{"id":"https://openalex.org/W1939700045","doi":"https://doi.org/10.1016/j.mod.2005.06.010","title":"Ablation of beta 1 integrin, focal adhesion kinase and integrin linked kinase in mammary epithelium reveals a critical role for integrin in glandular morphogenesis and differentiation [Abstract]","display_name":"Ablation of beta 1 integrin, focal adhesion kinase and integrin linked kinase in mammary epithelium reveals a critical role for integrin in glandular morphogenesis and differentiation [Abstract]","publication_year":2005,"publication_date":"2005-09-01","ids":{"openalex":"https://openalex.org/W1939700045","doi":"https://doi.org/10.1016/j.mod.2005.06.010","mag":"1939700045"},"language":"en","primary_location":{"id":"pmh:oai:https://orca.cardiff.ac.uk:61080","doi":"https://doi.org/10.1016/j.mod.2005.06.010","is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/61080/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066880553","display_name":"Matthew J. Naylor","orcid":"https://orcid.org/0000-0002-3549-3189","observed_orcids":["https://orcid.org/0000-0002-3549-3189"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naylor, M. J.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016526191","display_name":"N. Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li, N.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113537378","display_name":"Julia Cheung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cheung, J.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082136451","display_name":"Emma T. Lowe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lowe, E. T.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075152761","display_name":"Elise Lambert","orcid":"https://orcid.org/0000-0003-1192-0112","observed_orcids":["https://orcid.org/0000-0003-1192-0112"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lambert, E.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100704032","display_name":"Pengbo Wang","orcid":"https://orcid.org/0000-0003-1940-0269","observed_orcids":["https://orcid.org/0000-0003-1940-0269"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wang, P.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019992879","display_name":"Rebecca Marlow","orcid":"https://orcid.org/0000-0001-7525-7968","observed_orcids":["https://orcid.org/0000-0001-7525-7968"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marlow, R.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036577864","display_name":"Franziska Schatzmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Schatzmann, F.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071137290","display_name":"Tim M Wintermantel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wintermantel, T.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063821100","display_name":"G. Schueetz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Schueetz, G.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001013132","display_name":"Alan Richard Clarke","orcid":"https://orcid.org/0000-0002-4281-426X","observed_orcids":["https://orcid.org/0000-0002-4281-426X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clarke, Alan Richard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026004030","display_name":"Shoukat Dedhar","orcid":"https://orcid.org/0000-0003-4355-1657","observed_orcids":["https://orcid.org/0000-0003-4355-1657"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dedhar, S.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014593722","display_name":"Seth G. N. Grant","orcid":"https://orcid.org/0000-0001-8732-8735","observed_orcids":["https://orcid.org/0000-0001-8732-8735"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Grant, S. G. N.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101732294","display_name":"Ulrich W. Mueller","orcid":"https://orcid.org/0000-0003-2736-6494","observed_orcids":["https://orcid.org/0000-0003-2736-6494"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mueller, U.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023604575","display_name":"Nancy E. Hynes","orcid":"https://orcid.org/0000-0001-8802-2316","observed_orcids":["https://orcid.org/0000-0001-8802-2316"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hynes, N. E.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5022223788","display_name":"Charles H. Streuli","orcid":"https://orcid.org/0000-0001-7173-0172","observed_orcids":["https://orcid.org/0000-0001-7173-0172"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Streuli, C. H.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15875988,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.8920000195503235},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.9860000014305115},{"id":"https://openalex.org/keywords/integrin-linked-kinase","display_name":"integrin-linked kinase","score":0.9380000233650208},{"id":"https://openalex.org/keywords/mammary-gland-development","display_name":"mammary gland development","score":0.9350000023841858},{"id":"https://openalex.org/keywords/alveolarization","display_name":"alveolarization","score":0.8899999856948853},{"id":"https://openalex.org/keywords/mammary-epithelial-differentiation","display_name":"mammary epithelial differentiation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/lactation","display_name":"lactation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/stat5-signaling","display_name":"STAT5 signaling","score":0.6700000166893005},{"id":"https://openalex.org/keywords/prolactin-signaling","display_name":"prolactin signaling","score":0.871999979019165},{"id":"https://openalex.org/keywords/cell-matrix-adhesion","display_name":"cell-matrix adhesion","score":0.781000018119812},{"id":"https://openalex.org/keywords/conditional-gene-deletion","display_name":"conditional gene deletion","score":0.5820000171661377},{"id":"https://openalex.org/keywords/integrin-signaling","display_name":"integrin signaling","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.7817306518554688},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7678632736206055},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.7646622657775879},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7472720742225647},{"id":"https://openalex.org/C66417403","wikidata":"https://www.wikidata.org/wiki/Q20970072","display_name":"Integrin-linked kinase","level":5,"score":0.625367283821106},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.4686766266822815},{"id":"https://openalex.org/C4894155","wikidata":"https://www.wikidata.org/wiki/Q4201950","display_name":"CD49c","level":5,"score":0.4520459473133087},{"id":"https://openalex.org/C119524353","wikidata":"https://www.wikidata.org/wiki/Q5145908","display_name":"Collagen receptor","level":4,"score":0.43949267268180847},{"id":"https://openalex.org/C156585808","wikidata":"https://www.wikidata.org/wiki/Q18028043","display_name":"Integrin, beta 6","level":4,"score":0.4384411871433258},{"id":"https://openalex.org/C171779818","wikidata":"https://www.wikidata.org/wiki/Q3799301","display_name":"Integrin alpha M","level":3,"score":0.4251798093318939},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3713597059249878},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23177111148834229},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2027190923690796},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.16902217268943787},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.15988418459892273},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.05656766891479492},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:https://orca.cardiff.ac.uk:61080","doi":"https://doi.org/10.1016/j.mod.2005.06.010","is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/61080/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2119824668","https://openalex.org/W6950602234","https://openalex.org/W2043869555","https://openalex.org/W4298041761","https://openalex.org/W2128005026","https://openalex.org/W2058961362","https://openalex.org/W176708717","https://openalex.org/W1970069848","https://openalex.org/W2162045495","https://openalex.org/W2172254022"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}