{"id":"https://openalex.org/W1938414558","doi":null,"title":"Lung structure and function in a rat model of emphysema: A longitudinal study","display_name":"Lung structure and function in a rat model of emphysema: A longitudinal study","publication_year":2012,"publication_date":"2012-09-01","ids":{"openalex":"https://openalex.org/W1938414558","mag":"1938414558"},"language":"en","primary_location":{"id":"mag:1938414558","doi":null,"is_oa":false,"landing_page_url":"https://erj.ersjournals.com/content/erj/40/Suppl_56/3308.full.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"European Respiratory Journal","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053867380","display_name":"Margit V. Szabari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Margit V. Szabari","raw_affiliation_strings":["University of Szeged, Department of Medical Physics and Informa, Szeged, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Szeged, Department of Medical Physics and Informa, Szeged, Hungary","institution_ids":["https://openalex.org/I227486990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061385731","display_name":"J\u00f3zsef Tolnai","orcid":"https://orcid.org/0000-0002-7648-764X","observed_orcids":["https://orcid.org/0000-0002-7648-764X"]},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"J\u00f3 zsef Tolnai","raw_affiliation_strings":["University of Szeged, Department of Medical Physics and Informa, Szeged, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Szeged, Department of Medical Physics and Informa, Szeged, Hungary","institution_ids":["https://openalex.org/I227486990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078965063","display_name":"Bal\u00e1zs A. Ma\u00e1r","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Bal\u00e1zs Ma\u00e1r","raw_affiliation_strings":["University of Szeged, Department of Medical Physics and Informa, Szeged, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Szeged, Department of Medical Physics and Informa, Szeged, Hungary","institution_ids":["https://openalex.org/I227486990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056906438","display_name":"Harikrishnan Parameswaran","orcid":"https://orcid.org/0000-0002-5324-5517","observed_orcids":["https://orcid.org/0000-0002-5324-5517"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harikrishnan Parameswaran","raw_affiliation_strings":["Boston University, Biomedical Engineering Department, Boston, MA, United States"],"raw_orcid":"https://orcid.org/0000-0002-5324-5517","affiliations":[{"raw_affiliation_string":"Boston University, Biomedical Engineering Department, Boston, MA, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046278095","display_name":"Erzs\u00e9bet Bartol\u00e1k\u2010Suki","orcid":"https://orcid.org/0000-0003-1007-6394","observed_orcids":["https://orcid.org/0000-0003-1007-6394"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erzs\u00e9bet Bartol\u00e1k\u2010Suki","raw_affiliation_strings":["Boston University, Biomedical Engineering Department, Boston, MA, United States"],"raw_orcid":"https://orcid.org/0000-0003-1007-6394","affiliations":[{"raw_affiliation_string":"Boston University, Biomedical Engineering Department, Boston, MA, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045629242","display_name":"B\u00e9l\u00e2 Suki","orcid":"https://orcid.org/0000-0002-9720-1006","observed_orcids":["https://orcid.org/0000-0002-9720-1006"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B\u00e9l\u00e2 Suki","raw_affiliation_strings":["Boston University, Biomedical Engineering Department, Boston, MA, United States"],"raw_orcid":"https://orcid.org/0000-0002-9720-1006","affiliations":[{"raw_affiliation_string":"Boston University, Biomedical Engineering Department, Boston, MA, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064891839","display_name":"Zolt\u00e1n Hantos","orcid":"https://orcid.org/0000-0002-5696-7750","observed_orcids":["https://orcid.org/0000-0002-5696-7750"]},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Zolt\u00e1n Hantos","raw_affiliation_strings":["University of Szeged, Department of Medical Physics and Informa, Szeged, Hungary"],"raw_orcid":"https://orcid.org/0000-0002-5696-7750","affiliations":[{"raw_affiliation_string":"University of Szeged, Department of Medical Physics and Informa, Szeged, Hungary","institution_ids":["https://openalex.org/I227486990"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10673785,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":null,"first_page":"3308","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/emphysema","display_name":"emphysema","score":0.9819999933242798},{"id":"https://openalex.org/keywords/porcine-pancreatic-elastase","display_name":"porcine pancreatic elastase","score":0.9480000138282776},{"id":"https://openalex.org/keywords/elastase-induced-lung-injury","display_name":"elastase-induced lung injury","score":0.8040000200271606},{"id":"https://openalex.org/keywords/respiratory-impedance","display_name":"respiratory impedance","score":0.7739999890327454},{"id":"https://openalex.org/keywords/tissue-elastance","display_name":"tissue elastance","score":0.9819999933242798},{"id":"https://openalex.org/keywords/elastin","display_name":"elastin","score":0.9150000214576721},{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.9810000061988831},{"id":"https://openalex.org/keywords/proteoglycans","display_name":"proteoglycans","score":0.996999979019165},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.5519999861717224},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C2779869378","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Elastin","level":2,"score":0.8504257202148438},{"id":"https://openalex.org/C2776326425","wikidata":"https://www.wikidata.org/wiki/Q976747","display_name":"Pancreatic elastase","level":4,"score":0.7574796676635742},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7439395785331726},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.6074114441871643},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.5904478430747986},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.5570988059043884},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4905487895011902},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4782794415950775},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.42919477820396423},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.4282695949077606},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.4103925824165344},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.284429669380188},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.2027650773525238},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1131415069103241},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1938414558","doi":null,"is_oa":false,"landing_page_url":"https://erj.ersjournals.com/content/erj/40/Suppl_56/3308.full.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"European Respiratory Journal","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1975207518","https://openalex.org/W2117223781","https://openalex.org/W2047789369","https://openalex.org/W123409649","https://openalex.org/W2136007367","https://openalex.org/W4404407057","https://openalex.org/W2387027089","https://openalex.org/W1515804562","https://openalex.org/W2158025722","https://openalex.org/W1882274097"],"abstract_inverted_index":{"Our":[0],"aim":[1],"was":[2,48,58],"to":[3,86],"evaluate":[4],"the":[5,34,66,103,127,130],"long":[6],"term":[7],"structure-function":[8],"relations":[9],"in":[10,129],"a":[11],"rat":[12],"model":[13],"of":[14,106],"emphysema.":[15],"Rats":[16],"were":[17,68,71,95,99,122],"treated":[18,131],"with":[19,50,75],"porcine":[20],"pancreatic":[21],"elastase":[22],"(50":[23],"UI,":[24],"PPE,":[25],"n=21)":[26],"or":[27],"saline":[28],"(controls,":[29],"C,":[30],"n=19)":[31],"intratracheally.":[32],"Before":[33],"treatment":[35],"(day":[36],"0)":[37],"and":[38,42,54,63,73,77,82,90,102,117],"3,":[39,61],"10,":[40],"21":[41,62],"105":[43,64],"days":[44],"thereafter,":[45],"respiratory":[46],"impedance":[47],"measured":[49],"forced":[51],"oscillation":[52],"technique":[53],"tissue":[55],"elastance":[56],"(H)":[57],"calculated.":[59],"At":[60],"day":[65],"lungs":[67],"fixed,":[69],"sections":[70],"obtained":[72],"stained":[74],"hematoxylin":[76],"eosin,":[78],"modified":[79],"Movat9s,":[80],"Masson9s":[81],"Alcian":[83],"blue":[84],"method":[85],"visualize":[87],"elastin,":[88],"collagen":[89,114],"proteoglycans.":[91],"Randomly":[92],"selected":[93],"regions":[94],"photographed.":[96],"The":[97],"images":[98],"automatically":[100],"segmented":[101],"equivalent":[104],"diameter":[105],"alveolar":[107],"airspaces":[108],"(D),":[109],"mean":[110,113,118],"elastin":[111],"(Me),":[112],"content":[115],"(Mc)":[116],"proteoglycan":[119],"ratio":[120],"(Mp)":[121],"measured.":[123],"H":[124],"decreased":[125],"through":[126],"time-course":[128],"animals":[132],"(p":[133]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}