn":["0962-1075","1365-2583"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Insect Molecular Biology","raw_type":"journal-article"},{"id":"pmid:26304035","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26304035","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Insect molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3192993790","display_name":null,"funder_award_id":"31471765","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7743748891","display_name":null,"funder_award_id":"2010CB126205","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W103430187","https://openalex.org/W1483214151","https://openalex.org/W1502842407","https://openalex.org/W1718799863","https://openalex.org/W1883383070","https://openalex.org/W1933947420","https://openalex.org/W1980469442","https://openalex.org/W1981852894","https://openalex.org/W2005694873","https://openalex.org/W2007173081","https://openalex.org/W2043192037","https://openalex.org/W2060313551","https://openalex.org/W2064745493","https://openalex.org/W2065902289","https://openalex.org/W2073305407","https://openalex.org/W2078694471","https://openalex.org/W2095734084","https://openalex.org/W2097559365","https://openalex.org/W2099410592","https://openalex.org/W2102389229","https://openalex.org/W2107277218","https://openalex.org/W2109293107","https://openalex.org/W2110899053","https://openalex.org/W2128443399","https://openalex.org/W2137015675","https://openalex.org/W2142117414","https://openalex.org/W2144347789","https://openalex.org/W2144674265","https://openalex.org/W2155752459","https://openalex.org/W2170438129","https://openalex.org/W2322259245"],"related_works":["https://openalex.org/W1718799863","https://openalex.org/W1502842407","https://openalex.org/W2007173081","https://openalex.org/W4404609840","https://openalex.org/W2099410592","https://openalex.org/W2475217384","https://openalex.org/W2155752459","https://openalex.org/W4221026554","https://openalex.org/W4241962527","https://openalex.org/W4405494265"],"abstract_inverted_index":{"\u03b2-N-Acetylhexosaminidases":[0],"(HEXs)":[1],"are":[2,11,189],"enzymes":[3,176],"that":[4,10,61,64,81],"can":[5],"degrade":[6],"the":[7,14,66,72,90,107,115,124,129,155,203],"chitin":[8,19,187,200,218],"oligosaccharides":[9],"produced":[12],"by":[13,211],"activity":[15],"of":[16,65,71,74,94,174,199],"chitinases":[17],"on":[18,26,160],"in":[20,35,106,114,128,149,179,193,202],"insects.":[21],"Using":[22],"bioinformatic":[23],"methods":[24],"based":[25],"genome":[27],"and":[28,40,138,163,185,220],"transcriptome":[29],"databases,":[30],"11":[31],"\u03b2-N-acetylhexosaminidase":[32],"genes":[33],"(NlHexs)":[34],"Nilaparvata":[36],"lugens":[37],"were":[38,97,147],"identified":[39],"characterized.":[41],"Phylogenetic":[42],"analysis":[43],"revealed":[44,80],"a":[45,58,167],"six-grouped":[46],"tree":[47],"topology.":[48],"The":[49],"O-Linked":[50],"N-acetylglucosaminidase":[51],"(O-GlcNAcase)":[52],"group":[53],"includes":[54],"NlHex11,":[55],"which":[56,180],"harbours":[57],"catalytic":[59],"domain":[60],"differs":[62],"from":[63],"other":[67,156],"10":[68,157],"NlHexs.":[69,158],"Observations":[70],"expression":[73,92],"NlHexs":[75,96],"during":[76,87],"different":[77],"developmental":[78],"stages":[79],"NlHex4":[82,99],"is":[83,177],"expressed":[84,104],"with":[85,132,152],"periodicity":[86],"moulting.":[88],"Although":[89],"tissue-specific":[91],"patterns":[93],"most":[95],"nonspecific,":[98],"was":[100],"found":[101,148],"to":[102,122],"be":[103,209],"mainly":[105],"female":[108],"reproductive":[109],"system":[110],"as":[111,113],"well":[112],"integument.":[116],"RNA":[117,134],"interference":[118],"(RNAi)":[119],"demonstrated":[120],"failure":[121],"shed":[123],"old":[125],"cuticle":[126],"only":[127],"nymphs":[130,140],"treated":[131,151],"double-stranded":[133],"(dsRNA)":[135],"targeting":[136,154],"NlHex4,":[137],"these":[139],"eventually":[141],"died;":[142],"no":[143],"observable":[144],"morphological":[145],"abnormalities":[146],"insects":[150],"dsRNAs":[153],"Based":[159],"this":[161],"study":[162],"our":[164],"previous":[165],"analyses,":[166],"'5":[168],"+":[169,171],"1":[170],"3'":[172],"pattern":[173],"chitinolytic":[175,214],"proposed,":[178],"five":[181],"chitinases,":[182],"one":[183],"NlHEX":[184],"three":[186,213],"deacetylases":[188],"required":[190],"for":[191],"moulting":[192],"N.":[194,206],"lugens.":[195],"A":[196],"better":[197],"understanding":[198],"metabolism":[201],"hemimetabolous":[204],"insect,":[205],"lugens,":[207],"would":[208],"achieved":[210],"considering":[212],"enzyme":[215],"families:":[216],"chitinase,":[217],"deacetylase":[219],"\u03b2-N-acetylhexosaminidase.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}