{"id":"https://openalex.org/W1940356016","doi":"https://doi.org/10.1002/bdra.23371","title":"Placenta previa and risk of major congenital malformations among singleton births in Finland","display_name":"Placenta previa and risk of major congenital malformations among singleton births in Finland","publication_year":2015,"publication_date":"2015-03-24","ids":{"openalex":"https://openalex.org/W1940356016","doi":"https://doi.org/10.1002/bdra.23371","mag":"1940356016","pmid":"https://pubmed.ncbi.nlm.nih.gov/25808834"},"language":"en","primary_location":{"id":"doi:10.1002/bdra.23371","doi":"https://doi.org/10.1002/bdra.23371","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bdra.23371","pdf_url":null,"source":{"id":"https://openalex.org/S4394736882","display_name":"Birth Defects Research Part A Clinical and Molecular Teratology","issn_l":"1542-0752","issn":["1542-0752","1542-0760"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","poland-70"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth Defects Research Part A: Clinical and Molecular Teratology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062119948","display_name":"Vijaya Kancherla","orcid":"https://orcid.org/0000-0002-2803-8030","observed_orcids":["https://orcid.org/0000-0002-2803-8030"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vijaya Kancherla","raw_affiliation_strings":["Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073350415","display_name":"Sari R\u00e4is\u00e4nen","orcid":"https://orcid.org/0000-0002-2899-5885","observed_orcids":["https://orcid.org/0000-0002-2899-5885"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI","US"],"is_corresponding":false,"raw_author_name":"Sari R\u00e4is\u00e4nen","raw_affiliation_strings":["Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia","Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland","institution_ids":["https://openalex.org/I4210092991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044713639","display_name":"Mika Gissler","orcid":"https://orcid.org/0000-0001-8254-7525","observed_orcids":["https://orcid.org/0000-0001-8254-7525"]},"institutions":[{"id":"https://openalex.org/I39624965","display_name":"Finnish Institute for Health and Welfare","ror":"https://ror.org/03tf0c761","country_code":"FI","type":"funder","lineage":["https://openalex.org/I39624965"]},{"id":"https://openalex.org/I4210158614","display_name":"Nordic School of Public Health","ror":"https://ror.org/03gfs5c49","country_code":"SE","type":"education","lineage":["https://openalex.org/I4210158614"]}],"countries":["FI","SE"],"is_corresponding":false,"raw_author_name":"Mika Gissler","raw_affiliation_strings":["National Institute for Health and Welfare, Helsinki, Finland","Nordic School of Public Health, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Health and Welfare, Helsinki, Finland","institution_ids":["https://openalex.org/I39624965"]},{"raw_affiliation_string":"Nordic School of Public Health, Gothenburg, Sweden","institution_ids":["https://openalex.org/I4210158614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073716770","display_name":"Michael R. Kramer","orcid":"https://orcid.org/0000-0002-6372-6170","observed_orcids":["https://orcid.org/0000-0002-6372-6170"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Kramer","raw_affiliation_strings":["Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067068110","display_name":"Seppo T Heinonen","orcid":"https://orcid.org/0000-0001-5949-0874","observed_orcids":["https://orcid.org/0000-0001-5949-0874"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Seppo Heinonen","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland","School of Medicine, University of Eastern Finland, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland","institution_ids":["https://openalex.org/I4210092991"]},{"raw_affiliation_string":"School of Medicine, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5062119948"],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":null,"apc_paid":null,"fwci":2.3199,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.87594229,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"103","issue":"6","first_page":"527","last_page":"535"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11389","display_name":"Maternal and fetal healthcare","score":0.5967000126838684,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11389","display_name":"Maternal and fetal healthcare","score":0.5967000126838684,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12716","display_name":"Congenital Anomalies and Fetal Surgery","score":0.19900000095367432,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.04610000178217888,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/placenta-previa","display_name":"placenta previa","score":1.0},{"id":"https://openalex.org/keywords/major-congenital-anomalies","display_name":"major congenital malformations","score":0.9900000095367432},{"id":"https://openalex.org/keywords/singleton-births","display_name":"singleton births","score":0.9089999794960022},{"id":"https://openalex.org/keywords/congenital-malformations","display_name":"congenital malformations","score":0.5709999799728394},{"id":"https://openalex.org/keywords/pregnancy-risk-factors","display_name":"pregnancy risk factors","score":0.5490000247955322},{"id":"https://openalex.org/keywords/maternal-risk-factors","display_name":"maternal risk factors","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C2780081364","wikidata":"https://www.wikidata.org/wiki/Q1471410","display_name":"Placenta previa","level":5,"score":0.7872836589813232},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7843953371047974},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.7495703101158142},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.6912722587585449},{"id":"https://openalex.org/C117354338","wikidata":"https://www.wikidata.org/wiki/Q1165112","display_name":"Singleton","level":3,"score":0.5508766174316406},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.54579097032547},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4726490080356598},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4611198604106903},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3221243619918823},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.28403618931770325},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.24609482288360596},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0848088264465332},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05261734127998352},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000013","descriptor_name":"Congenital Abnormalities","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D000013","descriptor_name":"Congenital Abnormalities","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005387","descriptor_name":"Finland","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010923","descriptor_name":"Placenta Previa","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/bdra.23371","doi":"https://doi.org/10.1002/bdra.23371","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bdra.23371","pdf_url":null,"source":{"id":"https://openalex.org/S4394736882","display_name":"Birth Defects Research Part A Clinical and Molecular Teratology","issn_l":"1542-0752","issn":["1542-0752","1542-0760"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","poland-70"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth Defects Research Part A: Clinical and Molecular Teratology","raw_type":"journal-article"},{"id":"pmid:25808834","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25808834","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth defects research. Part A, Clinical and molecular teratology","raw_type":"Journal Article"},{"id":"pmh:oai:www.julkari.fi:10024/126581","doi":null,"is_oa":false,"landing_page_url":"http://www.julkari.fi/handle/10024/126581","pdf_url":null,"source":{"id":"https://openalex.org/S4306402058","display_name":"STM:n Hallinnonalan avoin julkaisuarkisto (Julkari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"WOS","raw_type":"A1"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320338281","display_name":"Army Research Office","ror":"https://ror.org/05epdh915"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W88411413","https://openalex.org/W1484178558","https://openalex.org/W1496748876","https://openalex.org/W1974194014","https://openalex.org/W1984048906","https://openalex.org/W1986616058","https://openalex.org/W1990295768","https://openalex.org/W1992227515","https://openalex.org/W2004505189","https://openalex.org/W2009862623","https://openalex.org/W2022852817","https://openalex.org/W2023295469","https://openalex.org/W2042693486","https://openalex.org/W2045298552","https://openalex.org/W2049586453","https://openalex.org/W2066411676","https://openalex.org/W2072761082","https://openalex.org/W2082023230","https://openalex.org/W2086238864","https://openalex.org/W2108753396","https://openalex.org/W2116689176","https://openalex.org/W2118652265","https://openalex.org/W2123592832","https://openalex.org/W2127495068","https://openalex.org/W2133512728","https://openalex.org/W2139934338","https://openalex.org/W2155741281","https://openalex.org/W2159904075","https://openalex.org/W2165291010","https://openalex.org/W2409677590","https://openalex.org/W2416848293","https://openalex.org/W4240685485"],"related_works":["https://openalex.org/W3013579171","https://openalex.org/W4389153601","https://openalex.org/W2072761082","https://openalex.org/W4385776736","https://openalex.org/W6920991217","https://openalex.org/W2024471054","https://openalex.org/W4391068258","https://openalex.org/W2108753396","https://openalex.org/W2135141611","https://openalex.org/W1990295768"],"abstract_inverted_index":{"BACKGROUND:":[0],"Placenta":[1,159],"previa":[2,24,119,140,160,220,245],"has":[3],"been":[4],"associated":[5,163,225],"with":[6,13,89,96,138,145,151,164,226],"adverse":[7],"birth":[8],"outcomes,":[9],"but":[10,223],"its":[11],"association":[12,21,95,242],"congenital":[14,27,98,148,171,232,250],"malformations":[15,28,172,233],"is":[16],"inconclusive.":[17],"We":[18,35,59,100],"examined":[19,81],"the":[20,65,70,75,174,241],"between":[22,243],"placenta":[23,92,118,139,219,244],"and":[25,74,80,84,90,105,197,246],"major":[26,97,147,170,231],"among":[29,87],"singleton":[30,126,143,235],"births":[31,127],"in":[32,53,94,128,173,234,253],"Finland.":[33],"METHODS:":[34],"performed":[36],"a":[37,142,146,212],"retrospective":[38],"population":[39],"register-based":[40],"study":[41],"on":[42],"all":[43],"singletons":[44],"born":[45],"at":[46],"or":[47],"after":[48,176],"22+0":[49],"weeks":[50],"of":[51,77,117,136,153,169,230,249],"gestation":[52],"Finland":[54,129],"during":[55],"2000":[56],"to":[57],"2010.":[58],"linked":[60],"three":[61],"national":[62],"health":[63],"registers:":[64],"Finnish":[66],"Medical":[67],"Birth":[68],"Register,":[69,73],"Hospital":[71],"Discharge":[72],"Register":[76],"Congenital":[78],"Malformations,":[79],"several":[82],"demographic":[83],"clinical":[85],"characteristics":[86],"women":[88,137,155],"without":[91],"previa,":[93],"malformations.":[99],"estimated":[101,121],"adjusted":[102],"odds":[103,202],"ratios":[104],"95%":[106,206],"confidence":[107,131,207],"intervals":[108],"using":[109],"multivariable":[110],"logistic":[111],"regression":[112],"models.":[113],"RESULTS:":[114],"The":[115],"prevalence":[116],"was":[120,161,221],"as":[122],"2.65":[123],"per":[124],"1000":[125],"(95%":[130],"interval,":[132,208],"2.53-2.79).":[133],"Overall,":[134],"6.2%":[135],"delivered":[141],"infant":[144],"malformation,":[149],"compared":[150],"3.8%":[152],"unaffected":[154],"(p":[156],"\u2264":[157],"0.001).":[158],"positively":[162],"almost":[165],"1.6-fold":[166],"increased":[167,228],"risk":[168,229],"offspring,":[175],"controlling":[177],"for":[178],"maternal":[179],"age,":[180],"parity,":[181],"fetal":[182],"sex,":[183],"smoking,":[184],"socio-economic":[185],"status,":[186],"chorionic":[187],"villus":[188],"biopsy,":[189],"In":[190],"vitro":[191],"fertilization,":[192],"pre-existing":[193],"diabetes,":[194],"depression,":[195],"preeclampsia,":[196],"prior":[198],"caesarean":[199],"section":[200],"(adjusted":[201],"ratio":[203],"=":[204],"1.55;":[205],"1.27-1.90).":[209],"CONCLUSION:":[210],"Using":[211],"large":[213],"population-based":[214],"study,":[215],"we":[216],"found":[217],"that":[218],"weakly,":[222],"significantly":[224],"an":[227],"births.":[236],"Future":[237],"studies":[238],"should":[239],"examine":[240],"individual":[247],"types":[248],"malformations,":[251],"specifically":[252],"high-risk":[254],"pregnancies.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}