{"id":"https://openalex.org/W1938186605","doi":null,"title":"Chronic glaucoma selectively damages large optic nerve fibers.","display_name":"Chronic glaucoma selectively damages large optic nerve fibers.","publication_year":1987,"publication_date":"1987-06-01","ids":{"openalex":"https://openalex.org/W1938186605","mag":"1938186605","pmid":"https://pubmed.ncbi.nlm.nih.gov/3583630"},"language":"en","primary_location":{"id":"pmid:3583630","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3583630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042154323","display_name":"Harry A. Quigley","orcid":"https://orcid.org/0000-0003-0095-8756","observed_orcids":["https://orcid.org/0000-0003-0095-8756"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H A Quigley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112812004","display_name":"R M Sanchez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R M Sanchez","raw_affiliation_strings":["Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109028501","display_name":"Gregory R. Dunkelberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G R Dunkelberger","raw_affiliation_strings":["Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113432684","display_name":"N L L'Hernault","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N L L'Hernault","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5069692479","display_name":"T A Baginski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T A Baginski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":15.4251,"has_fulltext":false,"cited_by_count":446,"citation_normalized_percentile":{"value":0.99578329,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"28","issue":"6","first_page":"913","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.9259999990463257},{"id":"https://openalex.org/keywords/optic-nerve-fibers","display_name":"optic nerve fibers","score":0.8379999995231628},{"id":"https://openalex.org/keywords/fiber-diameter","display_name":"fiber diameter","score":0.8309999704360962},{"id":"https://openalex.org/keywords/experimental-glaucoma","display_name":"experimental glaucoma","score":0.7390000224113464},{"id":"https://openalex.org/keywords/optic-disc","display_name":"optic nerve head","score":0.5220000147819519},{"id":"https://openalex.org/keywords/early-glaucoma-diagnosis","display_name":"early glaucoma detection","score":0.7760000228881836},{"id":"https://openalex.org/keywords/monkey-model","display_name":"monkey model","score":0.3700000047683716}],"concepts":[{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.9239370822906494},{"id":"https://openalex.org/C2780837183","wikidata":"https://www.wikidata.org/wiki/Q186029","display_name":"Optic nerve","level":2,"score":0.6979636549949646},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.6753910779953003},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.6394751071929932},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5240371823310852},{"id":"https://openalex.org/C2776823239","wikidata":"https://www.wikidata.org/wiki/Q48834737","display_name":"Nerve fiber","level":2,"score":0.5080528259277344},{"id":"https://openalex.org/C2909429682","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Nerve fibre","level":2,"score":0.5063036680221558},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3380989134311676},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1130506694316864}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008252","descriptor_name":"Macaca fascicularis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009900","descriptor_name":"Optic Nerve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:3583630","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3583630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Comparative Study"},{"id":"mag:1938186605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3583630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1993051562","https://openalex.org/W2032445406","https://openalex.org/W4290252244","https://openalex.org/W1994280517","https://openalex.org/W2116153835","https://openalex.org/W1601103168","https://openalex.org/W51395859","https://openalex.org/W3099921815","https://openalex.org/W2068502177","https://openalex.org/W4247195942"],"abstract_inverted_index":{"To":[0],"determine":[1],"whether":[2],"glaucoma":[3,21,147,190,200],"selectively":[4],"injures":[5],"a":[6,150],"particular":[7],"size":[8,68],"of":[9,26,37,103,105,127,143,153,166],"optic":[10,38,168],"nerve":[11,39,114,169],"fiber":[12,67,75],"(and":[13],"its":[14,48],"cell":[15],"body),":[16],"we":[17],"induced":[18],"chronic":[19],"experimental":[20,146],"in":[22,62,108,118,145,164,189,196],"one":[23],"eye":[24,46],"each":[25,44],"ten":[27,89],"monkeys.":[28],"With":[29],"automated":[30],"image":[31],"analysis,":[32],"the":[33,55,86,109,167],"number":[34],"and":[35,47,111],"diameter":[36,58,76,155],"fibers":[40,104,129,144,159,185],"were":[41,160],"compared":[42],"between":[43],"glaucomatous":[45,63,78],"normal":[49,56],"fellow":[50,90],"eye.":[51],"Fibers":[52],"larger":[53,128,154,158],"than":[54,85,96],"mean":[57,74,87],"atrophied":[59],"more":[60,124],"rapidly":[61],"eyes,":[64,91],"though":[65],"no":[66],"was":[69,80,99],"spared":[70],"from":[71,133],"damage.":[72,201],"The":[73,123,136,181],"for":[77,88,183,193,198],"eyes":[79,120],"0.74":[81],"micron,":[82],"significantly":[83],"lower":[84],"0.85":[92],"micron":[93],"(P":[94],"less":[95],"0.005).":[97],"There":[98],"preferentially":[100,162],"greater":[101],"atrophy":[102,126],"all":[106],"sizes":[107],"superior":[110],"inferior":[112],"peripheral":[113],"sectors,":[115],"as":[116],"seen":[117],"human":[119],"with":[121,170],"glaucoma.":[122,180],"rapid":[125,141],"appeared":[130],"to":[131,177,186],"result":[132],"two":[134],"causes.":[135],"areas":[137,165],"that":[138],"suffer":[139],"most":[140],"loss":[142],"normally":[148],"contain":[149],"high":[151],"proportion":[152],"fibers.":[156],"Furthermore,":[157],"lost":[161,188],"even":[163],"mild":[171],"damage,":[172],"indicating":[173],"their":[174],"inherent":[175],"susceptibility":[176],"injury":[178],"by":[179],"tendency":[182],"large":[184],"be":[187],"has":[191],"implications":[192],"future":[194],"improvements":[195],"testing":[197],"early":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}