{"id":"https://openalex.org/W1938957","doi":null,"title":"Beh\u00e7et's disease: an update on the pathogenesis.","display_name":"Beh\u00e7et's disease: an update on the pathogenesis.","publication_year":2001,"publication_date":"2001-09-01","ids":{"openalex":"https://openalex.org/W1938957","mag":"1938957","pmid":"https://pubmed.ncbi.nlm.nih.gov/11760403"},"language":"en","primary_location":{"id":"pmid:11760403","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11760403","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Editorial"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003591041","display_name":"Ahmet G\u00fcl","orcid":"https://orcid.org/0000-0001-8219-3720","observed_orcids":["https://orcid.org/0000-0001-8219-3720"]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"A G\u00fcl","raw_affiliation_strings":["Istanbul University#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istanbul University#TAB#","institution_ids":["https://openalex.org/I67581229"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003591041"],"corresponding_institution_ids":["https://openalex.org/I67581229"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":225,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"5  Suppl 24","first_page":"S6","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11571","display_name":"Sarcoidosis and Beryllium Toxicity Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12833","display_name":"Bartonella species infections research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/behcet-s-disease","display_name":"Beh\u00e7et's disease","score":1.0},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/hla-b51","display_name":"HLA-B51","score":0.9750000238418579},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.996999979019165},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.878000020980835},{"id":"https://openalex.org/keywords/th1-response","display_name":"Th1 response","score":0.9179999828338623},{"id":"https://openalex.org/keywords/heat-shock-proteins","display_name":"heat shock proteins","score":0.9150000214576721},{"id":"https://openalex.org/keywords/streptococcal-antigens","display_name":"streptococcal antigens","score":0.9309999942779541},{"id":"https://openalex.org/keywords/endothelial-activation","display_name":"endothelial activation","score":0.9639999866485596},{"id":"https://openalex.org/keywords/occlusive-vasculopathy","display_name":"occlusive vasculopathy","score":0.8859999775886536},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.8475221395492554},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7491210699081421},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7281011939048767},{"id":"https://openalex.org/C2781428731","wikidata":"https://www.wikidata.org/wiki/Q911427","display_name":"Behcet's disease","level":3,"score":0.67083340883255},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6423139572143555},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5579220056533813},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.5401721000671387},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.5138323903083801},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5084985494613647},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.42968690395355225},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3750253915786743},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1853460967540741}],"mesh":[{"descriptor_ui":"D001528","descriptor_name":"Behcet Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001528","descriptor_name":"Behcet Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001528","descriptor_name":"Behcet Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001528","descriptor_name":"Behcet Syndrome","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015235","descriptor_name":"HLA-B Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059949","descriptor_name":"HLA-B51 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11760403","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11760403","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Editorial"},{"id":"mag:1938957","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11760403","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":86,"referenced_works":["https://openalex.org/W108960469","https://openalex.org/W124255977","https://openalex.org/W1481190510","https://openalex.org/W1488930211","https://openalex.org/W1515868425","https://openalex.org/W1538599899","https://openalex.org/W1542129840","https://openalex.org/W1558407083","https://openalex.org/W1560393239","https://openalex.org/W1607249005","https://openalex.org/W1641804620","https://openalex.org/W1918337421","https://openalex.org/W1934694257","https://openalex.org/W1946805217","https://openalex.org/W1963742202","https://openalex.org/W1964444977","https://openalex.org/W1964922876","https://openalex.org/W1965912489","https://openalex.org/W1967947852","https://openalex.org/W1968046203","https://openalex.org/W1972554083","https://openalex.org/W1973695965","https://openalex.org/W1974219952","https://openalex.org/W1976650291","https://openalex.org/W1977598234","https://openalex.org/W1985744441","https://openalex.org/W1988283355","https://openalex.org/W1993424894","https://openalex.org/W1994474925","https://openalex.org/W1997200765","https://openalex.org/W2005189737","https://openalex.org/W2007252255","https://openalex.org/W2010305374","https://openalex.org/W2013181138","https://openalex.org/W2013298309","https://openalex.org/W2018299967","https://openalex.org/W2019140963","https://openalex.org/W2019323646","https://openalex.org/W2024483912","https://openalex.org/W2026403235","https://openalex.org/W2032853995","https://openalex.org/W2037709997","https://openalex.org/W2037998678","https://openalex.org/W2041565231","https://openalex.org/W2042110141","https://openalex.org/W2042678923","https://openalex.org/W2046586434","https://openalex.org/W2048819627","https://openalex.org/W2051141334","https://openalex.org/W2051445818","https://openalex.org/W2054099099","https://openalex.org/W2056204715","https://openalex.org/W2065625888","https://openalex.org/W2066902149","https://openalex.org/W2066976004","https://openalex.org/W2074807009","https://openalex.org/W2082066166","https://openalex.org/W2082255177","https://openalex.org/W2086961513","https://openalex.org/W2088242687","https://openalex.org/W2089330607","https://openalex.org/W2091169894","https://openalex.org/W2094102325","https://openalex.org/W2095991061","https://openalex.org/W2098499600","https://openalex.org/W2107634550","https://openalex.org/W2113598640","https://openalex.org/W2123051792","https://openalex.org/W2126297588","https://openalex.org/W2128412665","https://openalex.org/W2128635872","https://openalex.org/W2130451031","https://openalex.org/W2133658396","https://openalex.org/W2134579230","https://openalex.org/W2135761968","https://openalex.org/W2136354961","https://openalex.org/W2145149919","https://openalex.org/W2151429640","https://openalex.org/W2161288621","https://openalex.org/W2199111714","https://openalex.org/W2322924503","https://openalex.org/W2329206131","https://openalex.org/W2408999328","https://openalex.org/W2417117154","https://openalex.org/W2430550889","https://openalex.org/W2463465627"],"related_works":["https://openalex.org/W2978469686","https://openalex.org/W4233935842","https://openalex.org/W2614940751","https://openalex.org/W2149793107","https://openalex.org/W2944777679","https://openalex.org/W3205823848","https://openalex.org/W652596912","https://openalex.org/W2069860398","https://openalex.org/W2897025066","https://openalex.org/W38091371"],"abstract_inverted_index":{"Beh\u00e7et's":[0,52,65,87,118,162],"disease":[1,88],"is":[2,75,89],"a":[3],"chronic":[4],"inflammatory":[5,115],"disorder":[6],"of":[7,41,49,62,71,100,149,161],"unknown":[8],"etiology.":[9],"It":[10],"has":[11,155],"long":[12],"been":[13,156],"postulated":[14],"that":[15],"immunological":[16],"abnormalities,":[17],"which":[18],"are":[19,29],"possibly":[20],"induced":[21,98,138],"by":[22,139],"microbial":[23,153],"pathogens":[24],"in":[25,31,51,117],"genetically":[26],"susceptible":[27],"individuals,":[28],"important":[30],"its":[32,79],"pathogenesis.":[33],"Recent":[34],"findings":[35],"have":[36,57],"both":[37],"supported":[38],"the":[39,47,59,72,82,113,126,167,175],"significance":[40],"genetic":[42,55,84,127],"factors":[43],"and":[44,78,120,137,166],"better":[45],"defined":[46],"nature":[48],"inflammation":[50],"disease.":[53,66,163],"Molecular":[54],"studies":[56],"strengthened":[58],"primary":[60],"association":[61],"HLA-B51":[63,73],"with":[64,125],"The":[67],"exact":[68],"pathogenic":[69],"mechanism":[70],"molecule":[74],"still":[76],"unknown,":[77],"contribution":[80],"to":[81,86,91,158,174],"overall":[83],"susceptibility":[85],"estimated":[90],"be":[92,123],"less":[93],"than":[94],"20%.":[95],"Spontaneous":[96],"and/or":[97],"overexpression":[99],"pro-inflammatory":[101],"cytokines":[102],"(mainly":[103],"Th1":[104],"type)":[105],"from":[106,146],"various":[107],"cellular":[108],"sources":[109],"seems":[110],"responsible":[111],"for":[112],"enhanced":[114],"reaction":[116],"disease,":[119],"it":[121],"may":[122,171],"associated":[124],"susceptibility.":[128],"An":[129],"antigen-driven":[130],"immune":[131],"response":[132],"superimposed":[133],"on":[134],"this":[135],"primed-state":[136],"heat":[140],"shock":[141],"proteins":[142],"or":[143,151],"other":[144,152],"peptides":[145],"different":[147],"strains":[148],"streptoccocci":[150],"agents":[154],"suggested":[157],"trigger":[159],"manifestations":[160],"Endothelial":[164],"activation/injury":[165],"resultant":[168],"occlusive":[169],"vasculopathy":[170],"also":[172],"contribute":[173],"tissue":[176],"damage.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}